CEP70

Summary

CEP70 (centrosomal protein 70, HGNC:29972) is a protein-coding gene on chromosome 3q22.3, encoding Centrosomal protein of 70 kDa (Q8NHQ1). Plays a role in the organization of both preexisting and nascent microtubules in interphase cells.

Enables identical protein binding activity. Predicted to be involved in cilium assembly and regulation of microtubule cytoskeleton organization. Located in centrosome.

Source: NCBI Gene 80321 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 108 total
• MANE Select transcript: NM_024491

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29972
Approved symbol	CEP70
Name	centrosomal protein 70
Location	3q22.3
Locus type	gene with protein product
Status	Approved
Aliases	BITE, FLJ13036
Ensembl gene	ENSG00000114107
Ensembl biotype	protein_coding
OMIM	614310
Entrez	80321

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 28 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000264982, ENST00000459695, ENST00000460967, ENST00000462419, ENST00000464035, ENST00000468900, ENST00000470159, ENST00000474781, ENST00000478673, ENST00000481834, ENST00000484888, ENST00000485115, ENST00000489254, ENST00000882528, ENST00000882529, ENST00000882530, ENST00000882531, ENST00000882532, ENST00000882533, ENST00000882534, ENST00000882535, ENST00000923048, ENST00000923049, ENST00000923050, ENST00000923051, ENST00000923052, ENST00000923053, ENST00000923054, ENST00000968169, ENST00000968170

RefSeq mRNA: 8 — MANE Select: NM_024491 NM_001288964, NM_001288965, NM_001288966, NM_001288967, NM_001320598, NM_001320599, NM_001320600, NM_024491

CCDS: CCDS3102, CCDS75022, CCDS75023, CCDS75024, CCDS82842

Canonical transcript exons

ENST00000264982 — 18 exons

Exon	Start	End
ENSE00001234062	138498031	138498110
ENSE00001234070	138500110	138500224
ENSE00001234076	138500399	138500567
ENSE00001234084	138500735	138500881
ENSE00001234089	138505295	138505465
ENSE00001234092	138508439	138508544
ENSE00001234106	138529199	138529287
ENSE00001234110	138529375	138529462
ENSE00001296820	138494344	138495076
ENSE00001871979	138594198	138594260
ENSE00003488824	138537178	138537347
ENSE00003549068	138571266	138571356
ENSE00003582780	138591854	138591956
ENSE00003676297	138570318	138570498
ENSE00003677172	138532514	138532570
ENSE00003686624	138571034	138571157
ENSE00003787670	138525490	138525564
ENSE00003800729	138572859	138572932

Expression profiles

Bgee: expression breadth ubiquitous, 272 present calls, max score 96.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.6722 / max 387.5476, expressed in 1589 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44761	10.5121	1587
44762	0.1601	65

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.52	gold quality
sperm	CL:0000019	95.98	gold quality
right uterine tube	UBERON:0001302	95.92	gold quality
ventricular zone	UBERON:0003053	95.03	gold quality
left testis	UBERON:0004533	93.80	gold quality
right testis	UBERON:0004534	93.58	gold quality
ganglionic eminence	UBERON:0004023	92.87	gold quality
testis	UBERON:0000473	92.69	gold quality
male germ cell	CL:0000015	92.47	gold quality
body of pancreas	UBERON:0001150	92.03	gold quality
duodenum	UBERON:0002114	91.35	gold quality
tendon	UBERON:0000043	91.27	gold quality
jejunal mucosa	UBERON:0000399	90.79	gold quality
buccal mucosa cell	CL:0002336	90.72	gold quality
right lobe of thyroid gland	UBERON:0001119	90.71	gold quality
left lobe of thyroid gland	UBERON:0001120	90.58	gold quality
secondary oocyte	CL:0000655	90.56	gold quality
thyroid gland	UBERON:0002046	90.10	gold quality
pancreas	UBERON:0001264	89.44	gold quality
left ovary	UBERON:0002119	89.39	gold quality
endocervix	UBERON:0000458	89.12	gold quality
colonic epithelium	UBERON:0000397	89.01	gold quality
adenohypophysis	UBERON:0002196	88.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	88.34	gold quality
right ovary	UBERON:0002118	88.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.08	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.04	gold quality
rectum	UBERON:0001052	87.76	gold quality
right lobe of liver	UBERON:0001114	87.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.60	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-79	yes	233.73
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting CEP70, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-8084	99.73	69.57	1760
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-10393-5P	99.65	68.01	1368
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-216A-5P	99.50	68.02	1288

Literature-anchored findings (GeneRIF, showing 10)

