CCPG1

Summary

CCPG1 (cell cycle progression 1, HGNC:24227) is a protein-coding gene on chromosome 15q21.3, encoding Cell cycle progression protein 1 (Q9ULG6). Acts as an assembly platform for Rho protein signaling complexes.

Involved in positive regulation of cell cycle and positive regulation of cell population proliferation. Predicted to be active in membrane.

Source: NCBI Gene 9236 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 133 total — 3 pathogenic, 1 likely-pathogenic
• MANE Select transcript: NM_001204450

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24227
Approved symbol	CCPG1
Name	cell cycle progression 1
Location	15q21.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1254, CPR8
Ensembl gene	ENSG00000260916
Ensembl biotype	protein_coding
OMIM	611326
Entrez	9236

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 16 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000310958, ENST00000425574, ENST00000442196, ENST00000563171, ENST00000563294, ENST00000564092, ENST00000564663, ENST00000568372, ENST00000568543, ENST00000568592, ENST00000568808, ENST00000569205, ENST00000570272, ENST00000858134, ENST00000946864, ENST00000946865, ENST00000946866, ENST00000946867, ENST00000946868

RefSeq mRNA: 4 — MANE Select: NM_001204450 NM_001204450, NM_001204451, NM_004748, NM_020739

CCDS: CCDS42039, CCDS55966, CCDS55967

Canonical transcript exons

ENST00000442196 — 9 exons

Exon	Start	End
ENSE00002219653	55408221	55408359
ENSE00002624731	55355239	55356409
ENSE00003458310	55376949	55377150
ENSE00003486405	55371793	55372044
ENSE00003507746	55378300	55378376
ENSE00003521477	55385600	55385714
ENSE00003551192	55389365	55389433
ENSE00003600229	55365188	55365309
ENSE00003667678	55359539	55360944

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 98.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 53.2480 / max 1052.4816, expressed in 1818 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150094	30.5171	1792
150095	20.4779	1772
150092	1.6592	788
150093	0.3242	155
150091	0.1902	70
207529	0.0793	30

Top tissues by expression

266 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.37	gold quality
colonic epithelium	UBERON:0000397	97.69	gold quality
body of pancreas	UBERON:0001150	97.35	gold quality
gall bladder	UBERON:0002110	97.09	gold quality
descending thoracic aorta	UBERON:0002345	96.66	gold quality
thoracic aorta	UBERON:0001515	96.20	gold quality
ascending aorta	UBERON:0001496	96.15	gold quality
monocyte	CL:0000576	96.10	gold quality
mononuclear cell	CL:0000842	95.31	gold quality
pancreas	UBERON:0001264	95.27	gold quality
right coronary artery	UBERON:0001625	95.27	gold quality
aorta	UBERON:0000947	95.26	gold quality
stromal cell of endometrium	CL:0002255	95.23	gold quality
rectum	UBERON:0001052	95.20	gold quality
leukocyte	CL:0000738	95.19	gold quality
islet of Langerhans	UBERON:0000006	95.15	gold quality
adenohypophysis	UBERON:0002196	95.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.05	gold quality
popliteal artery	UBERON:0002250	94.85	gold quality
tibial artery	UBERON:0007610	94.85	gold quality
left coronary artery	UBERON:0001626	94.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.65	gold quality
right frontal lobe	UBERON:0002810	94.60	gold quality
cerebellar hemisphere	UBERON:0002245	94.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.36	gold quality
mucosa of stomach	UBERON:0001199	94.16	gold quality
gastrocnemius	UBERON:0001388	94.15	gold quality
cerebellar cortex	UBERON:0002129	94.12	gold quality
sural nerve	UBERON:0015488	94.11	gold quality
adrenal tissue	UBERON:0018303	93.99	gold quality

Single-cell (SCXA)

Detected in 13 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-MTAB-3929	yes	746.29
E-MTAB-6819	yes	538.89
E-CURD-88	yes	87.79
E-HCAD-4	yes	38.23
E-CURD-46	yes	31.04
E-MTAB-8410	yes	29.47
E-ANND-3	yes	15.02
E-MTAB-9801	yes	9.01
E-GEOD-110499	no	2460.32
E-GEOD-124858	no	1228.16
E-MTAB-6075	no	1086.80
E-MTAB-7303	no	216.67
E-MTAB-6142	no	140.32

