CCNJL

Summary

CCNJL (cyclin J like, HGNC:25876) is a protein-coding gene on chromosome 5q33.3, encoding Cyclin-J-like protein (Q8IV13).

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus.

Source: NCBI Gene 79616 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 77 total
• GTEx eGene: eQTL in 20 tissues, sQTL in 3 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.26 (unconstrained)
• MANE Select transcript: NM_001308173
• Notable: 77 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25876
Approved symbol	CCNJL
Name	cyclin J like
Location	5q33.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14166
Ensembl gene	ENSG00000135083
Ensembl biotype	protein_coding
Entrez	79616

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 13 protein_coding, 8 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined

MANE Select: ENST00000257536

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 2: 3, TSL 3: 2, TSL 4: 1

ENST00000257536, ENST00000377503, ENST00000393977, ENST00000518764, ENST00000519673, ENST00000520748, ENST00000521643, ENST00000643539, ENST00000643836, ENST00000644313, ENST00000644926, ENST00000870722, ENST00000870723, ENST00000870724, ENST00000917493, ENST00000917494, ENST00000978784, ENST00001046146, ENST00001046147, ENST00001076170, ENST00001076171, ENST00001076172, ENST00001107320, ENST00001136386

RefSeq mRNA: 2 — MANE Select: NM_001308173 NM_001308173, NM_024565

CCDS: CCDS4350, CCDS78082

Canonical transcript exons

ENST00000257536 — 6 exons

Exon	Start	End
ENSE00003559236	160255549	160255708
ENSE00003576798	160259469	160259771
ENSE00003632363	160311858	160311972
ENSE00003638862	160280525	160280738
ENSE00003900014	160312364	160312564
ENSE00003901787	160249083	160253798

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 88.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2053 / max 280.9875, expressed in 997 samples.

Highest expression (Bgee): blood, cerebellar hemisphere, cerebellar cortex, male germ line stem cell (sensu Vertebrata) in testis, hemisphere of cerebellum.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CCNJL is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 20 tissues and its splicing (sQTL) in 3 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 23 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Minor Salivary Gland	eqtl	4.5e-09	-0.55	5:160341624:G:A
Whole Blood	sqtl	1.7e-08	+0.81	5:160276387:C:T
Colon Transverse	eqtl	5.0e-06	+0.17	5:160280041:T:G
Small Intestine Terminal Ileum	eqtl	1.1e-05	+0.31	5:160282112:T:C
Esophagus Muscularis	eqtl	3.1e-05	+0.88	5:160273992:C:T
Brain Caudate basal ganglia	eqtl	4.5e-05	-0.56	5:160310402:A:T
Heart Atrial Appendage	eqtl	8.3e-05	+0.88	5:161086653:C:T
Artery Aorta	eqtl	1.7e-04	+0.20	5:160334584:AG:A
Artery Tibial	sqtl	4.8e-04	-0.24	5:160351752:C:T
Heart Left Ventricle	eqtl	6.4e-04	-0.32	5:160314383:C:T
Spleen	eqtl	1.3e-03	-0.35	5:160223607:G:A
Thyroid	eqtl	1.5e-03	+0.20	5:160260945:A:G
Whole Blood	eqtl	1.6e-03	-0.14	5:160298293:G:A
Esophagus Gastroesophageal Junction	eqtl	3.4e-03	+0.63	5:159969087:C:T
Adipose Visceral Omentum	eqtl	9.7e-03	-0.26	5:160308005:T:G
Nerve Tibial	sqtl	1.3e-02	+0.22	5:160341624:G:A
Artery Tibial	eqtl	2.5e-02	-0.15	5:160356833:G:A
Nerve Tibial	eqtl	2.9e-02	-0.15	5:160309404:T:C
Ovary	eqtl	3.3e-02	+1.18	5:159579418:G:T
Artery Coronary	eqtl	3.6e-02	-0.67	5:161070467:G:C

FANTOM5 promoters

7 alternative TSS:

Promoter ID	TPM avg	Samples expressed
64623	3.5404	944
64624	0.2306	40
64622	0.2158	85
64621	0.1108	27
64619	0.0431	12
64620	0.0365	9
64625	0.0280	5

