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CENPM

gene
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Also known as Pane1CENP-MMGC861

Summary

CENPM (centromere protein M, HGNC:18352) is a protein-coding gene on chromosome 22q13.2, encoding Centromere protein M (Q9NSP4). Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. It is a common-essential gene (DepMap: required in 95.9% of cancer cell lines).

The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 79019 — RefSeq curated summary.

At a glance

  • GWAS associations: 5
  • Clinical variants (ClinVar): 35 total
  • Cancer dependency (DepMap): dependent in 95.9% of screened cell lines (common-essential)
  • MANE Select transcript: NM_024053

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:18352
Approved symbolCENPM
Namecentromere protein M
Location22q13.2
Locus typegene with protein product
StatusApproved
AliasesPane1, CENP-M, MGC861
Ensembl geneENSG00000100162
Ensembl biotypeprotein_coding
OMIM610152
Entrez79019

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 2 retained_intron

ENST00000215980, ENST00000396437, ENST00000402338, ENST00000402420, ENST00000404067, ENST00000407253, ENST00000460824, ENST00000472374, ENST00000718240, ENST00000921393, ENST00000921394, ENST00000921395, ENST00000921396

RefSeq mRNA: 7 — MANE Select: NM_024053 NM_001002876, NM_001110215, NM_001304370, NM_001304371, NM_001304372, NM_001304373, NM_024053

CCDS: CCDS14025, CCDS46719, CCDS46720, CCDS77681, CCDS77682, CCDS77683

Canonical transcript exons

ENST00000215980 — 6 exons

ExonStartEnd
ENSE000006563274194522541945304
ENSE000019311224194702041947152
ENSE000034770844194591341946005
ENSE000035666464193873741939196
ENSE000035959374194641741946496
ENSE000036904164194361041943701

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 92.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.9631 / max 325.0378, expressed in 1504 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter IDTPM avgSamples expressed
19440114.64761427
1944001.4162735
1943951.1579131
1943991.0178508
1943980.4737219
1943970.184385
1943940.065626

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
mucosa of transverse colonUBERON:000499192.34gold quality
right uterine tubeUBERON:000130290.58gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099189.25gold quality
ventricular zoneUBERON:000305388.62gold quality
ganglionic eminenceUBERON:000402385.51gold quality
epithelium of bronchusUBERON:000203185.35silver quality
bronchusUBERON:000218584.40silver quality
bronchial epithelial cellCL:000232884.27gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047384.24gold quality
embryoUBERON:000092284.21gold quality
bone marrowUBERON:000237181.61gold quality
lower esophagus mucosaUBERON:003583481.27gold quality
vermiform appendixUBERON:000115480.44gold quality
right testisUBERON:000453479.82gold quality
bone marrow cellCL:000209279.81gold quality
left testisUBERON:000453379.69gold quality
lymph nodeUBERON:000002979.36gold quality
stromal cell of endometriumCL:000225579.08gold quality
esophagus mucosaUBERON:000246978.69gold quality
amniotic fluidUBERON:000017378.47silver quality
olfactory segment of nasal mucosaUBERON:000538678.01gold quality
testisUBERON:000047377.67gold quality
spleenUBERON:000210676.32gold quality
caecumUBERON:000115375.90gold quality
rectumUBERON:000105275.64gold quality
epithelium of nasopharynxUBERON:000195175.63silver quality
skin of abdomenUBERON:000141675.40gold quality
thymusUBERON:000237075.15silver quality
skin of legUBERON:000151174.60gold quality
trabecular bone tissueUBERON:000248374.01silver quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 10.

