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Atlas / Gene / CD300LG

CD300LG

gene
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Also known as Trem4CLM9

Summary

CD300LG (CD300 molecule like family member g, HGNC:30455) is a protein-coding gene on chromosome 17q21.31, encoding CMRF35-like molecule 9 (Q6UXG3). Receptor which may mediate L-selectin-dependent lymphocyte rollings.

Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).

Source: NCBI Gene 146894 — RefSeq curated summary.

At a glance

  • GWAS associations: 12
  • Clinical variants (ClinVar): 74 total
  • MANE Select transcript: NM_145273

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:30455
Approved symbolCD300LG
NameCD300 molecule like family member g
Location17q21.31
Locus typegene with protein product
StatusApproved
AliasesTrem4, CLM9
Ensembl geneENSG00000161649
Ensembl biotypeprotein_coding
OMIM610520
Entrez146894

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 18 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000293396, ENST00000317310, ENST00000377203, ENST00000539718, ENST00000586233, ENST00000588884, ENST00000589212, ENST00000700726, ENST00000877593, ENST00000877594, ENST00000877595, ENST00000877596, ENST00000877597, ENST00000877598, ENST00000877599, ENST00000971192, ENST00000971193, ENST00000971194, ENST00000971195

RefSeq mRNA: 5 — MANE Select: NM_145273 NM_001168322, NM_001168323, NM_001168324, NM_001411122, NM_145273

CCDS: CCDS11470, CCDS54131, CCDS54132, CCDS54133, CCDS92332

Canonical transcript exons

ENST00000317310 — 7 exons

ExonStartEnd
ENSE000010594534385710443857156
ENSE000011320094385520743855319
ENSE000011320244384855843848893
ENSE000011776694385291243853013
ENSE000013190554385380743854044
ENSE000027724094384717643847259
ENSE000039806674386179843863639

Expression profiles

Bgee: expression breadth ubiquitous, 184 present calls, max score 96.41.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6282 / max 146.5877, expressed in 89 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
1610910.515780
1610900.112547

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
adipose tissue of abdominal regionUBERON:000780896.41gold quality
adipose tissueUBERON:000101396.40gold quality
omental fat padUBERON:001041496.34gold quality
peritoneumUBERON:000235896.28gold quality
subcutaneous adipose tissueUBERON:000219095.87gold quality
apex of heartUBERON:000209892.16gold quality
skin of hipUBERON:000155489.86gold quality
heart left ventricleUBERON:000208489.01gold quality
thoracic mammary glandUBERON:000520088.98gold quality
mammary glandUBERON:000191188.92gold quality
cardiac ventricleUBERON:000208288.90gold quality
heart right ventricleUBERON:000208085.27gold quality
right testisUBERON:000453484.56gold quality
heartUBERON:000094884.37gold quality
spermCL:000001984.20gold quality
left testisUBERON:000453384.18gold quality
testisUBERON:000047383.27gold quality
right atrium auricular regionUBERON:000663183.15gold quality
mammary ductUBERON:000176582.79gold quality
gastrocnemiusUBERON:000138882.59gold quality
epithelium of mammary glandUBERON:000324482.58gold quality
hindlimb stylopod muscleUBERON:000425282.44gold quality
muscle of legUBERON:000138382.28gold quality
cardiac atriumUBERON:000208181.81gold quality
cardia of stomachUBERON:000116281.62gold quality
placentaUBERON:000198781.17gold quality
right lungUBERON:000216780.94gold quality
parietal pleuraUBERON:000240079.97gold quality
pharyngeal mucosaUBERON:000035579.83gold quality
vena cavaUBERON:000408779.76gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes14.84

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

77 targeting CD300LG, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4533100.0069.482758
HSA-MIR-4476100.0068.182030
HSA-MIR-6876-5P100.0067.682126
HSA-MIR-318599.9968.121959
HSA-MIR-6888-3P99.9765.951170
HSA-MIR-807599.9767.20962
HSA-MIR-314899.9775.066478
HSA-MIR-3688-3P99.9772.022834
HSA-MIR-6825-5P99.9669.813431
HSA-MIR-381-3P99.9371.872854
HSA-MIR-6753-3P99.9366.57637
HSA-MIR-7107-3P99.9366.73627
HSA-MIR-30099.9271.762856
HSA-MIR-3529-3P99.9073.553045
HSA-MIR-368699.9070.532432
HSA-MIR-612499.8769.783551
HSA-MIR-449299.8768.253611
HSA-MIR-4728-5P99.8569.394718
HSA-MIR-6785-5P99.8268.684428
HSA-MIR-3680-3P99.7572.513095
HSA-MIR-92A-2-5P99.7567.012164
HSA-MIR-149-3P99.7268.223963
HSA-MIR-6883-5P99.6968.053785
HSA-MIR-317599.6566.302031
HSA-MIR-613499.6365.681537
HSA-MIR-182799.6368.573265
HSA-MIR-548AV-5P99.6070.842107
HSA-MIR-548K99.6070.842107
HSA-MIR-4649-3P99.5666.901783
HSA-MIR-444199.4966.563216

