CCT6B

Summary

CCT6B (chaperonin containing TCP1 subunit 6B, HGNC:1621) is a protein-coding gene on chromosome 17q12, encoding Probable T-complex protein 1 subunit zeta-2 (Q92526). Could function as a component of a tissue-specific chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis.

This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 10693 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 93 total
• MANE Select transcript: NM_006584

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1621
Approved symbol	CCT6B
Name	chaperonin containing TCP1 subunit 6B
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	Cctz2, TSA303
Ensembl gene	ENSG00000132141
Ensembl biotype	protein_coding
OMIM	610730
Entrez	10693

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000314144, ENST00000421975, ENST00000436961, ENST00000577307, ENST00000585073, ENST00000885297, ENST00000885298

RefSeq mRNA: 3 — MANE Select: NM_006584 NM_001193529, NM_001193530, NM_006584

CCDS: CCDS32617, CCDS54105, CCDS54106

Canonical transcript exons

ENST00000314144 — 14 exons

Exon	Start	End
ENSE00000903595	34939183	34939330
ENSE00000903596	34939617	34939713
ENSE00000903600	34951950	34952053
ENSE00000903602	34958560	34958694
ENSE00000903604	34961257	34961460
ENSE00001017481	34942796	34942906
ENSE00001409265	34927861	34928117
ENSE00001631822	34942484	34942643
ENSE00001681555	34959587	34959650
ENSE00003557224	34928962	34929034
ENSE00003604854	34930949	34931051
ENSE00003648802	34940539	34940621
ENSE00003666799	34954426	34954599
ENSE00003674411	34932367	34932500

Expression profiles

Bgee: expression breadth ubiquitous, 210 present calls, max score 97.58.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0106 / max 202.0861, expressed in 878 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165322	0.9064	449
165320	0.6525	311
165323	0.3165	124
165321	0.1004	27
165324	0.0348	7

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.58	gold quality
male germ cell	CL:0000015	97.04	gold quality
left testis	UBERON:0004533	96.59	gold quality
right testis	UBERON:0004534	95.97	gold quality
testis	UBERON:0000473	94.59	gold quality
adult organism	UBERON:0007023	94.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.27	gold quality
calcaneal tendon	UBERON:0003701	77.20	gold quality
gastrocnemius	UBERON:0001388	76.54	gold quality
palpebral conjunctiva	UBERON:0001812	76.38	gold quality
muscle of leg	UBERON:0001383	76.21	gold quality
nasal cavity mucosa	UBERON:0001826	75.55	gold quality
mucosa of stomach	UBERON:0001199	74.78	gold quality
nasal cavity epithelium	UBERON:0005384	74.35	silver quality
epithelium of nasopharynx	UBERON:0001951	74.06	silver quality
nasopharynx	UBERON:0001728	74.05	silver quality
right adrenal gland cortex	UBERON:0035827	74.02	gold quality
tibia	UBERON:0000979	73.35	gold quality
left adrenal gland cortex	UBERON:0035825	73.30	gold quality
right adrenal gland	UBERON:0001233	73.10	gold quality
tibialis anterior	UBERON:0001385	73.08	silver quality
left adrenal gland	UBERON:0001234	72.93	gold quality
bronchial epithelial cell	CL:0002328	72.60	gold quality
corpus epididymis	UBERON:0004359	72.09	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.97	gold quality
right uterine tube	UBERON:0001302	71.68	gold quality
stromal cell of endometrium	CL:0002255	71.47	gold quality
skeletal muscle organ	UBERON:0014892	71.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.50

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ESR1

miRNA regulators (miRDB)

22 targeting CCT6B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-217-5P	99.49	69.93	1419
HSA-MIR-20A-3P	99.44	69.10	1575
HSA-MIR-548AV-3P	99.43	68.50	1721
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-1244	99.33	68.38	832
HSA-MIR-296-3P	99.21	66.56	474
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-6807-3P	99.15	69.23	1275
HSA-MIR-3606-3P	99.11	69.84	3254
HSA-MIR-548L	99.06	70.90	2560
HSA-MIR-452-3P	99.01	66.25	1241
HSA-MIR-5701	98.97	69.54	1502
HSA-MIR-3154	98.94	66.55	1455
HSA-MIR-3144-3P	98.15	67.34	677
HSA-MIR-8055	97.62	66.09	1023
HSA-MIR-3667-5P	97.16	64.87	591
HSA-MIR-3672	94.46	65.67	646
HSA-MIR-6864-3P	94.46	65.97	625

Literature-anchored findings (GeneRIF, showing 2)

• antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo (PMID:16415341)
• Describes the cloning of a very similar protein in mouse. (PMID:9013858)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cct6a	ENSDARG00000021252
mus_musculus	Cct6b	ENSMUSG00000020698
rattus_norvegicus	Cct6b	ENSRNOG00000007523
drosophila_melanogaster	CCT6	FBGN0027329
caenorhabditis_elegans		WBGENE00000381

Paralogs (13): PIKFYVE (ENSG00000115020), CCT4 (ENSG00000115484), TCP1 (ENSG00000120438), MKKS (ENSG00000125863), CCT7 (ENSG00000135624), HSPD1 (ENSG00000144381), CCT6A (ENSG00000146731), CCT5 (ENSG00000150753), CCT8 (ENSG00000156261), CCT3 (ENSG00000163468), CCT2 (ENSG00000166226), BBS12 (ENSG00000181004), CCT8L2 (ENSG00000198445)

Protein

Protein identifiers

Probable T-complex protein 1 subunit zeta-2 — Q92526 (reviewed: Q92526)

Alternative names: CCT-zeta-2, CCT-zeta-like, Chaperonin containing T-complex polypeptide 1 subunit 6B, TCP-1-zeta-like, Testis-specific Tcp20, Testis-specific protein TSA303

All UniProt accessions (2): Q92526, J3KRI6

UniProt curated annotations — full annotation on UniProt →

Function. Could function as a component of a tissue-specific chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis.

Subunit / interactions. Could be a component of a tissue-specific chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber. Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6, CCT7, CCT8.

Subcellular location. Cytoplasm.

Tissue specificity. Testis-specific.

Similarity. Belongs to the TCP-1 chaperonin family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q92526-1	1	yes
Q92526-2	2
Q92526-3	3

RefSeq proteins (3): NP_001180458, NP_001180459, NP_006575* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002194	Chaperonin_TCP-1_CS	Conserved_site
IPR002423	Cpn60/GroEL/TCP-1	Family
IPR012722	Chap_CCT_zeta	Family
IPR017998	TCP-1	Family
IPR027409	GroEL-like_apical_dom_sf	Homologous_superfamily
IPR027410	TCP-1-like_intermed_sf	Homologous_superfamily
IPR027413	GROEL-like_equatorial_sf	Homologous_superfamily
IPR053374

Pfam: PF00118

Catalyzed reactions (Rhea), 1 shown:

• ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)

UniProt features (21 total): binding site 9, sequence conflict 6, sequence variant 3, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92526-F1	89.98	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (9): 39; 90; 91; 92; 93; 411; 412; 496; 501

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450	Folding of actin by CCT/TriC
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-390466	Chaperonin-mediated protein folding
R-HSA-391251	Protein folding
R-HSA-392499	Metabolism of proteins

MSigDB gene sets: 141 (showing top): BROWNE_HCMV_INFECTION_4HR_UP, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, GOBP_PROTEIN_MATURATION, GOBP_PROTEIN_FOLDING, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, NFE2_01, MGGAAGTG_GABP_B, GOMF_UNFOLDED_PROTEIN_BINDING, GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES, GOMF_ATP_HYDROLYSIS_ACTIVITY, GOMF_ADENYL_NUCLEOTIDE_BINDING, FOSTER_KDM1A_TARGETS_UP

GO Biological Process (1): protein folding (GO:0006457)

GO Molecular Function (7): ATP binding (GO:0005524), ATP hydrolysis activity (GO:0016887), protein folding chaperone (GO:0044183), obsolete unfolded protein binding (GO:0051082), ATP-dependent protein folding chaperone (GO:0140662), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (3): cytosol (GO:0005829), chaperonin-containing T-complex (GO:0005832), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	3
Chaperonin-mediated protein folding	3
Protein folding	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ATP-dependent activity	2
cellular anatomical structure	2
cellular process	1
protein maturation	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
ribonucleoside triphosphate phosphatase activity	1
molecular_function	1
protein folding	1
protein folding chaperone	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
cytoplasm	1
cytosol	1
protein folding chaperone complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2792 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CCT6B	CCT5	P48643	748
CCT6B	CCT2	P78371	731
CCT6B	CCT3	P49368	719
CCT6B	CCT4	P50991	589
CCT6B	CCT8	P50990	574
CCT6B	CCT7	Q99832	555
CCT6B	TCP1	P17987	541
CCT6B	TUBA8	Q9NY65	511
CCT6B	RPA1	P27694	504
CCT6B	JADE1	Q6IE81	498
CCT6B	TUBA4A	P05215	440
CCT6B	TEX30	Q5JUR7	402
CCT6B	KIF3A	Q9Y496	393
CCT6B	C1orf185	Q5T7R7	391
CCT6B	HSPA4L	O95757	390

IntAct

281 interactions, top by confidence:

A	B	Type	Score
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
SEPTIN12	SEPTIN6	psi-mi:“MI:0914”(association)	0.830
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
MOB4	STK25	psi-mi:“MI:0914”(association)	0.730
CCT2	TXNDC9	psi-mi:“MI:0914”(association)	0.730
BUB3	ZNF207	psi-mi:“MI:0914”(association)	0.690
TUBA1B	TXNDC9	psi-mi:“MI:0914”(association)	0.640
DCTN5	DCTN6	psi-mi:“MI:0914”(association)	0.640
PDCL3	PEX7	psi-mi:“MI:0914”(association)	0.640
GNB1	GNG7	psi-mi:“MI:0914”(association)	0.640
TUBA1C	CCT6A	psi-mi:“MI:0914”(association)	0.640
CCT3	TXNDC9	psi-mi:“MI:0914”(association)	0.640
CCT5	TXNDC9	psi-mi:“MI:0914”(association)	0.640
LOXL4	CCT6B	psi-mi:“MI:0915”(physical association)	0.620
ACTBL2	POTEF	psi-mi:“MI:0914”(association)	0.530
DCAF8	DCAF8L1	psi-mi:“MI:0914”(association)	0.530
DYNC2I2	TCP1	psi-mi:“MI:0914”(association)	0.530
KLHDC8A	PEX7	psi-mi:“MI:0914”(association)	0.530
FBXW4	TXNDC9	psi-mi:“MI:0914”(association)	0.530
TUBG2	TXNDC9	psi-mi:“MI:0914”(association)	0.530
HCFC2	SETD1A	psi-mi:“MI:0914”(association)	0.530
GNB2	PFDN6	psi-mi:“MI:0914”(association)	0.530
DCAF5	PFDN6	psi-mi:“MI:0914”(association)	0.530
DCAF11	GNPAT	psi-mi:“MI:0914”(association)	0.530
KLHDC2	PFDN1	psi-mi:“MI:0914”(association)	0.530
THOC3	CLUH	psi-mi:“MI:0914”(association)	0.530
MRPL38	DUSP14	psi-mi:“MI:0914”(association)	0.530
TUBB2A	EML2	psi-mi:“MI:0914”(association)	0.530
EIPR1	LDHC	psi-mi:“MI:0914”(association)	0.530

BioGRID (297): CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6B (Affinity Capture-MS)

ESM2 similar proteins: O04450, O15891, O77622, O94515, P12612, P28769, P39078, P39079, P40227, P40412, P40413, P42943, P46550, P47208, P47209, P48643, P50991, P50999, P53451, P54409, P54411, P80315, P80316, P80317, P87153, Q2T9X2, Q3MHL7, Q3T084, Q4R6V2, Q54ER7, Q54TD3, Q5R637, Q5RCD2, Q5RF02, Q5ZJ54, Q61390, Q68FQ0, Q6C100, Q6CL82, Q6FQT2

Diamond homologs: A1TKQ5, A1W3W8, A9BXL3, B9MDC5, C0Z361, O04450, O15891, O24730, O24731, O24732, O24734, O24735, O26320, O26885, O28045, O28821, O30560, O30561, O57762, O74341, O77622, O93624, O94515, P21240, P28488, P39079, P40227, P40412, P40413, P46219, P46550, P47209, P48424, P48425, P48643, P50016, P50157, P50991, P53451, P54411

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 198 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of tubulin folding intermediates by CCT/TriC	13	43.3×	2e-16
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	13	41.8×	2e-16
Prefoldin mediated transfer of substrate to CCT/TriC	13	40.3×	3e-16
Chaperonin-mediated protein folding	14	33.1×	3e-16
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	7	30.0×	8e-08
Transport of connexons to the plasma membrane	7	30.0×	8e-08
Protein folding	14	28.6×	3e-15
Association of TriC/CCT with target proteins during biosynthesis	12	27.7×	6e-13

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of telomere maintenance via telomerase	8	34.5×	4e-08
binding of sperm to zona pellucida	5	12.4×	4e-03
microtubule cytoskeleton organization	14	10.0×	4e-08
mitotic cell cycle	12	9.4×	1e-06
protein folding	13	7.9×	2e-06
protein stabilization	15	5.9×	6e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

93 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	79
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2528 predictions. Top by Δscore:

Variant	Effect	Δscore
17:34928113:CTGTG:C	acceptor_gain	1.0000
17:34929032:CAC:C	acceptor_gain	1.0000
17:34929033:ACCT:A	acceptor_loss	1.0000
17:34929034:CCTGA:C	acceptor_loss	1.0000
17:34929035:CTGAA:C	acceptor_loss	1.0000
17:34930943:TCTTA:T	donor_loss	1.0000
17:34930944:CTTA:C	donor_loss	1.0000
17:34930945:TTA:T	donor_loss	1.0000
17:34930946:TA:T	donor_loss	1.0000
17:34930947:A:AG	donor_loss	1.0000
17:34930948:C:CA	donor_loss	1.0000
17:34931050:ACCT:A	acceptor_loss	1.0000
17:34931053:T:A	acceptor_loss	1.0000
17:34931393:T:A	donor_gain	1.0000
17:34932362:TGTAC:T	donor_loss	1.0000
17:34932364:TACC:T	donor_loss	1.0000
17:34932365:ACC:A	donor_loss	1.0000
17:34932421:T:TA	donor_gain	1.0000
17:34932496:ACAAC:A	acceptor_gain	1.0000
17:34932497:CAAC:C	acceptor_gain	1.0000
17:34932497:CAACC:C	acceptor_gain	1.0000
17:34932498:AAC:A	acceptor_gain	1.0000
17:34932499:AC:A	acceptor_gain	1.0000
17:34932499:ACCT:A	acceptor_loss	1.0000
17:34932500:CCTA:C	acceptor_loss	1.0000
17:34932500:CCTAT:C	acceptor_gain	1.0000
17:34932501:C:CC	acceptor_gain	1.0000
17:34932502:T:C	acceptor_loss	1.0000
17:34932504:T:TC	acceptor_gain	1.0000
17:34939176:AGCTT:A	donor_loss	1.0000

AlphaMissense

3459 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:34958580:C:G	A106P	0.995
17:34940557:T:A	K317I	0.993
17:34932387:C:G	A443P	0.991
17:34942490:A:C	N293K	0.990
17:34942490:A:T	N293K	0.990
17:34958675:G:T	A74D	0.990
17:34942497:A:T	V291D	0.989
17:34940563:C:G	R315T	0.988
17:34940572:G:T	A312D	0.987
17:34942829:A:G	L231P	0.987
17:34954560:C:G	A126P	0.987
17:34954572:C:G	G122R	0.987
17:34954572:C:T	G122R	0.987
17:34939648:C:T	G345E	0.985
17:34940562:T:A	R315S	0.985
17:34940562:T:G	R315S	0.985
17:34940567:G:T	R314S	0.985
17:34942500:A:T	V290D	0.985
17:34942539:A:G	L277P	0.985
17:34954559:G:T	A126E	0.985
17:34958690:A:G	I69T	0.984
17:34928085:T:A	D519V	0.983
17:34940563:C:A	R315I	0.983
17:34958666:A:T	I77K	0.983
17:34961314:G:T	A27D	0.983
17:34932393:C:G	A441P	0.982
17:34942824:A:G	C233R	0.982
17:34942889:A:T	V211D	0.982
17:34958627:T:A	D90V	0.982
17:34928117:G:C	C508W	0.981

dbSNP variants (sampled 300 via entrez): RS1000049411 (17:34946617 G>T), RS1000096608 (17:34934598 A>T), RS1000108026 (17:34940154 G>A), RS1000125341 (17:34978523 C>T), RS1000173473 (17:34947631 C>T), RS1000266842 (17:34947874 C>A,G,T), RS1000321814 (17:34940441 T>C), RS1000331702 (17:34933615 T>C,G), RS1000400432 (17:34946300 C>T), RS1000585743 (17:34959238 C>T), RS1000732041 (17:34953014 T>C), RS1000811711 (17:34951877 G>T), RS1000816643 (17:34954651 A>C), RS1000827107 (17:34959279 A>C,G), RS1000935173 (17:34959438 T>A)

Disease associations

OMIM: gene MIM:610730 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003542_132	Night sleep phenotypes	2.000000e-07
GCST003542_133	Night sleep phenotypes	4.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Silicon Dioxide	decreases expression	2
urushiol	decreases expression	1
methylmercuric chloride	decreases expression	1
bisphenol A	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
resorcinol	decreases expression	1
abrine	increases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	decreases expression	1
Cisplatin	decreases expression	1
Ivermectin	decreases expression	1
Thimerosal	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	decreases expression	1
Okadaic Acid	decreases expression	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.