CDC42EP1

Summary

CDC42EP1 (CDC42 effector protein 1, HGNC:17014) is a protein-coding gene on chromosome 22q13.1, encoding Cdc42 effector protein 1 (Q00587). Probably involved in the organization of the actin cytoskeleton.

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow.

Source: NCBI Gene 11135 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 97 total
• MANE Select transcript: NM_152243

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17014
Approved symbol	CDC42EP1
Name	CDC42 effector protein 1
Location	22q13.1
Locus type	gene with protein product
Status	Approved
Aliases	MSE55, CEP1, Borg5
Ensembl gene	ENSG00000128283
Ensembl biotype	protein_coding
OMIM	606084
Entrez	11135

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 protein_coding

ENST00000249014, ENST00000415670, ENST00000430687, ENST00000434728, ENST00000897681, ENST00000897682, ENST00000897683, ENST00000897684, ENST00000897685, ENST00000897686, ENST00000913122

RefSeq mRNA: 1 — MANE Select: NM_152243 NM_152243

CCDS: CCDS13949

Canonical transcript exons

ENST00000249014 — 3 exons

Exon	Start	End
ENSE00000880161	37566072	37566812
ENSE00001173877	37560480	37560588
ENSE00001173884	37568108	37569405

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 97.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 70.8210 / max 685.1733, expressed in 1648 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192139	58.4358	1633
192138	4.0959	1318
192147	1.9017	1000
192145	1.2598	758
192137	1.0908	641
192148	0.9362	559
192146	0.8779	549
192144	0.8279	469
192143	0.8020	509
192140	0.2961	133

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	97.93	gold quality
body of stomach	UBERON:0001161	97.45	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.40	gold quality
minor salivary gland	UBERON:0001830	96.74	gold quality
right coronary artery	UBERON:0001625	96.73	gold quality
spinal cord	UBERON:0002240	96.40	gold quality
left adrenal gland	UBERON:0001234	96.34	gold quality
left adrenal gland cortex	UBERON:0035825	96.34	gold quality
lower esophagus mucosa	UBERON:0035834	96.30	gold quality
right adrenal gland	UBERON:0001233	96.07	gold quality
left uterine tube	UBERON:0001303	96.07	gold quality
stomach	UBERON:0000945	96.06	gold quality
ascending aorta	UBERON:0001496	95.91	gold quality
ectocervix	UBERON:0012249	95.88	gold quality
thoracic aorta	UBERON:0001515	95.79	gold quality
right lobe of liver	UBERON:0001114	95.70	gold quality
right adrenal gland cortex	UBERON:0035827	95.64	gold quality
adrenal cortex	UBERON:0001235	95.59	gold quality
aorta	UBERON:0000947	95.56	gold quality
popliteal artery	UBERON:0002250	95.54	gold quality
tibial artery	UBERON:0007610	95.52	gold quality
omental fat pad	UBERON:0010414	95.37	gold quality
peritoneum	UBERON:0002358	95.31	gold quality
tibial nerve	UBERON:0001323	95.24	gold quality
left coronary artery	UBERON:0001626	95.15	gold quality
body of uterus	UBERON:0009853	94.93	gold quality
upper lobe of left lung	UBERON:0008952	94.89	gold quality
skin of leg	UBERON:0001511	94.84	gold quality
coronary artery	UBERON:0001621	94.67	gold quality
endocervix	UBERON:0000458	94.42	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	578.45
E-GEOD-81547	yes	476.09
E-MTAB-10553	yes	23.15
E-ANND-3	yes	13.58
E-CURD-112	yes	12.96

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

48 targeting CDC42EP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-4688	99.48	64.68	828
HSA-MIR-6743-5P	99.48	63.60	721
HSA-MIR-128-1-5P	99.33	60.46	332
HSA-MIR-128-2-5P	99.33	60.83	311
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-1227-5P	98.65	65.32	1549
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-619-5P	98.57	64.97	1988
HSA-MIR-3180	98.46	64.68	348
HSA-MIR-3180-3P	98.46	64.68	348

Literature-anchored findings (GeneRIF, showing 4)

• CDC42EP1 activation is required for mannose receptor-mediated phagocytosis by alveolar macrophages. (PMID:15574879)
• Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling. (PMID:27913681)
• hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis. (PMID:37757976)
• Salmonella engages CDC42 effector protein 1 for intracellular invasion. (PMID:37877586)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cdc42ep1b	ENSDARG00000077792
danio_rerio	cdc42ep1a	ENSDARG00000079549
mus_musculus	Cdc42ep1	ENSMUSG00000049521
rattus_norvegicus	Cdc42ep1	ENSRNOG00000008517

Paralogs (5): CDC42EP2 (ENSG00000149798), CDC42EP3 (ENSG00000163171), CDC42EP5 (ENSG00000167617), CDC42EP4 (ENSG00000179604), C15orf62 (ENSG00000188277)

Protein

Protein identifiers

Cdc42 effector protein 1 — Q00587 (reviewed: Q00587)

Alternative names: Binder of Rho GTPases 5, Serum protein MSE55

All UniProt accessions (4): Q00587, B0QYC6, B0QYC7, B0QYC8

UniProt curated annotations — full annotation on UniProt →

Function. Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.

Subunit / interactions. Interacts with RHOQ and CDC42, in a GTP-dependent manner.

Subcellular location. Endomembrane system. Cytoplasm. Cytoskeleton.

Tissue specificity. Endothelial and bone marrow stromal cells.

Domain organisation. The CRIB domain mediates interaction with CDC42.

Similarity. Belongs to the BORG/CEP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q00587-1	1	yes
Q00587-2	2

RefSeq proteins (1): NP_689449* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000095	CRIB_dom	Domain
IPR029273	Cdc42_effect-like	Domain
IPR051296	Cdc42_Effector_BORG/CEP	Family

Pfam: PF00786, PF14957

UniProt features (40 total): modified residue 19, repeat 8, compositionally biased region 5, region of interest 4, chain 1, domain 1, splice variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q00587-F1	54.46	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (19): 19, 27, 34, 39, 53, 65, 73, 77, 101, 113, 121, 139, 180, 190, 192, 195, 303, 350, 353

Mutagenesis-validated functional residues (1):

Position	Phenotype
36–47	no binding with cdc42.

Function

Pathways and Gene Ontology

Reactome pathways

11 pathways

ID	Pathway
R-HSA-9013148	CDC42 GTPase cycle
R-HSA-9013149	RAC1 GTPase cycle
R-HSA-9013404	RAC2 GTPase cycle
R-HSA-9013406	RHOQ GTPase cycle
R-HSA-9013408	RHOG GTPase cycle
R-HSA-9013409	RHOJ GTPase cycle
R-HSA-9013423	RAC3 GTPase cycle
R-HSA-162582	Signal Transduction
R-HSA-194315	Signaling by Rho GTPases
R-HSA-9012999	RHO GTPase cycle
R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 184 (showing top): GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, TGACCTY_ERR1_Q2, MODULE_16, GOMF_GTPASE_BINDING, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, GOBP_CELL_CELL_ADHESION, GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_DN, GOBP_ACTIN_FILAMENT_ORGANIZATION

GO Biological Process (5): Rho protein signal transduction (GO:0007266), regulation of cell shape (GO:0008360), positive regulation of actin filament polymerization (GO:0030838), positive regulation of pseudopodium assembly (GO:0031274), cell-cell adhesion (GO:0098609)

GO Molecular Function (3): small GTPase binding (GO:0031267), cadherin binding involved in cell-cell adhesion (GO:0098641), protein binding (GO:0005515)

GO Cellular Component (8): cytoplasm (GO:0005737), cytosol (GO:0005829), cytoskeleton (GO:0005856), plasma membrane (GO:0005886), adherens junction (GO:0005912), focal adhesion (GO:0005925), endomembrane system (GO:0012505), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
RHO GTPase cycle	7
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	1
Signaling by Rho GTPases	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
small GTPase-mediated signal transduction	1
regulation of cell morphogenesis	1
regulation of biological quality	1
actin filament polymerization	1
regulation of actin filament polymerization	1
positive regulation of protein polymerization	1
positive regulation of cytoskeleton organization	1
positive regulation of supramolecular fiber organization	1
pseudopodium assembly	1
regulation of pseudopodium assembly	1
positive regulation of plasma membrane bounded cell projection assembly	1
cell adhesion	1
GTPase binding	1
cadherin binding	1
cell-cell adhesion	1
cell-cell adhesion mediator activity	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1
cell-cell junction	1
cell-substrate junction	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

