CEBPZOS

Summary

CEBPZOS (CEBPZ opposite strand, HGNC:49288) is a protein-coding gene on chromosome 2p22.2, encoding Protein CEBPZOS (A8MTT3).

Located in mitochondrion.

Source: NCBI Gene 100505876 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001322374

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49288
Approved symbol	CEBPZOS
Name	CEBPZ opposite strand
Location	2p22.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000218739
Ensembl biotype	protein_coding
Entrez	100505876

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 42 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000392061, ENST00000397064, ENST00000397226, ENST00000402297, ENST00000406711, ENST00000438935, ENST00000470216, ENST00000898764, ENST00000898765, ENST00000898766, ENST00000898767, ENST00000898768, ENST00000898769, ENST00000898770, ENST00000898771, ENST00000898772, ENST00000898773, ENST00000898774, ENST00000898775, ENST00000898776, ENST00000898777, ENST00000898778, ENST00000898779, ENST00000898780, ENST00000938662, ENST00000938663, ENST00000938664, ENST00000938665, ENST00000938666, ENST00000938667, ENST00000938668, ENST00000938669, ENST00000938670, ENST00000938671, ENST00000938672, ENST00000938673, ENST00000938674, ENST00000938675, ENST00000938676, ENST00000938677, ENST00000938678, ENST00000938679, ENST00000938680, ENST00000963820

RefSeq mRNA: 4 — MANE Select: NM_001322374 NM_001322373, NM_001322374, NM_001322375, NM_001322376

CCDS: CCDS82435

Canonical transcript exons

ENST00000402297 — 5 exons

Exon	Start	End
ENSE00001547783	37201642	37201726
ENSE00001551955	37201048	37201092
ENSE00001553179	37201863	37204743
ENSE00003662260	37199704	37199819
ENSE00003843942	37196496	37196520

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 94.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.1134 / max 156.1556, expressed in 1794 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19753	22.1134	1794

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	94.25	gold quality
right adrenal gland	UBERON:0001233	93.29	gold quality
left adrenal gland cortex	UBERON:0035825	93.28	gold quality
left adrenal gland	UBERON:0001234	93.27	gold quality
right adrenal gland cortex	UBERON:0035827	93.16	gold quality
oviduct epithelium	UBERON:0004804	92.78	gold quality
islet of Langerhans	UBERON:0000006	92.60	gold quality
muscle of leg	UBERON:0001383	92.58	gold quality
gastrocnemius	UBERON:0001388	92.55	gold quality
buccal mucosa cell	CL:0002336	92.33	gold quality
left ovary	UBERON:0002119	92.24	gold quality
calcaneal tendon	UBERON:0003701	92.22	gold quality
rectum	UBERON:0001052	92.14	gold quality
adrenal gland	UBERON:0002369	91.98	gold quality
adrenal tissue	UBERON:0018303	91.98	gold quality
smooth muscle tissue	UBERON:0001135	91.91	gold quality
right ovary	UBERON:0002118	91.53	gold quality
adrenal cortex	UBERON:0001235	91.49	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.41	gold quality
adenohypophysis	UBERON:0002196	91.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	91.25	gold quality
anterior cingulate cortex	UBERON:0009835	91.21	gold quality
right uterine tube	UBERON:0001302	91.16	gold quality
body of uterus	UBERON:0009853	91.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.71	gold quality
heart left ventricle	UBERON:0002084	90.70	gold quality
lower esophagus	UBERON:0013473	90.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	90.65	gold quality
left lobe of thyroid gland	UBERON:0001120	90.61	gold quality
prefrontal cortex	UBERON:0000451	90.57	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-135	yes	1834.74
E-ANND-3	yes	6.79

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

117 targeting CEBPZOS, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-10395-5P	99.86	67.35	676
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-548AZ-5P	99.83	69.94	3230
HSA-MIR-548T-5P	99.83	69.91	3220
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-139-5P	99.80	69.50	1399

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cebpzos	ENSMUSG00000062691
rattus_norvegicus	Cebpzos	ENSRNOG00000064368

Protein

Protein identifiers

Protein CEBPZOS — A8MTT3 (reviewed: A8MTT3)

Alternative names: CEBPZ antisense RNA 1, CEBPZ opposite strand

All UniProt accessions (1): A8MTT3

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Mitochondrion membrane.