Literature-anchored findings (GeneRIF, showing 2)

  • Blood pressure, measured with a sensitive method, in a small sample of CD300LG rs72836561 CT-carriers was higher than in CC-carriers. (PMID:25314291)
  • Both mRNA and protein levels of CD300LG-g in pulmonary carcinoma tissues were significantly lower than that in tumor-adjacent tissues, which might lead to inhibition of killing function of immunocytes, resulting in immune escape of lung cancer cells. (PMID:26977771)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusCd300lgENSMUSG00000017309
rattus_norvegicusCd300lgENSRNOG00000020837

Paralogs (13): TREM2 (ENSG00000095970), TMIGD3 (ENSG00000121933), TREML1 (ENSG00000161911), FCMR (ENSG00000162894), PIGR (ENSG00000162896), FCAMR (ENSG00000162897), CD300C (ENSG00000167850), CD300A (ENSG00000167851), CD300LB (ENSG00000178789), CD300LF (ENSG00000186074), CD300E (ENSG00000186407), CD300LD (ENSG00000204345), CD300H (ENSG00000284690)

Protein

Protein identifiers

CMRF35-like molecule 9 — Q6UXG3 (reviewed: Q6UXG3)

Alternative names: CD300 antigen-like family member G, Triggering receptor expressed on myeloid cells 4

All UniProt accessions (3): A0A8V8TQK5, Q6UXG3, K7EL06

UniProt curated annotations — full annotation on UniProt →

Function. Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte.

Subcellular location. Apical cell membrane. Basolateral cell membrane. Endosome. Multivesicular body membrane.

Tissue specificity. Highly expressed in heart, skeletal muscle and placenta.

Post-translational modifications. O-glycosylated with sialylated oligosaccharides.

Domain organisation. Ig-like V-type domain mediates binding to lymphocyte.

Similarity. Belongs to the CD300 family.

Isoforms (5)

UniProt IDNamesCanonical?
Q6UXG3-11, CD300LG-gammayes
Q6UXG3-22, TREM4-alpha, CD300LG-alpha 1
Q6UXG3-33, TREM4-beta, CD300LG-alpha 2
Q6UXG3-44
Q6UXG3-55

RefSeq proteins (5): NP_001161794, NP_001161795, NP_001161796, NP_001398051, NP_660316* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR003599Ig_subDomain
IPR007110Ig-like_domDomain
IPR013106Ig_V-setDomain
IPR013783Ig-like_foldHomologous_superfamily
IPR036179Ig-like_dom_sfHomologous_superfamily
IPR050671CD300_family_receptorsFamily

Pfam: PF07686

UniProt features (49 total): glycosylation site 25, sequence conflict 6, compositionally biased region 4, splice variant 4, topological domain 2, sequence variant 2, signal peptide 1, chain 1, transmembrane region 1, disulfide bond 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q6UXG3-F169.780.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 37–107

Glycosylation sites (25): 96, 137, 143, 144, 155, 161, 170, 171, 177, 187, 195, 196, 199, 201, 202, 207, 208, 213, 214, 222 …

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

MSigDB gene sets: 63 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP, GSE45365_NK_CELL_VS_CD8A_DC_UP, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, GOCC_APICAL_PLASMA_MEMBRANE, GOCC_MULTIVESICULAR_BODY, GOCC_LATE_ENDOSOME_MEMBRANE, GOCC_APICAL_PART_OF_CELL, GOCC_PLASMA_MEMBRANE_REGION, GOCC_BASAL_PART_OF_CELL, THUM_SYSTOLIC_HEART_FAILURE_DN, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, CHYLA_CBFA2T3_TARGETS_UP, GOCC_MULTIVESICULAR_BODY_MEMBRANE, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY

GO Biological Process (2): immune system process (GO:0002376), signal transduction (GO:0007165)

GO Molecular Function (2): transmembrane signaling receptor activity (GO:0004888), protein binding (GO:0005515)

GO Cellular Component (6): plasma membrane (GO:0005886), basolateral plasma membrane (GO:0016323), apical plasma membrane (GO:0016324), multivesicular body membrane (GO:0032585), endosome (GO:0005768), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Adaptive Immune System1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
plasma membrane region2
biological_process1
cell communication1
cellular process1
signaling1
regulation of cellular process1
cellular response to stimulus1
signaling receptor activity1
binding1
membrane1
cell periphery1
basal plasma membrane1
apical part of cell1
multivesicular body1
late endosome membrane1
endomembrane system1
cytoplasmic vesicle1
cellular anatomical structure1