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GLI1

miRNA regulators (miRDB)

151 targeting CCPG1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-12119	99.87	68.35	1653

Literature-anchored findings (GeneRIF, showing 2)

• identification of cell-cycle progression gene 1 (CCPG1), an ER-resident protein, as a non-canonical cargo receptor that directly binds to core autophagy proteins via an LIR motif to mammalian ATG8 proteins and, independently and via a discrete motif, to FIP200. (PMID:29290589)
• Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma. (PMID:37702448)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ccpg1	ENSMUSG00000034563
rattus_norvegicus	Ccpg1	ENSRNOG00000053428

Protein

Protein identifiers

Cell cycle progression protein 1 — Q9ULG6 (reviewed: Q9ULG6)

Alternative names: Cell cycle progression restoration protein 8

All UniProt accessions (8): H3BN32, H3BNE2, H3BPP4, H3BQN1, H3BR24, H3BTZ1, H3BV63, Q9ULG6

UniProt curated annotations — full annotation on UniProt →

Function. Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation.

Subunit / interactions. Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC.

Subcellular location. Cytoplasmic granule membrane.

Similarity. Belongs to the CCPG1 family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9ULG6-1	1	yes
Q9ULG6-2	2
Q9ULG6-3	3
Q9ULG6-4	4
Q9ULG6-5	5

RefSeq proteins (4): NP_001191379, NP_001191380, NP_004739, NP_065790 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR051990	CCPG1/PBIP1	Family

UniProt features (38 total): sequence variant 12, splice variant 6, compositionally biased region 4, sequence conflict 4, region of interest 3, coiled-coil region 3, topological domain 2, chain 1, modified residue 1, transmembrane region 1, strand 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7D0E	X-RAY DIFFRACTION	1.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULG6-F1	62.96	0.13

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 186

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 230 (showing top): AGGAAGC_MIR5163P, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, RIZKI_TUMOR_INVASIVENESS_3D_DN, GOBP_MACROAUTOPHAGY, SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE, GOBP_REGULATION_OF_CELL_CYCLE, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, AAAGGGA_MIR204_MIR211, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, WHN_B, CUI_TCF21_TARGETS_2_DN, VECCHI_GASTRIC_CANCER_EARLY_DN, PODAR_RESPONSE_TO_ADAPHOSTIN_UP

GO Biological Process (4): positive regulation of cell population proliferation (GO:0008284), positive regulation of cell cycle (GO:0045787), positive regulation of transcription by RNA polymerase II (GO:0045944), reticulophagy (GO:0061709)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of cellular process	2
cell population proliferation	1
regulation of cell population proliferation	1
cell cycle	1
regulation of cell cycle	1
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
macroautophagy	1
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1382 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CCPG1	RB1CC1	Q8TDY2	989
CCPG1	GABARAP	O95166	881
CCPG1	RETREG1	Q9H6L5	818
CCPG1	ATL3	Q6DD88	817
CCPG1	SEC62	Q99442	816
CCPG1	TEX264	Q9Y6I9	816
CCPG1	RTN3	O95197	776
CCPG1	GABARAPL2	P60520	734
CCPG1	F5GZY7	F5GZY7	732
CCPG1	CD300C	Q08708	622
CCPG1	CALCOCO1	Q9P1Z2	601
CCPG1	OPTN	Q96CV9	545
CCPG1	RETREG3	Q86VR2	537
CCPG1	SQSTM1	Q13501	520
CCPG1	AGBL3	Q8NEM8	509
CCPG1	CALCOCO2	Q13137	509

IntAct

80 interactions, top by confidence:

