CDH6

Summary

CDH6 (cadherin 6, HGNC:1765) is a protein-coding gene on chromosome 5p13.3, encoding Cadherin-6 (P55285). Cadherins are calcium-dependent cell adhesion proteins.

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

Source: NCBI Gene 1004 — RefSeq curated summary.

At a glance

• GWAS associations: 26
• Clinical variants (ClinVar): 85 total
• MANE Select transcript: NM_004932

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1765
Approved symbol	CDH6
Name	cadherin 6
Location	5p13.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000113361
Ensembl biotype	protein_coding
OMIM	603007
Entrez	1004

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 3 retained_intron

ENST00000265071, ENST00000504835, ENST00000506396, ENST00000508132, ENST00000514738, ENST00000899823, ENST00000899824

RefSeq mRNA: 2 — MANE Select: NM_004932 NM_001362435, NM_004932

CCDS: CCDS3894

Canonical transcript exons

ENST00000265071 — 12 exons

Exon	Start	End
ENSE00000971065	31267346	31267701
ENSE00000971069	31302111	31302298
ENSE00000971070	31305174	31305427
ENSE00000971071	31313318	31313454
ENSE00000971072	31316208	31316329
ENSE00001006058	31293962	31294256
ENSE00001390780	31322818	31329146
ENSE00001701765	31317673	31317924
ENSE00003497071	31297289	31297408
ENSE00003544819	31317375	31317492
ENSE00003582736	31299464	31299631
ENSE00003842115	31193686	31193886

Expression profiles

Bgee: expression breadth ubiquitous, 228 present calls, max score 96.27.

FANTOM5 (CAGE): breadth broad, TPM avg 22.2447 / max 634.4456, expressed in 761 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55954	13.0349	678
55952	6.0245	619
55953	2.0013	493
55955	0.7106	373
55956	0.4439	259
55958	0.0295	11

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory bulb	UBERON:0002264	96.27	gold quality
type B pancreatic cell	CL:0000169	96.08	silver quality
tongue squamous epithelium	UBERON:0006919	88.14	gold quality
nephron tubule	UBERON:0001231	87.29	gold quality
tibial artery	UBERON:0007610	86.83	gold quality
popliteal artery	UBERON:0002250	86.82	gold quality
epithelial cell of pancreas	CL:0000083	84.86	gold quality
adult mammalian kidney	UBERON:0000082	84.83	gold quality
islet of Langerhans	UBERON:0000006	84.64	gold quality
endothelial cell	CL:0000115	84.47	gold quality
kidney epithelium	UBERON:0004819	84.30	gold quality
kidney	UBERON:0002113	83.84	gold quality
diaphragm	UBERON:0001103	82.68	gold quality
oviduct epithelium	UBERON:0004804	82.28	gold quality
vena cava	UBERON:0004087	82.12	gold quality
gall bladder	UBERON:0002110	82.11	gold quality
sural nerve	UBERON:0015488	82.07	gold quality
cortical plate	UBERON:0005343	81.87	gold quality
lateral nuclear group of thalamus	UBERON:0002736	81.70	gold quality
metanephros cortex	UBERON:0010533	81.68	gold quality
metanephric glomerulus	UBERON:0004736	81.22	gold quality
metanephros	UBERON:0000081	81.12	gold quality
cervix squamous epithelium	UBERON:0006922	80.84	gold quality
visceral pleura	UBERON:0002401	80.83	gold quality
renal glomerulus	UBERON:0000074	80.82	gold quality
dorsal plus ventral thalamus	UBERON:0001897	80.64	gold quality
putamen	UBERON:0001874	80.55	gold quality
cervix epithelium	UBERON:0004801	80.35	gold quality
Brodmann (1909) area 46	UBERON:0006483	80.29	gold quality
calcaneal tendon	UBERON:0003701	79.78	gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-GEOD-75140	yes	996.49
E-CURD-10	yes	728.25
E-MTAB-7407	yes	606.25
E-GEOD-130473	yes	407.34
E-GEOD-114530	yes	367.78
E-GEOD-75367	yes	39.79
E-HCAD-10	yes	22.86
E-ANND-3	yes	13.30
E-GEOD-70580	no	59.95

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): BARX2, DNMT3A, HOXA1

miRNA regulators (miRDB)

227 targeting CDH6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-4803	99.98	71.99	3117

Literature-anchored findings (GeneRIF, showing 10)

• The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells. (PMID:20634887)
• CDH6 is under the control of the transcription factor RUNX2, which we previously described as a crucial mediator of the Id1 pro-invasive function in thyroid tumor cells. (PMID:24069422)
• Data indicate that BRAFV600E, P-cadherin and cadherin 6 protein expressions were correlated with one another. (PMID:26285159)
• Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC (PMID:27593557)
• our findings demonstrate that CDH6 exerts as an important independent biomarker that could predict human osteosarcoma clinical outcomes. miR-223-3p can inhibit cell invasion, migration, growth, and proliferation in osteosarcoma by directly targeting CDH6 (PMID:29628305)
• The low endometrial expression of beta-catenin, E-cadherin and K-cadherin were associated to fertility-related problems, such as primary intertility and recurrent pregnancy loss. (PMID:30806528)
• CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE epsilon4 carriers. (PMID:32427856)
• Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity. (PMID:32600462)
• The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells. (PMID:37523816)
• Cadherin-6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell-derived factor-1. (PMID:38719785)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cdh6	ENSDARG00000014522
mus_musculus	Cdh6	ENSMUSG00000039385
rattus_norvegicus	Cdh6	ENSRNOG00000013535

Paralogs (33): CDH1 (ENSG00000039068), CDH10 (ENSG00000040731), CDH3 (ENSG00000062038), CDH19 (ENSG00000071991), CDHR2 (ENSG00000074276), CDH17 (ENSG00000079112), CDH7 (ENSG00000081138), PCDH11Y (ENSG00000099715), CDHR5 (ENSG00000099834), CDH20 (ENSG00000101542), PCDH11X (ENSG00000102290), CDH23 (ENSG00000107736), CDH9 (ENSG00000113100), CDH26 (ENSG00000124215), CDHR3 (ENSG00000128536), CDH15 (ENSG00000129910), CDH24 (ENSG00000139880), CDH11 (ENSG00000140937), CDH13 (ENSG00000140945), CDH18 (ENSG00000145526), CDHR1 (ENSG00000148600), CDH22 (ENSG00000149654), CDH8 (ENSG00000150394), CDH12 (ENSG00000154162), PCDH1 (ENSG00000156453), DCHS1 (ENSG00000166341), PCDH7 (ENSG00000169851), CDH2 (ENSG00000170558), CDH4 (ENSG00000179242), CDH5 (ENSG00000179776), PCDH9 (ENSG00000184226), DCHS2 (ENSG00000197410), PCDH20 (ENSG00000280165)

Protein

Protein identifiers

Cadherin-6 — P55285 (reviewed: P55285)

Alternative names: Kidney cadherin

All UniProt accessions (2): D6RF86, P55285

UniProt curated annotations — full annotation on UniProt →

Function. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location. Cell membrane.

Tissue specificity. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.

Domain organisation. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Isoforms (2)

UniProt ID	Names	Canonical?
P55285-1	1	yes
P55285-2	2

RefSeq proteins (2): NP_001349364, NP_004923* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000233	Cadherin_Y-type_LIR	Domain
IPR002126	Cadherin-like_dom	Domain
IPR015919	Cadherin-like_sf	Homologous_superfamily
IPR020894	Cadherin_CS	Conserved_site
IPR027397	Catenin-bd_sf	Homologous_superfamily
IPR039808	Cadherin	Family

Pfam: PF00028, PF01049

UniProt features (36 total): strand 9, glycosylation site 6, domain 5, modified residue 2, splice variant 2, sequence conflict 2, turn 2, topological domain 2, signal peptide 1, propeptide 1, region of interest 1, compositionally biased region 1, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
5VEB	X-RAY DIFFRACTION	2.34

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P55285-F1	78.67	0.47

Antibody-complex structures (SAbDab): 1 — 5VEB

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 786, 790

Glycosylation sites (6): 49, 255, 399, 437, 455, 536

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-418990	Adherens junctions interactions
R-HSA-1500931	Cell-Cell communication
R-HSA-421270	Cell-cell junction organization
R-HSA-446728	Cell junction organization

MSigDB gene sets: 221 (showing top): BENPORATH_ES_WITH_H3K27ME3, TGACCTY_ERR1_Q2, TAL1ALPHAE47_01, CHX10_01, CAGCTG_AP4_Q5, GOBP_CALCIUM_DEPENDENT_CELL_CELL_ADHESION, REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS, GOBP_CELL_CELL_ADHESION, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_CELL_JUNCTION_ORGANIZATION, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN, OCT1_03, IRF1_Q6, BROWNE_HCMV_INFECTION_14HR_DN, JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP

GO Biological Process (11): cell morphogenesis (GO:0000902), cell-cell junction assembly (GO:0007043), cell adhesion (GO:0007155), homophilic cell-cell adhesion (GO:0007156), Notch signaling pathway (GO:0007219), calcium-dependent cell-cell adhesion (GO:0016339), cell migration (GO:0016477), adherens junction organization (GO:0034332), cell-cell adhesion mediated by cadherin (GO:0044331), synaptic membrane adhesion (GO:0099560), cell-cell adhesion (GO:0098609)

GO Molecular Function (4): calcium ion binding (GO:0005509), beta-catenin binding (GO:0008013), cadherin binding (GO:0045296), metal ion binding (GO:0046872)

GO Cellular Component (8): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), adherens junction (GO:0005912), catenin complex (GO:0016342), cell junction (GO:0030054), glutamatergic synapse (GO:0098978), membrane (GO:0016020), synapse (GO:0045202)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Cell-cell junction organization	1
Cell junction organization	1
Cell-Cell communication	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell-cell adhesion	4
cellular anatomical structure	3
cell-cell junction organization	2
anatomical structure morphogenesis	1
cell junction assembly	1
cellular process	1
cell surface receptor signaling pathway	1
cell motility	1
synapse organization	1
cell adhesion	1
metal ion binding	1
protein binding	1
cell adhesion molecule binding	1
cation binding	1
nuclear lumen	1
membrane	1
cell periphery	1
cell-cell junction	1
extrinsic component of plasma membrane	1
plasma membrane protein complex	1
synapse	1
cell junction	1

Protein interactions and networks

STRING

1158 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CDH6	CTNNA1	P35221	720
CDH6	BNIP3L	O60238	689
CDH6	GABARAP	O95166	688
CDH6	CDH15	P55291	669
CDH6	CDH2	P19022	593
CDH6	CDH19	Q9H159	576
CDH6	CTNNB1	P35222	573
CDH6	CDH20	Q9HBT6	571
CDH6	CDH7	Q9ULB5	569
CDH6	CDH10	Q9Y6N8	539
CDH6	VEZT	Q9HBM0	525
CDH6	LIN7A	O14910	511
CDH6	TJP1	Q07157	504
CDH6	RUNX2	Q13950	502
CDH6	CDH3	P22223	482

IntAct

3 interactions, top by confidence:

A	B	Type	Score
TRPV2	CDH6	psi-mi:“MI:0915”(physical association)	0.370
CTNNB1	IGLL5	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): CDH6 (Positive Genetic), CDH6 (Affinity Capture-Western), CDH6 (Co-localization), CDH18 (Co-localization), CDH6 (Biochemical Activity), CDH6 (Affinity Capture-MS), CDH6 (Affinity Capture-MS), CDH6 (Protein-peptide)

ESM2 similar proteins: A0A8M2BIB6, F1QSQ0, F8W3X3, H2EQR6, O35902, O54800, O55111, O93319, P32926, P33545, P55280, P55285, P55286, P55287, P55288, P55289, P55292, P55849, P55850, P70407, P70408, P79995, P97291, P97326, Q01107, Q02413, Q02487, Q08554, Q08DJ5, Q13634, Q14126, Q14574, Q28060, Q3SWX5, Q5DWV1, Q5RJH3, Q61495, Q68SP4, Q6W3B0, Q7TMD7

Diamond homologs: A0A8M2BIB6, B0KW95, B2KI42, B4USZ0, F1PAA9, F1QSQ0, O02840, O35902, O54800, O55075, O55111, O93319, P08641, P09803, P10287, P10288, P12830, P15116, P19022, P19534, P19535, P20310, P22223, P24503, P30944, P32926, P33145, P33146, P33147, P33148, P33150, P33151, P33152, P33545, P39038, P55280, P55283, P55284, P55285, P55286

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
calcium(2+)	“up-regulates activity”	CDH6	“chemical activation”
CDH6	“up-regulates activity”	CTNNB1	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

85 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	68
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2655 predictions. Top by Δscore:

Variant	Effect	Δscore
5:31193873:G:GT	donor_gain	1.0000
5:31294217:G:GT	donor_gain	1.0000
5:31297285:ACAGG:A	acceptor_loss	1.0000
5:31297286:CAGGT:C	acceptor_loss	1.0000
5:31297287:A:AG	acceptor_gain	1.0000
5:31297287:A:AT	acceptor_loss	1.0000
5:31297288:G:GA	acceptor_gain	1.0000
5:31297288:GGT:G	acceptor_gain	1.0000
5:31297288:GGTA:G	acceptor_gain	1.0000
5:31297288:GGTAC:G	acceptor_gain	1.0000
5:31299454:A:AG	acceptor_gain	1.0000
5:31299455:C:G	acceptor_gain	1.0000
5:31299630:GA:G	donor_gain	1.0000
5:31299632:G:GG	donor_gain	1.0000
5:31302275:G:GT	donor_gain	1.0000
5:31302276:A:T	donor_gain	1.0000
5:31302295:AAAGG:A	donor_loss	1.0000
5:31302296:AAGG:A	donor_loss	1.0000
5:31302299:G:GA	donor_loss	1.0000
5:31302300:T:A	donor_loss	1.0000
5:31305159:A:AG	acceptor_gain	1.0000
5:31305160:C:G	acceptor_gain	1.0000
5:31305428:G:GG	donor_gain	1.0000
5:31313450:GATCA:G	donor_gain	1.0000
5:31313455:G:GG	donor_gain	1.0000
5:31316195:T:A	acceptor_gain	1.0000
5:31316196:G:A	acceptor_gain	1.0000
5:31316328:AG:A	donor_loss	1.0000
5:31316329:GG:G	donor_loss	1.0000
5:31316330:GTG:G	donor_loss	1.0000

AlphaMissense

5198 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:31294001:T:G	Y90D	1.000
5:31294035:T:C	F101S	1.000
5:31294056:G:A	G108D	1.000
5:31294056:G:T	G108V	1.000
5:31294062:T:A	I110K	1.000
5:31294110:T:C	L126P	1.000
5:31294116:C:A	A128D	1.000
5:31294167:T:C	F145S	1.000
5:31294185:A:C	D151A	1.000
5:31294185:A:T	D151V	1.000
5:31294194:A:C	D154A	1.000
5:31267636:T:A	W55R	0.999
5:31267636:T:C	W55R	0.999
5:31267638:G:C	W55C	0.999
5:31267638:G:T	W55C	0.999
5:31267642:T:A	W57R	0.999
5:31267642:T:C	W57R	0.999
5:31267644:G:C	W57C	0.999
5:31267644:G:T	W57C	0.999
5:31267696:G:C	G75R	0.999
5:31267697:G:A	G75D	0.999
5:31293963:T:C	L77S	0.999
5:31294001:T:C	Y90H	0.999
5:31294002:A:C	Y90S	0.999
5:31294008:T:A	L92H	0.999
5:31294008:T:C	L92P	0.999
5:31294035:T:G	F101C	0.999
5:31294055:G:C	G108R	0.999
5:31294055:G:T	G108C	0.999
5:31294062:T:G	I110R	0.999

dbSNP variants (sampled 300 via entrez): RS1000026608 (5:31286147 A>G), RS1000030210 (5:31248090 G>A), RS1000045012 (5:31197836 A>G), RS1000049449 (5:31313151 T>C), RS1000064624 (5:31200591 C>T), RS1000116398 (5:31210897 T>C), RS1000158371 (5:31258881 G>A,C), RS1000178652 (5:31298071 G>A), RS1000221609 (5:31262242 A>G), RS1000264638 (5:31207178 G>T), RS1000289070 (5:31291047 A>G), RS1000299943 (5:31260219 C>T), RS1000310953 (5:31247704 C>T), RS1000318491 (5:31220155 G>A), RS1000373249 (5:31213527 C>A,T)

Disease associations

OMIM: gene MIM:603007 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

26 associations (top):

Study	Trait	p-value
GCST000770_5	Emphysema-related traits	2.000000e-06
GCST001277_1	Liver enzyme levels (gamma-glutamyl transferase)	1.000000e-09
GCST002408_1	Response to methotrexate in juvenile idiopathic arthritis	6.000000e-07
GCST003251_17	Late-onset myasthenia gravis	4.000000e-06
GCST003818_21	Resting heart rate	4.000000e-11
GCST004172_2	Rheumatoid arthritis	1.000000e-08
GCST004174_2	Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive)	5.000000e-08
GCST006019_48	Gamma glutamyl transferase levels	2.000000e-08
GCST006288_212	Heel bone mineral density	7.000000e-07
GCST006288_531	Heel bone mineral density	2.000000e-09
GCST006979_763	Heel bone mineral density	7.000000e-24
GCST007324_146	Adventurousness	2.000000e-09
GCST007325_283	General risk tolerance (MTAG)	1.000000e-12
GCST007327_75	Smoking status (ever vs never smokers)	4.000000e-08
GCST008399_13	Cocaine dependence	9.000000e-06
GCST009144_28	Disease progression in age-related macular degeneration (adjusted for baseline)	8.000000e-07
GCST010292_6	Response to lamotrigine and valproic acid in genetic generalized epilepsy	4.000000e-06
GCST010572_2	Sweet taste preference	5.000000e-06
GCST011349_1	Gamma glutamyl transferase levels	2.000000e-11
GCST012033_10	Sleep (1/3-day periodicity)	9.000000e-09
GCST012322_30	Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder	4.000000e-09
GCST90011898_129	Alanine aminotransferase levels	6.000000e-25
GCST90011899_46	Aspartate aminotransferase levels	1.000000e-14
GCST90013407_180	Liver enzyme levels (gamma-glutamyl transferase)	1.000000e-170
GCST90013663_102	Alanine aminotransferase levels	1.000000e-36
GCST90013664_24	Aspartate aminotransferase levels	2.000000e-18

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0004532	serum gamma-glutamyl transferase measurement
EFO:0007791	rheumatoid factor seropositivity measurement
EFO:0007837	anti-citrullinated protein antibody seropositivity
EFO:0009270	heel bone mineral density
EFO:0008579	risk-taking behaviour
EFO:0004318	smoking behavior
EFO:0008336	disease progression measurement
EFO:0010156	sweet liking measurement
EFO:0004530	triglyceride measurement
EFO:0005658	response to selective serotonin reuptake inhibitor
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, decreases expression	8
methylmercuric chloride	increases expression, affects cotreatment	4
bisphenol A	affects cotreatment, increases methylation, increases expression, affects expression	3
trichostatin A	affects cotreatment, increases expression	3
Benzo(a)pyrene	increases expression, increases methylation, affects methylation	3
mercuric bromide	increases expression, affects cotreatment	2
entinostat	decreases expression, increases expression	2
Vorinostat	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Silicon Dioxide	decreases expression	2
p-Chloromercuribenzoic Acid	increases expression, affects cotreatment	2
aristolochic acid I	decreases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
2,5,2’,5’-tetrachlorobiphenyl	increases expression	1
sodium arsenite	increases expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	increases expression	1
aflatoxin B2	increases methylation	1
brequinar	decreases expression	1
27-hydroxycholesterol	decreases expression	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dimethylarsinous acid	decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	decreases expression	1

Cellosaurus cell lines

4 cell lines: 2 cancer cell line, 1 spontaneously immortalized cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1TL	HAP1 CDH6 (-) 2	Cancer cell line	Male
CVCL_E6PU	Genomeditech CHO-K1 H_CDH6	Spontaneously immortalized cell line	Female
CVCL_E6TJ	Genomeditech HEK-293 H_CDH6	Transformed cell line	Female
CVCL_XM68	HAP1 CDH6 (-) 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.