CEACAM7

Summary

CEACAM7 (CEA cell adhesion molecule 7, HGNC:1819) is a protein-coding gene on chromosome 19q13.2, encoding Cell adhesion molecule CEACAM7 (Q14002).

This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 1087 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_001291485

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1819
Approved symbol	CEACAM7
Name	CEA cell adhesion molecule 7
Location	19q13.2
Locus type	gene with protein product
Status	Approved
Aliases	CEA
Ensembl gene	ENSG00000007306
Ensembl biotype	protein_coding
OMIM	619160
Entrez	1087

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 15 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000006724, ENST00000401731, ENST00000599715, ENST00000602225, ENST00000869051, ENST00000869052, ENST00000869053, ENST00000869054, ENST00000869055, ENST00000869056, ENST00000869057, ENST00000869058, ENST00000869059, ENST00000869060, ENST00000869061, ENST00000948635

RefSeq mRNA: 2 — MANE Select: NM_001291485 NM_001291485, NM_006890

CCDS: CCDS12583

Canonical transcript exons

ENST00000401731 — 5 exons

Exon	Start	End
ENSE00000842466	41677376	41677503
ENSE00001555472	41688102	41688270
ENSE00001560913	41673303	41674739
ENSE00002517916	41683785	41684063
ENSE00003495567	41686859	41687221

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 99.62.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.9852 / max 1201.3699, expressed in 35 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181085	0.8573	35
181084	0.1279	12

Top tissues by expression

267 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	99.62	gold quality
rectum	UBERON:0001052	99.61	gold quality
colonic mucosa	UBERON:0000317	99.32	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.17	gold quality
ileal mucosa	UBERON:0000331	93.00	gold quality
vermiform appendix	UBERON:0001154	92.61	gold quality
transverse colon	UBERON:0001157	91.47	gold quality
islet of Langerhans	UBERON:0000006	89.42	gold quality
lower esophagus mucosa	UBERON:0035834	89.37	gold quality
gall bladder	UBERON:0002110	88.67	gold quality
esophagus mucosa	UBERON:0002469	85.96	gold quality
caecum	UBERON:0001153	85.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.95	gold quality
diaphragm	UBERON:0001103	79.56	gold quality
palpebral conjunctiva	UBERON:0001812	79.55	gold quality
large intestine	UBERON:0000059	79.13	gold quality
colon	UBERON:0001155	78.37	gold quality
vagina	UBERON:0000996	77.96	gold quality
cervix epithelium	UBERON:0004801	77.53	gold quality
pancreatic ductal cell	CL:0002079	77.32	silver quality
epithelium of esophagus	UBERON:0001976	76.26	gold quality
oral cavity	UBERON:0000167	75.90	gold quality
esophagus squamous epithelium	UBERON:0006920	75.86	gold quality
colonic epithelium	UBERON:0000397	75.23	gold quality
cervix squamous epithelium	UBERON:0006922	73.79	gold quality
epithelial cell of pancreas	CL:0000083	71.26	silver quality
olfactory bulb	UBERON:0002264	71.09	gold quality
pancreas	UBERON:0001264	70.93	gold quality
squamous epithelium	UBERON:0006914	70.58	gold quality
intestine	UBERON:0000160	70.33	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-83139	yes	3529.05
E-GEOD-125970	yes	2283.47
E-ANND-3	yes	13.54

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GLI2

miRNA regulators (miRDB)

59 targeting CEACAM7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-200A-5P	99.76	69.10	949
HSA-MIR-200B-5P	99.76	69.05	948
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-1303	99.65	69.77	1662
HSA-MIR-2053	99.57	69.15	1635
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-154-3P	99.50	70.05	831
HSA-MIR-487A-3P	99.50	69.95	840
HSA-MIR-548G-3P	99.48	68.67	2159
HSA-MIR-3123	99.47	67.15	2693
HSA-MIR-6839-3P	99.39	68.86	1301
HSA-MIR-940	99.37	66.14	2064
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-6893-5P	99.31	66.25	2119
HSA-MIR-329-5P	99.27	68.11	1597
HSA-MIR-10522-5P	99.26	68.50	2087
HSA-MIR-4263	99.18	69.25	2236
HSA-MIR-4504	99.10	69.14	1328