Protein interactions and networks

STRING

710 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
CD300LGSELLP14151809
CD300LGEMCNQ9ULC0689
CD300LGPODXLO00592638
CD300LGMADCAM1Q13477599
CD300LGNTAN1Q96AB6580
CD300LGCHST4Q8NCG5578
CD300LGCD34P28906549
CD300LGICAM1P05362503
CD300LGTYROBPO43914476
CD300LGFUT7Q11130400
CD300LGCHST2Q9Y4C5397
CD300LGCADM1Q9BY67393
CD300LGCD44P16070380
CD300LGELMOD3Q96FG2374
CD300LGC14orf180Q8N912371

IntAct

24 interactions, top by confidence:

ABTypeScore
CD300LGpsi-mi:“MI:0915”(physical association)0.560
CD300LGKRTAP10-9psi-mi:“MI:0915”(physical association)0.560
KRTAP10-9CD300LGpsi-mi:“MI:0915”(physical association)0.560
MALCD300LGpsi-mi:“MI:0915”(physical association)0.560
TMBIM6CD300LGpsi-mi:“MI:0915”(physical association)0.560
KRTAP1-1CD300LGpsi-mi:“MI:0915”(physical association)0.560
CYSRT1CD300LGpsi-mi:“MI:0915”(physical association)0.560
KRTAP5-7CD300LGpsi-mi:“MI:0915”(physical association)0.560
CD300LFCD300LGpsi-mi:“MI:0915”(physical association)0.400
ECE1CD300LGpsi-mi:“MI:0915”(physical association)0.370
CD300LGKRTAP1-1psi-mi:“MI:0915”(physical association)0.000
CD300LGCYSRT1psi-mi:“MI:0915”(physical association)0.000
CD300LGKRTAP5-7psi-mi:“MI:0915”(physical association)0.000

BioGRID (8): KRTAP10-9 (Two-hybrid), KRTAP10-3 (Two-hybrid), CD300LG (Two-hybrid), MAL (Two-hybrid), KRTAP1-1 (Two-hybrid), CYSRT1 (Two-hybrid), KRTAP5-7 (Two-hybrid), CD300LG (Negative Genetic)

ESM2 similar proteins: A2A7V7, A2TGX5, A5D7B2, A8K4G0, B6A8R8, C0HJX2, C0HJX3, O15389, O43699, O95944, P12318, P20138, P24071, P27645, P43626, P43627, P43628, P43629, P43630, P43631, P43632, P50283, Q1ERP8, Q3LRV9, Q3U497, Q566E6, Q60513, Q6DN72, Q6SJQ0, Q6SJQ5, Q6SJQ7, Q6UXG3, Q6UXN2, Q6UXZ3, Q7TSN2, Q8K249, Q8N109, Q8NHK3, Q8R4Y0, Q8SPV8

Diamond homologs: A0A0K2S4Q6, A2A7V7, A2TGX5, A5D7B2, A8K4G0, O70570, P01832, P01833, P0DUB1, P15083, P81265, Q08708, Q1ERP8, Q3LRV9, Q3U497, Q496F6, Q566E6, Q6SJQ0, Q6SJQ5, Q6SJQ7, Q6UXG3, Q6UXZ3, Q7TSN2, Q8K249, Q8TDQ1, Q8VCH2, Q99NH8, Q9UGN4, O95944, Q2TB54, G3X8R9, P0DMS9, Q2LA85, O60667, Q86YW5, Q8K558, A1KXC4, Q29244, Q5M871, Q5R770

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance67
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1326 predictions. Top by Δscore:

VariantEffectΔscore
17:43847256:CCAGG:Cdonor_loss1.0000
17:43847258:AGGTG:Adonor_loss1.0000
17:43848823:G:GTdonor_gain1.0000
17:43848823:G:Tdonor_gain1.0000
17:43853014:G:GGdonor_gain1.0000
17:43855315:GGAAG:Gdonor_gain1.0000
17:43855316:GAAGG:Gdonor_gain1.0000
17:43855317:A:Tdonor_gain1.0000
17:43861249:GCCAA:Gdonor_gain1.0000
17:43861254:G:GGdonor_gain1.0000
17:43847260:G:GGdonor_gain0.9900
17:43847261:T:Gdonor_loss0.9900
17:43848552:TTTTA:Tacceptor_loss0.9900
17:43848553:TTTA:Tacceptor_loss0.9900
17:43848557:GGTT:Gacceptor_gain0.9900
17:43848635:G:Tdonor_gain0.9900
17:43848655:G:GTdonor_gain0.9900
17:43848858:A:Gdonor_gain0.9900
17:43848889:TCCAG:Tdonor_loss0.9900
17:43848890:CCAGG:Cdonor_loss0.9900
17:43848891:CAG:Cdonor_loss0.9900
17:43848892:AG:Adonor_loss0.9900
17:43848893:GGTAA:Gdonor_loss0.9900
17:43848894:G:Tdonor_loss0.9900
17:43848895:T:Adonor_loss0.9900
17:43853008:GAT:Gdonor_gain0.9900
17:43853012:GA:Gdonor_gain0.9900
17:43853959:GGGA:Gacceptor_gain0.9900
17:43854042:CAG:Cdonor_loss0.9900
17:43854043:AGG:Adonor_loss0.9900

