CEP112

Summary

CEP112 (centrosomal protein 112, HGNC:28514) is a protein-coding gene on chromosome 17q24.1, encoding Centrosomal protein of 112 kDa (Q8N8E3). Recruits mRNAs essential for sperm development, such as CFAP61 and FSIP2 mRNAs, into phase-separated condensates, thereby regulating their translation through a mechanism of liquid-liquid phase separation.

This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 201134 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spermatogenic failure 44 (Limited, GenCC)
• GWAS associations: 16
• Clinical variants (ClinVar): 166 total — 2 pathogenic, 1 likely-pathogenic
• Phenotypes (HPO): 6
• MANE Select transcript: NM_001199165

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28514
Approved symbol	CEP112
Name	centrosomal protein 112
Location	17q24.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC33887
Ensembl gene	ENSG00000154240
Ensembl biotype	protein_coding
OMIM	618980
Entrez	201134

Gene structure

Transcript identifiers

Ensembl transcripts: 49 — 29 protein_coding, 12 protein_coding_CDS_not_defined, 5 nonsense_mediated_decay, 3 retained_intron

ENST00000317442, ENST00000392769, ENST00000535342, ENST00000537949, ENST00000577322, ENST00000578878, ENST00000578971, ENST00000580482, ENST00000580624, ENST00000580694, ENST00000581734, ENST00000581739, ENST00000582760, ENST00000582795, ENST00000582861, ENST00000583358, ENST00000583466, ENST00000584627, ENST00000584987, ENST00000585168, ENST00000706790, ENST00000706791, ENST00000706792, ENST00000706793, ENST00000706794, ENST00000706795, ENST00000706796, ENST00000706797, ENST00000706798, ENST00000706799, ENST00000859223, ENST00000859224, ENST00000859225, ENST00000859226, ENST00000859227, ENST00000859228, ENST00000932262, ENST00000932263, ENST00000932264, ENST00000952577, ENST00000952578, ENST00000952579, ENST00000952580, ENST00000952581, ENST00000952582, ENST00000952583, ENST00000952584, ENST00000952585, ENST00000952586

RefSeq mRNA: 6 — MANE Select: NM_001199165 NM_001037325, NM_001199165, NM_001302891, NM_001353127, NM_001353128, NM_001353129

CCDS: CCDS32710, CCDS32711, CCDS77093

Canonical transcript exons

ENST00000535342 — 27 exons

Exon	Start	End
ENSE00001014802	65961463	65961598
ENSE00001014805	66005690	66005769
ENSE00001014806	66028313	66028405
ENSE00001014809	66029123	66029252
ENSE00001014811	66029869	66030023
ENSE00001178274	66027501	66027560
ENSE00001468049	66069915	66070001
ENSE00001468051	66096251	66096328
ENSE00001468053	66096585	66096632
ENSE00001468056	66129746	66129823
ENSE00001468057	66132670	66132763
ENSE00001468060	66175044	66175216
ENSE00001468063	66176830	66177020
ENSE00002210852	66191997	66192133
ENSE00002261805	65635537	65635974
ENSE00003462498	66183194	66183307
ENSE00003480971	65640964	65641065
ENSE00003492907	65743068	65743217
ENSE00003505351	66066778	66066877
ENSE00003535591	66062963	66063081
ENSE00003612875	65750662	65750724
ENSE00003614695	65851804	65852034
ENSE00003616434	65927582	65927689
ENSE00003618823	66053736	66053879
ENSE00003630870	65637124	65637188
ENSE00003679213	65902152	65902334
ENSE00003689751	65689129	65689218

Expression profiles

Bgee: expression breadth ubiquitous, 251 present calls, max score 98.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.4425 / max 181.8984, expressed in 1291 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167653	3.8412	1131
167654	0.7746	402
167652	0.7711	390
167648	0.0473	3
167649	0.0082	3

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.58	gold quality
left testis	UBERON:0004533	96.78	gold quality
right testis	UBERON:0004534	96.59	gold quality
male germ cell	CL:0000015	95.81	gold quality
calcaneal tendon	UBERON:0003701	95.30	gold quality
testis	UBERON:0000473	94.88	gold quality
sural nerve	UBERON:0015488	92.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.63	gold quality
tendon	UBERON:0000043	90.12	gold quality
ventricular zone	UBERON:0003053	89.04	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.63	gold quality
colonic epithelium	UBERON:0000397	86.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.49	gold quality
omental fat pad	UBERON:0010414	85.42	gold quality
peritoneum	UBERON:0002358	85.35	gold quality
tibial nerve	UBERON:0001323	85.18	gold quality
adipose tissue of abdominal region	UBERON:0007808	84.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	84.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.60	gold quality
lower esophagus	UBERON:0013473	84.57	gold quality
adenohypophysis	UBERON:0002196	84.34	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.29	gold quality
mucosa of stomach	UBERON:0001199	83.49	gold quality
choroid plexus epithelium	UBERON:0003911	83.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	83.03	gold quality
adipose tissue	UBERON:0001013	83.00	gold quality
muscle of leg	UBERON:0001383	82.96	gold quality
pituitary gland	UBERON:0000007	82.76	gold quality
gastrocnemius	UBERON:0001388	82.68	gold quality
connective tissue	UBERON:0002384	82.66	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-110499	no	353.31
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NR1I2

Literature-anchored findings (GeneRIF, showing 2)

• We report that Maf1 interacts with a novel coiled-coil domain containing protein that we have called Macoco. (PMID:20417281)
• Loss-of-function mutations in centrosomal protein 112 is associated with human acephalic spermatozoa phenotype. (PMID:31654588)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cep112	ENSDARG00000079679
mus_musculus	Cep112	ENSMUSG00000020728
rattus_norvegicus	Cep112	ENSRNOG00000024557

Protein

Protein identifiers

Centrosomal protein of 112 kDa — Q8N8E3 (reviewed: Q8N8E3)

Alternative names: Coiled-coil domain-containing protein 46

All UniProt accessions (13): Q8N8E3, A0A9L9PXB5, A0A9L9PXI6, A0A9L9PXV5, A0A9L9PXX9, A0A9L9PYC3, A0A9L9PYC7, F5GYE8, J3KSN4, J3QL98, J3QQV3, J3QRD9, J3QSA5

UniProt curated annotations — full annotation on UniProt →

Function. Recruits mRNAs essential for sperm development, such as CFAP61 and FSIP2 mRNAs, into phase-separated condensates, thereby regulating their translation through a mechanism of liquid-liquid phase separation.

Subunit / interactions. Interacts with HNRNPA2B1, EEF1A1 and EIF4A1.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Nucleus. Cytoplasmic ribonucleoprotein granule. Flagellum axoneme. Centriole.

Disease relevance. Spermatogenic failure 44 (SPGF44) [MIM:619044] An autosomal recessive infertility disorder caused by spermatogenesis defects and characterized by the presence of acephalic spermatozoa in the semen of affected individuals. The disease is caused by variants affecting the gene represented in this entry.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N8E3-1	1	yes
Q8N8E3-2	2

RefSeq proteins (6): NP_001032402, NP_001186094, NP_001289820, NP_001340056, NP_001340057, NP_001340058 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027831	DUF4485	Domain
IPR055310	CEP112	Family

Pfam: PF14846

UniProt features (14 total): sequence variant 8, sequence conflict 2, splice variant 2, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N8E3-F1	76.22	0.35

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 121 (showing top): BROWNE_HCMV_INFECTION_6HR_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOCC_MICROTUBULE_ORGANIZING_CENTER, CAGCAGG_MIR370, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4, GOCC_CENTROSOME, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, RIGGI_EWING_SARCOMA_PROGENITOR_UP, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP, GOCC_SYNAPSE, GOCC_INHIBITORY_SYNAPSE, HAMAI_APOPTOSIS_VIA_TRAIL_UP

GO Biological Process (1): receptor localization to synapse (GO:0097120)

