CENPB

Summary

CENPB (centromere protein B, HGNC:1852) is a protein-coding gene on chromosome 20p13, encoding Major centromere autoantigen B (P07199). Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box.

This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Source: NCBI Gene 1059 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_001810

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1852
Approved symbol	CENPB
Name	centromere protein B
Location	20p13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000125817
Ensembl biotype	protein_coding
OMIM	117140
Entrez	1059

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000379751

RefSeq mRNA: 1 — MANE Select: NM_001810 NM_001810

CCDS: CCDS13064

Canonical transcript exons

ENST00000379751 — 1 exons

Exon	Start	End
ENSE00001482363	3783851	3786740

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 97.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 53.7529 / max 433.1438, expressed in 1819 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
186172	53.2324	1819
186171	0.5205	275

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	97.84	gold quality
spinal cord	UBERON:0002240	97.03	gold quality
amygdala	UBERON:0001876	95.72	gold quality
apex of heart	UBERON:0002098	95.61	gold quality
gastrocnemius	UBERON:0001388	94.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.85	gold quality
lower esophagus	UBERON:0013473	94.82	gold quality
putamen	UBERON:0001874	94.71	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.56	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	94.33	gold quality
muscle of leg	UBERON:0001383	94.32	gold quality
stromal cell of endometrium	CL:0002255	94.15	gold quality
nipple	UBERON:0002030	94.11	gold quality
inferior vagus X ganglion	UBERON:0005363	94.02	gold quality
nucleus accumbens	UBERON:0001882	93.96	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.60	gold quality
caudate nucleus	UBERON:0001873	93.44	gold quality
right coronary artery	UBERON:0001625	93.02	gold quality
hypothalamus	UBERON:0001898	93.00	gold quality
mucosa of stomach	UBERON:0001199	92.87	gold quality
endometrium epithelium	UBERON:0004811	92.87	gold quality
skin of leg	UBERON:0001511	92.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.52	gold quality
popliteal artery	UBERON:0002250	92.36	gold quality
cingulate cortex	UBERON:0003027	92.36	gold quality
tibial artery	UBERON:0007610	92.36	gold quality
anterior cingulate cortex	UBERON:0009835	92.32	gold quality
granulocyte	CL:0000094	92.26	gold quality
monocyte	CL:0000576	92.26	gold quality
aorta	UBERON:0000947	92.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.58

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FOXM1

miRNA regulators (miRDB)

28 targeting CENPB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-6762-3P	99.66	66.94	1188
HSA-MIR-4690-5P	99.65	66.24	813
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-7974	99.24	65.48	1137
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4717-3P	99.06	66.34	1072
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-6737-3P	98.95	68.56	1577
HSA-MIR-7157-3P	98.95	68.70	1582
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-4424	98.91	70.33	1145
HSA-MIR-4520-3P	98.75	66.55	963
HSA-MIR-5008-3P	98.73	67.50	1433
HSA-MIR-583	98.71	67.44	1791
HSA-MIR-4536-5P	98.47	64.39	657
HSA-MIR-10526-3P	97.86	64.97	1342
HSA-MIR-6895-5P	97.05	64.96	522
HSA-MIR-3918	96.13	64.65	1300

Literature-anchored findings (GeneRIF, showing 30)

• CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells (PMID:11884609)
• crystal structure of its dimerization domain (CENP-B-(540-599)), another functional domain of CENP-B, at 1.65-A resolution (PMID:14522975)
• the interaction between CENP-B and CENP-C may be involved in the correct assembly of CENP-C on alphoid DNA (PMID:14612452)
• CENP-B for the CENP-B box DNA is reduced nearly to the level of nonspecific DNA binding by CpG methylation (PMID:15634350)
• CENP-B may be a determinant for translational positioning of the centromere-specific nucleosomes through its binding to the nucleosomal CENP-B box (PMID:16183641)
• This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells. (PMID:17258208)
• CENP-B was found to bind specifically to the surface of human pulmonary artery smooth muscle cells and not to fibroblasts or endothelial cells (PMID:17968937)
• observation of FRET between CENP-A and CENP-B at centromere locations; this indicates that these proteins are in the molecular vicinity (<10 nm) of each other (PMID:18072184)
• Acceptor-bleaching FRET indicates that CENP-T directly associates with CENP-A and CENP-B. (PMID:19412974)
• CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells. (PMID:19714638)
• Study analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis. (PMID:19723035)
• Anti-CENP-B autoantibodies in breast cancer patients prolong disease-free and overall survival. (PMID:20222802)
• CENP-A and/or B status is predictive of the extent of skin involvement over time in systemic sclerosis. (PMID:22467948)
• Human Nap1, an acidic histone chaperone, inhibited the non-specific binding of CENP-B to nucleosomes and apparently stimulated CENP-B binding to its cognate CENP-B box DNA. (PMID:23325853)
• N-terminal methylation is required for CENP-B’s binding to the CENP-B box. (PMID:23978223)
• INMAP as a model regulator of CENP-B (PMID:24633075)
• Centromere protein B (CENP-B) as a novel interacting partner of HBZ. (PMID:25281565)
• The results revealed that CENP-B binding in the vicinity of the CENP-A nucleosome substantially stabilizes the CENP-A nucleosome on alphoid DNA in human cells. (PMID:25916850)
• CENP-B directly binds both CENP-A’s amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly (PMID:25942623)
• Findings indicate that expression of the scleroderma autoantigens IFI-16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens. (PMID:27159521)
• Upon cross-linking, the entire CENPA/CENPB/CENPC/CENPT complex is nuclease-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC and CENPT pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers. (PMID:27384170)
• The results indicated that CENPB boxes are highly conserved in Down syndrome (DS) patients and may not be responsible for Chr21 nondisjunction events. However, alphasatDNA in Chr21 is variable and deoxynucleotide deletions, mutations and polymorphisms may act as potential molecular diagnostic markers of DS. (PMID:28259924)
• Given that CENP-B is the only centromere protein that binds centromere-specific DNA elements, our study provides a new link between centromere DNA and unique epigenetic landscape of centromere chromatin (PMID:29273057)
• Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies. (PMID:32057908)
• From evolution to function: Two sides of the same CENP-B coin? (PMID:32173469)
• A genetic memory initiates the epigenetic loop necessary to preserve centromere position. (PMID:32945564)
• The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity? (PMID:33065112)
• Centromeric transcription maintains centromeric cohesion in human cells. (PMID:33881484)
• LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis. (PMID:34519373)
• CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA. (PMID:34547289)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cenpb	ENSMUSG00000068267
rattus_norvegicus	Cenpb	ENSRNOG00000057284

Paralogs (12): TIGD7 (ENSG00000140993), POGK (ENSG00000143157), POGZ (ENSG00000143442), TIGD6 (ENSG00000164296), TIGD4 (ENSG00000169989), TIGD3 (ENSG00000173825), TIGD5 (ENSG00000179886), TIGD2 (ENSG00000180346), JRKL (ENSG00000183340), TIGD1 (ENSG00000221944), JRK (ENSG00000234616), (ENSG00000293642)

Protein

Protein identifiers

Major centromere autoantigen B — P07199 (reviewed: P07199)

Alternative names: Centromere protein B

All UniProt accessions (1): P07199

UniProt curated annotations — full annotation on UniProt →

Function. Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.

Subunit / interactions. Antiparallel homodimer. Interacts with CENPT. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1.

Subcellular location. Nucleus. Chromosome. Centromere.

Post-translational modifications. Poly-ADP-ribosylated by PARP1. N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli, including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound CENP-B is primarily trimethylated.

RefSeq proteins (1): NP_001801* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004875	DDE_SF_endonuclease_dom	Domain
IPR006600	HTH_CenpB_DNA-bd_dom	Domain
IPR007889	HTH_Psq	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR015115	CenpB_C	Domain
IPR034882	Dimerisation_CENP-B_sf	Homologous_superfamily
IPR050863	CenT-Element_Derived	Family

Pfam: PF03184, PF03221, PF04218, PF09026

UniProt features (37 total): helix 11, modified residue 7, region of interest 4, compositionally biased region 3, domain 2, sequence conflict 2, strand 2, DNA-binding region 2, initiator methionine 1, chain 1, cross-link 1, mutagenesis site 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
1UFI	X-RAY DIFFRACTION	1.65
6KDR	X-RAY DIFFRACTION	2.11
1HLV	X-RAY DIFFRACTION	2.5
1BW6	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P07199-F1	66.88	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 2, 2, 2, 156, 165, 396, 398, 246

Mutagenesis-validated functional residues (1):

Position	Phenotype
4	abolishes n-terminal methylation.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 132 (showing top): MORF_MTA1, FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP, AAGCCAT_MIR135A_MIR135B, RIZ_ERYTHROID_DIFFERENTIATION_CCNE1, MARTINEZ_RB1_TARGETS_UP, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, MORF_ATOX1, BLALOCK_ALZHEIMERS_DISEASE_UP, MILI_PSEUDOPODIA_CHEMOTAXIS_UP, MARTINEZ_RB1_AND_TP53_TARGETS_UP, AP2GAMMA_01, RIZ_ERYTHROID_DIFFERENTIATION, GOMF_CHROMATIN_BINDING, GOCC_CHROMOSOMAL_REGION, GOCC_NUCLEAR_BODY

