CEP20

Summary

CEP20 (centrosomal protein 20, HGNC:26435) is a protein-coding gene on chromosome 16p13.11, encoding Centrosomal protein 20 (Q96NB1). Involved in the biogenesis of cilia.

Enables identical protein binding activity. Involved in cilium assembly. Located in centriolar satellite; ciliary basal body; and nucleoplasm.

Source: NCBI Gene 123811 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 46 total — 5 pathogenic, 3 likely-pathogenic
• MANE Select transcript: NM_144600

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26435
Approved symbol	CEP20
Name	centrosomal protein 20
Location	16p13.11
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp686N1651, FLJ31153, PHSECRG2, FOR20
Ensembl gene	ENSG00000133393
Ensembl biotype	protein_coding
OMIM	617149
Entrez	123811

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 13 protein_coding, 2 nonsense_mediated_decay

ENST00000255759, ENST00000572415, ENST00000573087, ENST00000573396, ENST00000573429, ENST00000573968, ENST00000575073, ENST00000575744, ENST00000575938, ENST00000870039, ENST00000929531, ENST00000929532, ENST00000929533, ENST00000962007, ENST00000962008

RefSeq mRNA: 6 — MANE Select: NM_144600 NM_001304497, NM_001304498, NM_001304499, NM_001304500, NM_001304502, NM_144600

CCDS: CCDS10567, CCDS76829, CCDS76830, CCDS76831, CCDS76832, CCDS76833

Canonical transcript exons

ENST00000255759 — 5 exons

Exon	Start	End
ENSE00000909153	15884008	15884205
ENSE00002660971	15865719	15867516
ENSE00002673342	15888558	15888603
ENSE00003470629	15873491	15873627
ENSE00003662092	15879804	15879888

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 93.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.4945 / max 332.3969, expressed in 1783 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
156523	14.4945	1783

Top tissues by expression

143 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	93.36	gold quality
skeletal muscle tissue	UBERON:0001134	93.08	gold quality
muscle of leg	UBERON:0001383	93.00	gold quality
calcaneal tendon	UBERON:0003701	93.00	gold quality
skeletal muscle organ	UBERON:0014892	93.00	gold quality
gastrocnemius	UBERON:0001388	92.99	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.10	gold quality
muscle tissue	UBERON:0002385	91.93	gold quality
monocyte	CL:0000576	91.72	gold quality
leukocyte	CL:0000738	91.52	gold quality
endometrium	UBERON:0001295	91.51	gold quality
lower esophagus mucosa	UBERON:0035834	91.38	gold quality
ventricular zone	UBERON:0003053	90.44	gold quality
esophagus mucosa	UBERON:0002469	90.42	gold quality
left testis	UBERON:0004533	90.37	gold quality
lymph node	UBERON:0000029	90.24	gold quality
pancreas	UBERON:0001264	90.08	gold quality
rectum	UBERON:0001052	90.01	gold quality
right testis	UBERON:0004534	90.00	gold quality
testis	UBERON:0000473	89.97	gold quality
colonic epithelium	UBERON:0000397	89.53	gold quality
smooth muscle tissue	UBERON:0001135	89.44	gold quality
adrenal tissue	UBERON:0018303	89.40	gold quality
embryo	UBERON:0000922	89.14	gold quality
ganglionic eminence	UBERON:0004023	89.14	gold quality
esophagus	UBERON:0001043	88.82	gold quality
body of pancreas	UBERON:0001150	88.74	gold quality
stromal cell of endometrium	CL:0002255	88.72	gold quality
urinary bladder	UBERON:0001255	88.65	gold quality
cortical plate	UBERON:0005343	88.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.82

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

84 targeting CEP20, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-3913-5P	99.78	67.26	968
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-1273H-5P	99.77	66.32	2471

Literature-anchored findings (GeneRIF, showing 6)

• Microdeletions at 16p13.11 are associated with a predisposition to idiopathic generalized epilepsy. (PMID:19843651)
• The depletion of FOR20 (FOP-related protein of 20 kDa), a conserved centrosomal protein, inhibits S-phase progression and prevents targeting of Plk1 (polo-like kinase 1) to centrosomes, where FOR20 interacts with Plk1. (PMID:24018379)
• FOPNL genomic variant is associated with multiple myeloma. (PMID:28691553)
• The results suggested that the centrosomal protein FOR20 is a new member of the microtubule-associated protein family and that it regulates the assembly and dynamics of microtubules while interacting with tubulin. (PMID:28694353)
• The S100A6 interacts with FOR20 and related centrosomal proteins through a conserved N-terminal domain, suggesting a novel Ca(2+)-dependent regulation of centrosomal function. (PMID:28765046)
• Results together with the limitations of the original studies indicate that the reported associations between the MTHFD1L and FOPNL loci and MM survival are false positives due to a winner’s curse effect. (PMID:31363079)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cep20	ENSDARG00000071198
mus_musculus	Cep20	ENSMUSG00000022677
rattus_norvegicus	Cep20	ENSRNOG00000053230