A	B	Type	Score
TNFSF14	TMEM11	psi-mi:“MI:0914”(association)	0.670
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
MANSC1	KLRG2	psi-mi:“MI:0914”(association)	0.530
CHRNA9	CHEK1	psi-mi:“MI:0914”(association)	0.530
GABRE	FZD6	psi-mi:“MI:0914”(association)	0.530
ADAM21	PLXNA2	psi-mi:“MI:0914”(association)	0.530
SLC22A15	ZFPL1	psi-mi:“MI:0914”(association)	0.530
GABRD	ATF6	psi-mi:“MI:0914”(association)	0.530
PKD2L2	PKD2	psi-mi:“MI:0914”(association)	0.530
TMED3	HS1BP3	psi-mi:“MI:0914”(association)	0.530
CYB5D2	ABLIM1	psi-mi:“MI:0914”(association)	0.530
EGFL8	MPO	psi-mi:“MI:0914”(association)	0.530
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
KCNK16	B3GAT3	psi-mi:“MI:0914”(association)	0.530
PIGT	ZNF609	psi-mi:“MI:0914”(association)	0.530
TMEM106A	B4GALT3	psi-mi:“MI:0914”(association)	0.530
MAP1LC3B	CCPG1	psi-mi:“MI:0407”(direct interaction)	0.440
MAP1LC3A	CCPG1	psi-mi:“MI:0407”(direct interaction)	0.440
	ESYT2	psi-mi:“MI:0914”(association)	0.350
	HAX1	psi-mi:“MI:0914”(association)	0.350
M2	IPO5	psi-mi:“MI:0914”(association)	0.350
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
	SURF4	psi-mi:“MI:0914”(association)	0.350
rep	MYCBP2	psi-mi:“MI:0914”(association)	0.350
INSR	HAX1	psi-mi:“MI:0914”(association)	0.350
NTRK3	ILVBL	psi-mi:“MI:0914”(association)	0.350
ATG101	EMC8	psi-mi:“MI:0914”(association)	0.350

BioGRID (147): CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8Q3S9, A2VCV0, A9ULX8, E1BN97, F1NVK6, F6UF99, P28236, P79169, P79368, Q06220, Q09108, Q0P557, Q0VA42, Q1LZF8, Q28132, Q29030, Q2T9I9, Q3B7T8, Q3V0J1, Q5PQX1, Q5R6R3, Q5T5J6, Q5ZM60, Q640L3, Q640U0, Q66H73, Q6PAV5, Q6PG04, Q7ZX27, Q7ZXV6, Q8K4Q9, Q8N4S0, Q8TDY2, Q90314, Q90WN7, Q91892, Q921T2, Q95M19, Q95MD2, Q95N18

Diamond homologs: A2VD12, A6QLY7, Q3TVI8, Q5R6R3, Q5ZM60, Q96AQ6, Q9ULG6, Q640L3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 133 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
ERAD pathway	7	11.1×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

133 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	1
Uncertain significance	110
Likely benign	15
Benign	2

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
2425233	NC_000015.9:g.(?55497705)(55790527_?)del	Pathogenic
3243875	NC_000015.9:g.(?55646976)(55647630_?)del	Pathogenic
58571	GRCh38/hg38 15q21.3(chr15:55279032-55622007)x3	Pathogenic
3243904	NC_000015.9:g.(?55611449)(55722997_?)del	Likely pathogenic

SpliceAI

2917 predictions. Top by Δscore:

Variant	Effect	Δscore
15:55340603:C:CA	acceptor_gain	1.0000
15:55340752:T:TA	acceptor_gain	1.0000
15:55341737:GCAT:G	acceptor_gain	1.0000
15:55341800:GTG:G	donor_gain	1.0000
15:55354794:A:AG	acceptor_gain	1.0000
15:55354795:T:G	acceptor_gain	1.0000
15:55354796:A:AG	acceptor_gain	1.0000
15:55354797:G:GA	acceptor_gain	1.0000
15:55354797:GCC:G	acceptor_gain	1.0000
15:55354797:GCCA:G	acceptor_gain	1.0000
15:55354797:GCCAT:G	acceptor_gain	1.0000
15:55354976:GAGGT:G	donor_loss	1.0000
15:55354978:GGT:G	donor_loss	1.0000
15:55354979:GTA:G	donor_loss	1.0000
15:55354980:T:A	donor_loss	1.0000
15:55355343:A:AG	acceptor_gain	1.0000
15:55365183:CATA:C	donor_loss	1.0000
15:55365184:ATACC:A	donor_loss	1.0000
15:55365185:TACC:T	donor_loss	1.0000
15:55371787:ACTT:A	donor_loss	1.0000
15:55371788:CTTA:C	donor_loss	1.0000
15:55371789:TTA:T	donor_loss	1.0000
15:55371790:TACCA:T	donor_loss	1.0000
15:55371792:C:A	donor_loss	1.0000
15:55371882:AACT:A	donor_gain	1.0000
15:55371882:AACTC:A	donor_gain	1.0000
15:55371883:A:C	donor_gain	1.0000
15:55372040:AAATA:A	acceptor_gain	1.0000
15:55372041:AATA:A	acceptor_gain	1.0000
15:55372042:ATA:A	acceptor_gain	1.0000