Top tissues by expression

showing 100 of 282 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	88.31	gold quality
cerebellar hemisphere	UBERON:0002245	87.33	gold quality
cerebellar cortex	UBERON:0002129	87.28	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.50	gold quality
cerebellum	UBERON:0002037	85.83	gold quality
mucosa of transverse colon	UBERON:0004991	85.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.63	gold quality
right testis	UBERON:0004534	77.48	gold quality
upper lobe of left lung	UBERON:0008952	77.14	gold quality
left testis	UBERON:0004533	77.10	gold quality
testis	UBERON:0000473	77.04	gold quality
ventricular zone	UBERON:0003053	76.84	gold quality
apex of heart	UBERON:0002098	76.29	gold quality
upper lobe of lung	UBERON:0008948	75.88	gold quality
transverse colon	UBERON:0001157	75.42	gold quality
rectum	UBERON:0001052	75.31	gold quality
ganglionic eminence	UBERON:0004023	75.30	gold quality
body of stomach	UBERON:0001161	75.06	gold quality
granulocyte	CL:0000094	74.15	gold quality
heart left ventricle	UBERON:0002084	73.47	gold quality
cardiac ventricle	UBERON:0002082	72.96	gold quality
cerebellar vermis	UBERON:0004720	72.96	silver quality
spleen	UBERON:0002106	72.43	gold quality
stomach	UBERON:0000945	72.28	gold quality
right ovary	UBERON:0002118	72.27	gold quality
right lung	UBERON:0002167	71.63	gold quality
tendon of biceps brachii	UBERON:0008188	71.21	silver quality
left adrenal gland	UBERON:0001234	71.12	gold quality
left ovary	UBERON:0002119	71.01	gold quality
metanephros cortex	UBERON:0010533	71.00	gold quality
right adrenal gland	UBERON:0001233	70.91	gold quality
left adrenal gland cortex	UBERON:0035825	70.87	gold quality
right atrium auricular region	UBERON:0006631	70.85	gold quality
right adrenal gland cortex	UBERON:0035827	70.76	gold quality
embryo	UBERON:0000922	70.30	gold quality
right lobe of thyroid gland	UBERON:0001119	70.16	gold quality
left lobe of thyroid gland	UBERON:0001120	70.13	gold quality
parotid gland	UBERON:0001831	69.84	gold quality
heart	UBERON:0000948	69.78	gold quality
ovary	UBERON:0000992	69.76	gold quality
lung	UBERON:0002048	69.68	gold quality
adenohypophysis	UBERON:0002196	69.53	gold quality
thyroid gland	UBERON:0002046	69.47	gold quality
cardiac atrium	UBERON:0002081	69.22	gold quality
adrenal cortex	UBERON:0001235	68.97	gold quality
adrenal gland	UBERON:0002369	68.61	gold quality
periodontal ligament	UBERON:0008266	68.24	gold quality
leukocyte	CL:0000738	67.87	gold quality
colon	UBERON:0001155	67.46	gold quality
large intestine	UBERON:0000059	67.35	gold quality
saliva-secreting gland	UBERON:0001044	67.35	gold quality
olfactory bulb	UBERON:0002264	67.31	gold quality
intestine	UBERON:0000160	66.89	gold quality
monocyte	CL:0000576	66.85	gold quality
minor salivary gland	UBERON:0001830	66.84	gold quality
mononuclear cell	CL:0000842	66.69	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.62	gold quality
descending thoracic aorta	UBERON:0002345	66.16	gold quality
endocervix	UBERON:0000458	66.12	gold quality
pituitary gland	UBERON:0000007	66.05	gold quality
colonic epithelium	UBERON:0000397	65.94	silver quality
small intestine	UBERON:0002108	65.47	gold quality
right coronary artery	UBERON:0001625	65.23	gold quality
pancreatic ductal cell	CL:0002079	65.01	silver quality
mouth mucosa	UBERON:0003729	64.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.73	gold quality
fundus of stomach	UBERON:0001160	64.59	gold quality
buccal mucosa cell	CL:0002336	64.41	gold quality
ascending aorta	UBERON:0001496	64.23	gold quality
thoracic aorta	UBERON:0001515	64.11	gold quality
islet of Langerhans	UBERON:0000006	63.34	gold quality
vermiform appendix	UBERON:0001154	63.32	gold quality
smooth muscle tissue	UBERON:0001135	63.10	gold quality
colonic mucosa	UBERON:0000317	62.97	gold quality
adult mammalian kidney	UBERON:0000082	62.88	gold quality
bone marrow	UBERON:0002371	62.88	gold quality
left uterine tube	UBERON:0001303	62.84	gold quality
tonsil	UBERON:0002372	62.83	gold quality
ectocervix	UBERON:0012249	62.54	gold quality
medial globus pallidus	UBERON:0002477	62.47	silver quality
cingulate cortex	UBERON:0003027	62.09	gold quality
anterior cingulate cortex	UBERON:0009835	62.09	gold quality
anatomical system	UBERON:0000467	62.04	gold quality
urinary bladder	UBERON:0001255	61.89	gold quality
caecum	UBERON:0001153	61.85	gold quality
multicellular organism	UBERON:0000468	61.74	gold quality
material anatomical entity	UBERON:0000465	61.73	gold quality
right frontal lobe	UBERON:0002810	61.71	gold quality
aorta	UBERON:0000947	61.69	gold quality
prefrontal cortex	UBERON:0000451	61.26	gold quality
stromal cell of endometrium	CL:0002255	61.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.10	gold quality
brain	UBERON:0000955	60.99	gold quality
cortical plate	UBERON:0005343	60.74	gold quality
gall bladder	UBERON:0002110	60.55	gold quality
heart right ventricle	UBERON:0002080	60.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.11	gold quality
Ammon’s horn	UBERON:0001954	60.10	gold quality
mucosa of sigmoid colon	UBERON:0004993	60.10	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.05
E-MTAB-7303	no	243.89

