CEACAM19

Summary

CEACAM19 (CEA cell adhesion molecule 19, HGNC:31951) is a protein-coding gene on chromosome 19q13.31, encoding Cell adhesion molecule CEACAM19 (Q7Z692).

Predicted to be located in membrane.

Source: NCBI Gene 56971 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 38 total — 1 pathogenic
• MANE Select transcript: NM_001127893

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31951
Approved symbol	CEACAM19
Name	CEA cell adhesion molecule 19
Location	19q13.31
Locus type	gene with protein product
Status	Approved
Aliases	CEAL1
Ensembl gene	ENSG00000186567
Ensembl biotype	protein_coding
OMIM	606691
Entrez	56971

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000358777, ENST00000403660, ENST00000459648, ENST00000480278, ENST00000591979, ENST00000592789, ENST00000618372, ENST00000619799, ENST00000622237, ENST00000911248

RefSeq mRNA: 3 — MANE Select: NM_001127893 NM_001127893, NM_001389722, NM_020219

CCDS: CCDS12641, CCDS46108

Canonical transcript exons

ENST00000358777 — 8 exons

Exon	Start	End
ENSE00001404578	44671482	44671986
ENSE00001407788	44672596	44672964
ENSE00001826287	44683437	44684355
ENSE00003465574	44681227	44681312
ENSE00003638981	44676271	44676421
ENSE00003657264	44682567	44682620
ENSE00003668088	44678853	44678936
ENSE00003678292	44680288	44680334

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 91.31.

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	91.31	gold quality
right uterine tube	UBERON:0001302	89.01	gold quality
metanephros cortex	UBERON:0010533	87.72	gold quality
tibial nerve	UBERON:0001323	87.18	gold quality
gastrocnemius	UBERON:0001388	86.61	gold quality
muscle of leg	UBERON:0001383	85.54	gold quality
body of pancreas	UBERON:0001150	85.15	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.56	gold quality
right lobe of liver	UBERON:0001114	84.27	gold quality
skin of leg	UBERON:0001511	83.98	gold quality
heart left ventricle	UBERON:0002084	83.74	gold quality
adenohypophysis	UBERON:0002196	83.17	gold quality
cardiac ventricle	UBERON:0002082	83.14	gold quality
stromal cell of endometrium	CL:0002255	82.70	gold quality
skin of abdomen	UBERON:0001416	82.66	gold quality
sural nerve	UBERON:0015488	82.53	gold quality
upper lobe of left lung	UBERON:0008952	82.42	gold quality
left uterine tube	UBERON:0001303	82.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.94	gold quality
lower esophagus	UBERON:0013473	81.90	gold quality
popliteal artery	UBERON:0002250	81.71	gold quality
tibial artery	UBERON:0007610	81.71	gold quality
left lobe of thyroid gland	UBERON:0001120	81.66	gold quality
ectocervix	UBERON:0012249	81.62	gold quality
cerebellar hemisphere	UBERON:0002245	81.53	gold quality
right adrenal gland	UBERON:0001233	81.50	gold quality
mucosa of stomach	UBERON:0001199	81.48	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.42	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.41	gold quality
right coronary artery	UBERON:0001625	81.36	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.13
E-MTAB-6386	no	21.69

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

37 targeting CEACAM19, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-1224-5P	99.48	65.59	803
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-153-3P	98.96	72.51	1644
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-6829-5P	98.86	65.12	1480
HSA-MIR-5008-5P	98.42	65.87	1019
HSA-MIR-4717-5P	98.19	67.97	894
HSA-MIR-6801-3P	98.04	64.64	805
HSA-MIR-6810-3P	97.96	64.57	1023
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-450A-2-3P	97.91	67.56	1459
HSA-MIR-4665-5P	97.91	67.69	1536
HSA-MIR-676-3P	97.86	65.70	668
HSA-MIR-4799-3P	97.78	65.97	893
HSA-MIR-6737-5P	97.75	66.54	1044
HSA-MIR-6812-5P	97.56	65.39	1059
HSA-MIR-4720-5P	97.46	65.67	893
HSA-MIR-5588-5P	97.46	65.70	913
HSA-MIR-2467-5P	97.36	67.71	991
HSA-MIR-6131	97.22	66.72	960
HSA-MIR-10398-5P	97.12	64.94	1051

Literature-anchored findings (GeneRIF, showing 4)

• Our results suggest that CEACAM19 mRNA expression represents a promising, novel and clinically useful tissue biomarker for breast cancer management. (PMID:23525470)
• In conclusion, CEACAM19 showed high expression in tumor samples compared to normal mammary tissue. (PMID:27909883)
• High CEACAM19 expression is associated with gastric cancer. (PMID:30217308)
• Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach. (PMID:32659328)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ceacam19	ENSMUSG00000049848
rattus_norvegicus	Ceacam19	ENSRNOG00000043088

