CEP162

Summary

CEP162 (centrosomal protein 162, HGNC:21107) is a protein-coding gene on chromosome 6q14.2-q14.3, encoding Centrosomal protein of 162 kDa (Q5TB80). Required to promote assembly of the transition zone in primary cilia.

Involved in cilium assembly. Located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and nucleoplasm.

Source: NCBI Gene 22832 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 247 total — 1 pathogenic
• MANE Select transcript: NM_014895

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21107
Approved symbol	CEP162
Name	centrosomal protein 162
Location	6q14.2-q14.3
Locus type	gene with protein product
Status	Approved
Aliases	QN1
Ensembl gene	ENSG00000135315
Ensembl biotype	protein_coding
OMIM	610201
Entrez	22832

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000257766, ENST00000403245, ENST00000435955, ENST00000461137, ENST00000487999, ENST00000497936, ENST00000617909, ENST00000962927

RefSeq mRNA: 2 — MANE Select: NM_014895 NM_001286206, NM_014895

CCDS: CCDS34494, CCDS69149

Canonical transcript exons

ENST00000403245 — 27 exons

Exon	Start	End
ENSE00000798103	84175214	84175347
ENSE00003461574	84215282	84215465
ENSE00003462315	84169328	84169433
ENSE00003476917	84200789	84200905
ENSE00003477620	84226337	84226452
ENSE00003480833	84201737	84201767
ENSE00003500734	84212957	84213024
ENSE00003501137	84194884	84195075
ENSE00003508334	84174048	84174188
ENSE00003526633	84185187	84185448
ENSE00003536819	84171606	84171718
ENSE00003554053	84149562	84149703
ENSE00003555492	84174727	84174954
ENSE00003559870	84146687	84146785
ENSE00003574484	84152545	84153179
ENSE00003576122	84193609	84193690
ENSE00003580638	84221057	84221171
ENSE00003605985	84155298	84155510
ENSE00003621680	84203981	84204096
ENSE00003624185	84126378	84126512
ENSE00003627477	84186332	84186623
ENSE00003631444	84215776	84215922
ENSE00003653590	84163144	84163270
ENSE00003677495	84161746	84161909
ENSE00003682304	84160812	84160916
ENSE00003850060	84124250	84125276
ENSE00003850282	84227580	84227643

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 91.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.8455 / max 223.8749, expressed in 1272 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74580	3.8455	1272

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	91.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.21	gold quality
sperm	CL:0000019	90.08	gold quality
left testis	UBERON:0004533	87.68	gold quality
male germ cell	CL:0000015	87.42	gold quality
right testis	UBERON:0004534	87.41	gold quality
tendon	UBERON:0000043	87.32	gold quality
testis	UBERON:0000473	86.51	gold quality
right uterine tube	UBERON:0001302	85.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.33	gold quality
buccal mucosa cell	CL:0002336	83.93	gold quality
ventricular zone	UBERON:0003053	82.20	gold quality
bronchial epithelial cell	CL:0002328	81.42	gold quality
tendon of biceps brachii	UBERON:0008188	81.24	gold quality
ganglionic eminence	UBERON:0004023	80.66	gold quality
monocyte	CL:0000576	79.62	gold quality
cortical plate	UBERON:0005343	79.44	gold quality
mononuclear cell	CL:0000842	79.34	gold quality
leukocyte	CL:0000738	79.18	gold quality
tibial nerve	UBERON:0001323	79.10	gold quality
sural nerve	UBERON:0015488	78.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.66	gold quality
body of uterus	UBERON:0009853	78.63	gold quality
left coronary artery	UBERON:0001626	78.42	gold quality
thyroid gland	UBERON:0002046	78.40	gold quality
right lobe of thyroid gland	UBERON:0001119	78.36	gold quality
left lobe of thyroid gland	UBERON:0001120	78.27	gold quality
descending thoracic aorta	UBERON:0002345	78.15	gold quality
metanephros cortex	UBERON:0010533	78.14	gold quality
right coronary artery	UBERON:0001625	78.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.15

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting CEP162, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-567	99.63	68.57	1219
HSA-MIR-1260A	99.61	66.67	1098
HSA-MIR-1260B	99.61	66.67	1098
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-891B	99.59	69.81	1083
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-7849-3P	99.47	68.17	1224
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-569	99.42	66.32	1009
HSA-MIR-4666A-5P	99.41	69.72	1887
HSA-MIR-580-5P	99.28	70.94	1776
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-138-2-3P	98.91	68.33	1643

Literature-anchored findings (GeneRIF, showing 4)

• QN1/KIAA1009 is a new microtubule-associated ATPase involved in cell division (PMID:16302001)
• CEP162 is an axoneme-recognition protein pre-tethered at centriole distal ends before ciliogenesis to promote and restrict transition zone formation specifically at the cilia base. (PMID:23644468)
• CEP162 deficiency causes human retinal degeneration and reveals a dual role in ciliogenesis and neurogenesis. (PMID:36862503)
• The association of five polymorphisms with diabetic retinopathy in a Chinese population. (PMID:37066695)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cep162	ENSDARG00000087369
mus_musculus	Cep162	ENSMUSG00000056919
rattus_norvegicus	Cep162	ENSRNOG00000010608

Protein

Protein identifiers

Centrosomal protein of 162 kDa — Q5TB80 (reviewed: Q5TB80)

Alternative names: Protein QN1 homolog

All UniProt accessions (2): F6V2J0, Q5TB80

UniProt curated annotations — full annotation on UniProt →

Function. Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.

Subunit / interactions. Interacts with CEP290. Interacts with CPNE4. Interacts with alpha-tubulin.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Spindle. Nucleus.

Miscellaneous. Promotes ectopic assembly of transition zone components at cilia tips when targeted outside distal ends of centrioles, generating extra-long cilia with strikingly swollen tips.

Similarity. Belongs to the CEP162 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5TB80-1	1	yes
Q5TB80-2	2

RefSeq proteins (2): NP_001273135, NP_055710* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR038774	CEP162-like	Family

UniProt features (20 total): modified residue 4, sequence variant 4, coiled-coil region 4, region of interest 3, compositionally biased region 2, chain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5TB80-F1	63.93	0.21

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 157, 160, 474, 475

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-1852241	Organelle biogenesis and maintenance
R-HSA-5617833	Cilium Assembly

MSigDB gene sets: 140 (showing top): MORF_MSH3, MODULE_255, MORF_BRCA1, MODULE_317, MORF_ESR1, MORF_RAD51L3, GOCC_MICROTUBULE_ORGANIZING_CENTER, BROWNE_HCMV_INFECTION_48HR_DN, MORF_CTSB, GOBP_CILIUM_ORGANIZATION, MORF_IL4, GOCC_CENTROSOME, MORF_PRKCA, GOBP_ORGANELLE_ASSEMBLY, MORF_THPO

GO Biological Process (2): cilium assembly (GO:0060271), cell projection organization (GO:0030030)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (16): nucleoplasm (GO:0005654), Golgi apparatus (GO:0005794), centrosome (GO:0005813), centriole (GO:0005814), spindle (GO:0005819), cytosol (GO:0005829), axonemal microtubule (GO:0005879), centriolar satellite (GO:0034451), ciliary basal body (GO:0036064), sperm midpiece (GO:0097225), sperm principal piece (GO:0097228), sperm head-tail coupling apparatus (GO:0120212), nucleus (GO:0005634), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), microtubule (GO:0005874)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Assembly of the 9+0 primary cilium	1
Organelle biogenesis and maintenance	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	7
microtubule organizing center	3
intracellular membraneless organelle	3
cytoplasm	2
intracellular membrane-bounded organelle	2
microtubule cytoskeleton	2
sperm flagellum	2
axoneme assembly	1
intraciliary transport involved in cilium assembly	1
cilium organization	1
protein localization to cilium	1
organelle assembly	1
trans-Golgi to periciliary membrane compartment transport	1
plasma membrane bounded cell projection assembly	1
ciliary transition zone assembly	1
cellular component organization	1
binding	1
nuclear lumen	1
endomembrane system	1
centriole	1
cytoplasmic microtubule	1
axoneme	1
centrosome	1
cilium	1
intracellular anatomical structure	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

1018 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEP162	TUBG1	P23258	762
CEP162	CEP290	O15078	743
CEP162	TCTN1	Q2MV58	590
CEP162	CEP120	Q8N960	574
CEP162	KIAA0753	Q2KHM9	557
CEP162	CEP164	Q9UPV0	550
CEP162	YEATS4	O95619	543
CEP162	CEP295	Q9C0D2	528
CEP162	CCP110	O43303	528
CEP162	IQCB1	Q15051	523
CEP162	POC1B	Q8TC44	519
CEP162	TMEM67	Q5HYA8	514
CEP162	CEP19	Q96LK0	508
CEP162	CEP89	Q96ST8	500
CEP162	SAXO1	Q8IYX7	494

