CD99L2

gene
On this page

Also known as CD99B

Summary

CD99L2 (CD99 molecule like 2, HGNC:18237) is a protein-coding gene on chromosome Xq28, encoding CD99 antigen-like protein 2 (Q8TCZ2). Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane.

This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants.

Source: NCBI Gene 83692 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 134 total — 2 pathogenic
  • MANE Select transcript: NM_031462

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:18237
Approved symbolCD99L2
NameCD99 molecule like 2
LocationXq28
Locus typegene with protein product
StatusApproved
AliasesCD99B
Ensembl geneENSG00000102181
Ensembl biotypeprotein_coding
OMIM300846
Entrez83692

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 21 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000346693, ENST00000355149, ENST00000370377, ENST00000418547, ENST00000437787, ENST00000466436, ENST00000491877, ENST00000634795, ENST00000881084, ENST00000881086, ENST00000881089, ENST00000881090, ENST00000881091, ENST00000881092, ENST00000954707, ENST00000954708, ENST00000954709, ENST00000954710, ENST00000954711, ENST00000954712, ENST00000954713, ENST00000954714, ENST00000954715

RefSeq mRNA: 5 — MANE Select: NM_031462 NM_001184808, NM_001242614, NM_031462, NM_134445, NM_134446

CCDS: CCDS14697, CCDS14698, CCDS35427, CCDS55527

Canonical transcript exons

ENST00000370377 — 11 exons

ExonStartEnd
ENSE00001261819150898522150898668
ENSE00001754630150777444150777482
ENSE00003466725150795418150795486
ENSE00003533345150814862150814936
ENSE00003547583150793691150793756
ENSE00003572850150776174150776293
ENSE00003594849150816007150816078
ENSE00003597636150795206150795289
ENSE00003608834150770304150770369
ENSE00003681174150766336150769101
ENSE00003682869150831231150831293

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 97.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.2702 / max 387.5476, expressed in 1817 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter IDTPM avgSamples expressed
20083041.95511816
2008312.0763975
2008330.5940259
2008320.3196137
2008280.209465
2008340.115949

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
prefrontal cortexUBERON:000045197.53gold quality
gastrocnemiusUBERON:000138897.45gold quality
right frontal lobeUBERON:000281097.15gold quality
lateral nuclear group of thalamusUBERON:000273697.11gold quality
muscle of legUBERON:000138397.08gold quality
Brodmann (1909) area 9UBERON:001354097.01gold quality
frontal cortexUBERON:000187096.58gold quality
C1 segment of cervical spinal cordUBERON:000646996.57gold quality
hindlimb stylopod muscleUBERON:000425296.37gold quality
hypothalamusUBERON:000189896.24gold quality
anterior cingulate cortexUBERON:000983596.22gold quality
spinal cordUBERON:000224096.09gold quality
dorsolateral prefrontal cortexUBERON:000983496.09gold quality
neocortexUBERON:000195096.04gold quality
ponsUBERON:000098895.99gold quality
cardiac muscle of right atriumUBERON:000337995.81gold quality
left ventricle myocardiumUBERON:000656695.72gold quality
tibialis anteriorUBERON:000138595.63gold quality
tibial nerveUBERON:000132395.52gold quality
cerebellar cortexUBERON:000212995.30gold quality
cerebellar hemisphereUBERON:000224595.29gold quality
right hemisphere of cerebellumUBERON:001489095.27gold quality
putamenUBERON:000187495.18gold quality
apex of heartUBERON:000209895.16gold quality
cerebral cortexUBERON:000095695.13gold quality
substantia nigraUBERON:000203895.13gold quality
stromal cell of endometriumCL:000225595.12gold quality
nucleus accumbensUBERON:000188295.12gold quality
postcentral gyrusUBERON:000258195.10gold quality
cerebellumUBERON:000203794.93gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-MTAB-5061yes28.39
E-ENAD-27yes7.81
E-GEOD-81608no344.90
E-ANND-3no0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