Paralogs (24): CEACAM21 (ENSG00000007129), CEACAM7 (ENSG00000007306), CEACAM1 (ENSG00000079385), CEACAM6 (ENSG00000086548), CEACAM4 (ENSG00000105352), CEACAM5 (ENSG00000105388), PSG8 (ENSG00000124467), CEACAM8 (ENSG00000124469), HEPACAM (ENSG00000165478), PSG6 (ENSG00000170848), CEACAM3 (ENSG00000170956), PSG9 (ENSG00000183668), HEPACAM2 (ENSG00000188175), PSG5 (ENSG00000204941), CEACAM18 (ENSG00000213822), CEACAM16 (ENSG00000213892), VSTM5 (ENSG00000214376), PSG3 (ENSG00000221826), PSG7 (ENSG00000221878), PSG1 (ENSG00000231924), PSG2 (ENSG00000242221), PSG11 (ENSG00000243130), PSG4 (ENSG00000243137), CEACAM20 (ENSG00000273777)

Protein

Protein identifiers

Cell adhesion molecule CEACAM19 — Q7Z692 (reviewed: Q7Z692)

Alternative names: Carcinoembryonic antigen-like 1, Carcinoembryonic antigen-related cell adhesion molecule 19

All UniProt accessions (4): A0A087WWX9, A0A158VUY4, Q7Z692, K7EK61

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal gland, skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver, pancreas, bone marrow and ovary.

Induction. Down-regulated by dexamethasone (in vitro).

Similarity. Belongs to the immunoglobulin superfamily. CEA family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q7Z692-1	1	yes
Q7Z692-2	2
Q7Z692-3	3

RefSeq proteins (3): NP_001121365, NP_001376651, NP_064604 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050831	CEA_cell_adhesion	Family

Pfam: PF07686

UniProt features (10 total): splice variant 3, topological domain 2, signal peptide 1, chain 1, transmembrane region 1, region of interest 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z692-F1	69.95	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 104

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 44 (showing top): GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN, GOBP_HETEROPHILIC_CELL_CELL_ADHESION, ROVERSI_GLIOMA_COPY_NUMBER_UP, GOBP_CELL_CELL_ADHESION, CDP_01, SRC_UP.V1_UP, CDP_02, GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP, CSHL1_TARGET_GENES, HES2_TARGET_GENES, TEAD2_TARGET_GENES, ZNF23_TARGET_GENES, ZNF362_TARGET_GENES, ZNF596_TARGET_GENES, ZNF92_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

276 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEACAM19	CEACAM18	A8MTB9	823
CEACAM19	CEACAM20	Q6UY09	741
CEACAM19	CEACAM21	Q3KPI0	651
CEACAM19	PRSS36	Q5K4E3	567
CEACAM19	CLPTM1	O96005	506
CEACAM19	BCL3	P20749	481
CEACAM19	LIPE	Q05469	436
CEACAM19	CEACAM4	O75871	434
CEACAM19	CD79A	P11912	425
CEACAM19	PVR	P15151	402
CEACAM19	TRAPPC6A	O75865	398
CEACAM19	MIEF1	L0R8F8	397
CEACAM19	CEACAM3	P40198	394
CEACAM19	P0DN79	P0DN79	393
CEACAM19	Q6ZT62	Q6ZT62	377

IntAct

3 interactions, top by confidence:

A	B	Type	Score
FSTL5	CEACAM19	psi-mi:“MI:0915”(physical association)	0.400
CEACAM19	sepZ	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (1): CEACAM19 (Affinity Capture-RNA)

ESM2 similar proteins: A0JNA2, A2RRU4, A4FUY1, A5D7V5, A8MVS5, D4A6L0, E1BBQ2, O19131, O54693, O75144, P09564, P15151, P19438, P29590, P31994, P32506, P32507, P50555, P97260, Q14CZ8, Q28110, Q3TEW6, Q53EL9, Q5BJT4, Q5DRQ8, Q5T848, Q61190, Q640R3, Q6AYP5, Q6AYT8, Q6BAA4, Q6GQT6, Q6P6J9, Q6UX15, Q70EL4, Q75VT8, Q7TSK2, Q7Z692, Q8C419, Q8N126

Diamond homologs: A0A0B4J1L0, D3ZQE1, E9QA28, O75871, P06731, P11464, P11465, P13688, P16573, P31809, P31997, P40198, P40199, Q00887, Q00888, Q00889, Q13046, Q14002, Q15238, Q16557, Q2WEN9, Q3KPI0, Q61400, Q63111, Q6UY09, Q7Z692, Q810J1, Q925P2, Q9D2Z1, Q9QZS7, Q9R044, Q9UQ72, Q9UQ74

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	27
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
816084	GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3	Pathogenic

SpliceAI

972 predictions. Top by Δscore:

Variant	Effect	Δscore
19:44672953:TCC:T	donor_gain	1.0000
19:44672962:CTG:C	donor_loss	1.0000
19:44672964:GGT:G	donor_loss	1.0000
19:44672965:G:GG	donor_gain	1.0000
19:44672966:TAAGT:T	donor_loss	1.0000
19:44676262:A:AG	acceptor_gain	1.0000
19:44676263:C:G	acceptor_gain	1.0000
19:44676266:CTCA:C	acceptor_loss	1.0000
19:44676268:CAGA:C	acceptor_loss	1.0000
19:44676269:A:AG	acceptor_gain	1.0000
19:44676269:AG:A	acceptor_loss	1.0000
19:44676270:G:GG	acceptor_gain	1.0000
19:44676270:G:GT	acceptor_loss	1.0000
19:44676430:TCCCC:T	donor_gain	1.0000
19:44681225:A:AG	acceptor_gain	1.0000
19:44681226:G:GG	acceptor_gain	1.0000
19:44682563:GCA:G	acceptor_loss	1.0000
19:44682565:A:AG	acceptor_gain	1.0000
19:44682566:G:A	acceptor_loss	1.0000
19:44682566:G:GA	acceptor_gain	1.0000
19:44682566:GC:G	acceptor_gain	1.0000
19:44682566:GCC:G	acceptor_gain	1.0000
19:44682566:GCCC:G	acceptor_gain	1.0000
19:44682566:GCCCC:G	acceptor_gain	1.0000
19:44682618:CAGGT:C	donor_loss	1.0000
19:44682619:AGG:A	donor_loss	1.0000
19:44682620:GGTAT:G	donor_loss	1.0000
19:44682621:GTAT:G	donor_loss	1.0000
19:44682622:T:G	donor_loss	1.0000
19:44672592:ACAG:A	acceptor_loss	0.9900

AlphaMissense

1928 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:44672733:T:A	W65R	0.993
19:44672733:T:C	W65R	0.993
19:44672735:G:C	W65C	0.993
19:44672735:G:T	W65C	0.993
19:44672898:T:G	Y120D	0.989
19:44672856:T:C	S106P	0.988
19:44672854:G:A	G105D	0.984
19:44672686:T:C	L49P	0.983
19:44672863:T:C	L108P	0.978
19:44672698:T:A	V53D	0.976
19:44672773:T:C	F78S	0.976
19:44672734:G:C	W65S	0.973
19:44672844:T:C	F102L	0.972
19:44672846:C:A	F102L	0.972
19:44672846:C:G	F102L	0.972
19:44672898:T:A	Y120N	0.971
19:44672940:G:C	A134P	0.971
19:44672692:T:A	L51Q	0.970
19:44672841:G:C	G101R	0.969
19:44672842:G:A	G101D	0.969
19:44672845:T:C	F102S	0.964
19:44672845:T:G	F102C	0.962
19:44672899:A:C	Y120S	0.962
19:44672773:T:G	F78C	0.961
19:44672772:T:C	F78L	0.959
19:44672774:T:A	F78L	0.959
19:44672774:T:G	F78L	0.959
19:44672907:G:C	A123P	0.959
19:44672854:G:T	G105V	0.957
19:44672804:G:C	Q88H	0.956

dbSNP variants (sampled 300 via entrez): RS1000032582 (19:44683861 C>G), RS1000060862 (19:44667186 C>A,T), RS1000085756 (19:44675532 T>A), RS1000426683 (19:44667517 A>G), RS1000566853 (19:44684400 AG>A,AGG), RS1000670380 (19:44681129 T>C,G), RS1000908561 (19:44672848 C>T), RS1001033678 (19:44670246 C>G), RS1001089318 (19:44676933 T>C), RS1001120458 (19:44676556 C>A,T), RS1001180165 (19:44666795 C>G,T), RS1001195688 (19:44668845 A>G), RS1001209032 (19:44678968 T>C), RS1001262121 (19:44675196 A>G), RS1001431288 (19:44680741 C>T)

Disease associations

OMIM: gene MIM:606691 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST007827_17	Alzheimer’s disease or HDL levels (pleiotropy)	3.000000e-12
GCST007827_5	Alzheimer’s disease or HDL levels (pleiotropy)	7.000000e-74
GCST007827_6	Alzheimer’s disease or HDL levels (pleiotropy)	7.000000e-54
GCST007827_8	Alzheimer’s disease or HDL levels (pleiotropy)	3.000000e-36

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	3
aristolochic acid I	increases expression	1
fluorene-9-bisphenol	increases expression	1
triphenyl phosphate	affects expression	1
2,5,2’,5’-tetrachlorobiphenyl	increases expression	1
sodium arsenite	decreases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects methylation	1
Cisplatin	decreases expression, affects cotreatment	1
Dimethyl Sulfoxide	affects expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.