GO Biological Process (0):

GO Molecular Function (7): DNA binding (GO:0003677), chromatin binding (GO:0003682), satellite DNA binding (GO:0003696), centromeric DNA binding (GO:0019237), sequence-specific DNA binding (GO:0043565), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (7): chromosome, centromeric region (GO:0000775), condensed chromosome, centromeric region (GO:0000779), nucleus (GO:0005634), nucleoplasm (GO:0005654), chromosome (GO:0005694), pericentric heterochromatin (GO:0005721), nuclear body (GO:0016604)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	3
sequence-specific double-stranded DNA binding	2
chromosome, centromeric region	2
intracellular membraneless organelle	2
nucleic acid binding	1
DNA binding	1
chromosomal region	1
condensed chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
heterochromatin	1
nucleoplasm	1

Protein interactions and networks

STRING

1218 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CENPB	CENPC	Q03188	993
CENPB	CENPA	P49450	990
CENPB	CENPS	Q8N2Z9	973
CENPB	CENPH	Q9H3R5	931
CENPB	CENPE	Q02224	901
CENPB	CENPI	Q92674	885
CENPB	TRIM21	P19474	815
CENPB	CENPW	Q5EE01	812
CENPB	CENPF	P49454	810
CENPB	RO60	P10155	805
CENPB	INCENP	Q9NQS7	786
CENPB	EXOSC10	Q01780	774
CENPB	PARP2	Q9UGN5	765
CENPB	CENPN	Q96H22	759
CENPB	KIF2C	Q99661	734

IntAct

150 interactions, top by confidence:

A	B	Type	Score
CSNK2B	NMT2	psi-mi:“MI:0914”(association)	0.660
CENPB	CSNK2B	psi-mi:“MI:0915”(physical association)	0.660
FOXP3	FOXP2	psi-mi:“MI:0914”(association)	0.530
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF707	ZNF316	psi-mi:“MI:0914”(association)	0.530
PES1	AP3B1	psi-mi:“MI:0914”(association)	0.530
ZNF331	USP9Y	psi-mi:“MI:0914”(association)	0.530
TSPYL6	NME4	psi-mi:“MI:0914”(association)	0.530
ZNF544	GNPAT	psi-mi:“MI:0914”(association)	0.530
ZNF223	PPM1G	psi-mi:“MI:0914”(association)	0.530
ZNF354C	IPO8	psi-mi:“MI:0914”(association)	0.530
KNOP1	DHX15	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ZNF816	LRP4	psi-mi:“MI:0914”(association)	0.530
ZNF669	LRP4	psi-mi:“MI:0914”(association)	0.530
ZNF214	LRP4	psi-mi:“MI:0914”(association)	0.530
ZNF517	GGPS1	psi-mi:“MI:0914”(association)	0.530
ZNF311	CENPB	psi-mi:“MI:0914”(association)	0.530
LRRTM4	AP3B1	psi-mi:“MI:0914”(association)	0.530
CCDC59	GAPDHS	psi-mi:“MI:0914”(association)	0.530
ZNF354C	LRP4	psi-mi:“MI:0914”(association)	0.530

BioGRID (153): CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Two-hybrid), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS), CENPB (Affinity Capture-MS)

ESM2 similar proteins: A0A061IR73, A0A1B0GUU1, A6H687, A8MYJ7, B1WC39, D3ZVB0, E1BD59, G3MY25, G3MZC5, O75064, P07199, P27790, P29597, P48988, P52333, P52824, Q08DF2, Q0VCE3, Q13608, Q1JPD6, Q2VPB7, Q3TAP4, Q3U1Y4, Q3ZBE0, Q499M4, Q53EQ6, Q5JZY3, Q62137, Q63272, Q6B0B8, Q6DI92, Q6ZPS2, Q6ZS72, Q7TM95, Q80VI1, Q86UT6, Q8BYG9, Q8N9M5, Q8R5G7, Q8TE96

Diamond homologs: P07199, P27790, P48988, P49451, Q17RP2, Q4W5G0, Q6B0B8, Q8IY51, Q8BUZ3, Q6NT04, Q7TM95

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

187 predictions. Top by Δscore:

Variant	Effect	Δscore
20:3784687:G:C	donor_gain	0.9700
20:3784734:T:TA	donor_gain	0.9500
20:3784719:G:A	donor_gain	0.9200
20:3784712:C:CA	donor_gain	0.8300
20:3785681:C:CT	donor_gain	0.8100
20:3784686:AG:A	donor_gain	0.8000
20:3784686:A:AC	donor_gain	0.7900
20:3784509:G:T	donor_gain	0.7600
20:3784883:T:TA	donor_gain	0.7500
20:3785682:C:CT	donor_gain	0.7500
20:3785502:C:A	donor_gain	0.7100
20:3784869:CCTCA:C	donor_gain	0.7000
20:3784969:TTCCA:T	acceptor_gain	0.6800
20:3785246:T:TA	donor_gain	0.6800
20:3784880:T:TA	donor_gain	0.6700
20:3784569:A:AC	donor_gain	0.6600
20:3784570:C:CC	donor_gain	0.6600
20:3785231:T:TA	donor_gain	0.6500
20:3784873:A:AC	donor_gain	0.6400
20:3785501:C:CA	donor_gain	0.6400
20:3784871:TCATC:T	donor_gain	0.6200
20:3784566:A:AC	donor_gain	0.6100
20:3784818:TCTTG:T	donor_gain	0.6100
20:3785218:T:A	donor_gain	0.6000
20:3784863:CAG:C	donor_gain	0.5900
20:3785201:T:TA	donor_gain	0.5900
20:3784745:TGA:T	donor_gain	0.5800
20:3785222:TC:T	donor_gain	0.5800
20:3785213:T:TA	donor_gain	0.5700
20:3785684:C:A	donor_gain	0.5700

AlphaMissense

3890 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:3786107:A:G	F126S	1.000
20:3786118:C:A	W122C	1.000
20:3786118:C:G	W122C	1.000
20:3786120:A:G	W122R	1.000
20:3786120:A:T	W122R	1.000
20:3786122:C:T	G121D	1.000
20:3786128:G:A	S119F	1.000
20:3786136:G:C	F116L	1.000
20:3786136:G:T	F116L	1.000
20:3786137:A:G	F116S	1.000
20:3786138:A:G	F116L	1.000
20:3786242:A:G	L81P	1.000
20:3786251:T:A	E78V	1.000
20:3786347:A:G	L46P	1.000
20:3786350:A:C	I45S	1.000
20:3786350:A:G	I45T	1.000
20:3786350:A:T	I45N	1.000
20:3786359:A:G	L42P	1.000
20:3786359:A:T	L42Q	1.000
20:3786365:G:A	S40F	1.000
20:3786374:A:C	I37S	1.000
20:3786374:A:G	I37T	1.000
20:3786374:A:T	I37N	1.000
20:3786389:G:T	A32E	1.000
20:3786434:A:T	I17N	1.000
20:3786437:A:C	I16S	1.000
20:3786445:C:A	K13N	1.000
20:3786445:C:G	K13N	1.000
20:3785909:A:G	F192S	0.999
20:3786098:C:G	R129P	0.999

dbSNP variants (sampled 300 via entrez): RS1001768567 (20:3784738 G>A,C), RS1003011500 (20:3788577 T>C,G), RS1003306815 (20:3787528 T>C), RS1003317446 (20:3787320 C>T), RS1003350074 (20:3786913 C>A,G,T), RS1005133073 (20:3784308 G>A), RS1005577078 (20:3783989 G>C), RS1006243082 (20:3786870 C>G), RS1007190611 (20:3786766 G>C,T), RS1009011936 (20:3783744 C>A), RS1010153765 (20:3784307 C>A,T), RS1010232744 (20:3786007 C>T), RS1010453627 (20:3784544 C>G,T), RS1010820621 (20:3787389 CTT>C), RS1011120075 (20:3787673 T>A,G)

Disease associations

OMIM: gene MIM:117140 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, decreases expression, increases expression	3
cobaltous chloride	decreases expression	2
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	decreases sumoylation	1
bisphenol A	decreases expression	1
2-methyl-4-isothiazolin-3-one	decreases expression	1
trichostatin A	affects expression	1
arsenite	increases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
ferrous chloride	decreases expression	1
1-nitropyrene	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	decreases phosphorylation	1
Cisplatin	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Lead	decreases expression	1
Potassium Dichromate	increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
Valproic Acid	increases methylation	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	affects expression	1
Aflatoxin B1	increases expression, increases response to substance	1
Acrylamide	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1BW	Abcam A-431 CENPB KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.