GO Molecular Function (2): molecular condensate scaffold activity (GO:0140693), protein binding (GO:0005515)

GO Cellular Component (5): centrosome (GO:0005813), plasma membrane (GO:0005886), inhibitory synapse (GO:0060077), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
localization	1
protein-macromolecule adaptor activity	1
binding	1
centriole	1
microtubule organizing center	1
membrane	1
cell periphery	1
synapse	1
intracellular anatomical structure	1
cellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

886 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEP112	PMFBP1	Q8TBY8	617
CEP112	TSGA10	Q9BZW7	582
CEP112	SUN5	Q8TC36	571
CEP112	TTC29	Q8NA56	514
CEP112	SPATC1L	Q9H0A9	449
CEP112	CEP131	Q9UPN4	426
CEP112	CEP135	Q66GS9	420
CEP112	BRDT	Q58F21	395
CEP112	HOOK1	Q9UJC3	386
CEP112	DNAH6	Q9C0G6	382
CEP112	A0A087WUM3	A0A087WUM3	380
CEP112	CNTLN	Q9NXG0	371
CEP112	WDR37	Q9Y2I8	362
CEP112	CEP128	Q6ZU80	357
CEP112	TTC21A	Q8NDW8	344

IntAct

41 interactions, top by confidence:

A	B	Type	Score
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
YWHAG	SHTN1	psi-mi:“MI:0914”(association)	0.560
CEP112	YWHAE	psi-mi:“MI:0915”(physical association)	0.540
YWHAQ	IGLC7	psi-mi:“MI:0914”(association)	0.530
rep	TBKBP1	psi-mi:“MI:0914”(association)	0.530
YWHAB	SHTN1	psi-mi:“MI:0914”(association)	0.530
YWHAE	SHTN1	psi-mi:“MI:0914”(association)	0.530
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
YWHAQ	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
SFN	CEP112	psi-mi:“MI:0915”(physical association)	0.470
CEP112	API5	psi-mi:“MI:0915”(physical association)	0.400
NFKB1	NFKB1	psi-mi:“MI:0914”(association)	0.350
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
YWHAG	C1orf226	psi-mi:“MI:0914”(association)	0.350
YWHAZ	SPEG	psi-mi:“MI:0914”(association)	0.350
BMI1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
YWHAH	SHTN1	psi-mi:“MI:0914”(association)	0.350
YWHAQ	SHTN1	psi-mi:“MI:0914”(association)	0.350
YWHAB	BRAF	psi-mi:“MI:0914”(association)	0.350
YWHAG	BRAF	psi-mi:“MI:0914”(association)	0.350
YWHAH	BRAF	psi-mi:“MI:0914”(association)	0.350
S100B	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
PNMA2	TARS3	psi-mi:“MI:0914”(association)	0.350
CEP112	PRPS2	psi-mi:“MI:0914”(association)	0.350

BioGRID (49): CEP112 (Affinity Capture-MS), CEP112 (Affinity Capture-MS), CEP112 (Biochemical Activity), CEP112 (Affinity Capture-MS), CEP112 (Affinity Capture-RNA), CEP112 (Affinity Capture-MS), API5 (Proximity Label-MS), CEP112 (Affinity Capture-MS), CEP112 (Proximity Label-MS), CEP112 (Affinity Capture-MS), CEP112 (Proximity Label-MS), CEP112 (Proximity Label-MS), CEP112 (Proximity Label-MS), PRPS2 (Affinity Capture-MS), CEP112 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8QCI3, A3KGV1, A3KNA5, A7MD70, B1WB65, B8JK76, F6ZDS4, G5E861, O35550, O35551, P55937, P85001, Q08DR9, Q15276, Q2T9U2, Q4R6W3, Q4R703, Q4R8C3, Q502I3, Q5BJF6, Q5M9N0, Q5PQ23, Q5PR68, Q5R829, Q5RG45, Q5ZKK5, Q66GS9, Q66KE8, Q6AYX5, Q6NRC9, Q6NRW2, Q6NY15, Q6P5D4, Q6ZU80, Q80UF4, Q811U3, Q86SQ7, Q8BI22, Q8CDI6, Q8CDI7