Literature-anchored findings (GeneRIF, showing 6)

• CGM2 RT-PCR assay provides no specific prognostic information and cannot be used as a decision criterion for adjuvant therapy after colorectal cancer surgery. (PMID:16627067)
• CEACAM-7 expression is significantly decreased in rectal cancer; a potential tumor marker (PMID:20004437)
• High CEACAM7 is associated with gastric carcinoma. (PMID:22195770)
• crystal structure of the N-terminal dimerization domain of CEACAM has been determined at 1.47 A resolution (PMID:26323304)
• CEACAM7 expression is significantly upregulated in human masticatory mucosa during wound healing (PMID:28005267)
• CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients. (PMID:34657826)

Cross-species orthologs

0 orthologs

Paralogs (24): CEACAM21 (ENSG00000007129), CEACAM1 (ENSG00000079385), CEACAM6 (ENSG00000086548), CEACAM4 (ENSG00000105352), CEACAM5 (ENSG00000105388), PSG8 (ENSG00000124467), CEACAM8 (ENSG00000124469), HEPACAM (ENSG00000165478), PSG6 (ENSG00000170848), CEACAM3 (ENSG00000170956), PSG9 (ENSG00000183668), CEACAM19 (ENSG00000186567), HEPACAM2 (ENSG00000188175), PSG5 (ENSG00000204941), CEACAM18 (ENSG00000213822), CEACAM16 (ENSG00000213892), VSTM5 (ENSG00000214376), PSG3 (ENSG00000221826), PSG7 (ENSG00000221878), PSG1 (ENSG00000231924), PSG2 (ENSG00000242221), PSG11 (ENSG00000243130), PSG4 (ENSG00000243137), CEACAM20 (ENSG00000273777)

Protein

Protein identifiers

Cell adhesion molecule CEACAM7 — Q14002 (reviewed: Q14002)

Alternative names: Carcinoembryonic antigen CGM2, Carcinoembryonic antigen-related cell adhesion molecule 7

All UniProt accessions (2): Q14002, A0A0A0MTT6

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Homodimer.

Subcellular location. Cell membrane. Apical cell membrane.

Tissue specificity. Expressed in columnar epithelial cells of the colon (at protein level). Strongly down-regulated in colonic adenocarcinomas.

Similarity. Belongs to the immunoglobulin superfamily. CEA family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q14002-1	2a	yes
Q14002-2	2b

RefSeq proteins (2): NP_001278414, NP_008821 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050831	CEA_cell_adhesion	Family

Pfam: PF07686, PF13927

UniProt features (32 total): strand 8, glycosylation site 7, sequence variant 3, sequence conflict 3, helix 2, domain 2, signal peptide 1, chain 1, disulfide bond 1, splice variant 1, propeptide 1, turn 1, lipid moiety-binding region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4Y89	X-RAY DIFFRACTION	1.47

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14002-F1	84.92	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 242

Disulfide bonds (1): 168–216

Glycosylation sites (7): 174, 183, 198, 57, 85, 105, 112

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification

MSigDB gene sets: 88 (showing top): GOCC_CELL_SURFACE, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, GOCC_APICAL_PLASMA_MEMBRANE, MODULE_113, SABATES_COLORECTAL_ADENOMA_DN, GOCC_APICAL_PART_OF_CELL, GOCC_SIDE_OF_MEMBRANE, GOCC_PLASMA_MEMBRANE_REGION, GOMF_KINASE_BINDING, GOMF_PROTEIN_TYROSINE_KINASE_BINDING, DODD_NASOPHARYNGEAL_CARCINOMA_DN, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, RICKMAN_HEAD_AND_NECK_CANCER_E, BOSCO_EPITHELIAL_DIFFERENTIATION_MODULE, REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS

GO Biological Process (2): regulation of immune system process (GO:0002682), signal transduction (GO:0007165)

GO Molecular Function (1): protein tyrosine kinase binding (GO:1990782)

GO Cellular Component (7): extracellular region (GO:0005576), cytosol (GO:0005829), plasma membrane (GO:0005886), cell surface (GO:0009986), apical plasma membrane (GO:0016324), side of membrane (GO:0098552), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Post-translational protein modification	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
membrane	2
immune system process	1
regulation of biological process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
protein kinase binding	1
cytoplasm	1
cell periphery	1
apical part of cell	1
plasma membrane region	1
leaflet of membrane bilayer	1

Protein interactions and networks

STRING

1126 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEACAM7	CYP2A13	Q16696	544
CEACAM7	ZNF574	Q6ZN55	526
CEACAM7	CYP2A7	P20853	524
CEACAM7	CYP2A6	P00190	469
CEACAM7	IQANK1	A8MXQ7	408
CEACAM7	GRB14	Q14449	395
CEACAM7	LRP6	O75581	378
CEACAM7	CD177	Q8N6Q3	372
CEACAM7	GRIK5	Q16478	363
CEACAM7	A1BG	P04217	359
CEACAM7	NCK2	O43639	353
CEACAM7	BCL10	O95999	353
CEACAM7	NCK1	P16333	353
CEACAM7	ZNF526	Q8TF50	353
CEACAM7	CARD9	Q9H257	353

IntAct

5 interactions, top by confidence:

A	B	Type	Score
CEACAM1	CEACAM7	psi-mi:“MI:0915”(physical association)	0.400
CEACAM7	CEACAM6	psi-mi:“MI:0915”(physical association)	0.400
CEACAM7	PBRM1	psi-mi:“MI:0915”(physical association)	0.400
CEACAM7	GPC1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (7): CEACAM7 (Proximity Label-MS), PBRM1 (Affinity Capture-MS), GPC1 (Affinity Capture-MS), PSG3 (Negative Genetic), PSG6 (Negative Genetic), CEACAM7 (Reconstituted Complex), CEACAM7 (Reconstituted Complex)

ESM2 similar proteins: A0A0K2S4Q6, A2A7V7, A5D7V5, A6NI73, A8K4G0, A8MVS5, O43699, O75022, O75023, O75871, P09564, P0C191, P13688, P16573, P20138, P24071, P31809, P31994, P40198, P43630, P59901, Q08708, Q13410, Q14002, Q28110, Q3KPI0, Q496F6, Q6GTX8, Q6UX52, Q6UXZ3, Q7TSN2, Q7Z692, Q810J1, Q863H2, Q8C567, Q8K249, Q8MJZ7, Q8N423, Q8N743, Q8NHJ6

Diamond homologs: A0A0B4J1L0, D3ZQE1, E9QA28, O75871, P06731, P11464, P11465, P13688, P16573, P31809, P31997, P40198, P40199, Q00887, Q00888, Q00889, Q13046, Q14002, Q15238, Q16557, Q2WEN9, Q3KPI0, Q3UKK2, Q61400, Q63111, Q810J1, Q925P2, Q9D2Z1, Q9UQ72, Q9UQ74, A8MTB9, Q9D871, Q0E9H9, Q6UY09, A0A140LHF2, Q8BFR2, Q8N475, Q9PWR4, P35329, Q4VAH7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

704 predictions. Top by Δscore:

Variant	Effect	Δscore
19:41674761:T:C	acceptor_gain	1.0000
19:41684811:C:CA	donor_gain	1.0000
19:41686857:A:AC	donor_gain	1.0000
19:41686858:C:CC	donor_gain	1.0000
19:41677375:CCACT:C	donor_gain	0.9900
19:41683783:A:AC	donor_gain	0.9900
19:41683784:C:CC	donor_gain	0.9900
19:41683784:CAG:C	donor_gain	0.9900
19:41684062:CG:C	acceptor_gain	0.9900
19:41684062:CGCTG:C	acceptor_gain	0.9900
19:41684064:C:CC	acceptor_gain	0.9900
19:41684066:G:C	acceptor_gain	0.9900
19:41686885:T:TA	donor_gain	0.9900
19:41687217:CGAGG:C	acceptor_gain	0.9900
19:41687222:C:CC	acceptor_gain	0.9900
19:41688097:CTCAC:C	donor_loss	0.9900
19:41688100:A:AG	donor_loss	0.9900
19:41688101:C:CT	donor_loss	0.9900
19:41674760:C:CC	acceptor_gain	0.9800
19:41683776:GATAC:G	donor_loss	0.9800
19:41683777:ATAC:A	donor_loss	0.9800
19:41683778:TACTC:T	donor_loss	0.9800
19:41683779:ACT:A	donor_loss	0.9800
19:41683780:C:G	donor_loss	0.9800
19:41683781:T:TA	donor_loss	0.9800
19:41683782:C:CG	donor_loss	0.9800
19:41683783:A:AG	donor_loss	0.9800
19:41683783:ACAG:A	donor_gain	0.9800
19:41683784:CA:C	donor_gain	0.9800
19:41683784:CAGC:C	donor_gain	0.9800

AlphaMissense

1724 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:41687085:C:A	W67C	0.992
19:41687085:C:G	W67C	0.992
19:41687087:A:G	W67R	0.989
19:41687087:A:T	W67R	0.989
19:41683844:C:G	C216S	0.983
19:41683845:A:T	C216S	0.983
19:41686963:A:G	L108P	0.983
19:41683954:C:A	W179C	0.982
19:41683954:C:G	W179C	0.982
19:41683988:C:G	C168S	0.982
19:41683989:A:T	C168S	0.982
19:41686925:A:C	Y121D	0.980
19:41683810:A:C	S227R	0.979
19:41683810:A:T	S227R	0.979
19:41683812:T:G	S227R	0.979
19:41683989:A:G	C168R	0.978
19:41683987:A:C	C168W	0.975
19:41686918:A:G	L123P	0.974
19:41683956:A:G	W179R	0.973
19:41683956:A:T	W179R	0.973
19:41687009:C:G	G93R	0.970
19:41687009:C:T	G93R	0.970
19:41683845:A:G	C216R	0.969
19:41683988:C:T	C168Y	0.964
19:41687008:C:T	G93E	0.964
19:41687053:C:G	R78P	0.964
19:41683851:A:C	Y214D	0.963
19:41686960:A:G	L109P	0.962
19:41687083:T:G	Y68S	0.960
19:41687084:A:C	Y68D	0.960

dbSNP variants (sampled 300 via entrez): RS1000248838 (19:41686221 A>G), RS1000303782 (19:41679458 G>A), RS1000525458 (19:41678287 T>A), RS1000582906 (19:41684832 A>G), RS1000592013 (19:41679799 C>T), RS1000971 (19:41676018 A>C), RS1001062 (19:41685546 A>C), RS1001200218 (19:41681832 G>A), RS1001254535 (19:41687460 C>A), RS1001307519 (19:41674531 G>T), RS1001704078 (19:41687173 A>G,T), RS1001713584 (19:41681369 C>T), RS1002036343 (19:41685917 C>T), RS1002789003 (19:41688441 G>A), RS1003086038 (19:41688201 G>C)

Disease associations

OMIM: gene MIM:619160 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	decreases expression	2
ethyl-p-hydroxybenzoate	decreases expression	1
sodium arsenite	decreases expression	1
1,2-dielaidoylphosphatidylethanolamine	decreases expression	1
Zoledronic Acid	increases expression	1
Benzo(a)pyrene	affects methylation	1
Estradiol	decreases expression	1
Malathion	decreases expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Tretinoin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.