CDC123

Summary

CDC123 (cell division cycle 123, HGNC:16827) is a protein-coding gene on chromosome 10p14-p13, encoding Translation initiation factor eIF2 assembly protein (O75794). ATP-dependent protein-folding chaperone for the eIF2 complex. It is a common-essential gene (DepMap: required in 99.9% of cancer cell lines).

Enables ATP binding activity and magnesium ion binding activity. Involved in eukaryotic translation initiation factor 2 complex assembly. Located in cytoplasm.

Source: NCBI Gene 8872 — RefSeq curated summary.

At a glance

• GWAS associations: 67
• Clinical variants (ClinVar): 73 total
• Cancer dependency (DepMap): dependent in 99.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_006023

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16827
Approved symbol	CDC123
Name	cell division cycle 123
Location	10p14-p13
Locus type	gene with protein product
Status	Approved
Aliases	D123
Ensembl gene	ENSG00000151465
Ensembl biotype	protein_coding
OMIM	617708
Entrez	8872

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 19 protein_coding, 2 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000281141, ENST00000378900, ENST00000429258, ENST00000440613, ENST00000442050, ENST00000455773, ENST00000467016, ENST00000497963, ENST00000498747, ENST00000900296, ENST00000900297, ENST00000900298, ENST00000932716, ENST00000932717, ENST00000932718, ENST00000932719, ENST00000932720, ENST00000932721, ENST00000932722, ENST00000932723, ENST00000932724, ENST00000932725, ENST00000932726

RefSeq mRNA: 1 — MANE Select: NM_006023 NM_006023

CCDS: CCDS7090

Canonical transcript exons

ENST00000281141 — 13 exons

Exon	Start	End
ENSE00000999748	12196188	12196319
ENSE00001760477	12250311	12250589
ENSE00003466501	12209967	12210024
ENSE00003505149	12210290	12210322
ENSE00003517660	12246149	12246277
ENSE00003529375	12230948	12230996
ENSE00003529580	12198705	12198776
ENSE00003581074	12249581	12249718
ENSE00003583673	12237144	12237266
ENSE00003596966	12238457	12238485
ENSE00003600398	12235048	12235123
ENSE00003630299	12215740	12215835
ENSE00003651605	12217361	12217467

Expression profiles

Bgee: expression breadth ubiquitous, 296 present calls, max score 96.30.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 51.6544 / max 598.3145, expressed in 1822 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103910	48.6205	1822
103909	2.2842	1404
103912	0.3872	172
103908	0.3625	190

Top tissues by expression

297 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	96.30	gold quality
cortical plate	UBERON:0005343	96.11	gold quality
secondary oocyte	CL:0000655	96.04	gold quality
islet of Langerhans	UBERON:0000006	95.95	gold quality
smooth muscle tissue	UBERON:0001135	95.93	gold quality
ventricular zone	UBERON:0003053	95.78	gold quality
embryo	UBERON:0000922	95.74	gold quality
ganglionic eminence	UBERON:0004023	95.71	gold quality
right atrium auricular region	UBERON:0006631	95.53	gold quality
cardiac atrium	UBERON:0002081	95.42	gold quality
monocyte	CL:0000576	95.40	gold quality
mucosa of transverse colon	UBERON:0004991	95.22	gold quality
mononuclear cell	CL:0000842	95.21	gold quality
leukocyte	CL:0000738	95.18	gold quality
epithelium of nasopharynx	UBERON:0001951	95.14	gold quality
nasopharynx	UBERON:0001728	95.12	gold quality
oocyte	CL:0000023	95.00	gold quality
stromal cell of endometrium	CL:0002255	94.97	gold quality
esophagus mucosa	UBERON:0002469	94.83	gold quality
nucleus accumbens	UBERON:0001882	94.82	gold quality
lymph node	UBERON:0000029	94.79	gold quality
caudate nucleus	UBERON:0001873	94.76	gold quality
left coronary artery	UBERON:0001626	94.73	gold quality
right coronary artery	UBERON:0001625	94.72	gold quality
descending thoracic aorta	UBERON:0002345	94.61	gold quality
heart	UBERON:0000948	94.57	gold quality
skin of abdomen	UBERON:0001416	94.56	gold quality
vermiform appendix	UBERON:0001154	94.55	gold quality
myocardium	UBERON:0002349	94.55	gold quality
skin of leg	UBERON:0001511	94.51	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.88
E-CURD-88	yes	4.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting CDC123, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-202-5P	99.78	67.65	991
HSA-MIR-2115-3P	99.31	69.68	2026
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-376A-3P	99.06	69.17	1128
HSA-MIR-376B-3P	99.06	69.17	1128
HSA-MIR-361-5P	98.95	70.16	1340
HSA-MIR-138-2-3P	98.91	68.33	1643
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-2355-5P	98.83	65.51	1589
HSA-MIR-1470	98.11	63.53	399
HSA-MIR-219B-5P	97.91	65.80	531
HSA-MIR-3156-5P	96.93	67.36	800

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 7)

• A significant association of rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 was identified with type 2 diabetes in a Japanese population. (PMID:21909839)
• Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). (PMID:22923468)
• CDC123 may have a role in novel protein modifications (PMID:25976611)
• There were no statistically significant differences in the distribution of CDC123/CAMK1D rs12779790 genotypes and alleles between women with gestational diabetes mellitus and healthy pregnant women. (PMID:28079868)
• USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. (PMID:37314216)
• Binding of human Cdc123 to eIF2gamma. (PMID:37507029)
• CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1. (PMID:38237400)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cdc123	ENSDARG00000075025
mus_musculus	Cdc123	ENSMUSG00000039128
rattus_norvegicus	Cdc123	ENSRNOG00000017770

Protein

Protein identifiers

Translation initiation factor eIF2 assembly protein — O75794 (reviewed: O75794)

Alternative names: Cell division cycle protein 123 homolog, HT-1080, PZ32

All UniProt accessions (5): O75794, H7BZW7, X6RA30, X6RF82, X6RKY7

UniProt curated annotations — full annotation on UniProt →

Function. ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits.

Subunit / interactions. Interacts with the eIF2 complex gamma subunit EIF2S3 (via C-terminus); the interaction is direct. Interacts with the eIF2 complex alpha subunit EIF2S1. Interacts with the eIF2 complex beta subunit EIF2S2.

Subcellular location. Cytoplasm.

Tissue specificity. Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.

Similarity. Belongs to the CDC123 family.

RefSeq proteins (1): NP_006014* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009772	CDC123	Family

Pfam: PF07065

UniProt features (49 total): binding site 16, helix 14, strand 10, turn 3, mutagenesis site 2, sequence conflict 2, chain 1, modified residue 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
8PHV	X-RAY DIFFRACTION	1.97
8PHD	X-RAY DIFFRACTION	2.08

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75794-F1	84.82	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (16): 104; 179; 193; 233; 246; 246; 248; 248; 107; 109; 111; 167 …

Post-translational modifications (1): 60

Mutagenesis-validated functional residues (2):

Position	Phenotype
233	severely disrupts assembly factor activity.
246	severely disrupts assembly factor activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 175 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, KAAB_HEART_ATRIUM_VS_VENTRICLE_UP, MORF_HDAC1, MORF_UBE2N, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, PUJANA_CHEK2_PCC_NETWORK, WEI_MYCN_TARGETS_WITH_E_BOX, MISSIAGLIA_REGULATED_BY_METHYLATION_UP, MORF_SKP1A, GOBP_PROTEIN_MATURATION, GOBP_PROTEIN_FOLDING, SCHLOSSER_SERUM_RESPONSE_DN, TIEN_INTESTINE_PROBIOTICS_24HR_UP

GO Biological Process (2): eukaryotic translation initiation factor 2 complex assembly (GO:1905143), protein folding (GO:0006457)

