CERS6-AS1

Summary

CERS6-AS1 (CERS6 antisense RNA 1, HGNC:44485) is a long non-coding RNA gene on chromosome 2q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44485
Approved symbol	CERS6-AS1
Name	CERS6 antisense RNA 1
Location	2q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227617
Ensembl biotype	lncRNA
Entrez	100861402
RNAcentral	URS0000759A59 — lncRNA, 2992 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 lncRNA, 1 retained_intron

ENST00000425636, ENST00000594898, ENST00000594941, ENST00000599361, ENST00000599755, ENST00000600693, ENST00000607993, ENST00000609665, ENST00000609766, ENST00000614990, ENST00000627467, ENST00000669918, ENST00000816033

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425636 — 3 exons

Exon	Start	End
ENSE00001667113	168774821	168774951
ENSE00001804299	168771953	168774638
ENSE00002265981	168786357	168786429

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 94.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0039 / max 4.9619, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31717	0.0039	2

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	94.37	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.82	gold quality
ventricular zone	UBERON:0003053	93.30	gold quality
mucosa of transverse colon	UBERON:0004991	93.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	93.22	gold quality
superior frontal gyrus	UBERON:0002661	92.79	gold quality
ganglionic eminence	UBERON:0004023	92.39	gold quality
primary visual cortex	UBERON:0002436	91.83	gold quality
cerebellar cortex	UBERON:0002129	91.76	gold quality
cerebellar hemisphere	UBERON:0002245	91.72	gold quality
anterior cingulate cortex	UBERON:0009835	91.60	gold quality
cerebellum	UBERON:0002037	91.54	gold quality
cerebral cortex	UBERON:0000956	91.15	gold quality
right frontal lobe	UBERON:0002810	91.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.02	gold quality
frontal cortex	UBERON:0001870	90.53	gold quality
prefrontal cortex	UBERON:0000451	90.47	gold quality
hypothalamus	UBERON:0001898	90.18	gold quality
brain	UBERON:0000955	89.55	gold quality
amygdala	UBERON:0001876	89.33	gold quality
Ammon’s horn	UBERON:0001954	89.24	gold quality
apex of heart	UBERON:0002098	89.24	gold quality
skin of abdomen	UBERON:0001416	89.17	gold quality
nucleus accumbens	UBERON:0001882	89.15	gold quality
temporal lobe	UBERON:0001871	89.11	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.84	gold quality
heart left ventricle	UBERON:0002084	88.79	gold quality
body of stomach	UBERON:0001161	88.54	gold quality
fundus of stomach	UBERON:0001160	88.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.27	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	1861.44
E-ANND-3	yes	3.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA. (PMID:31701672)
• lncRNA CERS6-AS1 as ceRNA promote cell proliferation of breast cancer by sponging miR-125a-5p to upregulate BAP1 expression. (PMID:32808708)
• Long Noncoding RNA CERS6-AS1 Accelerates the Proliferation and Migration of Pancreatic Cancer Cells by Sequestering MicroRNA-15a-5p and MicroRNA-6838-5p and Modulating HMGA1. (PMID:33939677)
• LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer. (PMID:34168120)
• Long non-coding RNA CERS6-AS1 plays a prognostic role in promoting the progression of gastric cancer. (PMID:34852705)
• CERS6-AS1 contributes to the malignant phenotypes of colorectal cancer cells by interacting with miR-15b-5p to regulate SPTBN2. (PMID:35146902)
• CERS6-AS1 promotes cell proliferation and represses cell apoptosis in pancreatic cancer via miR-195-5p/WIPI2 axis. (PMID:35199935)
• IGF2BP3 Worsens Lung Cancer through Modifying Long Non-coding RNA CERS6-AS1/microRNA-1202 Axis. (PMID:35702784)
• CERS6-AS1 Facilitates Oncogenesis and Restrains Ferroptosis in Papillary Thyroid Carcinoma by Serving as a ceRNA through miR-497-5p/LASP1 Axis. (PMID:35777805)
• Ceramide synthase 6 antisense RNA 1 contributes to the progression of breast cancer by sponging miR-16-5p to upregulate ubiquitin-conjugating enzyme E2C. (PMID:36136991)
• LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2. (PMID:36444938)
• The role of lncRNA CERS6-AS1 in cancer and its molecular mechanisms: A systematic review and meta-analysis. (PMID:36580796)
• LncRNA CERS6-AS1 Is a Tumor Promoter in Cervical Cancer by Sponging miR-195-5p. (PMID:36889776)
• MYC-activated CERS6-AS1 sponges miR-6838-5p and regulates the expression of RUBCNL in colorectal cancer. (PMID:37130182)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.