Protein

Protein identifiers

Centrosomal protein 20 — Q96NB1 (reviewed: Q96NB1)

Alternative names: FGFR1OP N-terminal-like protein, FOP-related protein of 20 kDa, LisH domain-containing protein FOPNL

All UniProt accessions (8): Q96NB1, I3L0K3, I3L0U4, I3L269, I3L2N4, I3L3N6, I3L4V2, I3NI25

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.

Subunit / interactions. Homooligomer; probably required for localization to centrosomes. Forms a complex with KIAA0753/OFIP and OFD1; within this complex may stabilize the interaction between OFD1 and KIAA0753/OFIP. Interacts with PCM1; this interaction may be mediated by KIAA0753/OFIP. Interacts with PLK1 in later G1, S, G2 and M phases of the cell cycle; this interaction recruits PLK1 to centrosomes.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Cell projection. Cilium. Cilium basal body. Cytoplasmic granule. Centriolar satellite.

Tissue specificity. Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.

Similarity. Belongs to the CEP43 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96NB1-1	1	yes
Q96NB1-2	2

RefSeq proteins (6): NP_001291426, NP_001291427, NP_001291428, NP_001291429, NP_001291431, NP_653201* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006594	LisH	Conserved_site
IPR018993	FOP_dimerisation-dom_N	Domain

Pfam: PF09398

UniProt features (13 total): mutagenesis site 6, region of interest 2, chain 1, domain 1, compositionally biased region 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96NB1-F1	73.95	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 144

Mutagenesis-validated functional residues (6):

Position	Phenotype
76	loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with
76	strongly decreased interaction with kiaa0753; when associated with a-49. loss of interaction with kiaa0753; when associa
106	no effect on interaction with kiaa0753.
49	loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with
49	strongly decreased interaction with kiaa0753; when associated with a-76.
53	loss of interaction with kiaa0753; when associated with a-76.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 109 (showing top): GOBP_MICROTUBULE_ANCHORING, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_CILIUM_ORGANIZATION, GOCC_CENTROSOME, GOBP_ORGANELLE_ASSEMBLY, FISCHER_DREAM_TARGETS, SENESE_HDAC1_TARGETS_UP, GOBP_CELL_PROJECTION_ORGANIZATION, SENESE_HDAC3_TARGETS_DN, GOCC_CENTRIOLE, GOCC_MOTILE_CILIUM, GOCC_CILIUM, GOCC_CILIARY_BASAL_BODY, GOCC_CENTRIOLAR_SATELLITE

GO Biological Process (3): microtubule anchoring (GO:0034453), cilium assembly (GO:0060271), cell projection organization (GO:0030030)

GO Molecular Function (2): identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (12): nucleoplasm (GO:0005654), centrosome (GO:0005813), centriole (GO:0005814), motile cilium (GO:0031514), centriolar satellite (GO:0034451), ciliary basal body (GO:0036064), cytoplasm (GO:0005737), microtubule organizing center (GO:0005815), cytoskeleton (GO:0005856), cilium (GO:0005929), microtubule cytoskeleton (GO:0015630), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
microtubule organizing center	3
intracellular membraneless organelle	2
cilium	2
microtubule cytoskeleton organization	1
axoneme assembly	1
intraciliary transport involved in cilium assembly	1
cilium organization	1
protein localization to cilium	1
organelle assembly	1
trans-Golgi to periciliary membrane compartment transport	1
plasma membrane bounded cell projection assembly	1
ciliary transition zone assembly	1
cellular component organization	1
protein binding	1
binding	1
nuclear lumen	1
centriole	1
centrosome	1
intracellular anatomical structure	1
microtubule cytoskeleton	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cytoskeleton	1

Protein interactions and networks

STRING

656 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEP20	MARF1	Q9Y4F3	753
CEP20	OFD1	O75665	745
CEP20	KIAA0753	Q2KHM9	737
CEP20	BMERB1	Q96MC5	716
CEP20	PIBF1	Q8WXW3	665
CEP20	MPV17L	Q2QL34	660
CEP20	CCDC61	Q9Y6R9	626
CEP20	H3BMD7	H3BMD7	624
CEP20	NDE1	Q9NXR1	587
CEP20	CEP19	Q96LK0	577
CEP20	NOMO3	P69849	573
CEP20	CEP350	Q5VT06	553
CEP20	ABCC6	P78420	540
CEP20	CCDC138	Q96M89	523
CEP20	TBC1D31	Q96DN5	488

