CCR5AS

Summary

CCR5AS (CCR5 antisense RNA, HGNC:54398) is a long non-coding RNA gene on chromosome 3p21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54398
Approved symbol	CCR5AS
Name	CCR5 antisense RNA
Location	3p21.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223552
Ensembl biotype	lncRNA
Entrez	102724297
RNAcentral	URS00026A1C41 — lncRNA, 1634 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000451485, ENST00000686150, ENST00000691693, ENST00000701066, ENST00000701879, ENST00000717843, ENST00000717844, ENST00000717851, ENST00000717852, ENST00000717853, ENST00000717854, ENST00000717855, ENST00000741266, ENST00000741267, ENST00000741268, ENST00000741269, ENST00000741270, ENST00000741271, ENST00000741272, ENST00000741273, ENST00000741274, ENST00000741275, ENST00000741276, ENST00000741277, ENST00000741278

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000451485 — 4 exons

Exon	Start	End
ENSE00001603846	46363984	46365045
ENSE00001674136	46392825	46393052
ENSE00001704648	46406897	46407066
ENSE00001740682	46371244	46371417

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 75.90.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6980 / max 112.0451, expressed in 260 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41971	1.1880	208
41974	0.1492	40
41970	0.1063	39
41972	0.1027	48
41973	0.0933	35
41975	0.0586	28

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	75.90	gold quality
monocyte	CL:0000576	75.58	gold quality
leukocyte	CL:0000738	74.60	gold quality
vermiform appendix	UBERON:0001154	70.84	gold quality
blood	UBERON:0000178	70.27	gold quality
right lung	UBERON:0002167	69.85	gold quality
granulocyte	CL:0000094	69.61	gold quality
upper lobe of left lung	UBERON:0008952	66.44	gold quality
duodenum	UBERON:0002114	65.75	gold quality
lung	UBERON:0002048	65.52	gold quality
rectum	UBERON:0001052	64.70	gold quality
sural nerve	UBERON:0015488	64.22	silver quality
tonsil	UBERON:0002372	63.06	gold quality
skeletal muscle tissue	UBERON:0001134	62.39	gold quality
gall bladder	UBERON:0002110	62.22	gold quality
quadriceps femoris	UBERON:0001377	61.63	gold quality
lymph node	UBERON:0000029	61.10	gold quality
spleen	UBERON:0002106	60.82	gold quality
muscle tissue	UBERON:0002385	58.80	gold quality
islet of Langerhans	UBERON:0000006	58.77	gold quality
cerebellar vermis	UBERON:0004720	58.50	gold quality
mucosa of transverse colon	UBERON:0004991	57.97	gold quality
thymus	UBERON:0002370	57.29	silver quality
placenta	UBERON:0001987	56.67	gold quality
prefrontal cortex	UBERON:0000451	56.09	gold quality
bone marrow	UBERON:0002371	55.73	gold quality
spinal cord	UBERON:0002240	55.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.65	gold quality
smooth muscle tissue	UBERON:0001135	55.47	gold quality
endometrium	UBERON:0001295	55.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CCR5AS interfered with interactions between the RNA-binding protein Raly and the CCR5 3’ untranslated region, protecting CCR5 messenger RNA from Raly-mediated degradation. Reduction in CCR5 expression through inhibition of CCR5AS diminished infection of CD4(+) T cells with CCR5-tropic HIV in vitro. (PMID:31209403)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.