Diamond homologs: Q5PR68, Q8N8E3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 29 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	313.5×	3e-15
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	276.6×	4e-15
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	276.6×	4e-15
Activation of BH3-only proteins	7	204.4×	4e-14
RHO GTPases activate PKNs	7	130.6×	1e-12
Intrinsic Pathway for Apoptosis	7	120.6×	2e-12
FOXO-mediated transcription	5	98.8×	1e-08
SARS-CoV-1-host interactions	7	72.3×	7e-11

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	83.3×	4e-07
intracellular protein localization	7	33.3×	2e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

166 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	1
Uncertain significance	123
Likely benign	11
Benign	1

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
981489	NM_001199165.4(CEP112):c.496C>T (p.Arg166Ter)	Pathogenic
981491	NM_001199165.4(CEP112):c.2104C>T (p.Arg702Cys)	Pathogenic
4526594	NM_001199165.4(CEP112):c.1252C>T (p.Gln418Ter)	Likely pathogenic

SpliceAI

6789 predictions. Top by Δscore:

Variant	Effect	Δscore
17:65635879:T:C	donor_gain	1.0000
17:65640959:ATTAC:A	donor_loss	1.0000
17:65640960:TTA:T	donor_loss	1.0000
17:65640961:TACCT:T	donor_loss	1.0000
17:65640962:A:C	donor_loss	1.0000
17:65641061:GTTAT:G	acceptor_gain	1.0000
17:65641062:TTAT:T	acceptor_gain	1.0000
17:65641063:TAT:T	acceptor_gain	1.0000
17:65641064:ATC:A	acceptor_loss	1.0000
17:65641065:TCTA:T	acceptor_loss	1.0000
17:65641066:C:CC	acceptor_gain	1.0000
17:65641067:T:C	acceptor_loss	1.0000
17:65641071:T:TC	acceptor_gain	1.0000
17:65743064:TTA:T	donor_loss	1.0000
17:65743067:CCTT:C	donor_loss	1.0000
17:65743214:TGAT:T	acceptor_gain	1.0000
17:65743215:GAT:G	acceptor_gain	1.0000
17:65743216:AT:A	acceptor_gain	1.0000
17:65743218:C:CC	acceptor_gain	1.0000
17:65743218:CTA:C	acceptor_loss	1.0000
17:65851798:TCTTA:T	donor_loss	1.0000
17:65851799:CTTAC:C	donor_loss	1.0000
17:65851800:TTA:T	donor_loss	1.0000
17:65851801:TAC:T	donor_loss	1.0000
17:65851802:A:AC	donor_gain	1.0000
17:65851802:A:AT	donor_loss	1.0000
17:65851802:AC:A	donor_gain	1.0000
17:65851803:C:CG	donor_gain	1.0000
17:65851803:CC:C	donor_gain	1.0000
17:65851803:CCT:C	donor_gain	1.0000

AlphaMissense

6359 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:66177000:A:G	W43R	0.998
17:66177000:A:T	W43R	0.998
17:66063018:A:G	L340P	0.997
17:66176939:C:G	R63P	0.996
17:65927667:A:G	L632P	0.995
17:66176906:A:G	L74P	0.995
17:66176987:A:G	L47P	0.995
17:66053779:A:G	L392P	0.994
17:66176879:A:G	F83S	0.994
17:66176998:C:A	W43C	0.994
17:66176998:C:G	W43C	0.994
17:65961540:C:G	A599P	0.993
17:66176878:A:C	F83L	0.993
17:66176878:A:T	F83L	0.993
17:66176880:A:G	F83L	0.993
17:66176906:A:T	L74H	0.993
17:66176928:C:G	A67P	0.992
17:66183217:A:T	V28D	0.992
17:66183225:C:A	K25N	0.992
17:66183225:C:G	K25N	0.992
17:65640974:A:G	L930P	0.991
17:66053878:A:G	L359P	0.991
17:65961531:C:G	A602P	0.990
17:66053782:C:G	R391P	0.990
17:66066789:A:G	L315P	0.990
17:65961549:C:G	A596P	0.989
17:66176918:A:G	L70S	0.989
17:65927646:C:G	R639P	0.988
17:66030004:A:G	L413P	0.988
17:66053800:A:G	L385P	0.988

