CEP170B

Summary

CEP170B (centrosomal protein 170B, HGNC:20362) is a protein-coding gene on chromosome 14q32.33, encoding Centrosomal protein of 170 kDa protein B (Q9Y4F5). Plays a role in microtubule organization.

Predicted to be located in cytoplasm and microtubule.

Source: NCBI Gene 283638 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 447 total
• MANE Select transcript: NM_001112726

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20362
Approved symbol	CEP170B
Name	centrosomal protein 170B
Location	14q32.33
Locus type	gene with protein product
Status	Approved
Aliases	FAM68C, Cep170R
Ensembl gene	ENSG00000099814
Ensembl biotype	protein_coding
OMIM	620251
Entrez	283638

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 retained_intron

ENST00000251181, ENST00000414716, ENST00000556508, ENST00000864421, ENST00000864422, ENST00000926145

RefSeq mRNA: 2 — MANE Select: NM_001112726 NM_001112726, NM_015005

CCDS: CCDS45175, CCDS45176

Canonical transcript exons

ENST00000414716 — 19 exons

Exon	Start	End
ENSE00000655780	104880287	104880425
ENSE00000655782	104882728	104882832
ENSE00000655787	104883831	104884549
ENSE00000655789	104885369	104885542
ENSE00000655791	104886040	104886130
ENSE00000655792	104886275	104887978
ENSE00000901774	104893761	104893849
ENSE00000901775	104893523	104893666
ENSE00001604178	104889620	104889758
ENSE00001674345	104868424	104868555
ENSE00001680489	104883035	104883508
ENSE00001717488	104892976	104893135
ENSE00001736696	104878443	104878501
ENSE00003483403	104894537	104894588
ENSE00003500689	104894285	104894378
ENSE00003576886	104876256	104876345
ENSE00003621293	104877885	104877963
ENSE00003845175	104894711	104896747
ENSE00003849867	104865268	104865513

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 98.36.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0163 / max 12.5365, expressed in 4 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141847	16.2325	1664
141852	0.0163	4

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	98.36	gold quality
Brodmann (1909) area 10	UBERON:0013541	97.41	gold quality
endometrium epithelium	UBERON:0004811	95.75	gold quality
frontal pole	UBERON:0002795	94.91	gold quality
CA1 field of hippocampus	UBERON:0003881	94.76	gold quality
ileal mucosa	UBERON:0000331	94.74	gold quality
orbitofrontal cortex	UBERON:0004167	94.57	gold quality
cerebellar vermis	UBERON:0004720	94.52	gold quality
paraflocculus	UBERON:0005351	94.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.86	gold quality
pharyngeal mucosa	UBERON:0000355	93.73	gold quality
nipple	UBERON:0002030	93.68	gold quality
tongue squamous epithelium	UBERON:0006919	93.55	gold quality
nasal cavity epithelium	UBERON:0005384	93.43	gold quality
Brodmann (1909) area 46	UBERON:0006483	93.29	gold quality
middle frontal gyrus	UBERON:0002702	93.08	gold quality
cerebellar cortex	UBERON:0002129	93.04	gold quality
cerebellar hemisphere	UBERON:0002245	93.01	gold quality
cerebellum	UBERON:0002037	93.00	gold quality
trachea	UBERON:0003126	92.85	gold quality
parietal lobe	UBERON:0001872	92.84	gold quality
pylorus	UBERON:0001166	92.82	gold quality
mucosa of transverse colon	UBERON:0004991	92.82	gold quality
oocyte	CL:0000023	92.72	gold quality
right frontal lobe	UBERON:0002810	92.69	gold quality
superior frontal gyrus	UBERON:0002661	92.62	gold quality
cardia of stomach	UBERON:0001162	92.59	gold quality
cervix squamous epithelium	UBERON:0006922	92.55	gold quality
postcentral gyrus	UBERON:0002581	92.47	gold quality
frontal cortex	UBERON:0001870	92.40	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-137537	yes	4.39
E-ANND-3	yes	4.01

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

108 targeting CEP170B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-4492	99.87	68.25	3611
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-4447	99.85	67.81	2900
HSA-LET-7G-3P	99.85	70.43	1929

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cep170ba	ENSDARG00000074636
danio_rerio	cep170bb	ENSDARG00000078327
mus_musculus	Cep170b	ENSMUSG00000072825
rattus_norvegicus	Cep170b	ENSRNOG00000033688

Paralogs (1): CEP170 (ENSG00000143702)

Protein

Protein identifiers

Centrosomal protein of 170 kDa protein B — Q9Y4F5 (reviewed: Q9Y4F5)

Alternative names: Centrosomal protein 170B

All UniProt accessions (1): Q9Y4F5

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in microtubule organization.

Subcellular location. Cytoplasm. Cytoskeleton.

