CD44-DT

Summary

CD44-DT (CD44 divergent transcript, HGNC:56175) is a long non-coding RNA gene on chromosome 11p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56175
Approved symbol	CD44-DT
Name	CD44 divergent transcript
Location	11p13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255521
Ensembl biotype	lncRNA
Entrez	100507144
RNAcentral	URS000075AE0C — lncRNA, 1123 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000528366, ENST00000530263, ENST00000661581, ENST00000841280, ENST00000841281

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000528366 — 3 exons

Exon	Start	End
ENSE00002167455	35132655	35133140
ENSE00002198801	35136346	35136626
ENSE00002200161	35137698	35138032

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 71.32.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	71.32	gold quality
bone marrow cell	CL:0002092	67.49	silver quality
corpus callosum	UBERON:0002336	64.74	gold quality
pancreas	UBERON:0001264	64.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.43	gold quality
tonsil	UBERON:0002372	60.33	gold quality
body of pancreas	UBERON:0001150	60.21	gold quality
skeletal muscle tissue	UBERON:0001134	59.68	silver quality
lymph node	UBERON:0000029	59.27	gold quality
bone marrow	UBERON:0002371	58.72	silver quality
gall bladder	UBERON:0002110	58.38	gold quality
vermiform appendix	UBERON:0001154	58.16	gold quality
body of uterus	UBERON:0009853	57.79	gold quality
ganglionic eminence	UBERON:0004023	57.12	gold quality
smooth muscle tissue	UBERON:0001135	56.88	gold quality
skin of abdomen	UBERON:0001416	56.80	gold quality
granulocyte	CL:0000094	56.56	gold quality
monocyte	CL:0000576	56.26	gold quality
zone of skin	UBERON:0000014	56.12	gold quality
myometrium	UBERON:0001296	55.50	gold quality
skin of leg	UBERON:0001511	55.44	gold quality
blood	UBERON:0000178	55.37	gold quality
calcaneal tendon	UBERON:0003701	55.26	gold quality
prefrontal cortex	UBERON:0000451	55.09	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.03	gold quality
rectum	UBERON:0001052	54.38	gold quality
substantia nigra	UBERON:0002038	54.38	gold quality
descending thoracic aorta	UBERON:0002345	53.87	gold quality
right lobe of thyroid gland	UBERON:0001119	53.36	gold quality
endometrium	UBERON:0001295	53.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR-302/miR-21 axis in colorectal cancer. (PMID:34882869)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.