CCNYL1B

Summary

CCNYL1B (cyclin Y like 1B, HGNC:56313) is a protein-coding gene on chromosome 16p11.2, encoding Cyclin-Y-like protein 1B (A0A8V8TMC4).

Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane.

Source: NCBI Gene 102724485 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56313
Approved symbol	CCNYL1B
Name	cyclin Y like 1B
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284209
Ensembl biotype	protein_coding
Entrez	102724485

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000638228, ENST00000850918, ENST00000850919

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638228 — 10 exons

Exon	Start	End
ENSE00003802531	34355567	34355729
ENSE00003803274	34371564	34371664
ENSE00003806840	34368551	34368586
ENSE00003807463	34360433	34360599
ENSE00003809143	34351499	34353684
ENSE00003809367	34365365	34365416
ENSE00003810143	34364659	34364778
ENSE00003894960	34380784	34381110
ENSE00003970439	34377015	34377049
ENSE00003970440	34379399	34379458

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 79.84.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.84	gold quality
left testis	UBERON:0004533	69.53	gold quality
testis	UBERON:0000473	69.41	gold quality
right testis	UBERON:0004534	69.20	gold quality
bone marrow	UBERON:0002371	47.64	gold quality
colonic epithelium	UBERON:0000397	42.24	gold quality
adrenal tissue	UBERON:0018303	41.78	silver quality
hindlimb stylopod muscle	UBERON:0004252	40.14	silver quality
calcaneal tendon	UBERON:0003701	39.77	gold quality
bone marrow cell	CL:0002092	39.13	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
body of pancreas	UBERON:0001150	36.35	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.48	gold quality
monocyte	CL:0000576	35.38	gold quality
muscle of leg	UBERON:0001383	35.32	silver quality
pancreas	UBERON:0001264	34.73	silver quality
leukocyte	CL:0000738	34.68	gold quality
gastrocnemius	UBERON:0001388	34.19	silver quality
blood	UBERON:0000178	32.27	gold quality
islet of Langerhans	UBERON:0000006	31.37	silver quality
corpus callosum	UBERON:0002336	31.19	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	31.08	silver quality
right uterine tube	UBERON:0001302	30.67	gold quality
lymph node	UBERON:0000029	30.40	silver quality
cerebellum	UBERON:0002037	30.23	gold quality
prefrontal cortex	UBERON:0000451	30.18	gold quality
right hemisphere of cerebellum	UBERON:0014890	30.18	gold quality
cerebellar hemisphere	UBERON:0002245	30.16	gold quality
cerebellar cortex	UBERON:0002129	30.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ccnyl1	ENSDARG00000099692
drosophila_melanogaster	CycY	FBGN0032378
caenorhabditis_elegans		WBGENE00022697

Paralogs (2): CCNY (ENSG00000108100), CCNYL1 (ENSG00000163249)

Protein

Protein identifiers

Cyclin-Y-like protein 1B — A0A8V8TMC4 (reviewed: A0A8V8TMC4)

All UniProt accessions (1): A0A8V8TMC4

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the cyclin family. Cyclin Y subfamily.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006671	Cyclin_N	Domain
IPR036915	Cyclin-like_sf	Homologous_superfamily

Pfam: PF00134

UniProt features (2 total): chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A8V8TMC4-F1	71.85	0.29

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 13 (showing top): GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, GOMF_KINASE_ACTIVATOR_ACTIVITY, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, chr16p11, GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY, GOMF_ENZYME_ACTIVATOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY, GOMF_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY, GOBP_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY, GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY, GOBP_WNT_SIGNALING_PATHWAY, GOMF_CYCLIN_DEPENDENT_PROTEIN_KINASE_REGULATOR_ACTIVITY, GOMF_KINASE_REGULATOR_ACTIVITY

GO Biological Process (1): regulation of canonical Wnt signaling pathway (GO:0060828)

GO Molecular Function (0):

GO Cellular Component (1): plasma membrane (GO:0005886)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A7H0DN99, A0A8V8TMC4, D3YUJ3, I2HAA0, O01501, O13818, O14260, O14332, O17657, O42575, O43008, P06776, P0C7X3, P17214, P25009, P30645, P34624, P36034, P38729, P52924, P53053, P53124, Q03080, Q05930, Q07788, Q08C99, Q08CI4, Q09792, Q10326, Q10PQ9, Q22695, Q28EL0, Q4R871, Q5IBH7, Q5ICL9, Q5MJ70, Q5T2Q4, Q5U5D0, Q6NRF4, Q75D04

Diamond homologs: A0A8V8TMC4, A6NIR3, D3YUJ3, P0C7X3, P34624, Q08CI4, Q28EL0, Q4R871, Q5T2Q4, Q5U5D0, Q5VUJ5, Q5VW22, Q6NRF4, Q8BGU5, Q8N7R7, Q8ND76, Q96P64, A1L520, A5PK26, O74345, O75689, O80925, O82171, O94601, O97902, P35197, P38682, P40529, Q04412, Q09531, Q0WQQ1, Q10165, Q10367, Q14161, Q15027, Q15057, Q17R07, Q1AAU6, Q1ZXH8, Q28CM8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1156332255 (16:34352899 T>A), RS1158545589 (16:34366099 A>G), RS1159807100 (16:34375548 A>G,T), RS1159967311 (16:34365969 G>A), RS1159969578 (16:34354273 G>A), RS1160124320 (16:34352889 G>C), RS1163012912 (16:34375381 T>C), RS1163221116 (16:34353814 C>T), RS1163649042 (16:34352796 T>C), RS1163654078 (16:34365814 T>C), RS1163670031 (16:34375927 C>A), RS1166789759 (16:34375274 T>G), RS1168815628 (16:34353189 T>C), RS1169126811 (16:34375790 C>T), RS1170595694 (16:34375762 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.