RefSeq proteins (4): NP_001309302, NP_001309303, NP_001309304, NP_001309305 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR037764	CEBPZOS	Family

UniProt features (2 total): chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MTT3-F1	91.70	0.86

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 82 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP, GOCC_MITOCHONDRIAL_ENVELOPE, GOCC_ORGANELLE_ENVELOPE, chr2p22, LHX9_TARGET_GENES, NKX2_2_TARGET_GENES, MIR616_5P, MIR371B_5P, MIR373_5P, MIR548P, MIR10527_5P, MIR4728_5P, MIR551B_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial membrane (GO:0031966), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEBPZOS	RUSF1	Q96GQ5	608
CEBPZOS	ATOSB	Q7L5A3	586
CEBPZOS	MTRES1	Q9P0P8	522
CEBPZOS	CCDC127	Q96BQ5	479
CEBPZOS	EXOG	Q9Y2C4	461
CEBPZOS	SAMD4B	Q5PRF9	453
CEBPZOS	COA7	Q96BR5	446
CEBPZOS	FXYD4	P59646	422
CEBPZOS	TMT1A	Q9H8H3	410
CEBPZOS	POLG2	Q9UHN1	394
CEBPZOS	ABRAXAS2	Q15018	377
CEBPZOS	APOO	Q9BUR5	370
CEBPZOS	FOXN2	P32314	357
CEBPZOS	RAB20	Q9NX57	353
CEBPZOS	UQCC4	Q4G0I0	352

IntAct

8 interactions, top by confidence:

A	B	Type	Score
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
CEBPZOS	H1-4	psi-mi:“MI:0915”(physical association)	0.400
rep	CEBPZOS	psi-mi:“MI:0914”(association)	0.350
NDRG2	CEBPZOS	psi-mi:“MI:0914”(association)	0.350
PBXIP1	CEBPZOS	psi-mi:“MI:0914”(association)	0.350
SLC39A8	CEBPZOS	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A1L2P2, A1XQT2, A5PJ82, A8MTT3, D2H617, D4ACP2, E2R5I0, F6USH3, G1QDE8, G1S9B8, O95139, P04038, P09669, P0CB93, P0CB94, P11951, P80977, Q02367, Q0MQ88, Q0MQ89, Q0MQ90, Q0MQE0, Q0MQE1, Q0Q4Z0, Q28EM2, Q28GF4, Q29259, Q3UIU2, Q4I8P5, Q5BKW8, Q5RK28, Q68EV8, Q78RX3, Q7YRJ8, Q7YRJ9, Q7YRK0, Q7YRK1, Q7YRK2, Q7YRK3, Q7YRK7

Diamond homologs: A8MTT3, Q8BTE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1941 predictions. Top by Δscore:

Variant	Effect	Δscore
2:37201640:A:AG	acceptor_gain	1.0000
2:37201641:G:GG	acceptor_gain	1.0000
2:37202780:TTA:T	donor_loss	1.0000
2:37202781:TAC:T	donor_loss	1.0000
2:37202782:A:AC	donor_gain	1.0000
2:37202782:ACTT:A	donor_loss	1.0000
2:37202782:ACTTG:A	donor_gain	1.0000
2:37202783:C:CG	donor_gain	1.0000
2:37202783:CTT:C	donor_gain	1.0000
2:37202783:CTTG:C	donor_gain	1.0000
2:37202783:CTTGC:C	donor_gain	1.0000
2:37202861:CCAAA:C	acceptor_gain	1.0000
2:37202862:CAAA:C	acceptor_gain	1.0000
2:37202862:CAAAC:C	acceptor_gain	1.0000
2:37202863:AAA:A	acceptor_gain	1.0000
2:37202863:AAAC:A	acceptor_loss	1.0000
2:37202864:AA:A	acceptor_gain	1.0000
2:37202864:AAC:A	acceptor_loss	1.0000
2:37202866:C:CA	acceptor_loss	1.0000
2:37202866:C:CC	acceptor_gain	1.0000
2:37202867:T:C	acceptor_gain	1.0000
2:37202868:T:TC	acceptor_gain	1.0000
2:37202869:T:C	acceptor_gain	1.0000
2:37202869:T:TC	acceptor_gain	1.0000
2:37202943:GCCTT:G	donor_loss	1.0000
2:37202944:CCTTA:C	donor_loss	1.0000
2:37202945:CTTA:C	donor_loss	1.0000
2:37202946:TTACC:T	donor_loss	1.0000
2:37202947:TACC:T	donor_loss	1.0000
2:37202948:A:AG	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000055694 (2:37204976 A>C), RS1000098043 (2:37213654 T>A,C), RS1000113618 (2:37199207 C>G), RS1000140487 (2:37197054 C>A), RS1000229262 (2:37199423 T>C), RS1000300464 (2:37194574 C>G), RS1000730535 (2:37194781 G>A), RS1000928946 (2:37200884 A>T), RS1001182216 (2:37216175 C>A,T), RS1001199992 (2:37205410 G>A), RS1001349534 (2:37209884 T>A,C), RS1001552730 (2:37198636 G>A), RS1001876418 (2:37205761 C>A,G), RS1001878456 (2:37199803 G>C), RS1001939760 (2:37204383 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	decreases expression, increases abundance	2
dicrotophos	decreases expression	1
beta-lapachone	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Cadmium	decreases expression, increases abundance	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Valproic Acid	increases expression	1
Aflatoxin B1	increases expression	1
Okadaic Acid	decreases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.