608 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CDC42EP1	RHOQ	P17081	810
CDC42EP1	CDC42	P21181	663
CDC42EP1	PAK4	O96013	473
CDC42EP1	SLC24A3	Q9HC58	401
CDC42EP1	DEPDC4	Q8N2C3	400
CDC42EP1	STXBP6	Q8NFX7	397
CDC42EP1	KRTAP4-8	Q9BYQ9	393
CDC42EP1	CDC42EP3	Q9UKI2	385
CDC42EP1	OR5H1	A6NKK0	369
CDC42EP1	AKT1	P31749	366
CDC42EP1	CDH18	Q13634	357
CDC42EP1	SEPTIN7	Q16181	356
CDC42EP1	CDC42EP4	Q9H3Q1	355
CDC42EP1	AKAP11	Q9UKA4	326
CDC42EP1	NPIPB12	F8W0I5	316
CDC42EP1	ARHGEF16	Q5VV41	316

IntAct

147 interactions, top by confidence:

A	B	Type	Score
CDC42EP1	CDC42	psi-mi:“MI:0915”(physical association)	0.890
CDC42	CDC42EP1	psi-mi:“MI:0915”(physical association)	0.890
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
PKN3	ARHGAP10	psi-mi:“MI:0914”(association)	0.680
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
CA10	WDHD1	psi-mi:“MI:0914”(association)	0.640
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
CDC42EP1	RHOJ	psi-mi:“MI:0915”(physical association)	0.560
DEF6	CDC42EP1	psi-mi:“MI:0915”(physical association)	0.560
RHOJ	CDC42EP1	psi-mi:“MI:0915”(physical association)	0.560
CDC42EP1	DEF6	psi-mi:“MI:0915”(physical association)	0.560
FAM174A	BLTP3B	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
STK16	UNC119B	psi-mi:“MI:0914”(association)	0.530
TIMP3	ZZEF1	psi-mi:“MI:0914”(association)	0.530
ANTXR1	WFS1	psi-mi:“MI:0914”(association)	0.530
CDC42EP1	MDFI	psi-mi:“MI:0915”(physical association)	0.490
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480

BioGRID (173): CDC42EP1 (Two-hybrid), DEF6 (Two-hybrid), RHOJ (Two-hybrid), CDC42EP1 (Two-hybrid), CDC42EP1 (Two-hybrid), CDC42EP1 (Two-hybrid), KRTAP4-12 (Two-hybrid), MAPKAP1 (Two-hybrid), CDC42EP1 (Two-hybrid), CDC42EP1 (Affinity Capture-MS), CDC42EP1 (Affinity Capture-MS), CDC42EP1 (Proximity Label-MS), CDC42EP1 (Proximity Label-MS), CDC42EP1 (Affinity Capture-MS), CDC42EP1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2Z4LIS9, A6QPM6, A7X8B3, A7X8B5, A7X8B7, A7X8C4, A7X8C7, A7X8C9, A7XW16, A7XW20, A7XW25, O08664, O15054, O43151, O70218, O89113, P09066, P14652, P17542, P19419, P19622, P22091, P23683, P49640, P70061, P78412, P82976, P97503, Q00587, Q04890, Q05916, Q05917, Q12950, Q15270, Q17QW1, Q3U133, Q5JPB2, Q5NCY0, Q6ZW13, Q80WY3

Diamond homologs: A1A5P0, Q00587, Q08DN6, Q17QW1, Q5PQP4, Q6NZY7, Q8JZX9, Q91W92, Q9CQC5, Q9H3Q1, Q9I7F7, Q9JM96, Q9UKI2, Q9Z0X0, O14613

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
MAPK1	unknown	CDC42EP1	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 134 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	66.6×	8e-10
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	58.8×	1e-09
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	58.8×	1e-09
Activation of BH3-only proteins	7	43.5×	1e-08
RHO GTPases activate PKNs	9	35.7×	6e-10
Intrinsic Pathway for Apoptosis	7	25.6×	5e-07
RHO GTPases activate IQGAPs	5	21.6×	6e-05
RAF activation	5	21.0×	7e-05

GO biological processes:

GO term	Partners	Fold	FDR
substantia nigra development	6	19.4×	5e-04
protein targeting	5	16.2×	4e-03
intracellular protein localization	9	8.3×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

97 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	5
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

589 predictions. Top by Δscore:

Variant	Effect	Δscore
22:37560585:CCAGG:C	donor_loss	1.0000
22:37560586:CAGG:C	donor_loss	1.0000
22:37560587:AGGT:A	donor_loss	1.0000
22:37560588:GGT:G	donor_loss	1.0000
22:37560589:GTAAC:G	donor_loss	1.0000
22:37560590:T:G	donor_loss	1.0000
22:37560584:GCCAG:G	donor_gain	0.9900
22:37566808:C:G	donor_gain	0.9900
22:37566810:ACGG:A	donor_loss	0.9900
22:37566811:CGGT:C	donor_loss	0.9900
22:37566812:GGT:G	donor_loss	0.9900
22:37566813:GT:G	donor_loss	0.9900
22:37566814:TGAG:T	donor_loss	0.9900
22:37566815:GAGG:G	donor_loss	0.9900
22:37560589:G:GG	donor_gain	0.9800
22:37566813:G:GG	donor_gain	0.9800
22:37568102:TTCTA:T	acceptor_loss	0.9700
22:37568103:TCTA:T	acceptor_loss	0.9700
22:37568104:CTAG:C	acceptor_loss	0.9700
22:37568105:TA:T	acceptor_loss	0.9700
22:37568106:A:AG	acceptor_gain	0.9700
22:37568106:A:C	acceptor_loss	0.9700
22:37568107:G:GG	acceptor_gain	0.9700
22:37568107:GGC:G	acceptor_gain	0.9700
22:37568107:GGCCT:G	acceptor_gain	0.9700
22:37566794:G:GT	donor_gain	0.9600
22:37568107:GGCC:G	acceptor_gain	0.9500
22:37568106:AG:A	acceptor_gain	0.9400
22:37568107:GG:G	acceptor_gain	0.9400
22:37563475:G:T	donor_gain	0.9300

AlphaMissense

2518 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:37566521:T:C	F58L	0.998
22:37566523:C:A	F58L	0.998
22:37566523:C:G	F58L	0.998
22:37566536:T:C	F63L	0.998
22:37566538:C:A	F63L	0.998
22:37566538:C:G	F63L	0.998
22:37566700:G:C	K117N	0.997
22:37566700:G:T	K117N	0.997
22:37566537:T:G	F63C	0.996
22:37566482:T:C	F45L	0.995
22:37566483:T:C	F45S	0.995
22:37566484:C:A	F45L	0.995
22:37566484:C:G	F45L	0.995
22:37566537:T:C	F63S	0.995
22:37566522:T:G	F58C	0.994
22:37566525:G:A	G59E	0.994
22:37566483:T:G	F45C	0.993
22:37566488:C:G	H47D	0.993
22:37566497:C:G	H50D	0.993
22:37566462:T:C	I38T	0.992
22:37566490:C:A	H47Q	0.992
22:37566490:C:G	H47Q	0.992
22:37566499:T:A	H50Q	0.992
22:37566499:T:G	H50Q	0.992
22:37566480:A:T	D44V	0.991
22:37566522:T:C	F58S	0.991
22:37566699:A:T	K117M	0.991
22:37566462:T:A	I38N	0.990
22:37566525:G:T	G59V	0.990
22:37566705:C:A	A119D	0.990

dbSNP variants (sampled 300 via entrez): RS1000573568 (22:37568508 TG>T), RS1000807351 (22:37568955 T>C,G), RS1000963281 (22:37564306 C>T), RS1001007609 (22:37559714 T>A,G), RS1001090009 (22:37569208 G>A), RS1001183772 (22:37563596 T>G), RS1001206015 (22:37564004 C>G), RS1001237779 (22:37561315 G>A,T), RS1001505664 (22:37563114 G>A), RS1001637608 (22:37566109 G>A), RS1001864095 (22:37563382 T>A), RS1001959917 (22:37559111 C>T), RS1002244761 (22:37567303 G>T), RS1002607029 (22:37566516 A>G), RS1002966604 (22:37560254 G>T)

Disease associations

OMIM: gene MIM:606084 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	3
Air Pollutants	increases abundance, increases expression, decreases expression	3
Cadmium Chloride	decreases expression, increases abundance	3
sodium arsenite	increases expression	2
Benzo(a)pyrene	decreases methylation, increases expression, increases methylation	2
Estradiol	increases expression	2
Smoke	decreases expression, increases abundance	2
Particulate Matter	increases expression, increases abundance	2
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
testosterone undecanoate	decreases expression	1
beta-lapachone	increases expression	1
cobaltous chloride	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
coumarin	increases phosphorylation	1
muconaldehyde	decreases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
perfluoro-n-nonanoic acid	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
jinfukang	affects cotreatment, decreases expression	1
theaflavin-3,3’-digallate	affects expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Atrazine	increases expression	1
Cadmium	decreases expression, increases abundance	1
Caffeine	affects phosphorylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.