CERNA1

Summary

CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767, HGNC:52664) is a long non-coding RNA gene on chromosome 15q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52664
Approved symbol	CERNA1
Name	competing endogenous lncRNA 1 for miR-4707-5p and miR-4767
Location	15q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC100129973
Ensembl gene	ENSG00000259577
Ensembl biotype	lncRNA
Entrez	100129973
RNAcentral	URS000075CAB2 — lncRNA, 1520 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000559779, ENST00000560518, ENST00000654724, ENST00000821889, ENST00000821891

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000559779 — 3 exons

Exon	Start	End
ENSE00002564801	52204889	52205963
ENSE00003862846	52180550	52181202
ENSE00003877887	52179999	52180401

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 79.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1365 / max 10.7190, expressed in 68 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
146718	0.1365	68

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.07	gold quality
endothelial cell	CL:0000115	68.98	gold quality
prefrontal cortex	UBERON:0000451	67.58	gold quality
calcaneal tendon	UBERON:0003701	67.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.94	gold quality
right frontal lobe	UBERON:0002810	63.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.64	gold quality
monocyte	CL:0000576	63.44	gold quality
colonic epithelium	UBERON:0000397	63.33	silver quality
mononuclear cell	CL:0000842	63.30	gold quality
cerebellar cortex	UBERON:0002129	63.20	gold quality
cerebellar hemisphere	UBERON:0002245	63.16	gold quality
leukocyte	CL:0000738	62.96	gold quality
cingulate cortex	UBERON:0003027	62.76	gold quality
right uterine tube	UBERON:0001302	62.66	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.58	gold quality
anterior cingulate cortex	UBERON:0009835	62.44	gold quality
stromal cell of endometrium	CL:0002255	62.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.83	gold quality
cortical plate	UBERON:0005343	61.66	gold quality
frontal cortex	UBERON:0001870	61.58	gold quality
neocortex	UBERON:0001950	61.50	gold quality
mucosa of stomach	UBERON:0001199	61.47	gold quality
body of pancreas	UBERON:0001150	61.42	gold quality
cerebellum	UBERON:0002037	61.41	gold quality
adenohypophysis	UBERON:0002196	61.12	gold quality
ventricular zone	UBERON:0003053	61.07	gold quality
nucleus accumbens	UBERON:0001882	60.23	gold quality
hypothalamus	UBERON:0001898	60.20	gold quality
granulocyte	CL:0000094	60.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Study provides evidence that Long Noncoding RNA LOC100129973 suppresses apoptosis by targeting miR-4707-5p and miR-4767 in vascular endothelial cells. (PMID:26887505)
• Nuclear long noncoding RNA CERNA1 positively regulates BCL2-like 10 (apoptosis facilitator) protein, which accelerates the serum and FGF-2 starvation-induced apoptosis of vascular endothelial cells (VECs). Annexin A7 inhibitor, ABO (6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine), increases the expression of CERNA1 and improves its cytoplasm distribution proportion so as to inhibit the apoptosis of VECs. (PMID:30911960)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.