GO Molecular Function (6): magnesium ion binding (GO:0000287), ATP binding (GO:0005524), protein folding chaperone (GO:0044183), nucleotide binding (GO:0000166), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein-containing complex assembly	1
cellular process	1
protein maturation	1
metal ion binding	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
molecular_function	1
protein folding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
cation binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1448 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CDC123	CAMK1D	Q8IU85	873
CDC123	JAZF1	Q86VZ6	820
CDC123	CDKAL1	Q5VV42	780
CDC123	TSPAN8	P19075	720
CDC123	HHEX	Q03014	720
CDC123	ADAMTS9	Q9P2N4	720
CDC123	SLC30A8	Q8IWU4	719
CDC123	EIF2S3	P41091	705
CDC123	IGF2BP2	Q9Y6M1	670
CDC123	WFS1	O76024	668
CDC123	MTNR1B	P49286	668
CDC123	TCF7L2	Q9NQB0	659
CDC123	KCNQ1	P51787	644
CDC123	KCNJ11	Q14654	644
CDC123	C2CD4A	Q8NCU7	621

IntAct

45 interactions, top by confidence:

A	B	Type	Score
MED17	MED19	psi-mi:“MI:0914”(association)	0.840
EIF2S3	CDC123	psi-mi:“MI:0407”(direct interaction)	0.760
CDC123	EIF2S3	psi-mi:“MI:0407”(direct interaction)	0.760
EIF2S2	CDC123	psi-mi:“MI:0914”(association)	0.710
CDC123	EIF2S2	psi-mi:“MI:0914”(association)	0.710
CDC123	EIF2S2	psi-mi:“MI:0915”(physical association)	0.710
TGIF2LY	PGP	psi-mi:“MI:0914”(association)	0.640
HLA-DRA	ENTPD6	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
OIP5	CYTH3	psi-mi:“MI:0914”(association)	0.530
SUI2	CDC123	psi-mi:“MI:0915”(physical association)	0.500
	CDC123	psi-mi:“MI:0407”(direct interaction)	0.440
CDC123	FXR1	psi-mi:“MI:0915”(physical association)	0.370
EIF2S1	CDC123	psi-mi:“MI:0915”(physical association)	0.370
HSPB1	CDC123	psi-mi:“MI:0915”(physical association)	0.370
CDC123	ZNF512B	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
EIF2S3	EIF3CL	psi-mi:“MI:0914”(association)	0.350
EIF5	EIF3CL	psi-mi:“MI:0914”(association)	0.350
EIF2S2	TOR1B	psi-mi:“MI:0914”(association)	0.350
CDC123	CLTCL1	psi-mi:“MI:0914”(association)	0.350
FCGRT	WBP4	psi-mi:“MI:0914”(association)	0.350
CDC123	SUI3	psi-mi:“MI:0914”(association)	0.350
FAM111A	DFFA	psi-mi:“MI:0914”(association)	0.350
GJA1	CDC123	psi-mi:“MI:0914”(association)	0.350

BioGRID (1869): GCD11 (Two-hybrid), CDC123 (Affinity Capture-MS), CDC123 (Two-hybrid), CDC123 (Proximity Label-MS), CDC123 (Proximity Label-MS), CDC123 (Proximity Label-MS), CDC123 (Proximity Label-MS), CDC123 (Proximity Label-MS), CDC123 (Affinity Capture-MS), CDC123 (Affinity Capture-MS), CDC123 (Affinity Capture-RNA), CDC123 (Affinity Capture-MS), CDC123 (Affinity Capture-MS), CDC123 (Affinity Capture-MS), CDC123 (Reconstituted Complex)

ESM2 similar proteins: A2Z4C5, A7X672, A7X680, B0K012, B8AJL9, B8AR41, B9SQI7, E0CSI1, O08848, O75794, O81770, O82730, P0C0T1, P10155, P42694, P57060, P93115, Q0J035, Q10PL5, Q13572, Q1PET6, Q28559, Q2PG37, Q2R483, Q2YDG3, Q33BI9, Q3U2J5, Q5F477, Q5F480, Q5R9U9, Q62834, Q69QJ7, Q6AY91, Q6DFV5, Q75GI4, Q7SY78, Q80YV4, Q8BYN3, Q8CII2, Q8LB01

Diamond homologs: A1CMB9, A1DLP3, A2R4R1, A5E3J7, A6R687, A6SDA8, A7A1A3, A7EUE6, A7RFT2, A7TPB3, O75794, Q05791, Q0CH08, Q0V340, Q2PG37, Q2U988, Q2YDG3, Q4WDA4, Q5AFX2, Q5AYN6, Q5BKN5, Q62834, Q641C9, Q6C101, Q6CL84, Q6FNU7, Q6PC40, Q75A37, Q75JF9, Q8CII2, Q9P7N5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2453 predictions. Top by Δscore:

Variant	Effect	Δscore
10:12198703:A:AG	acceptor_gain	1.0000
10:12198704:G:GC	acceptor_gain	1.0000
10:12198704:GT:G	acceptor_gain	1.0000
10:12198704:GTGT:G	acceptor_gain	1.0000
10:12198704:GTGTC:G	acceptor_gain	1.0000
10:12198772:GGAAG:G	donor_gain	1.0000
10:12198773:G:GT	donor_gain	1.0000
10:12198774:A:T	donor_gain	1.0000
10:12209965:A:AG	acceptor_gain	1.0000
10:12209965:AG:A	acceptor_gain	1.0000
10:12209966:G:GG	acceptor_gain	1.0000
10:12209966:GG:G	acceptor_gain	1.0000
10:12215776:G:GT	donor_gain	1.0000
10:12215834:GG:G	donor_gain	1.0000
10:12215835:GG:G	donor_gain	1.0000
10:12215846:A:AG	donor_gain	1.0000
10:12215846:A:G	donor_gain	1.0000
10:12215850:G:GG	donor_gain	1.0000
10:12217002:A:T	donor_gain	1.0000
10:12217463:CAGCC:C	donor_gain	1.0000
10:12217464:AGCC:A	donor_gain	1.0000
10:12217465:GCC:G	donor_gain	1.0000
10:12217465:GCCG:G	donor_gain	1.0000
10:12217466:CC:C	donor_gain	1.0000
10:12217466:CCGTA:C	donor_loss	1.0000
10:12217467:CGTA:C	donor_loss	1.0000
10:12217468:G:GG	donor_gain	1.0000
10:12217469:TAA:T	donor_loss	1.0000
10:12235039:T:TA	acceptor_gain	1.0000
10:12235042:TTACA:T	acceptor_loss	1.0000

AlphaMissense

2271 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:12217370:T:A	W115R	1.000
10:12217370:T:C	W115R	1.000
10:12217437:C:T	S137F	1.000
10:12217364:G:C	A113P	0.999
10:12217365:C:A	A113E	0.999
10:12217433:A:C	S136R	0.999
10:12217435:T:A	S136R	0.999
10:12217435:T:G	S136R	0.999
10:12217437:C:A	S137Y	0.999
10:12235058:G:C	R167P	0.999
10:12235094:G:C	R179P	0.999
10:12235103:T:A	V182D	0.999
10:12196285:T:A	W14R	0.998
10:12196285:T:C	W14R	0.998
10:12196318:A:C	S25R	0.998
10:12198705:T:A	S25R	0.998
10:12198705:T:G	S25R	0.998
10:12215771:T:A	V90D	0.998
10:12215810:C:A	P103H	0.998
10:12215814:G:C	K104N	0.998
10:12215814:G:T	K104N	0.998
10:12215816:T:C	L105P	0.998
10:12215821:T:A	W107R	0.998
10:12215821:T:C	W107R	0.998
10:12215831:C:A	P110Q	0.998
10:12215831:C:G	P110R	0.998
10:12217361:G:C	D112H	0.998
10:12217372:G:C	W115C	0.998
10:12217372:G:T	W115C	0.998
10:12217374:T:A	I116K	0.998