AlphaMissense

2111 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:43848828:A:GY105C0.991
17:43848658:G:CK48N0.987
17:43848658:G:TK48N0.987
17:43848623:T:AC37S0.986
17:43848624:G:CC37S0.986
17:43848665:T:AC51S0.985
17:43848666:G:CC51S0.985
17:43848833:T:AC107S0.984
17:43848834:G:CC107S0.984
17:43848827:T:CY105H0.981
17:43848664:G:CW50C0.980
17:43848664:G:TW50C0.980
17:43848828:A:CY105S0.980
17:43848827:T:GY105D0.976
17:43848660:A:GY49C0.975
17:43848662:T:AW50R0.973
17:43848662:T:CW50R0.973
17:43848623:T:CC37R0.971
17:43848656:A:GK48E0.971
17:43848695:T:AC61S0.969
17:43848696:G:CC61S0.969
17:43848816:A:TD101V0.965
17:43848816:A:CD101A0.964
17:43848783:T:CL90P0.961
17:43848665:T:CC51R0.960
17:43848833:T:CC107R0.960
17:43848666:G:AC51Y0.959
17:43848659:T:GY49D0.958
17:43848667:C:GC51W0.958
17:43848804:T:AL97H0.957

dbSNP variants (sampled 300 via entrez): RS1000151140 (17:43849519 G>A), RS1000379453 (17:43855138 G>A), RS1000386621 (17:43856278 G>A), RS1000497665 (17:43862061 G>A), RS1000883395 (17:43849163 C>T), RS1001027184 (17:43848467 C>A,G), RS1001081583 (17:43860178 C>A,T), RS1001562870 (17:43848230 A>G), RS1001660378 (17:43856610 C>G), RS1001826634 (17:43850804 T>A), RS1002465556 (17:43847401 G>C,T), RS1002525892 (17:43848196 C>G,T), RS1002769862 (17:43853657 C>G,T), RS1003071514 (17:43847917 C>G,T), RS1003189384 (17:43858281 T>C)

Disease associations

OMIM: gene MIM:610520 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

StudyTraitp-value
GCST004207_15HDL cholesterol2.000000e-11
GCST006611_76HDL cholesterol1.000000e-123
GCST006613_98Triglycerides8.000000e-84
GCST009602_29Metabolic syndrome5.000000e-43
GCST010173_8Triglyceride levels1.000000e-84
GCST010241_271Apolipoprotein A1 levels5.000000e-140
GCST010242_485HDL cholesterol levels2.000000e-212
GCST010244_13Triglyceride levels2.000000e-126
GCST011345_23Triglyceride levels2.000000e-12
GCST90002381_119Eosinophil count2.000000e-16
GCST90002388_498Lymphocyte count6.000000e-11
GCST90002404_164Red cell distribution width9.000000e-16

EFO canonical traits (7, from GWAS)

EFO IDTrait name
EFO:0004612high density lipoprotein cholesterol measurement
EFO:0004530triglyceride measurement
EFO:0000195metabolic syndrome
EFO:0004614apolipoprotein A 1 measurement
EFO:0004842eosinophil count
EFO:0004587lymphocyte count
EFO:0009188Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

ChemicalActions (top 5)PubMed papers
perfluorooctanoic acidincreases expression1
S-(1,2-dichlorovinyl)cysteineaffects response to substance, increases expression1
perfluorooctane sulfonic acidincreases expression1
Resveratrolaffects cotreatment, decreases expression1
Acetaminophendecreases expression1
Benzo(a)pyreneaffects methylation, decreases methylation1
Diethylhexyl Phthalatedecreases expression1
Lipopolysaccharidesdecreases expression, affects response to substance, increases expression1
Nickeldecreases expression1
Plant Extractsaffects cotreatment, decreases expression1
Silicon Dioxideincreases expression1
Aflatoxin B1increases methylation1
Permethrinincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot