CERNA2

Summary

CERNA2 (competing endogenous lncRNA 2 for microRNA let-7b, HGNC:51354) is a long non-coding RNA gene on chromosome 10q23.1.

This gene produces a long non-coding transcript that functions in ovarian carcinogenesis by promoting tumor cell migration, invasion and proliferation. It binds to the microRNA let-7b (MIRLET7B), which is a potent tumor suppressor, thereby inhibiting the functions of that microRNA by modulating its availability to its targets.

Source: NCBI Gene 642934 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51354
Approved symbol	CERNA2
Name	competing endogenous lncRNA 2 for microRNA let-7b
Location	10q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	HOST2
Ensembl gene	ENSG00000285972
Ensembl biotype	lncRNA
OMIM	617434
Entrez	642934
RNAcentral	URS0000A76542 — lncRNA, 1875 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000647830

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000647830 — 2 exons

Exon	Start	End
ENSE00003835220	84167228	84168729
ENSE00004234458	84171722	84172094

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 99.39.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2115 / max 40.6991, expressed in 61 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110381	0.0884	21
110378	0.0588	23
110379	0.0412	18
110380	0.0232	8

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	99.39	gold quality
cerebellar vermis	UBERON:0004720	94.83	gold quality
right uterine tube	UBERON:0001302	93.11	gold quality
quadriceps femoris	UBERON:0001377	91.18	gold quality
endometrium	UBERON:0001295	90.17	gold quality
metanephros cortex	UBERON:0010533	78.51	gold quality
fallopian tube	UBERON:0003889	78.30	gold quality
esophagus mucosa	UBERON:0002469	77.55	gold quality
tonsil	UBERON:0002372	75.83	gold quality
lower esophagus mucosa	UBERON:0035834	75.69	gold quality
cortex of kidney	UBERON:0001225	75.35	gold quality
kidney	UBERON:0002113	74.82	gold quality
lymph node	UBERON:0000029	74.05	gold quality
mucosa of transverse colon	UBERON:0004991	73.06	gold quality
adult mammalian kidney	UBERON:0000082	73.05	gold quality
bone marrow cell	CL:0002092	71.55	silver quality
spleen	UBERON:0002106	70.87	gold quality
urinary bladder	UBERON:0001255	69.68	gold quality
endocervix	UBERON:0000458	68.00	gold quality
prostate gland	UBERON:0002367	67.89	gold quality
vagina	UBERON:0000996	67.37	gold quality
vermiform appendix	UBERON:0001154	67.27	gold quality
left uterine tube	UBERON:0001303	67.27	gold quality
spinal cord	UBERON:0002240	65.99	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.90	gold quality
right lobe of thyroid gland	UBERON:0001119	64.87	gold quality
esophagus	UBERON:0001043	64.42	gold quality
thyroid gland	UBERON:0002046	64.02	gold quality
left lobe of thyroid gland	UBERON:0001120	63.99	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.68

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Study demonstrated that lncRNA-HOST2, which acts as a miRNA sponge, sequesters let-7b to maintain the expression of oncogenes and further maintains epithelial ovarian cancer biological functions. (PMID:25292198)
• up-regulation of lnc-HOST2 led to Bcl-2 downregulation and Bax upregulation in osteosarcoma cells; We provided the first evidence that lnc-HOST2 may serve as a novel prognostic marker in osteosarcoma. (PMID:29509239)
• In response to treatment with si-lncRNA HOST2, si-PBX3, and let-7b mimic, glioma cell lines exhibited decreased cell viability, suppressed cell migration, invasion, and reduced colony formation of glioma cells. This was accompanied by an attenuated tumor formation with smaller volume and weight in nude mice, suggesting that down-regulated HOST2 could inhibit the tumorigenicity of glioma cells (PMID:30290058)
• The Long Noncoding RNA HOST2 Promotes Gemcitabine Resistance in Human Pancreatic Cancer Cells. (PMID:30406400)
• The expression of let7b was negatively correlated with the expression of HOST2 and CDK6 in tumor tissues. (PMID:30483747)
• Long non-coding RNA HOST2 enhances proliferation and metastasis in gastric cancer (PMID:30509094)
• The expression and significance of lncRNA HOST2 and microRNA let-7b in HPV-positive cervical cancer tissues and cell lines. (PMID:30964163)
• LncRNA HOST2 enhances gefitinib-resistance in non-small cell lung cancer by down-regulating miRNA-621. (PMID:31799663)
• Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer. (PMID:32248842)
• LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1. (PMID:38387687)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.