CEBPG

Summary

CEBPG (CCAAT enhancer binding protein gamma, HGNC:1837) is a protein-coding gene on chromosome 19q13.11, encoding CCAAT/enhancer-binding protein gamma (P53567). Transcription factor that binds to the promoter and the enhancer regions of target genes.

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene.

Source: NCBI Gene 1054 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 28 total — 1 pathogenic
• Transcription factor: yes — 220 downstream targets (CollecTRI)
• MANE Select transcript: NM_001806

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1837
Approved symbol	CEBPG
Name	CCAAT enhancer binding protein gamma
Location	19q13.11
Locus type	gene with protein product
Status	Approved
Aliases	GPE1BP, IG/EBP-1
Ensembl gene	ENSG00000153879
Ensembl biotype	protein_coding
OMIM	138972
Entrez	1054

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 protein_coding, 1 nonsense_mediated_decay

ENST00000284000, ENST00000585933, ENST00000652630, ENST00000893394, ENST00000893395, ENST00000893396, ENST00000893397, ENST00000917803, ENST00000917804

RefSeq mRNA: 2 — MANE Select: NM_001806 NM_001252296, NM_001806

CCDS: CCDS12432

Canonical transcript exons

ENST00000284000 — 2 exons

Exon	Start	End
ENSE00001012842	33379144	33382686
ENSE00003847339	33373709	33373895

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 96.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.0427 / max 339.7998, expressed in 1813 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175084	30.7285	1810
175083	1.9423	1044
175086	0.9071	407
175088	0.2004	84
175085	0.1599	79
175087	0.1045	37

Top tissues by expression

297 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.02	gold quality
colonic mucosa	UBERON:0000317	94.35	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.50	gold quality
middle temporal gyrus	UBERON:0002771	93.47	gold quality
mucosa of transverse colon	UBERON:0004991	93.03	gold quality
gingival epithelium	UBERON:0001949	92.94	gold quality
body of tongue	UBERON:0011876	92.94	gold quality
esophagus squamous epithelium	UBERON:0006920	92.87	gold quality
jejunum	UBERON:0002115	92.60	gold quality
jejunal mucosa	UBERON:0000399	92.54	gold quality
gastrocnemius	UBERON:0001388	92.43	gold quality
biceps brachii	UBERON:0001507	92.34	gold quality
muscle of leg	UBERON:0001383	92.23	gold quality
gingiva	UBERON:0001828	92.18	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.97	gold quality
rectum	UBERON:0001052	91.96	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	91.95	gold quality
medial globus pallidus	UBERON:0002477	91.82	gold quality
ganglionic eminence	UBERON:0004023	91.54	gold quality
upper leg skin	UBERON:0004262	90.96	gold quality
duodenum	UBERON:0002114	90.80	gold quality
islet of Langerhans	UBERON:0000006	90.71	gold quality
monocyte	CL:0000576	90.65	gold quality
mammalian vulva	UBERON:0000997	90.26	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.26	gold quality
globus pallidus	UBERON:0001875	90.22	gold quality
mononuclear cell	CL:0000842	90.21	gold quality
cortical plate	UBERON:0005343	90.06	gold quality
squamous epithelium	UBERON:0006914	90.05	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	11.45
E-GEOD-124858	no	122.72
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

220 targets.

Target	Regulation
ABCC2
ABCC3
ADAM2
ADAMTS4
ADH1B
ADH1C
ADH4
ADIPOQ
ADRA1D
AFP
AGT	Unknown
AHSG
AKR1A1
AKR1B10
AKR1B15
ALB
ALDH2
ALDOB
ALOX5AP	Repression
APOA1
APOA2	Activation
APOB
APOC3
APOE
APP
ASNS	Unknown
ATF3
AVP
BAK1
BCL2

JASPAR motifs

Motif	Name	Family
MA0838.1	CEBPG	CEBP-related
MA1636.1	CEBPG	CEBP-related
MA1636.2	CEBPG	CEBP-related