ExperimentMarker?Max mean expression
E-MTAB-11121yes195.58
E-HCAD-10yes35.84
E-MTAB-9467yes30.41
E-GEOD-125970yes25.91
E-CURD-122yes25.02
E-HCAD-13yes20.92
E-HCAD-1yes19.53
E-MTAB-6678yes8.80
E-ANND-3yes7.76
E-MTAB-10553yes7.75
E-MTAB-6108no109.73
E-HCAD-30no37.59

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

13 targeting CENPM, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-574-5P100.0066.01989
HSA-MIR-4694-3P99.7969.532640
HSA-MIR-33A-3P99.7070.273362
HSA-MIR-6739-3P99.2268.841843
HSA-MIR-3194-3P98.8366.221167
HSA-MIR-2276-3P98.7667.751384
HSA-MIR-6778-5P98.1966.591239
HSA-MIR-1233-5P98.1966.711201
HSA-MIR-375-3P97.9165.12483
HSA-MIR-5196-3P97.5765.98979
HSA-MIR-6779-3P97.5165.82789
HSA-MIR-4786-5P97.4567.89924
HSA-MIR-797695.7565.671186

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 95.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 13)

  • Expression of the human PANE1 gene was detected preferentially in immune cells (PMID:15183305)
  • an alternative transcript of the proliferation-associated nuclear element 1 (PANE1) gene encodes a novel (HLA)-A(*)0301-restricted mHAg that is selectively expressed in B-lymphoid cells (PMID:16391015)
  • PANE1 localizes to the centromere throughout the cell cycle and its localization is dependent on the centromere specific histone variant CENP-A. (PMID:16622419)
  • CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches. (PMID:25006165)
  • CENPM was closely associated with HCC progression and it could be considered as a new possible biomarker along with a therapeutic target for HCC. (PMID:31703591)
  • LncRNA HCG18 contributes to the progression of hepatocellular carcinoma via miR-214-3p/CENPM axis. (PMID:32663252)
  • Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer. (PMID:32705259)
  • Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans. (PMID:33000180)
  • TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma. (PMID:33591950)
  • Upregulation of CENPM facilitates lung adenocarcinoma progression via PI3K/AKT/mTOR signaling pathway. (PMID:35130633)
  • CENPM upregulation by E5 oncoprotein of human papillomavirus promotes radiosensitivity in head and neck squamous cell carcinoma. (PMID:35462155)
  • Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma. (PMID:36635779)
  • Upregulation of CENPM promotes breast carcinogenesis by altering immune infiltration. (PMID:38200449)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriopane1ENSDARG00000024681
mus_musculusCenpmENSMUSG00000068101
rattus_norvegicusCenpmENSRNOG00000023262

Protein

Protein identifiers

Centromere protein M — Q9NSP4 (reviewed: Q9NSP4)

Alternative names: Interphase centromere complex protein 39, Proliferation-associated nuclear element protein 1

All UniProt accessions (4): Q9NSP4, B1AHQ6, B1AHQ7, B1AHQ8

UniProt curated annotations — full annotation on UniProt →

Function. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Subunit / interactions. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.

Subcellular location. Nucleus. Cytoplasm. Chromosome. Centromere. Kinetochore.

Tissue specificity. Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

Miscellaneous. Due to intron retention.

Isoforms (4)

UniProt IDNamesCanonical?
Q9NSP4-11yes
Q9NSP4-22
Q9NSP4-33
Q9NSP4-44

RefSeq proteins (7): NP_001002876, NP_001103685, NP_001291299, NP_001291300, NP_001291301, NP_001291302, NP_076958* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR020987Centromere_Cenp-MFamily
IPR027417P-loop_NTPaseHomologous_superfamily

Pfam: PF11111

UniProt features (20 total): strand 7, helix 7, splice variant 5, chain 1

Structure

Experimental structures (PDB)

14 structures.

PDBMethodResolution (Å)
4P0TX-RAY DIFFRACTION1.49
4WAUX-RAY DIFFRACTION2.2
28OPELECTRON MICROSCOPY2.7
7R5SELECTRON MICROSCOPY2.83
7PKNELECTRON MICROSCOPY3.2
7XHOELECTRON MICROSCOPY3.29
9TAWELECTRON MICROSCOPY3.54
7XHNELECTRON MICROSCOPY3.71
9TAXELECTRON MICROSCOPY4.5
7R5VELECTRON MICROSCOPY4.55
7QOOELECTRON MICROSCOPY4.6
7YYHELECTRON MICROSCOPY8.9
7YWXELECTRON MICROSCOPY12
9TAYELECTRON MICROSCOPY15.5

