CEROX1

Summary

CEROX1 (cytoplasmic endogenous regulator of oxidative phosphorylation 1, HGNC:53928) is a long non-coding RNA gene on chromosome 16p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53928
Approved symbol	CEROX1
Name	cytoplasmic endogenous regulator of oxidative phosphorylation 1
Location	16p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000260807
Ensembl biotype	lncRNA
Entrez	115804232
RNAcentral	URS000194B0E0 — lncRNA, 2046 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000562570, ENST00000563837, ENST00000563863, ENST00000565069, ENST00000565139, ENST00000565467, ENST00000567961, ENST00000568394, ENST00000655952, ENST00000662104, ENST00000669274, ENST00000711632, ENST00000711633, ENST00000711634, ENST00000711635, ENST00000711636, ENST00000711637, ENST00000711638, ENST00000711639, ENST00000711640, ENST00000711641, ENST00000711642, ENST00000711643, ENST00000711644, ENST00000711645, ENST00000711646, ENST00000711651, ENST00000711652, ENST00000711653

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000562570 — 2 exons

Exon	Start	End
ENSE00002605286	979025	981612
ENSE00003853630	975761	977093

Expression profiles

Bgee: expression breadth ubiquitous, 216 present calls, max score 99.22.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2305 / max 162.8225, expressed in 68 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155800	7.2705	774
155798	0.9146	241
155799	0.2305	68

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lateral globus pallidus	UBERON:0002476	99.22	gold quality
putamen	UBERON:0001874	99.14	gold quality
nucleus accumbens	UBERON:0001882	99.05	gold quality
caudate nucleus	UBERON:0001873	98.76	gold quality
inferior vagus X ganglion	UBERON:0005363	98.63	gold quality
parotid gland	UBERON:0001831	98.35	gold quality
middle temporal gyrus	UBERON:0002771	98.03	gold quality
amygdala	UBERON:0001876	98.00	gold quality
subthalamic nucleus	UBERON:0001906	98.00	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.70	gold quality
medulla oblongata	UBERON:0001896	97.67	gold quality
spinal cord	UBERON:0002240	97.63	gold quality
occipital lobe	UBERON:0002021	97.29	gold quality
primary visual cortex	UBERON:0002436	97.27	gold quality
temporal lobe	UBERON:0001871	97.26	gold quality
right frontal lobe	UBERON:0002810	97.25	gold quality
superior vestibular nucleus	UBERON:0007227	97.24	gold quality
substantia nigra pars reticulata	UBERON:0001966	97.23	gold quality
ventral tegmental area	UBERON:0002691	97.16	gold quality
dorsal plus ventral thalamus	UBERON:0001897	97.13	gold quality
midbrain	UBERON:0001891	97.12	gold quality
substantia nigra	UBERON:0002038	97.10	gold quality
Ammon’s horn	UBERON:0001954	96.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.70	gold quality
anterior cingulate cortex	UBERON:0009835	96.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	96.49	gold quality
entorhinal cortex	UBERON:0002728	95.79	gold quality
substantia nigra pars compacta	UBERON:0001965	95.62	gold quality
Brodmann (1909) area 46	UBERON:0006483	95.53	gold quality
tibia	UBERON:0000979	95.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Cerox1 is the first lncRNA demonstrated, to our knowledge, to regulate mitochondrial oxidative phosphorylation and, with miR-488-3p, represent novel targets for the modulation of complex I activity. (PMID:31045494)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.