Similarity. Belongs to the CEP170 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y4F5-1	1	yes
Q9Y4F5-2	2
Q9Y4F5-3	3

RefSeq proteins (2): NP_001106197, NP_055820 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000253	FHA_dom	Domain
IPR008984	SMAD_FHA_dom_sf	Homologous_superfamily
IPR029300	CEP170_C	Domain
IPR051176	Cent_Immune-Sig_Mod	Family

Pfam: PF00498, PF15308

UniProt features (58 total): modified residue 30, compositionally biased region 15, region of interest 8, splice variant 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y4F5-F1	47.31	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (30): 360, 421, 480, 492, 536, 542, 597, 619, 655, 711, 721, 746, 748, 751, 753, 772, 829, 853, 954, 972 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 109 (showing top): WANG_CLIM2_TARGETS_UP, BROWNE_HCMV_INFECTION_48HR_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP, chr14q32, WANG_PROSTATE_CANCER_ANDROGEN_INDEPENDENT, WINNEPENNINCKX_MELANOMA_METASTASIS_DN, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP, DODD_NASOPHARYNGEAL_CARCINOMA_DN, RADAEVA_RESPONSE_TO_IFNA1_DN, MEISSNER_NPC_HCP_WITH_H3K4ME2, MARTENS_TRETINOIN_RESPONSE_UP, DURAND_STROMA_S_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): microtubule (GO:0005874), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
intracellular anatomical structure	1
cellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1429 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEP170B	CWF19L2	Q2TBE0	557
CEP170B	Q6NXN5	Q6NXN5	480
CEP170B	RAB39A	Q14964	462
CEP170B	INTS9	Q9NV88	461
CEP170B	SPATA7	Q9P0W8	442
CEP170B	YEATS2	Q9ULM3	441
CEP170B	WDR89	Q96FK6	437
CEP170B	STK38L	Q9Y2H1	417
CEP170B	RAI14	Q9P0K7	408
CEP170B	TAFA2	Q8N3H0	407
CEP170B	TMEM268	Q5VZI3	400
CEP170B	RFX2	P48378	390
CEP170B	CRYL1	Q9Y2S2	381
CEP170B	CCDC24	Q8N4L8	376
CEP170B	ANKRD28	O15084	373

IntAct

62 interactions, top by confidence:

A	B	Type	Score
SLMAP	STRN	psi-mi:“MI:2364”(proximity)	0.710
CSNK2B	NMT2	psi-mi:“MI:0914”(association)	0.660
CEP170	KIF2A	psi-mi:“MI:2364”(proximity)	0.650
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
DEFA5	NUDT19	psi-mi:“MI:0914”(association)	0.530
KIF2B	BACH1	psi-mi:“MI:0914”(association)	0.530
CENPH	PSMD11	psi-mi:“MI:0914”(association)	0.530
PNMA2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
Cep170	WDR62	psi-mi:“MI:0915”(physical association)	0.400
CEP170B	rep	psi-mi:“MI:0915”(physical association)	0.370
TYK2	BAG2	psi-mi:“MI:0914”(association)	0.350
KIF2A	EIF3F	psi-mi:“MI:0914”(association)	0.350
OFD1	SUPT5H	psi-mi:“MI:0914”(association)	0.350
RPGRIP1L	KIF2A	psi-mi:“MI:0914”(association)	0.350
TUBA1A	CAPZB	psi-mi:“MI:0914”(association)	0.350
TUBA1A	KIF2A	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
E	RAB34	psi-mi:“MI:0914”(association)	0.350
BMI1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
PRKAA2	DFFA	psi-mi:“MI:0914”(association)	0.350
TUBB4B	TUBA1B	psi-mi:“MI:0914”(association)	0.350
YWHAB	BRAF	psi-mi:“MI:0914”(association)	0.350

BioGRID (90): CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS), CEP170B (Proximity Label-MS), CEP170B (Proximity Label-MS), CEP170B (Proximity Label-MS), CEP170B (Proximity Label-MS), CEP170B (Proximity Label-MS), CEP170B (Proximity Label-MS), CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS), CEP170B (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GTI1, A2BIL8, A5PKK9, C5DY61, E2QSX5, E7F555, O35147, O43151, P11805, P19416, P24940, P27579, Q06616, Q17QE3, Q1LZE2, Q1RMQ5, Q1T763, Q28CW2, Q2HR82, Q2TBN9, Q3B8E9, Q3ZBS1, Q567C6, Q5RDK8, Q62417, Q68FW2, Q6AY26, Q6DFB0, Q6P6I6, Q6PKN7, Q80U49, Q86YL5, Q8C3W1, Q8QVM1, Q8VEB3, Q8VI59, Q96FT9, Q96GV9, Q96GY3, Q99618

Diamond homologs: A0JM08, Q498L0, Q5M9G6, Q5SW79, Q6A065, Q80U49, Q8BIZ6, Q8TAD8, Q96L14, Q9BWU0, Q9Y4F5, A6PWD2, B1AJZ9, P66800, P9WGJ8, P9WGJ9, B7SY83, Q12972, Q28147, Q4JVU0, Q8R3G1, Q9FIK2, A6ZRW7, O74388, P0C219, P38823, P46017, P53924, Q03944, Q06001, Q10322, Q14BN4, Q28623, Q3URD3, Q07930, Q54VU4, Q8W4D8, A0QNG6, P34648

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 70 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	106.6×	2e-11
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	94.0×	3e-11
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	94.0×	3e-11
Activation of BH3-only proteins	7	69.5×	2e-10
RHO GTPases activate PKNs	7	44.4×	6e-09
Intrinsic Pathway for Apoptosis	7	41.0×	9e-09
Translocation of SLC2A4 (GLUT4) to the plasma membrane	11	34.0×	5e-12
FOXO-mediated transcription	5	33.6×	4e-06

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	30.0×	2e-04
intracellular protein localization	9	15.4×	3e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

447 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	349
Likely benign	53
Benign	30

Top pathogenic / likely-pathogenic (0)

SpliceAI

3318 predictions. Top by Δscore:

Variant	Effect	Δscore
14:104865510:GCAG:G	donor_gain	1.0000
14:104865512:AGG:A	donor_loss	1.0000
14:104865513:GGTAG:G	donor_loss	1.0000
14:104865514:GTAGG:G	donor_loss	1.0000
14:104868537:GT:G	donor_gain	1.0000
14:104868564:G:GT	donor_gain	1.0000
14:104876254:A:AG	acceptor_gain	1.0000
14:104876255:G:GA	acceptor_gain	1.0000
14:104876255:GT:G	acceptor_gain	1.0000
14:104876255:GTCCC:G	acceptor_gain	1.0000
14:104876341:ATGGG:A	donor_gain	1.0000
14:104876342:TGGG:T	donor_gain	1.0000
14:104876343:GGG:G	donor_gain	1.0000
14:104876343:GGGG:G	donor_gain	1.0000
14:104876344:GG:G	donor_gain	1.0000
14:104876344:GGG:G	donor_gain	1.0000
14:104876344:GGGT:G	donor_loss	1.0000
14:104876345:GG:G	donor_gain	1.0000
14:104876346:G:GC	donor_loss	1.0000
14:104876346:G:GG	donor_gain	1.0000
14:104883507:GG:G	donor_gain	1.0000
14:104883508:GG:G	donor_gain	1.0000
14:104883828:CAGGC:C	acceptor_loss	1.0000
14:104883829:A:AG	acceptor_gain	1.0000
14:104883829:A:AT	acceptor_loss	1.0000
14:104883830:G:GG	acceptor_gain	1.0000
14:104884567:G:GG	donor_gain	1.0000
14:104885540:CAG:C	donor_loss	1.0000
14:104885543:GTAC:G	donor_loss	1.0000
14:104886273:A:AG	acceptor_gain	1.0000

AlphaMissense

10074 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000055506 (14:104895241 G>A,T), RS1000067146 (14:104883806 AGGTG>A), RS1000358416 (14:104884401 C>A,G,T), RS1000477212 (14:104865338 G>C), RS1000534006 (14:104869807 C>T), RS1000566363 (14:104889571 G>A,C), RS1000636107 (14:104888634 C>T), RS1000693009 (14:104885824 G>A), RS1000721330 (14:104864439 C>G), RS1000783984 (14:104865208 C>G,T), RS1000785822 (14:104865669 C>G,T), RS1000863112 (14:104879641 G>A,C), RS1000999437 (14:104874770 C>T), RS1001040519 (14:104876981 G>A), RS1001170231 (14:104876595 C>A,T)

Disease associations

OMIM: gene MIM:620251 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007002_7	Cerebrospinal fluid t-tau levels in normal cognition	7.000000e-09
GCST007007_3	Cerebrospinal fluid t-tau levels	7.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004760	t-tau measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression, increases methylation, affects methylation, decreases expression	4
sodium arsenite	increases expression	3
bisphenol F	affects cotreatment, increases methylation, decreases expression	2
Acetaminophen	increases expression	2
Valproic Acid	affects expression, increases methylation	2
Cyclosporine	increases expression	2
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
bisphenol A	affects cotreatment, decreases expression	1
testosterone undecanoate	affects cotreatment, decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
coumarin	affects phosphorylation	1
K 7174	increases expression	1
nutlin 3	affects cotreatment, increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	affects methylation	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Fulvestrant	increases methylation, affects cotreatment	1
Air Pollutants	increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Quercetin	increases expression	1
Thiram	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.