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9NSP4-F189.380.71

Function

Pathways and Gene Ontology

Reactome pathways

21 pathways

IDPathway
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813Separation of Sister Chromatids
R-HSA-2500257Resolution of Sister Chromatid Cohesion
R-HSA-5663220RHO GTPases Activate Formins
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877Mitotic Prometaphase
R-HSA-9648025EML4 and NUDC in mitotic spindle formation
R-HSA-141424Amplification of signal from the kinetochores
R-HSA-162582Signal Transduction
R-HSA-1640170Cell Cycle
R-HSA-194315Signaling by Rho GTPases
R-HSA-195258RHO GTPase Effectors
R-HSA-2555396Mitotic Metaphase and Anaphase
R-HSA-68882Mitotic Anaphase
R-HSA-68886M Phase
R-HSA-69278Cell Cycle, Mitotic
R-HSA-69618Mitotic Spindle Checkpoint
R-HSA-69620Cell Cycle Checkpoints
R-HSA-73886Chromosome Maintenance
R-HSA-774815Nucleosome assembly
R-HSA-9716542Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 245 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8A_DC_DN, HORIUCHI_WTAP_TARGETS_DN, KANG_DOXORUBICIN_RESISTANCE_UP, GNF2_MCM5, GNF2_RRM2, GNF2_RRM1, SHEPARD_BMYB_MORPHOLINO_DN, PATIL_LIVER_CANCER, LIAO_METASTASIS, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, FISCHER_DREAM_TARGETS, BASAKI_YBX1_TARGETS_UP

GO Biological Process (1): chromosome segregation (GO:0007059)

GO Molecular Function (0):

GO Cellular Component (8): inner kinetochore (GO:0000939), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), chromosome, centromeric region (GO:0000775), kinetochore (GO:0000776), chromosome (GO:0005694), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-14 pathways:

CategoryPathways
Cell Cycle3
Mitotic Prometaphase2
M Phase2
Amplification of signal from the kinetochores1
Mitotic Anaphase1
RHO GTPase Effectors1
Nucleosome assembly1
Mitotic Spindle Checkpoint1
Signaling by Rho GTPases, Miro GTPases and RHOBTB31
Signaling by Rho GTPases1
Mitotic Metaphase and Anaphase1
Cell Cycle, Mitotic1
Cell Cycle Checkpoints1
Chromosome Maintenance1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
intracellular membraneless organelle2
cell cycle process1
kinetochore1
protein-containing complex1
intracellular membrane-bounded organelle1
nuclear lumen1
cytoplasm1
chromosomal region1
condensed chromosome, centromeric region1
supramolecular complex1
intracellular anatomical structure1

Protein interactions and networks

STRING

1084 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
CENPMCENPHQ9H3R5999
CENPMCENPKQ9BS16998
CENPMCENPIQ92674995
CENPMCENPUQ71F23977
CENPMCENPNQ96H22976
CENPMCENPOQ9BU64972
CENPMCENPTQ96BT3966
CENPMCENPAP49450956
CENPMCENPPQ6IPU0948
CENPMCENPQQ7L2Z9943
CENPMCENPCQ03188939
CENPMCENPLQ8N0S6937
CENPMCENPSQ8N2Z9920
CENPMITGB3BPQ13352851
CENPMCENPWQ5EE01817

IntAct

16 interactions, top by confidence:

ABTypeScore
CENPHNDC80psi-mi:“MI:0914”(association)0.800
CENPHITGB3BPpsi-mi:“MI:0914”(association)0.530
CENPHPSMD11psi-mi:“MI:0914”(association)0.530
CENPKDHRS12psi-mi:“MI:0914”(association)0.530
HTRA2HAX1psi-mi:“MI:2364”(proximity)0.420
CenpiCENPKpsi-mi:“MI:0914”(association)0.350
CenphCENPXpsi-mi:“MI:0914”(association)0.350
CENPOCENPXpsi-mi:“MI:0914”(association)0.350
CENPQCENPXpsi-mi:“MI:0914”(association)0.350
CENPUCENPXpsi-mi:“MI:0914”(association)0.350
MKI67ARHGAP10psi-mi:“MI:0914”(association)0.350
CENPMCENPIpsi-mi:“MI:0914”(association)0.350
CENPMDNM1Lpsi-mi:“MI:0914”(association)0.350
DGCR8VWA8psi-mi:“MI:2364”(proximity)0.270

