CDK6-AS1

Summary

CDK6-AS1 (CDK6 antisense RNA 1, HGNC:40141) is a long non-coding RNA gene on chromosome 7q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40141
Approved symbol	CDK6-AS1
Name	CDK6 antisense RNA 1
Location	7q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	BALR-2, AC002454.1
Ensembl gene	ENSG00000237819
Ensembl biotype	lncRNA
Entrez	101927497
RNAcentral	URS000075E91D — lncRNA, 868 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000419668, ENST00000424523, ENST00000435695, ENST00000452050, ENST00000686356, ENST00000689753, ENST00000702515, ENST00000752968, ENST00000752969, ENST00000752970, ENST00000752971, ENST00000752972, ENST00000752973, ENST00000752974, ENST00000752975, ENST00000752976, ENST00000752977, ENST00000752978, ENST00000752979, ENST00000752980, ENST00000752981, ENST00000752982, ENST00000752983, ENST00000752984, ENST00000752985, ENST00000752986, ENST00000752987, ENST00000752988, ENST00000752989

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419668 — 4 exons

Exon	Start	End
ENSE00001773875	92855684	92855827
ENSE00001792101	92854909	92854953
ENSE00004099668	92836305	92836563
ENSE00004099695	92916837	92917185

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 93.09.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2999 / max 372.1174, expressed in 381 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79543	1.7577	274
79542	0.2637	81
79541	0.1249	43
79544	0.0880	26
79540	0.0655	17

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.13	gold quality
bone marrow	UBERON:0002371	76.28	gold quality
bone marrow cell	CL:0002092	72.85	silver quality
ventricular zone	UBERON:0003053	72.09	gold quality
ganglionic eminence	UBERON:0004023	71.09	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.98	gold quality
leukocyte	CL:0000738	66.34	gold quality
monocyte	CL:0000576	66.01	gold quality
prefrontal cortex	UBERON:0000451	64.38	gold quality
tonsil	UBERON:0002372	63.01	gold quality
stromal cell of endometrium	CL:0002255	62.50	gold quality
putamen	UBERON:0001874	62.43	gold quality
superior frontal gyrus	UBERON:0002661	62.43	gold quality
adrenal tissue	UBERON:0018303	61.24	gold quality
skeletal muscle tissue	UBERON:0001134	61.21	gold quality
duodenum	UBERON:0002114	60.72	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.45	gold quality
left adrenal gland cortex	UBERON:0035825	60.32	gold quality
frontal cortex	UBERON:0001870	60.19	gold quality
right adrenal gland cortex	UBERON:0035827	59.88	gold quality
adrenal gland	UBERON:0002369	59.73	gold quality
left adrenal gland	UBERON:0001234	59.50	gold quality
right adrenal gland	UBERON:0001233	59.40	gold quality
blood	UBERON:0000178	58.93	gold quality
caudate nucleus	UBERON:0001873	58.83	gold quality
primary visual cortex	UBERON:0002436	58.42	gold quality
nucleus accumbens	UBERON:0001882	58.17	gold quality
cerebral cortex	UBERON:0000956	57.80	gold quality
vermiform appendix	UBERON:0001154	57.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• both AC002454.1 and CDK6 positively regulated the proliferation, migration and invasion ability of eutopic endometrial cells and could promote the transformation of cells from G0/G1 phase to S phase (PMID:30884467)
• AC002454.1 is in leukemia cells (PMID:31775489)
• Differential gene expression of BCL-2, ZEB2-AS1 and BALR-2 in prostate cancer and benign prostatic hyperplasia. (PMID:34866225)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.