JASPAR matrix evidence (PMIDs): PMID:8632009, PMID:21543584

Upstream regulators (CollecTRI, top): CEBPB, IRF6

miRNA regulators (miRDB)

115 targeting CEBPG, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-589-3P	99.91	69.62	2088

Literature-anchored findings (GeneRIF, showing 11)

• Ig/EBP (C/EBPgamma)is constitutively multiubiquitinated & then degraded by the proteasome. Ubiquitination and degradation are suppressed by forming dimers through the leucine zipper domains. (PMID:12618752)
• CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals (PMID:16255782)
• CEBPG regulates ERCC5 expression and this regulation is modified by E2F1/YY1 interactions. (PMID:17893230)
• C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR signaling. (PMID:22437320)
• CEBPG mediates the myeloid differentiation arrest induced by CEBPA deficiency in acute myeloid leukemia. (PMID:23160200)
• High CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBP gamma depletion decreased proliferation and induced senescence in lung tumor cells. (PMID:23775115)
• HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways (PMID:24244375)
• These findings suggest that CEBPG may play an oncogenic role in BCP-ALL and relies on a mechanism different from CEBPA. (PMID:25669928)
• The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN, CEBPB, PRKCB, ENO2, or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset. (PMID:27495086)
• C/EBPgamma is a critical negative regulator of LPS-/IgG immune complex-induced acute lung injury through the downregulation of C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation. (PMID:32786052)
• C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC. (PMID:36675048)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cebpg	ENSMUSG00000056216
rattus_norvegicus	Cebpg	ENSRNOG00000021144

Paralogs (4): CEBPE (ENSG00000092067), CEBPB (ENSG00000172216), CEBPD (ENSG00000221869), CEBPA (ENSG00000245848)

Protein

Protein identifiers

CCAAT/enhancer-binding protein gamma — P53567 (reviewed: P53567)

All UniProt accessions (1): P53567

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

Subunit / interactions. Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB. Interacts with ZNF638; this interaction increases transcriptional activation.

Subcellular location. Nucleus.

Similarity. Belongs to the bZIP family. C/EBP subfamily.

RefSeq proteins (2): NP_001239225, NP_001797* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004827	bZIP	Domain
IPR031106	C/EBP	Family
IPR046347	bZIP_sf	Homologous_superfamily

Pfam: PF07716

UniProt features (8 total): region of interest 3, compositionally biased region 2, chain 1, domain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P53567-F1	76.64	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-380994	ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9648895	Response of EIF2AK1 (HRI) to heme deficiency
R-HSA-2262752	Cellular responses to stress
R-HSA-381042	PERK regulates gene expression
R-HSA-381119	Unfolded Protein Response (UPR)
R-HSA-8953897	Cellular responses to stimuli
R-HSA-9711097	Cellular response to starvation

MSigDB gene sets: 270 (showing top): GOBP_MYELOID_CELL_DIFFERENTIATION, GSE45365_NK_CELL_VS_CD8_TCELL_UP, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GOBP_HEPATICOBILIARY_SYSTEM_DEVELOPMENT, REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, GOBP_MYELOID_CELL_HOMEOSTASIS, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_B_CELL_ACTIVATION, HOFMANN_CELL_LYMPHOMA_UP, ENK_UV_RESPONSE_KERATINOCYTE_UP, BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_ERYTHROCYTE_HOMEOSTASIS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

GO Biological Process (16): liver development (GO:0001889), DNA-templated transcription (GO:0006351), regulation of transcription by RNA polymerase II (GO:0006357), immune response (GO:0006955), mRNA metabolic process (GO:0016071), B cell differentiation (GO:0030183), positive regulation of type II interferon production (GO:0032729), natural killer cell mediated cytotoxicity (GO:0042267), enucleate erythrocyte differentiation (GO:0043353), positive regulation of DNA binding (GO:0043388), obsolete negative regulation of DNA-binding transcription factor activity (GO:0043433), positive regulation of DNA repair (GO:0045739), positive regulation of transcription by RNA polymerase II (GO:0045944), obsolete positive regulation of DNA-binding transcription factor activity (GO:0051091), integrated stress response signaling (GO:0140467), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (10): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), DNA binding (GO:0003677), identical protein binding (GO:0042802), sequence-specific DNA binding (GO:0043565), DNA-binding transcription factor binding (GO:0140297), sequence-specific double-stranded DNA binding (GO:1990837), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), RNA polymerase II transcription regulator complex (GO:0090575)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Cellular responses to stress	3
PERK regulates gene expression	1
Cellular response to starvation	1
Cellular responses to stimuli	1
Unfolded Protein Response (UPR)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
DNA binding	2
regulation of transcription by RNA polymerase II	2
cellular anatomical structure	2
gland development	1
hepaticobiliary system development	1
gene expression	1
RNA biosynthetic process	1
immune system process	1
response to stimulus	1
RNA metabolic process	1
lymphocyte differentiation	1
B cell activation	1
positive regulation of cytokine production	1
type II interferon production	1
regulation of type II interferon production	1
leukocyte mediated cytotoxicity	1
natural killer cell mediated immunity	1
erythrocyte differentiation	1
positive regulation of binding	1
regulation of DNA binding	1
DNA repair	1
regulation of DNA repair	1
positive regulation of response to stimulus	1
positive regulation of DNA metabolic process	1
positive regulation of DNA-templated transcription	1
cellular response to stress	1
intracellular signaling cassette	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
nucleic acid binding	1

Protein interactions and networks

STRING

1195 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEBPG	JDP2	Q8WYK2	768
CEBPG	ATF5	Q9Y2D1	645
CEBPG	JUN	P05412	623
CEBPG	SPI1	P17947	598
CEBPG	ATF4	P18848	581
CEBPG	ATF3	P18847	533
CEBPG	HNF1A	P20823	519
CEBPG	GRPEL2	Q8TAA5	514
CEBPG	HNF4A	P41235	506
CEBPG	RELA	Q04206	505
CEBPG	CEBPA	P49715	495
CEBPG	CEBPB	P17676	481
CEBPG	TRIB3	Q96RU7	481
CEBPG	CSF3	P09919	475
CEBPG	XBP1	P17861	464
CEBPG	DDIT3	P35638	464

IntAct

92 interactions, top by confidence:

A	B	Type	Score
CEBPG	ATF4	psi-mi:“MI:0915”(physical association)	0.880
ATF4	CEBPG	psi-mi:“MI:0915”(physical association)	0.880
ATF4	CEBPG	psi-mi:“MI:0407”(direct interaction)	0.880
CEBPG	ATF4	psi-mi:“MI:0407”(direct interaction)	0.880
DDIT3	CEBPG	psi-mi:“MI:0407”(direct interaction)	0.830
CEBPG	DDIT3	psi-mi:“MI:0407”(direct interaction)	0.830
CEBPG	DDIT3	psi-mi:“MI:0915”(physical association)	0.830
ATF5	CEBPG	psi-mi:“MI:0407”(direct interaction)	0.820
CEBPG	ATF5	psi-mi:“MI:0915”(physical association)	0.820
CEBPG	ATF5	psi-mi:“MI:0407”(direct interaction)	0.820
CEBPG	ATF3	psi-mi:“MI:0407”(direct interaction)	0.710
ATF2	CEBPG	psi-mi:“MI:0407”(direct interaction)	0.710
ATF3	CEBPG	psi-mi:“MI:0407”(direct interaction)	0.710
CEBPG	ATF2	psi-mi:“MI:0407”(direct interaction)	0.710

BioGRID (82): CEBPG (Two-hybrid), DDIT3 (Two-hybrid), MLLT6 (Two-hybrid), POLR2M (Two-hybrid), DDIT3 (Two-hybrid), KLF5 (Two-hybrid), CEBPG (Affinity Capture-Western), KLF5 (Affinity Capture-Western), CEBPG (Affinity Capture-MS), CEBPG (Affinity Capture-MS), CEBPG (Two-hybrid), ATF5 (Two-hybrid), PFDN6 (Two-hybrid), CEBPG (Reconstituted Complex), CEBPG (Two-hybrid)

ESM2 similar proteins: A0JMF8, A7YY54, B1WAV2, O77627, O93602, P05411, P05412, P05627, P09450, P12981, P15066, P15336, P15408, P16951, P17275, P17325, P17535, P17544, P18625, P18870, P24898, P26801, P27921, P47930, P48380, P48381, P51145, P52909, P53567, P53568, P54864, P56432, P79703, Q00969, Q02930, Q06455, Q0V9K5, Q0VBZ5, Q4R3I8, Q5EY87

Diamond homologs: O02754, O02755, O02756, O77728, P05554, P17676, P21272, P26801, P28033, P49715, P49716, P53566, P53567, P53568, P56261, Q00322, Q02638, Q03484, Q05826, Q15744, Q3T0B9, Q6PZD9, Q9N0J3, Q8IG69, Q02637

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
CEBPE	“up-regulates activity”	CEBPG	binding
CEBPG	“up-regulates quantity by expression”	LTF	“transcriptional regulation”
CEBPG	“up-regulates quantity by expression”	SFTPD	“transcriptional regulation”
CEBPG	“up-regulates quantity by expression”	SLCO1B3	“transcriptional regulation”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 31 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Response of EIF2AK1 (HRI) to heme deficiency	5	178.4×	6e-09
Response of EIF2AK4 (GCN2) to amino acid deficiency	5	27.7×	2e-05
Cellular responses to stress	7	12.9×	2e-05
Cellular responses to stimuli	7	11.0×	4e-05

GO biological processes:

GO term	Partners	Fold	FDR
integrated stress response signaling	14	339.0×	4e-32
endoplasmic reticulum unfolded protein response	5	51.0×	4e-06
response to endoplasmic reticulum stress	5	28.8×	4e-05
positive regulation of gene expression	6	8.0×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	22
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4279213	GRCh37/hg19 19q13.11(chr19:33868258-34019755)x1	Pathogenic

SpliceAI

493 predictions. Top by Δscore:

Variant	Effect	Δscore
19:33378866:G:GT	donor_gain	0.9900
19:33374630:G:GT	donor_gain	0.9800
19:33378864:TGG:T	donor_gain	0.9800
19:33378866:G:T	donor_gain	0.9800
19:33374659:A:T	donor_gain	0.9600
19:33373893:CAGG:C	donor_loss	0.9500
19:33373894:AG:A	donor_loss	0.9500
19:33373895:GGTAA:G	donor_loss	0.9500
19:33373896:G:GA	donor_loss	0.9500
19:33373897:T:G	donor_loss	0.9500
19:33373892:GCAG:G	donor_gain	0.9400
19:33374418:A:T	donor_gain	0.9400
19:33374611:G:GT	donor_gain	0.9300
19:33376140:C:G	donor_gain	0.9300
19:33374634:G:GT	donor_gain	0.9100
19:33378411:GT:G	donor_gain	0.9000
19:33378412:TT:T	donor_gain	0.9000
19:33374417:G:T	donor_gain	0.8900
19:33374622:A:G	donor_gain	0.8900
19:33374635:A:T	donor_gain	0.8900
19:33374372:A:AG	donor_gain	0.8800
19:33374677:GCTG:G	donor_gain	0.8800
19:33374384:TTCAG:T	donor_gain	0.8700
19:33374388:G:GT	donor_gain	0.8700
19:33374703:GTT:G	donor_gain	0.8600
19:33374704:TTT:T	donor_gain	0.8600
19:33373732:G:T	donor_gain	0.8400
19:33373896:G:GG	donor_gain	0.8400
19:33374640:C:T	donor_gain	0.8400
19:33379139:ACTAG:A	acceptor_loss	0.8400