BioGRID (162): ARRB2 (Affinity Capture-MS), DOK2 (Affinity Capture-MS), CENPM (Affinity Capture-MS), CENPM (Affinity Capture-MS), CENPM (Affinity Capture-MS), CENPM (Affinity Capture-MS), CENPM (Affinity Capture-MS), OXLD1 (Affinity Capture-MS), DOK2 (Affinity Capture-MS), PCP2 (Affinity Capture-MS), CENPM (Negative Genetic), CENPM (Negative Genetic), CENPM (Negative Genetic), CENPM (Negative Genetic), CENPM (Negative Genetic)

ESM2 similar proteins: A1L1L6, A2A825, A6QL63, C9J798, O14908, O43374, O94844, O95278, O95294, Q0P5N6, Q15126, Q1LVW0, Q2HJF8, Q2TBH1, Q3UMR5, Q3UNW5, Q4R4U1, Q5E9M9, Q5R5F8, Q5ZIW1, Q5ZM73, Q5ZM83, Q66JN8, Q6DFV5, Q6GQW0, Q6IE70, Q6NVC5, Q6NYU2, Q7TSA0, Q7Z6G3, Q8BG51, Q8BGF7, Q8BHT7, Q8CIW5, Q8IXI1, Q8IXI2, Q8JZN7, Q8VCX6, Q91XQ2, Q923S8

Diamond homologs: Q1T7B9, Q2TBH1, Q3KQ10, Q7ZZC6, Q9CQA0, Q9NSP4

SIGNOR signaling

1 interactions.

AEffectBMechanism
CENPM“form complex”“CCAN complex”binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 20 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Nucleosome assembly8271.9×4e-17
Chromosome Maintenance8120.8×3e-14
Amplification of signal from the kinetochores8112.5×3e-14
Deposition of new CENPA-containing nucleosomes at the centromere890.6×1e-13
Mitotic Spindle Checkpoint890.6×1e-13
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal866.6×1e-12
Mitotic Metaphase and Anaphase855.3×4e-12
Mitotic Anaphase855.3×4e-12

GO biological processes:

GO termPartnersFoldFDR
chromosome segregation10108.6×2e-17

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance27
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1060 predictions. Top by Δscore:

VariantEffectΔscore
22:41945315:C:CTacceptor_gain1.0000
22:41945320:C:Tacceptor_gain1.0000
22:41945320:CAGGG:Cacceptor_gain1.0000
22:41945321:A:Tacceptor_gain1.0000
22:41945324:G:Cacceptor_gain1.0000
22:41945324:G:GCacceptor_gain1.0000
22:41946415:A:ACdonor_gain1.0000
22:41946415:ACAC:Adonor_gain1.0000
22:41946416:C:CAdonor_gain1.0000
22:41946416:CA:Cdonor_gain1.0000
22:41946416:CACC:Cdonor_gain1.0000
22:41946416:CACCT:Cdonor_gain1.0000
22:41946492:ACCAG:Aacceptor_gain1.0000
22:41946493:CCAG:Cacceptor_gain1.0000
22:41946493:CCAGC:Cacceptor_gain1.0000
22:41946494:CAGC:Cacceptor_gain1.0000
22:41946495:AG:Aacceptor_gain1.0000
22:41946497:C:CCacceptor_gain1.0000
22:41946497:C:Tacceptor_loss1.0000
22:41946500:C:CTacceptor_gain1.0000
22:41947017:TA:Tdonor_loss1.0000
22:41947018:A:ACdonor_gain1.0000
22:41947018:A:ATdonor_loss1.0000
22:41947019:C:CCdonor_gain1.0000
22:41939194:CACCT:Cacceptor_loss0.9900
22:41939195:ACCTG:Aacceptor_loss0.9900
22:41939196:CCTGC:Cacceptor_loss0.9900
22:41939197:C:CAacceptor_loss0.9900
22:41939198:T:Cacceptor_loss0.9900
22:41945219:A:ACdonor_gain0.9900