IntAct

62 interactions, top by confidence:

A	B	Type	Score
CEP290	CCP110	psi-mi:“MI:2364”(proximity)	0.890
CSNK1E	PER1	psi-mi:“MI:0914”(association)	0.840
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
CEP20	OFD1	psi-mi:“MI:0914”(association)	0.710
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
CEP20	CEP20	psi-mi:“MI:0915”(physical association)	0.590
CCDC116	CEP20	psi-mi:“MI:0915”(physical association)	0.560
LIN7B	CASK	psi-mi:“MI:0914”(association)	0.530
MRPS14	PSME3	psi-mi:“MI:0914”(association)	0.530
NDEL1	OFD1	psi-mi:“MI:0914”(association)	0.530
CEP20	PCM1	psi-mi:“MI:0403”(colocalization)	0.520
PCM1	CEP20	psi-mi:“MI:0403”(colocalization)	0.520
KIAA0753	OFD1	psi-mi:“MI:2364”(proximity)	0.480
CEP20	S100A1	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A2	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A3	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A4	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A5	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A6	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A7	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A7A	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100B	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100G	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100P	psi-mi:“MI:0915”(physical association)	0.400
Cep135		psi-mi:“MI:0914”(association)	0.350
Ppp2r1a	CCHCR1	psi-mi:“MI:0914”(association)	0.350
Nedd1		psi-mi:“MI:0914”(association)	0.350
Cep152	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350

BioGRID (54): FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Proximity Label-MS), FOPNL (Affinity Capture-MS), FOPNL (Affinity Capture-MS), FOPNL (Affinity Capture-MS), FOPNL (Affinity Capture-MS), FOPNL (Affinity Capture-MS), FOPNL (Affinity Capture-MS), FOPNL (Affinity Capture-MS)

ESM2 similar proteins: A0JMA8, A1A5P5, A2RVA7, B0S6J3, D2KC46, D3ZY60, E7F187, F1MS15, O43295, O60308, O94868, Q05B30, Q08CX1, Q08DB0, Q0IH24, Q10113, Q15057, Q17AF4, Q2KI89, Q39238, Q3B7T8, Q3USJ8, Q4R7I0, Q567U6, Q58DA1, Q5BJT7, Q5FVC7, Q5R629, Q5TZ80, Q5U245, Q5W7F2, Q5ZJ27, Q5ZK62, Q6IVG4, Q6NRB0, Q6ZQK5, Q7Z3E5, Q8BHR2, Q8BIL5, Q8RW96

Diamond homologs: O95684, P0CAX8, Q2YDD1, Q4R7V3, Q4V7C1, Q5ZJ24, Q66JX5, Q96NB1, Q9CZS3, Q9FQ24, Q9FQ25, Q4V7R8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 66 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Loss of Nlp from mitotic centrosomes	9	49.2×	6e-12
Loss of proteins required for interphase microtubule organization from the centrosome	9	49.2×	6e-12
AURKA Activation by TPX2	9	47.3×	7e-12
Recruitment of mitotic centrosome proteins and complexes	9	42.2×	2e-11
Regulation of PLK1 Activity at G2/M Transition	9	39.4×	2e-11
Anchoring of the basal body to the plasma membrane	10	39.0×	6e-12
Recruitment of NuMA to mitotic centrosomes	9	36.2×	5e-11
Cilium Assembly	5	18.8×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
cilium assembly	7	11.7×	3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	5
Likely pathogenic	3
Uncertain significance	29
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (8)

Variant ID	HGVS	Classification
3777760	Single allele	Pathogenic
4820133	NC_000016.9:g.15459752_16367752del	Pathogenic
625573	GRCh37/hg19 16p13.11(chr16:15493046-16053729)	Pathogenic
625598	GRCh37/hg19 16p13.11(chr16:15168667-16291983)	Pathogenic
980082	GRCh37/hg19 16p13.11-12.3(chr16:15375911-18198455)x1	Pathogenic
1711420	GRCh37/hg19 16p13.11-12.3(chr16:15458733-18520588)x3	Likely pathogenic
3235935	GRCh38/hg38 16p13.12-12.3(chr16:15034129-16187150)	Likely pathogenic
503581	GRCh37/hg19 16p13.11-12.3(chr16:15499057-18264837)x4	Likely pathogenic

SpliceAI

1159 predictions. Top by Δscore:

Variant	Effect	Δscore
16:15873487:ATAC:A	donor_gain	1.0000
16:15879802:A:AC	donor_gain	1.0000
16:15879803:C:CC	donor_gain	1.0000
16:15881503:A:AC	donor_gain	1.0000
16:15881504:C:CC	donor_gain	1.0000
16:15881506:T:TA	donor_gain	1.0000
16:15881506:TC:T	donor_gain	1.0000
16:15881541:T:TA	donor_gain	1.0000
16:15888556:ACCAG:A	donor_gain	1.0000
16:15888557:CCAGC:C	donor_gain	1.0000
16:15879803:CA:C	donor_gain	0.9900
16:15881284:C:CT	donor_gain	0.9900
16:15881285:T:TT	donor_gain	0.9900
16:15881287:CTG:C	donor_gain	0.9900
16:15881288:TGT:T	donor_gain	0.9900
16:15881490:A:C	donor_gain	0.9900
16:15881504:CT:C	donor_gain	0.9900
16:15881505:TT:T	donor_gain	0.9900
16:15881542:C:A	donor_gain	0.9900
16:15884001:CACTT:C	donor_loss	0.9900
16:15884002:ACTTA:A	donor_loss	0.9900
16:15884003:CTTA:C	donor_loss	0.9900
16:15884004:TTAC:T	donor_loss	0.9900
16:15884005:TACC:T	donor_loss	0.9900
16:15884206:C:CC	acceptor_gain	0.9900
16:15888551:CACT:C	donor_loss	0.9900
16:15888552:ACTC:A	donor_loss	0.9900
16:15888555:CACC:C	donor_loss	0.9900
16:15888556:A:AC	donor_gain	0.9900
16:15888556:A:C	donor_loss	0.9900

AlphaMissense

1129 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:15884146:C:G	A30P	0.996
16:15884016:A:G	L73P	0.994
16:15884019:A:T	V72D	0.992
16:15884061:C:G	R58P	0.992
16:15884045:G:C	F63L	0.990
16:15884045:G:T	F63L	0.990
16:15884047:A:G	F63L	0.990
16:15884158:C:G	A26P	0.989
16:15884148:C:G	R29P	0.986
16:15884139:A:T	V32D	0.985
16:15888566:A:G	L7S	0.985
16:15884056:A:G	Y60H	0.984
16:15884072:A:C	N54K	0.984
16:15884072:A:T	N54K	0.984
16:15879837:A:G	L93P	0.983
16:15884131:C:G	A35P	0.982
16:15884190:A:G	L15S	0.982
16:15884202:A:G	L11S	0.982
16:15884064:A:T	I57N	0.981
16:15884082:A:G	L51P	0.981
16:15884028:G:T	T69K	0.977
16:15884056:A:C	Y60D	0.977
16:15884135:G:C	F33L	0.977
16:15884135:G:T	F33L	0.977
16:15884137:A:G	F33L	0.977
16:15879886:A:G	S77P	0.976
16:15884055:T:G	Y60S	0.974
16:15884151:A:T	I28N	0.972
16:15884070:T:A	E55V	0.971
16:15884052:A:G	L61S	0.970

dbSNP variants (sampled 300 via entrez): RS1000100124 (16:15879574 A>T), RS1000156667 (16:15887005 C>T), RS1000275775 (16:15884765 A>T), RS1000282587 (16:15874165 C>G,T), RS1000341967 (16:15873411 G>A,C), RS1000461989 (16:15889677 G>A), RS1000565864 (16:15868339 G>A,C,T), RS1000576337 (16:15883148 G>A), RS1000693475 (16:15884966 A>C), RS1000705348 (16:15869920 C>T), RS1000759025 (16:15888177 C>G), RS1001076580 (16:15869727 A>T), RS1001172812 (16:15878790 C>T), RS1001317677 (16:15874653 C>T), RS1001407126 (16:15874270 A>G)

Disease associations

OMIM: gene MIM:617149 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): 16p13.11 microduplication syndrome (MONDO:0016837)

Orphanet (1): 16p13.11 microduplication syndrome (Orphanet:261243)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003051_1	Multiple myeloma (survival)	7.000000e-09
GCST003225_26	Pelvic organ prolapse (moderate/severe)	3.000000e-07
GCST90000015_13	Parkinson’s disease motor subtype (tremor to postural instability/gait difficulty score ratio)	3.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0000638	overall survival
EFO:0600011	Parkinson’s disease symptom measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases expression, affects expression	3
dicrotophos	decreases expression	1
arsenite	affects binding, increases reaction	1
sulforaphane	increases expression	1
sodium arsenite	increases abundance, increases expression	1
2-palmitoylglycerol	increases expression	1
abrine	decreases expression	1
bisphenol S	affects cotreatment, decreases methylation	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Zoledronic Acid	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Coal	decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Plant Extracts	increases expression, affects cotreatment	1
Smoke	decreases expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Zinc	decreases expression	1
Cyclosporine	increases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	decreases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.