AlphaMissense

996 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:33379452:G:C	R71S	1.000
19:33379452:G:T	R71S	1.000
19:33379453:A:G	N72D	1.000
19:33379454:A:T	N72I	1.000
19:33379455:C:A	N72K	1.000
19:33379455:C:G	N72K	1.000
19:33379462:G:C	A75P	1.000
19:33379463:C:A	A75D	1.000
19:33379498:G:C	A87P	1.000
19:33379520:T:A	V94D	1.000
19:33379529:T:A	L97H	1.000
19:33379529:T:C	L97P	1.000
19:33379540:A:G	N101D	1.000
19:33379541:A:T	N101I	1.000
19:33379550:T:C	L104S	1.000
19:33379571:T:C	L111P	1.000
19:33379592:T:C	L118P	1.000
19:33379442:G:C	R68P	0.999
19:33379444:C:G	R69G	0.999
19:33379445:G:C	R69P	0.999
19:33379451:G:C	R71T	0.999
19:33379451:G:T	R71M	0.999
19:33379453:A:C	N72H	0.999
19:33379454:A:C	N72T	0.999
19:33379456:A:G	N73D	0.999
19:33379458:C:A	N73K	0.999
19:33379458:C:G	N73K	0.999
19:33379462:G:A	A75T	0.999
19:33379463:C:T	A75V	0.999
19:33379471:A:G	K78E	0.999

dbSNP variants (sampled 300 via entrez): RS1000446465 (19:33377969 A>T), RS1000448307 (19:33373274 C>A), RS1000500390 (19:33372904 C>A,T), RS1000569140 (19:33371821 C>T), RS1000738517 (19:33373576 A>C,T), RS1001244191 (19:33372433 A>C,G), RS1001590616 (19:33372121 C>T), RS1002189811 (19:33373391 C>T), RS1002778250 (19:33379125 C>T), RS1002880061 (19:33376237 G>A), RS1002932314 (19:33376564 TAA>T), RS1002984126 (19:33380014 G>A), RS1003004993 (19:33373542 G>A,C), RS1003162264 (19:33373686 T>C), RS1003276996 (19:33379861 C>A,T)

Disease associations

OMIM: gene MIM:138972 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001725_61	Inflammatory bowel disease	6.000000e-15
GCST003048_326	Schizophrenia	3.000000e-08
GCST012228_610	Waist-hip index	7.000000e-09
GCST012230_165	Waist-to-hip ratio adjusted for BMI	4.000000e-08
GCST90016675_2	Pancreas fat	2.000000e-22
GCST90016675_4	Pancreas fat	2.000000e-08
GCST90020025_1517	Waist-to-hip ratio adjusted for BMI	2.000000e-15
GCST90020027_234	Waist-hip index	3.000000e-16

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

80 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	4
bisphenol A	affects expression, decreases expression, increases expression	3
sodium arsenite	decreases expression, increases expression	3
Benzo(a)pyrene	increases methylation, affects methylation, decreases expression	3
Tretinoin	decreases expression	3
didecyldimethylammonium	increases expression	2
Acetaminophen	increases expression	2
Cisplatin	decreases expression, increases reaction, increases expression	2
Estradiol	increases expression, increases reaction	2
Tetrachlorodibenzodioxin	decreases expression	2
Tunicamycin	increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
Thapsigargin	increases expression	2
Particulate Matter	increases abundance, increases expression, affects cotreatment	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
geraniol	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
cobaltous chloride	increases expression	1
nickel chloride	increases expression	1
perfluorooctanoic acid	increases expression	1
cupric oxide	increases expression	1
1-nitropyrene	increases expression	1
S-(1,2-dichlorovinyl)cysteine	increases expression	1
beta-methylcholine	affects expression	1
tamibarotene	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1

Cellosaurus cell lines

6 cell lines: 3 embryonic stem cell, 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A0Q2	SEES3-1V human CEBPG, clone1	Embryonic stem cell	Male
CVCL_A0Q3	SEES3-1V human CEBPG, clone2	Embryonic stem cell	Male
CVCL_A0Q4	SEES3-1V human CEBPG, clone3	Embryonic stem cell	Male
CVCL_D3XF	HepG2/8F_HS	Cancer cell line	Male
CVCL_GZ77	K562 eGFP-CEBPG	Cancer cell line	Female
CVCL_HA11	MCF-7 eGFP-CEBPG	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.