AlphaMissense

1153 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
22:41945949:A:GL65P0.984
22:41943634:G:CS126R0.980
22:41943634:G:TS126R0.980
22:41943636:T:GS126R0.980
22:41945239:A:GF99S0.979
22:41945251:C:AG95V0.967
22:41945304:A:CS77R0.966
22:41945304:A:TS77R0.966
22:41945914:T:GS77R0.966
22:41939162:A:GL146P0.956
22:41945252:C:AG95W0.952
22:41945940:A:GF68S0.951
22:41939150:A:GL150P0.949
22:41945236:A:GL100P0.947
22:41945281:A:GL85P0.941
22:41943650:G:TA121D0.939
22:41945943:A:TV67E0.939
22:41947021:A:GL19S0.939
22:41947024:A:TI18N0.939
22:41945252:C:GG95R0.936
22:41945252:C:TG95R0.936
22:41939139:C:GA154P0.935
22:41945259:G:CF92L0.935
22:41945259:G:TF92L0.935
22:41945261:A:GF92L0.935
22:41946417:A:TV46D0.935
22:41945939:A:CF68L0.933
22:41945939:A:TF68L0.933
22:41945941:A:GF68L0.933
22:41945952:T:AD64V0.932

dbSNP variants (sampled 300 via entrez): RS1000003454 (22:41928787 G>A), RS1000052048 (22:41934524 G>A,C), RS1000059379 (22:41933964 T>A), RS1000256694 (22:41948269 A>C), RS1000311569 (22:41942766 G>A), RS1000363111 (22:41938822 C>T), RS1000428588 (22:41943088 C>G), RS1000439692 (22:41928609 G>T), RS1001080917 (22:41927355 C>T), RS1001317190 (22:41937866 C>T), RS1001378232 (22:41947167 C>A,T), RS1001407710 (22:41927569 G>A), RS1001468470 (22:41948959 G>A), RS1001498760 (22:41932012 G>C), RS1001654166 (22:41937322 G>A,T)

Disease associations

OMIM: gene MIM:610152 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

StudyTraitp-value
GCST001758_2Birth weight3.000000e-06
GCST002539_95Schizophrenia2.000000e-09
GCST006803_13Schizophrenia2.000000e-14
GCST010002_83Refractive error2.000000e-27
GCST010132_1Processed meat consumption1.000000e-08

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0004344birth weight
EFO:0008111diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

VariantGenesLevelScore#Clin annotsDrugs
rs8140869CENPM, SMIM450.000

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arseniteaffects cotreatment, increases abundance, increases expression, decreases expression3
Arsenicaffects methylation, decreases expression, increases abundance, affects cotreatment3
Air Pollutantsdecreases expression, increases abundance, increases expression2
Benzo(a)pyrenedecreases expression, increases expression2
Smokedecreases expression, increases abundance, increases expression2
Testosteroneaffects cotreatment, decreases expression, increases expression2
Cyclosporinedecreases expression2
Particulate Matterdecreases expression, increases abundance, affects cotreatment, increases expression2
bisphenol Adecreases expression1
sodium arsenatedecreases expression, increases abundance1
N(4)-hydroxycytidineincreases expression1
tris(1,3-dichloro-2-propyl)phosphatedecreases expression1
cobaltous chloridedecreases expression1
perfluorooctanoic aciddecreases expression1
zinc chromatedecreases expression, increases abundance1
manganese chlorideaffects cotreatment, decreases expression, increases abundance1
diallyl trisulfidedecreases expression1
beta-methylcholineaffects expression1
16-hydroxycleroda-3,13(14)-dien-15,16-olidedecreases expression1
chromium hexavalent iondecreases expression, increases abundance1
K 7174decreases expression1
erucylphospho-N,N,N-trimethylpropylammoniumdecreases expression1
palbociclibdecreases expression1
jinfukangincreases expression1
NSC 689534affects binding, decreases expression1
Resveratrolaffects cotreatment, increases expression1
Sunitinibdecreases expression1
Zoledronic Aciddecreases expression1
Ethanolincreases abundance, increases expression, affects cotreatment1
Allergensdecreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot