CD27-AS1

Summary

CD27-AS1 (CD27 antisense RNA 1, HGNC:43896) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43896
Approved symbol	CD27-AS1
Name	CD27 antisense RNA 1
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000215039
Ensembl biotype	lncRNA
Entrez	678655
RNAcentral	URS0000351B7C — lncRNA, 2364 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 29 lncRNA, 7 retained_intron

ENST00000399492, ENST00000417058, ENST00000447687, ENST00000504270, ENST00000535639, ENST00000536388, ENST00000537003, ENST00000538616, ENST00000545339, ENST00000653829, ENST00000655473, ENST00000659623, ENST00000659820, ENST00000667738, ENST00000669354, ENST00000670713, ENST00000689782, ENST00000762171, ENST00000762172, ENST00000762173, ENST00000762174, ENST00000762175, ENST00000762176, ENST00000762177, ENST00000762178, ENST00000762179, ENST00000762180, ENST00000762181, ENST00000762182, ENST00000762183, ENST00000762184, ENST00000762185, ENST00000762186, ENST00000762187, ENST00000762188, ENST00000762189

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000399492 — 7 exons

Exon	Start	End
ENSE00002214292	6448037	6448150
ENSE00002223950	6443546	6443717
ENSE00002231392	6450870	6450980
ENSE00002239534	6451469	6451502
ENSE00002289602	6446961	6447087
ENSE00002298070	6448640	6448737
ENSE00002313235	6439239	6439676

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 98.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1532 / max 271.3708, expressed in 1649 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129095	8.7334	1643
129094	0.4197	239

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	98.62	gold quality
spinal cord	UBERON:0002240	97.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.66	gold quality
substantia nigra	UBERON:0002038	97.32	gold quality
nucleus accumbens	UBERON:0001882	97.28	gold quality
body of uterus	UBERON:0009853	96.85	gold quality
right uterine tube	UBERON:0001302	96.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.69	gold quality
putamen	UBERON:0001874	96.67	gold quality
caudate nucleus	UBERON:0001873	96.54	gold quality
amygdala	UBERON:0001876	96.22	gold quality
tibial nerve	UBERON:0001323	96.18	gold quality
temporal lobe	UBERON:0001871	96.16	gold quality
left ovary	UBERON:0002119	96.15	gold quality
right coronary artery	UBERON:0001625	96.10	gold quality
hypothalamus	UBERON:0001898	96.07	gold quality
myometrium	UBERON:0001296	96.00	gold quality
left uterine tube	UBERON:0001303	95.87	gold quality
right ovary	UBERON:0002118	95.83	gold quality
endocervix	UBERON:0000458	95.82	gold quality
descending thoracic aorta	UBERON:0002345	95.72	gold quality
ovary	UBERON:0000992	95.69	gold quality
Ammon’s horn	UBERON:0001954	95.69	gold quality
ascending aorta	UBERON:0001496	95.61	gold quality
thoracic aorta	UBERON:0001515	95.61	gold quality
popliteal artery	UBERON:0002250	95.51	gold quality
tibial artery	UBERON:0007610	95.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.47	gold quality
lower esophagus	UBERON:0013473	95.45	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.37
E-MTAB-9543	yes	11.52

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit. (PMID:34006845)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.