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 80 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Hippocampus	tissue	7.3	low
Testis	tissue	6.7	medium
Cerebellum	tissue	6.6	low
Colon	tissue	5.7	medium
Rectum	tissue	5.2	medium
Lung	tissue	4.7	low
Salivary gland	tissue	4.4	low
Spleen	tissue	3.5	not detected
Locus coeruleus	tissue	3.5
Heart muscle	tissue	2.9	medium
Urinary bladder	tissue	2.9	medium
Stomach 1	tissue	2.8	medium
Ovary	tissue	2.8	not detected
Hippocampal formation	tissue	2.7
Choroid plexus	tissue	2.5
Thyroid gland	tissue	2.5	medium
Pituitary gland	tissue	2.3
Tongue	tissue	2.3
Thymus	tissue	2.3
Caudate putamen	tissue	2.2
Frontal cortex	tissue	1.9
Cerebral cortex	tissue	1.8	medium
Amygdala	tissue	1.8
Nucleus accumbens	tissue	1.8
Temporal cortex	tissue	1.8
Spinal cord	tissue	1.6
Adrenal gland	tissue	1.6	low
Postcentral gyrus	tissue	1.6
Insular cortex	tissue	1.6
Motor cortex	tissue	1.5
Medulla oblongata	tissue	1.5
Cervix	tissue	1.4	medium
Prefrontal cortex	tissue	1.4
Basal ganglia	tissue	1.4	low
Superior colliculi	tissue	1.4
Small intestine	tissue	1.4	medium
Entorhinal cortex	tissue	1.4
Retrosplenial and cingulate cortex	tissue	1.4
Periaqueductal gray	tissue	1.4
Somatosensory cortex	tissue	1.4
Retrosplenial cortex	tissue	1.4
Appendix	tissue	1.4	not detected
Kidney	tissue	1.3	low
Ventral forebrain	tissue	1.3
Retina	tissue	1.2
Pons	tissue	1.2
Midbrain	tissue	1.2
Thalamus	tissue	1.2
Duodenum	tissue	1.2	medium
Bone marrow	tissue	1.2	not detected
Septum	tissue	1.2
Occipital cortex	tissue	1.2
Seminal vesicle	tissue	1.1	low
Putamen	tissue	1.1
Hypothalamus	tissue	1.1
Substantia nigra	tissue	1.1
Vagina	tissue	0.9	medium
Tonsil	tissue	0.9	low
Olfactory bulb	tissue	0.9
Placenta	tissue	0.8	low

Brain sub-regions (HPA Brain Atlas): detected in 192; highest nTPM — Flocculonodular lobe (38.9), Cerebellar cortex (35.4), Vermis (34.7), Dentate gyrus (9.5), Hippocampus, CA1 (8.5).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting CCNJL by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 62 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-23A-5P	99.94	65.39	468
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690

Functional genomics

gnomAD constraint: pLI 2.58e-11, LOEUF 1.26, missense Z 0.00976 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000257536 — one region, missense o/e 1.02.

