CDC42EP4

Summary

CDC42EP4 (CDC42 effector protein 4, HGNC:17147) is a protein-coding gene on chromosome 17q25.1, encoding Cdc42 effector protein 4 (Q9H3Q1). Probably involved in the organization of the actin cytoskeleton.

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.

Source: NCBI Gene 23580 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 85 total — 1 pathogenic
• MANE Select transcript: NM_012121

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17147
Approved symbol	CDC42EP4
Name	CDC42 effector protein 4
Location	17q25.1
Locus type	gene with protein product
Status	Approved
Aliases	CEP4, KAIA1777, BORG4, MGC3740, MGC17125
Ensembl gene	ENSG00000179604
Ensembl biotype	protein_coding
OMIM	605468
Entrez	23580

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 13 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000335793, ENST00000439510, ENST00000578516, ENST00000579611, ENST00000580315, ENST00000581014, ENST00000581045, ENST00000582303, ENST00000858293, ENST00000858294, ENST00000858295, ENST00000858296, ENST00000858297, ENST00000858298, ENST00000943416, ENST00000943417

RefSeq mRNA: 1 — MANE Select: NM_012121 NM_012121

CCDS: CCDS11695

Canonical transcript exons

ENST00000335793 — 2 exons

Exon	Start	End
ENSE00001432603	73283624	73286612
ENSE00002710895	73311893	73312001

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 98.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.7125 / max 258.3081, expressed in 1750 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167908	30.1295	1741
167906	1.2645	834
167905	0.6874	373
167907	0.5830	350
167904	0.0282	11
167903	0.0200	9

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cranial nerve II	UBERON:0000941	98.82	gold quality
paraflocculus	UBERON:0005351	98.62	gold quality
olfactory bulb	UBERON:0002264	96.69	gold quality
left uterine tube	UBERON:0001303	96.67	gold quality
ventricular zone	UBERON:0003053	96.38	gold quality
middle frontal gyrus	UBERON:0002702	95.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.53	gold quality
medial globus pallidus	UBERON:0002477	95.29	gold quality
corpus epididymis	UBERON:0004359	95.19	gold quality
globus pallidus	UBERON:0001875	95.17	gold quality
lateral globus pallidus	UBERON:0002476	95.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.09	gold quality
right ovary	UBERON:0002118	95.03	gold quality
nipple	UBERON:0002030	94.85	gold quality
left ovary	UBERON:0002119	94.84	gold quality
caudate nucleus	UBERON:0001873	94.82	gold quality
pericardium	UBERON:0002407	94.72	gold quality
putamen	UBERON:0001874	94.64	gold quality
peritoneum	UBERON:0002358	94.59	gold quality
omental fat pad	UBERON:0010414	94.59	gold quality
trachea	UBERON:0003126	94.58	gold quality
cerebellar vermis	UBERON:0004720	94.57	gold quality
ganglionic eminence	UBERON:0004023	94.55	gold quality
ovary	UBERON:0000992	94.46	gold quality
left adrenal gland cortex	UBERON:0035825	94.39	gold quality
adipose tissue of abdominal region	UBERON:0007808	94.32	gold quality
body of pancreas	UBERON:0001150	94.31	gold quality
type B pancreatic cell	CL:0000169	94.27	silver quality
endocervix	UBERON:0000458	94.27	gold quality
left adrenal gland	UBERON:0001234	94.24	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-9435	yes	369.67
E-GEOD-137537	yes	34.68
E-MTAB-7316	yes	31.49
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

87 targeting CDC42EP4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3679-3P	99.64	69.88	1599
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-6758-3P	99.57	67.55	1078
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-4472	99.56	66.08	1478

Literature-anchored findings (GeneRIF, showing 3)

• This study showed that CDC42EP4 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. (PMID:25981171)
• Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling. (PMID:27913681)
• Cell division cycle 42 effector protein 4 inhibits prostate cancer progression by suppressing ERK signaling pathway. (PMID:38153517)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cdc42ep4b	ENSDARG00000045036
danio_rerio	cdc42ep4a	ENSDARG00000101457
mus_musculus	Cdc42ep4	ENSMUSG00000041598
rattus_norvegicus	Cdc42ep4	ENSRNOG00000028946

Paralogs (5): CDC42EP1 (ENSG00000128283), CDC42EP2 (ENSG00000149798), CDC42EP3 (ENSG00000163171), CDC42EP5 (ENSG00000167617), C15orf62 (ENSG00000188277)

Protein

Protein identifiers

Cdc42 effector protein 4 — Q9H3Q1 (reviewed: Q9H3Q1)

Alternative names: Binder of Rho GTPases 4

All UniProt accessions (5): B2R6D8, Q9H3Q1, J3KRZ9, J3QQS6, J3QR93

UniProt curated annotations — full annotation on UniProt →

Function. Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

Subunit / interactions. Interacts with CDC42 and RHOQ, in a GTP-dependent manner.

Subcellular location. Endomembrane system. Cytoplasm. Cytoskeleton.

Tissue specificity. Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.

Similarity. Belongs to the BORG/CEP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H3Q1-1	1	yes
Q9H3Q1-2	2

RefSeq proteins (1): NP_036253* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000095	CRIB_dom	Domain
IPR029273	Cdc42_effect-like	Domain
IPR051296	Cdc42_Effector_BORG/CEP	Family

Pfam: PF00786, PF14957

UniProt features (30 total): modified residue 12, compositionally biased region 6, sequence conflict 6, region of interest 3, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H3Q1-F1	58.67	0.05

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (12): 5, 18, 64, 105, 109, 118, 138, 140, 142, 174, 292, 295

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-9013148	CDC42 GTPase cycle
R-HSA-9013149	RAC1 GTPase cycle
R-HSA-9013404	RAC2 GTPase cycle
R-HSA-9013406	RHOQ GTPase cycle
R-HSA-162582	Signal Transduction
R-HSA-194315	Signaling by Rho GTPases
R-HSA-9012999	RHO GTPase cycle
R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 262 (showing top): GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_RESPONSE_TO_PEPTIDE, PEREZ_TP63_TARGETS, TAL1ALPHAE47_01, GOMF_GTPASE_BINDING, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE, CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, BLALOCK_ALZHEIMERS_DISEASE_UP

GO Biological Process (5): Rho protein signal transduction (GO:0007266), regulation of cell shape (GO:0008360), positive regulation of actin filament polymerization (GO:0030838), positive regulation of pseudopodium assembly (GO:0031274), cellular response to type II interferon (GO:0071346)

GO Molecular Function (3): RNA binding (GO:0003723), small GTPase binding (GO:0031267), protein binding (GO:0005515)

GO Cellular Component (10): cytoplasm (GO:0005737), cytosol (GO:0005829), cytoskeleton (GO:0005856), plasma membrane (GO:0005886), adherens junction (GO:0005912), endomembrane system (GO:0012505), actin cytoskeleton (GO:0015629), microtubule cytoskeleton (GO:0015630), phagocytic vesicle (GO:0045335), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
RHO GTPase cycle	4
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	1
Signaling by Rho GTPases	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoskeleton	2
small GTPase-mediated signal transduction	1
regulation of cell morphogenesis	1
regulation of biological quality	1
actin filament polymerization	1
regulation of actin filament polymerization	1
positive regulation of protein polymerization	1
positive regulation of cytoskeleton organization	1
positive regulation of supramolecular fiber organization	1
pseudopodium assembly	1
regulation of pseudopodium assembly	1
positive regulation of plasma membrane bounded cell projection assembly	1
response to type II interferon	1
cellular response to cytokine stimulus	1
nucleic acid binding	1
GTPase binding	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1
cell-cell junction	1
vacuole	1
plasma membrane	1
endocytic vesicle	1

Protein interactions and networks

STRING

690 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CDC42EP4	RHOQ	P17081	951
CDC42EP4	CDC42	P21181	830
CDC42EP4	CDC42BPB	Q9Y5S2	562
CDC42EP4	PROSER2	Q86WR7	499
CDC42EP4	CCDC102A	Q96A19	495
CDC42EP4	CDC42SE1	Q9NRR8	473
CDC42EP4	CDC42SE2	Q9NRR3	450
CDC42EP4	SEPTIN7	Q16181	435
CDC42EP4	CMIP	Q8IY22	435
CDC42EP4	WDPCP	O95876	423
CDC42EP4	SERTAD2	Q14140	411
CDC42EP4	WHAMM	Q8TF30	410
CDC42EP4	BAIAP2L1	Q9UHR4	407
CDC42EP4	SEPTIN6	Q14141	401
CDC42EP4	ARHGEF3	Q9NR81	394

IntAct

48 interactions, top by confidence:

A	B	Type	Score
HOMER1	TRAF5	psi-mi:“MI:0914”(association)	0.740
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
CDC42EP4	FAM9B	psi-mi:“MI:0915”(physical association)	0.670
FAM9B	CDC42EP4	psi-mi:“MI:0915”(physical association)	0.670
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
HTT	CDC42EP4	psi-mi:“MI:0915”(physical association)	0.560
RTN4IP1	HEXIM1	psi-mi:“MI:0914”(association)	0.530
CDC42EP4	SEPTIN6	psi-mi:“MI:0914”(association)	0.530
RBFA	METTL15	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
CDC42EP4	SRPK2	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
SRPK1	CDC42EP4	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
SPRY2	CDC42EP4	psi-mi:“MI:0915”(physical association)	0.400
PCNA	CDC42EP4	psi-mi:“MI:0915”(physical association)	0.370
CDC42EP4	PA	psi-mi:“MI:0915”(physical association)	0.370
WDR6	CDC42EP4	psi-mi:“MI:0915”(physical association)	0.370
Kctd5		psi-mi:“MI:0914”(association)	0.350
Septin9	SEPTIN8	psi-mi:“MI:0914”(association)	0.350
Septin2	SEPTIN8	psi-mi:“MI:0914”(association)	0.350
Septin7	SEPTIN8	psi-mi:“MI:0914”(association)	0.350
CDC42EP4	SEPTIN4	psi-mi:“MI:0914”(association)	0.350
CDC42	PPP1R12A	psi-mi:“MI:0914”(association)	0.350
POLR1D	BDP1	psi-mi:“MI:0914”(association)	0.350

BioGRID (131): FAM9B (Two-hybrid), CDC42EP4 (Affinity Capture-MS), SEPT4 (Affinity Capture-MS), SEPT2 (Affinity Capture-MS), SEPT7 (Affinity Capture-MS), SEPT5 (Affinity Capture-MS), SEPT6 (Affinity Capture-MS), SEPT8 (Affinity Capture-MS), SEPT11 (Affinity Capture-MS), SEPT9 (Affinity Capture-MS), SEPT3 (Affinity Capture-MS), KLHL15 (Affinity Capture-MS), SEPT10 (Affinity Capture-MS), YBEY (Affinity Capture-MS), FHL2 (Affinity Capture-MS)

ESM2 similar proteins: A0A098DPY0, A0A0D1DRJ3, A0A194W8T8, A0A3G1DJJ7, A4R227, A6RHW0, A7KAN7, B0XXN8, G1XLI4, G4NDR3, J9VT33, O13412, O13415, O13508, P10071, P17429, P19970, P37938, P53289, Q01115, Q01582, Q01631, Q09033, Q0U6W8, Q10060, Q1K8E7, Q2GW22, Q4I5R3, Q4P328, Q4PFA7, Q4WXK4, Q4WXY0, Q5AYT1, Q5IS56, Q6BWK6, Q6C449, Q6MW04, Q6MW50, Q6SW99, Q74ZL3

Diamond homologs: A1A5P0, Q00587, Q08DN6, Q17QW1, Q5PQP4, Q6NZY7, Q8JZX9, Q91W92, Q9CQC5, Q9H3Q1, Q9I7F7, Q9JM96, Q9UKI2, Q9Z0X0, O14613

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
PRKCA	“down-regulates activity”	CDC42EP4	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 54 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RHO GTPase Effectors	6	12.0×	2e-04
SARS-CoV Infections	5	8.2×	2e-03
Signaling by Rho GTPases	7	7.0×	4e-04
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	7	6.9×	4e-04
Infectious disease	7	5.1×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
intracellular protein localization	6	13.4×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

85 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	76
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2685607	GRCh37/hg19 17q24.3-25.1(chr17:69501527-71380722)x1	Pathogenic

SpliceAI

440 predictions. Top by Δscore:

Variant	Effect	Δscore
17:73286608:TAAGG:T	acceptor_gain	1.0000
17:73286613:C:CC	acceptor_gain	1.0000
17:73286610:AGG:A	acceptor_gain	0.9900
17:73286611:GG:G	acceptor_gain	0.9900
17:73286611:GGCTG:G	acceptor_loss	0.9900
17:73286612:GCT:G	acceptor_loss	0.9900
17:73286613:C:CG	acceptor_loss	0.9900
17:73286614:T:A	acceptor_loss	0.9900
17:73286609:AAGG:A	acceptor_gain	0.9800
17:73286576:A:T	acceptor_gain	0.9700
17:73311888:CCTA:C	donor_loss	0.9700
17:73311889:CTAC:C	donor_loss	0.9700
17:73311890:TAC:T	donor_loss	0.9700
17:73311891:ACC:A	donor_loss	0.9700
17:73311892:C:CT	donor_loss	0.9700
17:73310880:CCGG:C	donor_gain	0.9600
17:73286620:C:CT	acceptor_gain	0.9500
17:73286621:A:T	acceptor_gain	0.9500
17:73310873:GCACT:G	donor_loss	0.9400
17:73310874:CACTC:C	donor_loss	0.9400
17:73310875:ACTC:A	donor_loss	0.9400
17:73310876:CT:C	donor_loss	0.9400
17:73310877:TCACC:T	donor_loss	0.9400
17:73310878:CACC:C	donor_loss	0.9400
17:73310879:A:C	donor_loss	0.9400
17:73310880:C:G	donor_loss	0.9400
17:73310872:GGCAC:G	donor_loss	0.9300
17:73311862:C:CT	donor_gain	0.9300
17:73310879:A:AC	donor_gain	0.9200
17:73310880:C:CC	donor_gain	0.9200

AlphaMissense

2320 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:73286345:G:C	F52L	1.000
17:73286345:G:T	F52L	1.000
17:73286346:A:C	F52C	1.000
17:73286346:A:G	F52S	1.000
17:73286347:A:G	F52L	1.000
17:73286358:C:T	G48E	1.000
17:73286360:A:C	F47L	1.000
17:73286360:A:T	F47L	1.000
17:73286361:A:C	F47C	1.000
17:73286362:A:G	F47L	1.000
17:73286382:A:T	V40D	1.000
17:73286386:G:C	H39D	1.000
17:73286395:G:C	H36D	1.000
17:73286400:A:G	F34S	1.000
17:73286421:A:T	I27N	1.000
17:73285860:C:T	G214E	0.999
17:73285861:C:G	G214R	0.999
17:73285861:C:T	G214R	0.999
17:73286159:C:A	K114N	0.999
17:73286159:C:G	K114N	0.999
17:73286343:A:G	L53P	0.999
17:73286343:A:T	L53H	0.999
17:73286355:T:C	D49G	0.999
17:73286358:C:A	G48V	0.999
17:73286359:C:A	G48W	0.999
17:73286359:C:G	G48R	0.999
17:73286359:C:T	G48R	0.999
17:73286361:A:G	F47S	0.999
17:73286380:C:G	G41R	0.999
17:73286384:G:C	H39Q	0.999

dbSNP variants (sampled 300 via entrez): RS1000004200 (17:73288556 C>G,T), RS1000379924 (17:73291834 T>C), RS1000427596 (17:73308784 C>T), RS1000562866 (17:73297869 G>A), RS1000689724 (17:73303729 T>C), RS1000859444 (17:73310244 C>T), RS1000912962 (17:73297678 A>G), RS1001035948 (17:73299826 C>A), RS1001347478 (17:73293384 T>C), RS1001443245 (17:73287822 G>A), RS1001451352 (17:73287993 C>T), RS1001603712 (17:73312601 C>T), RS1001669645 (17:73297430 C>T), RS1001819156 (17:73313690 A>G), RS1001841075 (17:73293704 A>T)

Disease associations

OMIM: gene MIM:605468 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases expression, affects expression	2
Air Pollutants	increases oxidation, decreases expression, affects cotreatment, increases abundance	2
Benzo(a)pyrene	affects methylation, decreases expression	2
Valproic Acid	decreases expression, increases methylation, affects expression	2
Cyclosporine	decreases expression	2
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
pirinixic acid	increases expression, affects binding, increases activity	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression	1
perfluorooctanoic acid	decreases expression	1
coumarin	affects phosphorylation	1
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
chloropicrin	increases expression	1
2-palmitoylglycerol	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
Sunitinib	decreases expression	1
Vorinostat	decreases expression	1
Leflunomide	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Caffeine	affects phosphorylation	1
Dactinomycin	affects cotreatment, increases secretion	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Demecolcine	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Ethyl Methanesulfonate	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1MX	Abcam HeLa CDC42EP4 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.