AlphaMissense

5428 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:55360187:A:T	V529D	0.999
15:55360199:A:G	F525S	0.999
15:55360208:A:G	L522P	0.999
15:55360233:C:G	A514P	0.999
15:55360264:A:C	F503L	0.999
15:55360264:A:T	F503L	0.999
15:55360265:A:C	F503C	0.999
15:55360266:A:G	F503L	0.999
15:55371815:G:C	S228R	0.999
15:55371815:G:T	S228R	0.999
15:55371817:T:G	S228R	0.999
15:55360198:G:C	F525L	0.998
15:55360198:G:T	F525L	0.998
15:55360200:A:G	F525L	0.998
15:55360224:C:G	A517P	0.998
15:55360249:T:A	K508N	0.998
15:55360249:T:G	K508N	0.998
15:55360250:T:A	K508I	0.998
15:55360254:G:C	H507D	0.998
15:55360265:A:G	F503S	0.998
15:55371822:G:T	A226E	0.998
15:55360166:A:G	F536S	0.997
15:55360175:A:G	F533S	0.997
15:55360191:A:G	S528P	0.997
15:55360199:A:C	F525C	0.997
15:55360229:T:A	K515I	0.997
15:55360241:A:C	I511S	0.997
15:55360241:A:G	I511T	0.997
15:55360282:C:A	K497N	0.997
15:55360282:C:G	K497N	0.997

dbSNP variants (sampled 300 via entrez): RS1000026981 (15:55364787 C>T), RS1000204296 (15:55357084 A>G), RS1000220301 (15:55380422 A>G), RS1000232796 (15:55369192 G>A), RS1000233727 (15:55358472 T>A,C), RS1000277444 (15:55406617 T>C,G), RS1000383328 (15:55380472 T>C,G), RS1000393831 (15:55385540 A>C), RS1000478191 (15:55380587 G>A), RS1000568519 (15:55370650 G>A,T), RS1000674171 (15:55392501 A>T), RS1000731524 (15:55386562 C>T), RS1000853031 (15:55358063 T>C), RS1000866996 (15:55370505 C>T), RS1000870888 (15:55408029 G>A)

Disease associations

OMIM: gene MIM:611326 | disease phenotypes: MIM:618580

GenCC curated gene-disease

Mondo (1): developmental and epileptic encephalopathy, 80 (MONDO:0032822)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_1101	Metabolite levels	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010447	3-hydroxyanthranilic acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

69 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	6
bisphenol A	affects expression, increases expression	3
sodium arsenite	decreases expression, increases expression	3
Air Pollutants	increases expression, decreases expression, increases abundance	3
Cyclosporine	increases expression	3
sulforaphane	increases expression	2
Bortezomib	increases expression	2
Benzo(a)pyrene	increases expression	2
Copper	affects binding, increases expression	2
Silicon Dioxide	decreases expression	2
Tobacco Smoke Pollution	increases expression	2
Tretinoin	increases expression	2
Tunicamycin	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
kojic acid	decreases expression	1
trichostatin A	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	increases expression	1
potassium chromate(VI)	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
bicalutamide	increases expression	1
phenethyl isothiocyanate	increases expression	1
CGP 52608	affects binding, increases reaction	1

Cellosaurus cell lines

6 cell lines: 6 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1IE	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- CCPG1-/-	Embryonic stem cell	Female
CVCL_D1IJ	H9 AAVS1-TRE3G-NGN2 CCPG1-/-	Embryonic stem cell	Female
CVCL_D1IK	H9 AAVS1-TRE3G-NGN2 CCPG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IL	H9 AAVS1-TRE3G-NGN2 CCPG1-/- Keima-REEP5	Embryonic stem cell	Female
CVCL_D1IX	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- CCPG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IY	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- CCPG1-/- Keima-REEP5	Embryonic stem cell	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.