dbSNP variants (sampled 300 via entrez): RS1000007864 (10:12233967 TAGTG>T), RS1000094391 (10:12217055 C>T), RS1000114906 (10:12227817 A>C), RS1000126099 (10:12230843 T>A,C,G), RS1000167002 (10:12239118 G>A), RS1000234817 (10:12194378 T>C), RS1000276893 (10:12196593 T>C), RS1000289386 (10:12248465 T>C), RS1000291019 (10:12222967 C>T), RS1000331269 (10:12201460 T>A), RS1000344504 (10:12236598 C>T), RS1000427151 (10:12238947 G>A,T), RS1000444045 (10:12242473 TTG>T), RS1000576619 (10:12221310 C>T), RS1000587352 (10:12244629 T>G)

Disease associations

OMIM: gene MIM:617708 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

67 associations (top):

Study	Trait	p-value
GCST000167_2	Type 2 diabetes	1.000000e-10
GCST000796_1	Type 2 diabetes	1.000000e-08
GCST001248_9	Pulmonary function	6.000000e-13
GCST001251_9	Pulmonary function	3.000000e-12
GCST001666_5	Type 2 diabetes	7.000000e-09
GCST001784_5	Pulmonary function (smoking interaction)	2.000000e-11
GCST002352_8	Type 2 diabetes	3.000000e-09
GCST003400_48	Type 2 diabetes	1.000000e-12
GCST004183_23	Lung function (FEV1)	1.000000e-11
GCST004184_19	Lung function (FVC)	5.000000e-06
GCST004185_42	Lung function (FEV1/FVC)	2.000000e-16
GCST004894_101	Type 2 diabetes	3.000000e-29
GCST004894_72	Type 2 diabetes	3.000000e-10
GCST004904_158	Body mass index	1.000000e-09
GCST004904_49	Body mass index	7.000000e-09
GCST005047_11	Type 2 diabetes	2.000000e-06
GCST005413_13	Type 2 diabetes	4.000000e-10
GCST006001_26	Hemoglobin A1c levels	1.000000e-11
GCST006801_10	Type 2 diabetes	5.000000e-06
GCST006867_114	Type 2 diabetes	2.000000e-17
GCST007096_172	Pulse pressure	5.000000e-08
GCST007099_34	Systolic blood pressure	7.000000e-07
GCST007429_138	Lung function (FVC)	7.000000e-11
GCST007430_81	Peak expiratory flow	9.000000e-36
GCST007431_155	Lung function (FEV1/FVC)	4.000000e-67
GCST007432_185	FEV1	1.000000e-47
GCST007692_64	Chronic obstructive pulmonary disease	6.000000e-23
GCST007847_39	Type 2 diabetes	8.000000e-27
GCST007847_62	Type 2 diabetes	3.000000e-07
GCST008662_7	Lung function in never smokers (low FEV1 vs high FEV1)	2.000000e-10

EFO canonical traits (12, from GWAS)

EFO ID	Trait name
EFO:0003892	pulmonary function measurement
EFO:0004713	FEV/FVC ratio
EFO:0004314	forced expiratory volume
EFO:0004312	vital capacity
EFO:0004340	body mass index
EFO:0004541	HbA1c measurement
EFO:0005763	pulse pressure measurement
EFO:0006335	systolic blood pressure
EFO:0009718	peak expiratory flow
EFO:0005000	leptin measurement
EFO:0004327	electrocardiography
EFO:0007800	body fat percentage

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, decreases expression	1
salinomycin	decreases expression	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	increases methylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
K 7174	decreases expression	1
7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	decreases expression	1
Resveratrol	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Doxorubicin	increases expression	1
Ivermectin	decreases expression	1
Methapyrilene	increases methylation	1
Ozone	decreases expression, increases abundance, affects cotreatment	1
Rotenone	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	decreases methylation	1
Aflatoxin B1	increases methylation	1
Particulate Matter	decreases expression, increases abundance	1
Volatile Organic Compounds	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.