IntAct

81 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
CEP290	CCP110	psi-mi:“MI:2364”(proximity)	0.890
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
CEP162	CEP290	psi-mi:“MI:0915”(physical association)	0.600
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
CEP162	CEP135	psi-mi:“MI:0915”(physical association)	0.540
CEP120	CEP162	psi-mi:“MI:0915”(physical association)	0.540
CEP104	CCDC66	psi-mi:“MI:2364”(proximity)	0.540
CAPN6	UBA6	psi-mi:“MI:0914”(association)	0.530
PCM1	CEP162	psi-mi:“MI:0914”(association)	0.420
CEP162	OFD1	psi-mi:“MI:0914”(association)	0.420
CEP128	PCM1	psi-mi:“MI:0914”(association)	0.420
CEP162	CCP110	psi-mi:“MI:2364”(proximity)	0.420
CEP162	CCDC47	psi-mi:“MI:0915”(physical association)	0.400
ATXN1	CEP162	psi-mi:“MI:0915”(physical association)	0.400
CEP162	KCTD8	psi-mi:“MI:0915”(physical association)	0.400
CEP162	KDM1A	psi-mi:“MI:0915”(physical association)	0.370
PRMT8	CEP162	psi-mi:“MI:0915”(physical association)	0.370
PRMT1	CEP162	psi-mi:“MI:0915”(physical association)	0.370
ANLN	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MYO18A	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MYO1C	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
FLNA	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Myh10	LMO7	psi-mi:“MI:0914”(association)	0.350
Actb		psi-mi:“MI:0914”(association)	0.350
Lima1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Tmod3	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Tpm1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350

BioGRID (240): CEP162 (Proximity Label-MS), CEP162 (Affinity Capture-Western), CEP120 (Affinity Capture-Western), CEP170 (Affinity Capture-Western), CEP97 (Affinity Capture-Western), KIAA0753 (Affinity Capture-Western), OFD1 (Affinity Capture-Western), PCM1 (Affinity Capture-Western), SPICE1 (Affinity Capture-Western), CEP162 (Affinity Capture-Western), CEP162 (Affinity Capture-Western), CEP162 (Affinity Capture-Western), CEP162 (Affinity Capture-MS), CEP131 (Affinity Capture-MS), CCDC138 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8GUX5, A0A1L8GXY6, A0A1W2P884, A2AIW0, A2AM05, A2CE83, A6H5Y1, E7F5E1, F7DP49, H2MTR9, O08970, O60296, P27628, P28290, P57077, Q08AD1, Q0VF96, Q28GJ0, Q2KJD6, Q2MJV9, Q3KQW7, Q3V036, Q4KLH6, Q4KM62, Q4R815, Q5R9L2, Q5SZL2, Q5TB80, Q5U2Y9, Q5U4W1, Q66H35, Q6AW69, Q6IRN6, Q6PD31, Q6ZQ06, Q70YC5, Q7ZX27, Q80ST9, Q86VQ0, Q8C115

Diamond homologs: E7F5E1, Q4KLH6, Q5TB80, Q6ZQ06, Q91365

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 82 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	5	82.8×	8e-08
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	5	73.0×	1e-07
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	5	73.0×	1e-07
Activation of BH3-only proteins	5	54.0×	5e-07
RHO GTPases activate PKNs	7	48.3×	5e-09
Intrinsic Pathway for Apoptosis	5	31.8×	7e-06
Loss of Nlp from mitotic centrosomes	9	31.0×	2e-09
Loss of proteins required for interphase microtubule organization from the centrosome	9	31.0×	2e-09

GO biological processes:

GO term	Partners	Fold	FDR
intracellular protein localization	7	10.5×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

247 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	202
Likely benign	15
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1340905	GRCh37/hg19 6q14.1-15(chr6:83141523-88023466)x1	Pathogenic

SpliceAI

4163 predictions. Top by Δscore:

Variant	Effect	Δscore
6:84125273:TTAT:T	acceptor_gain	1.0000
6:84125275:ATCT:A	acceptor_loss	1.0000
6:84125276:TC:T	acceptor_loss	1.0000
6:84125277:C:CA	acceptor_loss	1.0000
6:84125277:C:CC	acceptor_gain	1.0000
6:84126371:A:AC	donor_gain	1.0000
6:84126372:C:CC	donor_gain	1.0000
6:84126372:CTTTA:C	donor_gain	1.0000
6:84126373:TTTA:T	donor_loss	1.0000
6:84126375:TACCT:T	donor_loss	1.0000
6:84126508:GTAAT:G	acceptor_gain	1.0000
6:84126509:TAAT:T	acceptor_gain	1.0000
6:84126510:AAT:A	acceptor_gain	1.0000
6:84126510:AATCT:A	acceptor_loss	1.0000
6:84126511:AT:A	acceptor_gain	1.0000
6:84126511:ATCTA:A	acceptor_loss	1.0000
6:84126512:TCTAA:T	acceptor_loss	1.0000
6:84126513:C:CA	acceptor_loss	1.0000
6:84126513:C:CC	acceptor_gain	1.0000
6:84126514:T:C	acceptor_loss	1.0000
6:84126519:T:C	acceptor_gain	1.0000
6:84126519:T:TC	acceptor_gain	1.0000
6:84126523:C:CT	acceptor_gain	1.0000
6:84126524:A:C	acceptor_gain	1.0000
6:84149557:TCTAC:T	donor_loss	1.0000
6:84149558:CTAC:C	donor_loss	1.0000
6:84149559:TACC:T	donor_loss	1.0000
6:84149560:A:C	donor_loss	1.0000
6:84149561:C:CA	donor_loss	1.0000
6:84149561:CCT:C	donor_gain	1.0000

AlphaMissense

9407 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:84125164:A:G	L1373P	0.997
6:84126482:C:G	A1301P	0.996
6:84160816:C:G	R926P	0.996
6:84160822:A:G	L924P	0.996
6:84125134:A:G	L1383P	0.995
6:84125143:A:G	L1380P	0.995
6:84125175:G:C	F1369L	0.995
6:84125175:G:T	F1369L	0.995
6:84125177:A:G	F1369L	0.995
6:84155377:A:G	L972P	0.995
6:84174064:A:G	L717P	0.995
6:84125219:A:G	W1355R	0.994
6:84125219:A:T	W1355R	0.994
6:84126502:A:G	L1294P	0.994
6:84155365:A:G	L976P	0.994
6:84125173:C:G	R1370P	0.993
6:84155332:A:G	L987P	0.993
6:84161849:A:G	L858P	0.993
6:84126385:A:G	L1333P	0.992
6:84146697:A:G	L1287P	0.992
6:84155444:C:G	A950P	0.992
6:84171684:A:G	L734P	0.992
6:84174067:A:G	L716P	0.992
6:84174076:T:G	Q713P	0.992
6:84126396:T:A	R1329S	0.991
6:84126396:T:G	R1329S	0.991
6:84146709:C:G	R1283P	0.991
6:84155329:C:G	R988P	0.991
6:84155468:A:G	S942P	0.991
6:84174737:A:G	L672P	0.991

dbSNP variants (sampled 300 via entrez): RS1000001373 (6:84145626 C>T), RS1000035564 (6:84147333 G>A,C,T), RS1000049974 (6:84223864 C>A), RS1000083753 (6:84140560 C>A,T), RS1000136765 (6:84195464 T>C), RS1000158644 (6:84176949 T>A), RS1000200567 (6:84134070 C>A), RS1000202527 (6:84193957 C>A,T), RS1000203314 (6:84165469 AC>A), RS1000228453 (6:84158741 TA>T), RS1000241811 (6:84146931 T>C,G), RS1000285861 (6:84172221 A>C), RS1000307032 (6:84206311 T>G), RS1000311500 (6:84225664 T>G), RS1000331194 (6:84140207 G>A)

Disease associations

OMIM: gene MIM:610201 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002684_1	Diabetic retinopathy in type 2 diabetes	1.000000e-06
GCST003996_36	Monobrow	2.000000e-19
GCST009391_112	Metabolite levels	4.000000e-08
GCST009391_125	Metabolite levels	2.000000e-07
GCST009391_1841	Metabolite levels	3.000000e-07
GCST009391_1854	Metabolite levels	3.000000e-06
GCST009391_62	Metabolite levels	5.000000e-06

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007906	synophrys measurement
EFO:0010354	diacylglycerol 36:1 measurement
EFO:0010355	diacylglycerol 36:2 measurement
EFO:0010413	triacylglycerol 52:1 measurement
EFO:0010410	triacylglycerol 50:3 measurement
EFO:0010352	diacylglycerol 34:1 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases methylation, increases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation	1
sodium arsenite	affects methylation	1
butyraldehyde	decreases expression	1
ferrous chloride	decreases expression	1
coumarin	increases phosphorylation	1
perfluorooctane sulfonic acid	decreases expression	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Atrazine	decreases expression	1
Cisplatin	decreases expression	1
Gallic Acid	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Progesterone	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin M1	decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.