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	ccnjl	ENSDARG00000077116
mus_musculus	Ccnjl	ENSMUSG00000044707
rattus_norvegicus	Ccnjl	ENSRNOG00000003893
drosophila_melanogaster	CycB	FBGN0000405
drosophila_melanogaster	CycD	FBGN0010315
drosophila_melanogaster	CycE	FBGN0010382
caenorhabditis_elegans		WBGENE00000865
caenorhabditis_elegans		WBGENE00000866
caenorhabditis_elegans	cyb-2.2	WBGENE00000867
caenorhabditis_elegans		WBGENE00000870
caenorhabditis_elegans	cye-1	WBGENE00000871

Paralogs (18): CCNE1 (ENSG00000105173), CCNP (ENSG00000105219), CCNJ (ENSG00000107443), CCND1 (ENSG00000110092), CCND3 (ENSG00000112576), CCNG1 (ENSG00000113328), CCNI (ENSG00000118816), CCND2 (ENSG00000118971), CCNA1 (ENSG00000133101), CCNB1 (ENSG00000134057), CCNG2 (ENSG00000138764), CCNA2 (ENSG00000145386), CCNB3 (ENSG00000147082), CCNO (ENSG00000152669), CCNB2 (ENSG00000157456), CCNF (ENSG00000162063), CCNE2 (ENSG00000175305), CCNI2 (ENSG00000205089)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Xenopus laevis	Q6DFJ9	73.5%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
C1QTNF2	protein-coding	114898
ZBED8	protein-coding	63920
PWWP2A	protein-coding	114825
FABP6	protein-coding	2172
TTC1	protein-coding	7265
FABP6-AS1	ncRNA	105377690
ADRA1B	protein-coding	147
SLU7	protein-coding	10569
PTTG1	protein-coding	9232

Protein

Protein identifiers

Cyclin-J-like protein — Q8IV13 (reviewed: Q8IV13)

All UniProt accessions (7): A0A2R8Y754, A0A2R8Y7P8, A0A2R8YFU1, B4DZA8, E5RFJ6, E7EN43, Q8IV13

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the cyclin family. Cyclin J subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IV13-1	1	yes
Q8IV13-2	2

RefSeq proteins (2): NP_001295102, NP_078841 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004367	Cyclin_C-dom	Domain
IPR006671	Cyclin_N	Domain
IPR013763	Cyclin-like_dom	Domain
IPR036915	Cyclin-like_sf	Homologous_superfamily
IPR039361	Cyclin	Family

Pfam: PF00134, PF02984

UniProt features (7 total): splice variant 3, chain 1, domain 1, region of interest 1, sequence variant 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IV13-F1	68.40	0.35

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nuclear speckles

Antibody reliability (HPA): IH approved · IF approved

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 118 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_UP, GOBP_CELL_CYCLE_PHASE_TRANSITION, GOCC_MICROTUBULE_ORGANIZING_CENTER, MYOD_01, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4, GOBP_CELL_CYCLE_G1_S_PHASE_TRANSITION, GOBP_MITOTIC_CELL_CYCLE, MYOD_Q6, AACTTT_UNKNOWN, RYTTCCTG_ETS2_B, E12_Q6, APPIERTO_RESPONSE_TO_FENRETINIDE_UP, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOCC_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS, GOCC_TRANSFERASE_COMPLEX

GO Biological Process (3): G1/S transition of mitotic cell cycle (GO:0000082), mitotic cell cycle phase transition (GO:0044772), cell division (GO:0051301)

GO Molecular Function (2): cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538), protein binding (GO:0005515)

GO Cellular Component (4): cyclin-dependent protein kinase holoenzyme complex (GO:0000307), nucleus (GO:0005634), cytoplasm (GO:0005737), microtubule organizing center (GO:0005815)

GO top-level categories

14 GO namespaces:

Category	Terms
mitotic cell cycle	2
cellular anatomical structure	2
mitotic cell cycle phase transition	1
cell cycle G1/S phase transition	1
cell cycle phase transition	1
mitotic cell cycle process	1
cellular process	1
cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein kinase regulator activity	1
binding	1
serine/threonine protein kinase complex	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
microtubule cytoskeleton	1