• These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. (PMID:21795687)
• data showed that Cep70 increased the microtubule length without affecting the microtubule number in the purified system; results demonstrate that Cep70 could directly regulate microtubule assembly by promoting microtubule elongation instead of microtubule nucleation (PMID:22427462)
• findings suggest that Cep70 promotes microtubule stability by interaction with HDAC6 and regulation of tubulin acetylation (PMID:26112604)
• Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization (PMID:26893288)
• these results demonstrate a critical role for Cep70 in the development and progression of breast cancer. (PMID:28063737)
• Cep70 interacts with tubulin, and promotes the ability of paclitaxel to stimulate microtubule assembly. These data demonstrate that Cep70 mediates paclitaxel sensitivity in breast cancer. (PMID:28632150)
• Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis. (PMID:33980814)
• Identification of biallelic variations of CEP70 in patients with male infertility. (PMID:36967801)
• BiTE secretion by adoptively transferred stem-like T cells improves FRalpha+ ovarian cancer control. (PMID:37647218)
• Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters. (PMID:38122899)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cep70	ENSDARG00000076965
mus_musculus	Cep70	ENSMUSG00000056267
rattus_norvegicus	Cep70	ENSRNOG00000022845

Protein

Protein identifiers

Centrosomal protein of 70 kDa — Q8NHQ1 (reviewed: Q8NHQ1)

Alternative names: p10-binding protein

All UniProt accessions (8): A0A140VJG2, B7Z2D2, C9J0F4, C9J710, C9J966, C9JZ04, Q8NHQ1, H7C4Y6

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Subunit / interactions. Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome.

Domain organisation. The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.

Isoforms (5)

UniProt ID	Names	Canonical?
Q8NHQ1-1	1	yes
Q8NHQ1-2	2
Q8NHQ1-3	3
Q8NHQ1-4	4
Q8NHQ1-5	5

RefSeq proteins (8): NP_001275893, NP_001275894, NP_001275895, NP_001275896, NP_001307527, NP_001307528, NP_001307529, NP_077817* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019734	TPR_rpt	Repeat
IPR037692	CEP70	Family

UniProt features (19 total): sequence conflict 7, splice variant 5, sequence variant 2, coiled-coil region 2, chain 1, repeat 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NHQ1-F1	76.91	0.24

Function

Pathways and Gene Ontology

Reactome pathways

16 pathways

ID	Pathway
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259	Loss of Nlp from mitotic centrosomes
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-8854518	AURKA Activation by TPX2
R-HSA-1640170	Cell Cycle
R-HSA-1852241	Organelle biogenesis and maintenance
R-HSA-380287	Centrosome maturation
R-HSA-453274	Mitotic G2-G2/M phases
R-HSA-5617833	Cilium Assembly
R-HSA-68877	Mitotic Prometaphase
R-HSA-68886	M Phase
R-HSA-69275	G2/M Transition
R-HSA-69278	Cell Cycle, Mitotic

MSigDB gene sets: 174 (showing top): GOBP_SINGLE_FERTILIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_VESICLE_ORGANIZATION, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GOBP_MALE_GAMETE_GENERATION, GOCC_MICROTUBULE_ORGANIZING_CENTER, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, GOBP_SECRETORY_GRANULE_ORGANIZATION, GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS, FISCHER_G2_M_CELL_CYCLE, GOBP_CILIUM_ORGANIZATION, GOBP_CILIUM_MOVEMENT, GOCC_CENTROSOME, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY, GOBP_ACROSOME_ASSEMBLY

GO Biological Process (2): cilium assembly (GO:0060271), regulation of microtubule cytoskeleton organization (GO:0070507)

GO Molecular Function (3): identical protein binding (GO:0042802), gamma-tubulin binding (GO:0043015), protein binding (GO:0005515)

GO Cellular Component (5): centrosome (GO:0005813), microtubule organizing center (GO:0005815), cytosol (GO:0005829), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-10 pathways:

Category	Pathways
G2/M Transition	3
Centrosome maturation	2
Cell Cycle, Mitotic	2
Loss of proteins required for interphase microtubule organization from the centrosome	1
Mitotic Prometaphase	1
Assembly of the 9+0 primary cilium	1
Organelle biogenesis and maintenance	1
M Phase	1
Mitotic G2-G2/M phases	1
Cell Cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
axoneme assembly	1
intraciliary transport involved in cilium assembly	1
cilium organization	1
protein localization to cilium	1
organelle assembly	1
trans-Golgi to periciliary membrane compartment transport	1
plasma membrane bounded cell projection assembly	1
ciliary transition zone assembly	1
microtubule cytoskeleton organization	1
regulation of microtubule-based process	1
regulation of cytoskeleton organization	1
protein binding	1
tubulin binding	1
binding	1
centriole	1
microtubule organizing center	1
microtubule cytoskeleton	1
cytoplasm	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1000 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CEP70	CD19	P15391	979
CEP70	CD33	P20138	751
CEP70	FOLH1	Q04609	732
CEP70	GPRC5D	Q9NZD1	705
CEP70	TNFRSF17	Q02223	684
CEP70	EGFR	P00533	658
CEP70	ERBB2	P04626	643
CEP70	CD22	P20273	622
CEP70	CD47	Q08722	606
CEP70	EPCAM	P16422	605
CEP70	CEACAM5	P06731	602
CEP70	TNFRSF9	Q07011	587
CEP70	CD274	Q9NZQ7	581
CEP70	CXXC1	Q9P0U4	563
CEP70	CSPG4	Q6UVK1	562

IntAct

1008 interactions, top by confidence:

A	B	Type	Score
CEP70	CDC73	psi-mi:“MI:0915”(physical association)	0.850
ZNF408	CEP70	psi-mi:“MI:0915”(physical association)	0.840
CEP70	UTP25	psi-mi:“MI:0915”(physical association)	0.830
ZNF366	CEP70	psi-mi:“MI:0915”(physical association)	0.830
UTP25	CEP70	psi-mi:“MI:0915”(physical association)	0.830
CEP70	ZNF366	psi-mi:“MI:0915”(physical association)	0.830
PRPF31	CEP70	psi-mi:“MI:0915”(physical association)	0.810
ZGPAT	CEP70	psi-mi:“MI:0915”(physical association)	0.810
CEP70	PRPF31	psi-mi:“MI:0915”(physical association)	0.810
AKAP17A	CEP70	psi-mi:“MI:0915”(physical association)	0.780
CEP70	TSGA10IP	psi-mi:“MI:0915”(physical association)	0.780
CEP70	TXLNB	psi-mi:“MI:0915”(physical association)	0.780
CEP70	ZNF329	psi-mi:“MI:0915”(physical association)	0.780
CEP70	ZNF227	psi-mi:“MI:0915”(physical association)	0.780
LENG1	CEP70	psi-mi:“MI:0915”(physical association)	0.780
CDCA7L	CEP70	psi-mi:“MI:0915”(physical association)	0.780
METTL17	CEP70	psi-mi:“MI:0915”(physical association)	0.780
ARHGEF3	CEP70	psi-mi:“MI:0915”(physical association)	0.780
ZNF490	CEP70	psi-mi:“MI:0915”(physical association)	0.780
CEP70	AKAP17A	psi-mi:“MI:0915”(physical association)	0.780
ZNF329	CEP70	psi-mi:“MI:0915”(physical association)	0.780
ZNF227	CEP70	psi-mi:“MI:0915”(physical association)	0.780
CEP70	LENG1	psi-mi:“MI:0915”(physical association)	0.780
CEP70	CDCA7L	psi-mi:“MI:0915”(physical association)	0.780
TRIM29	CEP70	psi-mi:“MI:0915”(physical association)	0.740
CEP70	ZBTB49	psi-mi:“MI:0915”(physical association)	0.740

BioGRID (364): CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid), CEP70 (Two-hybrid)

ESM2 similar proteins: A0JMQ7, A0JP75, A1A600, A2BGP7, B1A193, B1WBU8, B2RPU2, G9G127, H2MTR9, O88869, Q0VFN8, Q2TAA8, Q32LC2, Q3ULW6, Q3UP38, Q4R7V1, Q4V7B0, Q5EB20, Q5JU67, Q5PQQ9, Q5RDE3, Q5U4W1, Q5XIR4, Q61043, Q6AXZ4, Q6IP02, Q6IQY5, Q6IRU7, Q6NRK1, Q6NRX3, Q6PA69, Q6ZQ12, Q7Z3E5, Q86YF9, Q86YS3, Q8BIJ7, Q8BQP8, Q8CGZ2, Q8CJ96, Q8K342

Diamond homologs: Q4R7V1, Q5PQQ9, Q5RDE3, Q6IQY5, Q8NHQ1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 105 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing - Major Pathway	10	10.1×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

108 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3310 predictions. Top by Δscore:

Variant	Effect	Δscore
3:138500221:CTAT:C	acceptor_gain	1.0000
3:138505289:CCTTA:C	donor_loss	1.0000
3:138505290:CTTA:C	donor_loss	1.0000
3:138505291:TTA:T	donor_loss	1.0000
3:138505292:TAC:T	donor_loss	1.0000
3:138508433:CAATA:C	donor_loss	1.0000
3:138508434:AATAC:A	donor_loss	1.0000
3:138508435:ATACC:A	donor_loss	1.0000
3:138508436:TACCT:T	donor_loss	1.0000
3:138508437:ACCTG:A	donor_loss	1.0000
3:138508438:CCTGA:C	donor_loss	1.0000
3:138508461:AGGG:A	donor_gain	1.0000
3:138508540:GTAAT:G	acceptor_gain	1.0000
3:138508541:TAAT:T	acceptor_gain	1.0000
3:138508543:AT:A	acceptor_gain	1.0000
3:138508545:C:CC	acceptor_gain	1.0000
3:138525488:A:AC	donor_gain	1.0000
3:138525489:C:CC	donor_gain	1.0000
3:138525489:CTTGA:C	donor_gain	1.0000
3:138525491:TG:T	donor_gain	1.0000
3:138529284:ATGA:A	acceptor_gain	1.0000
3:138529285:TGA:T	acceptor_gain	1.0000
3:138529287:AC:A	acceptor_loss	1.0000
3:138529288:C:CC	acceptor_gain	1.0000
3:138537176:A:AC	donor_gain	1.0000
3:138537177:C:CC	donor_gain	1.0000
3:138537177:CTGT:C	donor_gain	1.0000
3:138537256:T:TA	donor_gain	1.0000
3:138570831:C:CC	acceptor_gain	1.0000
3:138571028:TCTCA:T	donor_loss	1.0000

AlphaMissense

3981 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:138505321:A:G	W399R	0.995
3:138505321:A:T	W399R	0.995
3:138498045:A:G	L573P	0.992
3:138571341:A:G	W29R	0.990
3:138571341:A:T	W29R	0.990
3:138500505:A:C	F477L	0.985
3:138500505:A:T	F477L	0.985
3:138500507:A:G	F477L	0.985
3:138498077:A:C	F562L	0.984
3:138498077:A:T	F562L	0.984
3:138498079:A:G	F562L	0.984
3:138500419:A:G	L506P	0.983
3:138571339:C:A	W29C	0.982
3:138571339:C:G	W29C	0.982
3:138505318:C:G	A400P	0.979
3:138571058:A:G	L87P	0.979
3:138498065:A:C	F566L	0.978
3:138498065:A:T	F566L	0.978
3:138498067:A:G	F566L	0.978
3:138495055:A:T	I585N	0.977
3:138505319:C:A	W399C	0.976
3:138505319:C:G	W399C	0.976
3:138498066:A:G	F566S	0.975
3:138500509:A:G	L476S	0.973
3:138495034:A:G	L592S	0.972
3:138498033:A:G	L577S	0.972
3:138500473:C:G	R488P	0.972
3:138500517:G:C	F473L	0.972
3:138500517:G:T	F473L	0.972
3:138500519:A:G	F473L	0.972

dbSNP variants (sampled 300 via entrez): RS1000005889 (3:138513430 T>G), RS1000007382 (3:138537680 A>G), RS1000079825 (3:138557666 G>T), RS1000093204 (3:138503392 T>C), RS1000102623 (3:138509418 G>A,T), RS1000142859 (3:138513051 G>C), RS1000162696 (3:138560533 C>A,G), RS1000240548 (3:138540334 A>G), RS1000355330 (3:138525215 G>T), RS1000359984 (3:138527664 C>T), RS1000364975 (3:138574623 C>T), RS1000372577 (3:138518675 C>A), RS1000382923 (3:138573811 T>A,C), RS1000384523 (3:138525019 G>A), RS1000423000 (3:138534310 A>G)

Disease associations

OMIM: gene MIM:614310 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST005919_1	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease	8.000000e-08
GCST006661_139	Male-pattern baldness	3.000000e-19
GCST012490_497	Femur bone mineral density x serum urate levels interaction	2.000000e-08
GCST012490_94	Femur bone mineral density x serum urate levels interaction	4.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006520	carbon monoxide exhalation measurement
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, decreases methylation	8
trichostatin A	decreases expression, increases expression, affects cotreatment	3
Benzo(a)pyrene	affects methylation, decreases expression	3
sodium arsenite	affects expression, affects cotreatment, decreases expression, increases abundance	2
entinostat	decreases expression, affects cotreatment	2
Acetaminophen	increases expression	2
Nickel	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tretinoin	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
beta-lapachone	decreases expression	1
sulforaphane	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1
Vorinostat	increases expression	1
Air Pollutants	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.