CDKN2A-AS1

Summary

CDKN2A-AS1 (CDKN2A antisense RNA 1, HGNC:23831) is a long non-coding RNA gene on chromosome 9p21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23831
Approved symbol	CDKN2A-AS1
Name	CDKN2A antisense RNA 1
Location	9p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	bA149I2.3
Ensembl gene	ENSG00000224854
Ensembl biotype	lncRNA
Entrez	51198
RNAcentral	URS000075B2D1 — lncRNA, 616 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000441769, ENST00000731046, ENST00000731047

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441769 — 1 exons

Exon	Start	End
ENSE00001795962	21966929	21967751

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 68.08.

Top tissues by expression

168 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.08	gold quality
gingival epithelium	UBERON:0001949	58.38	gold quality
parotid gland	UBERON:0001831	57.71	gold quality
buccal mucosa cell	CL:0002336	57.66	gold quality
gingiva	UBERON:0001828	56.25	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.29	gold quality
calcaneal tendon	UBERON:0003701	53.83	silver quality
myocardium	UBERON:0002349	53.33	gold quality
cartilage tissue	UBERON:0002418	52.94	gold quality
monocyte	CL:0000576	51.60	silver quality
nasal cavity epithelium	UBERON:0005384	51.22	gold quality
bone marrow	UBERON:0002371	50.48	gold quality
islet of Langerhans	UBERON:0000006	50.31	gold quality
sperm	CL:0000019	48.68	gold quality
right lobe of liver	UBERON:0001114	46.94	silver quality
nasal cavity mucosa	UBERON:0001826	46.59	gold quality
vastus lateralis	UBERON:0001379	45.96	gold quality
quadriceps femoris	UBERON:0001377	45.82	gold quality
right coronary artery	UBERON:0001625	45.26	gold quality
pancreas	UBERON:0001264	44.99	gold quality
prefrontal cortex	UBERON:0000451	44.68	silver quality
adenohypophysis	UBERON:0002196	44.29	gold quality
esophagus mucosa	UBERON:0002469	44.07	gold quality
Brodmann (1909) area 23	UBERON:0013554	44.03	gold quality
synovial joint	UBERON:0002217	44.01	gold quality
gastrocnemius	UBERON:0001388	43.96	silver quality
popliteal artery	UBERON:0002250	43.92	gold quality
tibial artery	UBERON:0007610	43.87	gold quality
omental fat pad	UBERON:0010414	43.65	silver quality
Brodmann (1909) area 9	UBERON:0013540	43.50	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The C allele of rs1333049 in the vascular disease susceptibility locus is associated with vascular dementia and late-onset Alzheimer’s disease, independent of traditional risk factors. (PMID:19664850)
• Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction. (PMID:21385355)
• A chromosome 9p21.3 variant predicts the risk of myocardial infarction among white men. (PMID:21406102)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.