Protein interactions and networks

STRING

showing 15 of 356 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CCNJL	PRR20G	P0DPQ3	430
CCNJL	OR8A1	Q8NGG7	387
CCNJL	CCNC	P24863	339
CCNJL	PRRT4	C9JH25	333
CCNJL	RASSF6	Q6ZTQ3	309
CCNJL	CCNF	P41002	299
CCNJL	CNPPD1	Q9BV87	298
CCNJL	TMEM169	Q96HH4	290
CCNJL	TMEM217	Q8N7C4	288
CCNJL	TMEM217B	A0A494BZU4	288
CCNJL	DYNLT4	Q5JR98	286
CCNJL	NKPD1	Q17RQ9	285
CCNJL	CCNY	Q8ND76	282
CCNJL	WDR86	Q86TI4	280
CCNJL	CDK18	Q07002	273

IntAct

Human interaction partners of CCNJL in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

10 partners by confidence:

Partner	Interaction type	MIscore	Records
KRTAP10-8	physical association	0.670	4
KRTAP26-1	physical association	0.670	4
C1orf94	physical association	0.560	3
PKN1	physical association	0.560	3
REL	physical association	0.560	3
TLE5	physical association	0.560	3
TRAF2	physical association	0.560	3
UQCRC1	physical association	0.560	3
HSPA5	association	0.530	2
PIK3C2A	association	0.530	2

BioGRID (76 interactions; top human partners by supporting records): AP5B1 (Affinity Capture-MS; 3 records), C15orf39 (Affinity Capture-MS; 3 records), HSPA5 (Affinity Capture-MS; 3 records), JMJD4 (Affinity Capture-MS; 3 records), MSTO1 (Affinity Capture-MS; 3 records), MTO1 (Affinity Capture-MS; 3 records), PIK3C2A (Affinity Capture-MS; 3 records), STC2 (Affinity Capture-MS; 3 records), STIL (Affinity Capture-MS; 3 records), TRIM65 (Affinity Capture-MS; 3 records), TRMT44 (Affinity Capture-MS; 3 records), TROAP (Affinity Capture-MS; 3 records), TUBA4A (Affinity Capture-MS; 3 records), ARHGEF1 (Affinity Capture-MS; 2 records), FOXF2 (Affinity Capture-MS; 2 records)

Disease & clinical

Genetic variants

Variant evidence for CCNJL: 77 ClinVar records (0 pathogenic / likely pathogenic); 2 GWAS associations.

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	5
Benign	2

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 32 predictions of 731):

Position(s)	Effect	Δscore	Sites
5:160255709–160255710	acceptor_loss	1.0000	6
5:160280523–160280524	donor_loss	1.0000	5
5:160280739–160280740	acceptor_loss	1.0000	5
5:160255547–160255548	donor_loss	0.9900	5
5:160259447	donor_gain	0.9900
5:160259772–160259773	acceptor_loss	0.9900	6
5:160280527	donor_gain	0.9900
5:160280739	acceptor_loss	0.9900
5:160280748	acceptor_gain	0.9900
5:160310249	donor_gain	0.9900

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Pancreatic Adenocarcinoma (validation)	unfavorable	0.000148
Kidney Renal Papillary Cell Carcinoma (TCGA)	unfavorable	0.000216

Disease associations

OMIM: gene `` | disease phenotypes:

GWAS associations

2 associations:

Study	Trait	p-value
GCST004063_72	Waist circumference adjusted for body mass index	4e-8
GCST009391_12	Metabolite levels	6e-6

EFO canonical traits (from GWAS)

2 canonical traits:

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference
EFO:0007813	cotinine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, increases expression	2
Ozone	increases oxidation, increases abundance, increases expression, affects cotreatment	2
Tetrachlorodibenzodioxin	increases expression	2
Cyclosporine	increases expression	2
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	affects cotreatment, decreases methylation	1
sodium arsenate	increases abundance, increases expression	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
sulforaphane	increases expression	1
sodium arsenite	decreases expression	1
ferrous chloride	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Leflunomide	increases expression	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Doxorubicin	decreases expression	1
Estradiol	increases expression, affects cotreatment	1
Fluorouracil	affects expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.