49 targeting CD99L2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-6867-5P100.0082.213464
HSA-MIR-4747-5P100.0067.902681
HSA-MIR-5196-5P100.0067.982761
HSA-MIR-118499.9968.191458
HSA-MIR-4650-5P99.9864.69999
HSA-MIR-4725-3P99.9669.532520
HSA-MIR-6780B-5P99.9669.602562
HSA-MIR-6768-5P99.9267.361942
HSA-MIR-427199.8868.322244
HSA-MIR-6875-3P99.8270.262983
HSA-MIR-129999.7771.242389
HSA-MIR-548M99.7068.871749
HSA-MIR-10394-5P99.6566.831852
HSA-MIR-120599.6566.761826
HSA-MIR-9851-3P99.6369.681110
HSA-MIR-613299.6065.831554
HSA-MIR-6836-5P99.6065.621538
HSA-MIR-17-3P99.5566.771311
HSA-MIR-444199.4966.563216
HSA-MIR-616599.4467.121389
HSA-MIR-5580-5P99.3866.961139
HSA-MIR-568399.3668.592083
HSA-MIR-593-5P99.3469.50965
HSA-MIR-612899.3367.831581
HSA-MIR-465199.0667.572002
HSA-MIR-60898.9367.832013
HSA-MIR-3190-5P98.8764.891345
HSA-MIR-3124-3P98.8768.952123
HSA-MIR-7851-3P98.7264.88980
HSA-MIR-1227-5P98.6565.321549

Literature-anchored findings (GeneRIF, showing 2)

  • This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes CD99L2. (PMID:25666757)
  • Human CD99L2 Regulates a Unique Step in Leukocyte Transmigration. (PMID:35914838)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_reriocd99l2ENSDARG00000056722
mus_musculusCd99l2ENSMUSG00000035776
rattus_norvegicusENSRNOG00000088438
rattus_norvegicusCd99l2ENSRNOG00000089435

Paralogs (1): CD99 (ENSG00000002586)

Protein

Protein identifiers

CD99 antigen-like protein 2Q8TCZ2 (reviewed: Q8TCZ2)

Alternative names: MIC2-like protein 1

All UniProt accessions (5): Q8TCZ2, A0A024RC16, A0A0S2Z5R8, A0A0U1RQT8, H0Y4H3

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation.

Subcellular location. Cell membrane. Cell junction. Secreted.

Tissue specificity. Detected in cerebrospinal fluid (at protein level). Expressed in many tissues, with low expression in thymus.

Post-translational modifications. O-glycosylated.

Similarity. Belongs to the CD99 family.

Isoforms (6)

UniProt IDNamesCanonical?
Q8TCZ2-11yes
Q8TCZ2-22
Q8TCZ2-33
Q8TCZ2-44
Q8TCZ2-55
Q8TCZ2-66

RefSeq proteins (5): NP_001171737, NP_001229543, NP_113650, NP_604394, NP_604395 (=MANE)

Domains & families (InterPro)

IDNameType
IPR022078CD99L2Family

Pfam: PF12301

UniProt features (24 total): splice variant 8, sequence conflict 5, compositionally biased region 4, topological domain 2, signal peptide 1, chain 1, glycosylation site 1, transmembrane region 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8TCZ2-F155.710.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 178

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

IDPathway
R-HSA-202733Cell surface interactions at the vascular wall
R-HSA-109582Hemostasis

MSigDB gene sets: 155 (showing top): GOBP_MYELOID_LEUKOCYTE_MIGRATION, GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION, GOBP_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOCC_CELL_SURFACE, CAGCTG_AP4_Q5, GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION, GOBP_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION, GOBP_CELLULAR_EXTRAVASATION, GOBP_LEUKOCYTE_MIGRATION, GOBP_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION, GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION, HEN1_01, GOBP_GRANULOCYTE_MIGRATION, GOBP_REGULATION_OF_CELLULAR_EXTRAVASATION

GO Biological Process (4): cell adhesion (GO:0007155), diapedesis (GO:0050904), positive regulation of neutrophil extravasation (GO:2000391), positive regulation of T cell extravasation (GO:2000409)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): extracellular region (GO:0005576), plasma membrane (GO:0005886), adherens junction (GO:0005912), focal adhesion (GO:0005925), cell surface (GO:0009986), membrane (GO:0016020), anchoring junction (GO:0070161)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Hemostasis1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
positive regulation of cellular extravasation2
cellular process1
cellular extravasation1
leukocyte migration1
neutrophil extravasation1
positive regulation of neutrophil migration1
regulation of neutrophil extravasation1
T cell extravasation1
positive regulation of T cell migration1
regulation of T cell extravasation1
binding1
membrane1
cell periphery1
cell-cell junction1
cell-substrate junction1
cell junction1

Protein interactions and networks

STRING

1124 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
CD99L2PILRAQ9UKJ1968
CD99L2PILRBQ9UKJ0936
CD99L2CD99P14209849
CD99L2CD34P28906840
CD99L2EWSR1Q01844825
CD99L2SYPP08247791
CD99L2PECAM1P16284775
CD99L2ENO2P09104773
CD99L2PTPRCP08575726
CD99L2KITP10721720
CD99L2BCL2P10415720
CD99L2MMEP08473720
CD99L2NCAM1P13591720
CD99L2SPNP16150719
CD99L2MYOGP15173713
CD99L2CALB2P22676713

IntAct

65 interactions, top by confidence:

ABTypeScore
CAPN1CAPNS1psi-mi:“MI:0914”(association)0.840
CD99L2UBQLN1psi-mi:“MI:0915”(physical association)0.720
UBQLN1CD99L2psi-mi:“MI:0915”(physical association)0.720
CD99L2SGTApsi-mi:“MI:0915”(physical association)0.720
SGTACD99L2psi-mi:“MI:0915”(physical association)0.720
CFTRESYT2psi-mi:“MI:2364”(proximity)0.710
TMBIM6CD99L2psi-mi:“MI:0915”(physical association)0.560
TRAM1L1CD99L2psi-mi:“MI:0915”(physical association)0.560
SLC30A8CD99L2psi-mi:“MI:0915”(physical association)0.560
CD99L2UBQLN2psi-mi:“MI:0915”(physical association)0.560
CD99L2SGTBpsi-mi:“MI:0915”(physical association)0.560

BioGRID (52): CD99L2 (Two-hybrid), CD99L2 (Proximity Label-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS), CD99L2 (Affinity Capture-MS)

ESM2 similar proteins: A1A4K1, B1H3G4, E9PV24, O35988, O61704, O75167, O93383, P14209, P14599, P15514, P24338, P31431, P31955, P34741, P34900, P34901, P43322, P43407, P49414, P49416, P50605, P55808, P58239, Q02297, Q0VFF9, Q1RMT9, Q27913, Q56A20, Q58DD4, Q5RAT9, Q5RCS3, Q5RE35, Q5REP3, Q5XG99, Q6DBW9, Q6GR51, Q6PKG0, Q6ZQ58, Q7SXB3, Q7TMJ8

Diamond homologs: A1A4K1, B1H3G4, P14209, Q5RE35, Q6DBW9, Q8BIF0, Q8R1R5, Q8TCZ2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 36 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO termPartnersFoldFDR
regulation of macroautophagy543.5×3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

134 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic2
Likely pathogenic0
Uncertain significance51
Likely benign4
Benign1

Top pathogenic / likely-pathogenic (2)

Variant IDHGVSClassification
2685725GRCh37/hg19 Xq28(chrX:149650839-149937387)x1Pathogenic
4076026GRCh37/hg19 Xq28(chrX:149348005-150139922)x0Pathogenic

SpliceAI

2417 predictions. Top by Δscore:

VariantEffectΔscore
X:150770365:ACCCT:Aacceptor_gain1.0000
X:150770366:CCCT:Cacceptor_gain1.0000
X:150770366:CCCTC:Cacceptor_gain1.0000
X:150770367:CCTC:Cacceptor_gain1.0000
X:150770368:CT:Cacceptor_gain1.0000
X:150770368:CTCTG:Cacceptor_loss1.0000
X:150770370:C:CCacceptor_gain1.0000
X:150770371:T:Aacceptor_loss1.0000
X:150776166:GCACT:Gdonor_loss1.0000
X:150776169:CTTAC:Cdonor_loss1.0000
X:150776170:T:TCdonor_loss1.0000
X:150776171:T:TGdonor_loss1.0000
X:150776172:A:ACdonor_gain1.0000
X:150776172:A:ATdonor_loss1.0000
X:150776172:ACG:Adonor_gain1.0000
X:150776173:C:CGdonor_gain1.0000
X:150776173:CG:Cdonor_gain1.0000
X:150776173:CGC:Cdonor_gain1.0000
X:150776173:CGCTG:Cdonor_gain1.0000
X:150776289:CATGC:Cacceptor_gain1.0000
X:150776290:ATGC:Aacceptor_gain1.0000
X:150776291:TGC:Tacceptor_gain1.0000
X:150776292:GC:Gacceptor_gain1.0000
X:150776293:CC:Cacceptor_gain1.0000
X:150776293:CCTG:Cacceptor_loss1.0000
X:150776294:C:CAacceptor_loss1.0000
X:150776294:C:CCacceptor_gain1.0000
X:150776298:G:Cacceptor_gain1.0000
X:150776298:G:GCacceptor_gain1.0000
X:150795201:CTCA:Cdonor_loss1.0000

AlphaMissense

1698 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
X:150776253:G:CS192R0.998
X:150776253:G:TS192R0.998
X:150776255:T:GS192R0.998
X:150776217:G:CS204R0.997
X:150776217:G:TS204R0.997
X:150776219:T:GS204R0.997
X:150776230:C:TG200D0.995
X:150776227:G:TA201D0.994
X:150776239:G:TA197D0.994
X:150776242:A:TM196K0.994
X:150776184:G:CF215L0.993
X:150776184:G:TF215L0.993
X:150776186:A:GF215L0.993
X:150776242:A:CM196R0.993
X:150776245:G:TA195D0.993
X:150776251:G:TA193D0.992
X:150776224:A:TV202D0.991
X:150776216:A:CY205D0.989
X:150776236:A:TL198H0.989
X:150776228:C:GA201P0.988
X:150776231:C:GG200R0.986
X:150776257:G:TA191D0.986
X:150776188:C:TC214Y0.985
X:150776266:G:TA188D0.983
X:150776236:A:GL198P0.982
X:150776189:A:GC214R0.980
X:150776233:A:TI199N0.979
X:150776236:A:CL198R0.979
X:150776188:C:GC214S0.978
X:150776189:A:TC214S0.978

dbSNP variants (sampled 300 via entrez): RS1000004106 (X:150878712 T>C,G), RS1000022512 (X:150781463 G>A), RS1000182860 (X:150832459 A>G), RS1000296065 (X:150845741 A>C), RS1000300751 (X:150770767 T>C), RS1000412242 (X:150895534 G>A), RS1000417005 (X:150818793 G>A), RS1000597803 (X:150843239 A>G), RS1000630431 (X:150843577 G>A), RS1000701679 (X:150785105 C>G,T), RS1000736911 (X:150893399 T>C), RS1000745109 (X:150893732 T>C), RS1000783323 (X:150834170 A>C), RS1000790321 (X:150776346 C>G,T), RS1000849360 (X:150836211 G>A)

Disease associations

OMIM: gene MIM:300846 | disease phenotypes: MIM:310400, MIM:310440, MIM:147421

GenCC curated gene-disease

Mondo (4): X-linked myotubular myopathy (MONDO:0010683), X-linked myopathy with excessive autophagy (MONDO:0010684), inclusion body myositis (MONDO:0007827), neurodevelopmental disorder (MONDO:0700092)

Orphanet (3): X-linked myopathy with excessive autophagy (Orphanet:25980), X-linked centronuclear myopathy (Orphanet:596), Inclusion body myositis (Orphanet:611)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (3)

DescriptorNameTree numbers
D018979Myositis, Inclusion BodyC05.651.594.600; C10.668.491.562.500
D065886Neurodevelopmental DisordersF03.625
C536522Vacuolar myopathy (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arseniteaffects expression, decreases expression, affects cotreatment, increases abundance, increases expression4
Valproic Acidaffects cotreatment, decreases expression, increases methylation4
entinostatdecreases expression, affects cotreatment2
Benzo(a)pyreneaffects methylation, decreases expression, decreases methylation2
aristolochic acid Idecreases expression1
FR900359decreases phosphorylation1
methylmercuric chloridedecreases expression1
bisphenol Adecreases expression, increases methylation1
tris(1,3-dichloro-2-propyl)phosphatedecreases expression1
butyraldehydedecreases expression1
manganese chlorideaffects cotreatment, decreases expression, increases abundance1
isobutyl alcoholaffects cotreatment, decreases expression, increases abundance1
di-n-butylphosphoric acidaffects expression1
CGP 52608affects binding, increases reaction1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
ICG 001increases expression1
bisphenol Bincreases expression1
abrinedecreases expression1
Grape Seed Proanthocyanidinsaffects cotreatment, increases expression1
dorsomorphinaffects cotreatment, decreases expression1
jinfukangincreases expression1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acidincreases expression1
Acetaminophenincreases expression1
Air Pollutantsdecreases expression1
Arsenicaffects cotreatment, decreases expression, increases abundance1
Atrazineincreases expression1
Carbamazepineaffects expression1
Catechinaffects cotreatment, increases expression1
Doxorubicindecreases expression1
Estradiolincreases expression, affects cotreatment1

Clinical trials (associated diseases)

284 trials via MONDO — disease-level, not drug-specific.

TrialPhaseStatusTitle
NCT07240649PHASE4NOT_YET_RECRUITINGOutcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications
NCT04586348PHASE4UNKNOWNPrenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115PHASE4UNKNOWNDouble-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT02573467PHASE3COMPLETEDAn Extension Study of the Efficacy, Safety and Tolerability of BYM338 (Bimagrumab) in Patients With Sporadic Inclusion Body Myositis Who Previously Participated in the Core Study CBYM338B2203
NCT04049097PHASE3TERMINATEDArimoclomol in Sporadic Inclusion Body Myositis - Open Label Extension Trial
NCT04789070PHASE3ACTIVE_NOT_RECRUITINGPhase III Trial of Sirolimus in IBM
NCT02559102PHASE3COMPLETEDDexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079PHASE3COMPLETEDStudy of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480PHASE3RECRUITINGReducing Missed Appointments
NCT07377032PHASE3RECRUITINGTAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT00001261PHASE2COMPLETEDIntravenousimmunoglobulin (IVIg) for the Treatment of Inflammatory Myopathies
NCT01423110PHASE2COMPLETEDEfficacy, Safety and Tolerability of BYM338 in Patients With Sporadic Inclusion Body Myositis
NCT02753530PHASE2COMPLETEDStudy of Arimoclomol in Inclusion Body Myositis (IBM)
NCT03710941PHASE2WITHDRAWNSafety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis
NCT04062019PHASE2UNKNOWNLow-dose Interleukin-2 Treatment on Idiopathic Inflammatory Myopathy
NCT04237987PHASE2UNKNOWNLow-dose Interleukin-2 in Combination With Standard Therapy on Idiopathic Inflammatory Myopathy
NCT04687111PHASE2UNKNOWNPersonalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation
NCT06794008PHASE2RECRUITINGBCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
NCT02909959PHASE2COMPLETEDSulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348PHASE2RECRUITINGSertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372PHASE2COMPLETEDSafety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT01519349PHASE1COMPLETEDFollistatin Gene Transfer to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body Myositis
NCT02483845PHASE1UNKNOWNNatalizumab in Inclusion Body Myositis (IBM)
NCT03440034PHASE1COMPLETEDStudy of Pioglitazone in Sporadic Inclusion Body Myositis
NCT04421677PHASE1COMPLETEDSafety and Tolerability of Phenylbutyrate in Inclusion Body Myositis
NCT04659031PHASE1COMPLETEDA Phase 1 Study of ABC008 in Ascending (Single Ascending Dose/Multiple Ascending Dose) Study in Patients With (IBM)
NCT05032131PHASE1UNKNOWNCell Therapy for IBM by Muscle Injection of ADSVF
NCT06524687PHASE1TERMINATEDA Study of Imvotamab in Active, Refractory Idiopathic Inflammatory Myopathies
NCT06941129PHASE1RECRUITINGCAR T-cell Therapy Targeting CD19 and BCMA in Patients With Relapse/Refractory Autoimmune Diseases
NCT06978647PHASE1RECRUITINGA Clinical Study of YTS109 Cell in R/R Autoimmune Diseases
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