dbSNP variants (sampled 300 via entrez): RS1000012702 (17:66177911 G>A), RS1000013855 (17:66070990 A>T), RS1000015231 (17:65637205 G>C), RS1000020278 (17:66152162 G>A), RS1000020939 (17:66185070 G>A), RS1000023964 (17:65696102 A>G,T), RS1000030396 (17:66063837 T>A,C), RS1000035934 (17:65667330 G>C), RS1000040546 (17:65971346 A>G), RS1000048204 (17:65647587 C>T), RS1000059279 (17:65759194 T>A,C), RS1000065123 (17:65726167 C>T), RS1000069870 (17:66021704 C>T), RS1000077132 (17:66063738 T>C), RS1000082335 (17:65673612 A>G)

Disease associations

OMIM: gene MIM:618980 | disease phenotypes: MIM:619044

GenCC curated gene-disease

Disease	Classification	Inheritance
spermatogenic failure 44	Limited	Unknown

Mondo (1): spermatogenic failure 44 (MONDO:0033622)

Orphanet (0):

HPO phenotypes

6 total (6 of 6 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0003251	Male infertility
HP:0008734	Decreased testicular size
HP:0012207	Reduced sperm motility
HP:0012869	Acephalic spermatozoa
HP:0030087	Abnormal circulating testosterone concentration

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST000684_6	Attention deficit hyperactivity disorder	1.000000e-06
GCST001800_4	β2-Glycoprotein I (β2-GPI) plasma levels	7.000000e-07
GCST001800_6	β2-Glycoprotein I (β2-GPI) plasma levels	1.000000e-06
GCST003262_303	Post bronchodilator FEV1	2.000000e-06
GCST003262_885	Post bronchodilator FEV1	5.000000e-06
GCST003563_1	Presence of antiphospholipid antibodies	1.000000e-11
GCST003563_2	Presence of antiphospholipid antibodies	1.000000e-11
GCST003563_8	Presence of antiphospholipid antibodies	6.000000e-11
GCST003989_21	Chin dimples	1.000000e-14
GCST005348_28	Total body bone mineral density	7.000000e-10
GCST007741_16	Iris color (b* coordinate)	5.000000e-06
GCST009159_4	Blood protein levels	2.000000e-08
GCST010703_202	Brain morphology (MOSTest)	1.000000e-11
GCST011011_17	Youthful appearance (self-reported)	6.000000e-13
GCST90000654_67	Central corneal thickness	3.000000e-09
GCST90002400_228	Plateletcrit	1.000000e-11

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0004555	glycoprotein measurement
EFO:0004314	forced expiratory volume
EFO:0009764	eye colour measurement
EFO:0004747	protein measurement
EFO:0004813	alpha globulin measurement
EFO:0004346	neuroimaging measurement
EFO:0005213	central corneal thickness
EFO:0007985	platelet crit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases methylation	4
Valproic Acid	decreases methylation, increases expression, affects expression	3
trichostatin A	affects cotreatment, decreases expression	2
entinostat	affects cotreatment, decreases expression	2
Aflatoxin B1	decreases methylation, increases methylation	2
aristolochic acid I	decreases expression	1
bisphenol A	affects cotreatment, increases methylation	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
perfluorooctane sulfonic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Cisplatin	decreases expression, affects cotreatment	1
Dexamethasone	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, increases expression	1
Indomethacin	increases expression, affects cotreatment	1
Phthalic Acids	increases methylation	1
Tobacco Smoke Pollution	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	increases expression	1
Asbestos, Serpentine	increases methylation	1
Antirheumatic Agents	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.