CETN3

Summary

CETN3 (centrin 3, HGNC:1868) is a protein-coding gene on chromosome 5q14.3, encoding Centrin-3 (O15182). Plays a fundamental role in microtubule-organizing center structure and function.

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 1070 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 22 total
• MANE Select transcript: NM_004365

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1868
Approved symbol	CETN3
Name	centrin 3
Location	5q14.3
Locus type	gene with protein product
Status	Approved
Aliases	CEN3
Ensembl gene	ENSG00000153140
Ensembl biotype	protein_coding
OMIM	602907
Entrez	1070

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 14 protein_coding, 1 nonsense_mediated_decay

ENST00000283122, ENST00000518458, ENST00000522083, ENST00000522565, ENST00000522842, ENST00000522864, ENST00000909756, ENST00000909757, ENST00000919887, ENST00000919888, ENST00000919889, ENST00000919890, ENST00000919891, ENST00000919892, ENST00000919893

RefSeq mRNA: 3 — MANE Select: NM_004365 NM_001297765, NM_001297768, NM_004365

CCDS: CCDS4066, CCDS75274, CCDS78036

Canonical transcript exons

ENST00000283122 — 5 exons

Exon	Start	End
ENSE00001009040	90409645	90409756
ENSE00001009041	90405685	90405799
ENSE00001009043	90407699	90407834
ENSE00001266530	90392257	90394107
ENSE00003666848	90399358	90399549

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 99.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.5221 / max 1085.4831, expressed in 1790 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62521	31.6679	1785
62518	0.4760	266
62520	0.3782	139

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	99.09	gold quality
adult organism	UBERON:0007023	98.82	gold quality
left testis	UBERON:0004533	98.77	gold quality
right testis	UBERON:0004534	98.77	gold quality
testis	UBERON:0000473	97.66	gold quality
secondary oocyte	CL:0000655	97.40	gold quality
bronchial epithelial cell	CL:0002328	97.35	gold quality
palpebral conjunctiva	UBERON:0001812	96.98	gold quality
germinal epithelium of ovary	UBERON:0001304	96.84	gold quality
ventricular zone	UBERON:0003053	96.57	gold quality
calcaneal tendon	UBERON:0003701	96.32	gold quality
sperm	CL:0000019	96.29	gold quality
amniotic fluid	UBERON:0000173	95.88	gold quality
epithelium of bronchus	UBERON:0002031	95.85	gold quality
male germ cell	CL:0000015	95.81	gold quality
parietal pleura	UBERON:0002400	95.57	gold quality
mucosa of paranasal sinus	UBERON:0005030	95.57	gold quality
bronchus	UBERON:0002185	95.53	gold quality
pigmented layer of retina	UBERON:0001782	95.51	gold quality
embryo	UBERON:0000922	95.46	gold quality
ganglionic eminence	UBERON:0004023	95.22	gold quality
pleura	UBERON:0000977	95.01	gold quality
visceral pleura	UBERON:0002401	94.87	gold quality
endometrium	UBERON:0001295	94.81	gold quality
esophagus squamous epithelium	UBERON:0006920	94.59	gold quality
caput epididymis	UBERON:0004358	94.40	gold quality
epithelium of nasopharynx	UBERON:0001951	94.19	gold quality
corpus epididymis	UBERON:0004359	94.04	gold quality
seminal vesicle	UBERON:0000998	93.98	gold quality
corpus callosum	UBERON:0002336	93.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

56 targeting CETN3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-548AZ-5P	99.83	69.94	3230
HSA-MIR-548T-5P	99.83	69.91	3220
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-199A-3P	99.75	70.48	929
HSA-MIR-199B-3P	99.75	70.48	929
HSA-MIR-3129-5P	99.75	70.46	914
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-651-5P	99.64	68.49	1104
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-3923	99.52	69.21	446
HSA-MIR-203A-3P	99.49	70.56	2806

Literature-anchored findings (GeneRIF, showing 2)

• could be classified as a Ca(2+) sensor protein (PMID:15654740)
• Cetn3 inhibits Mps1 autophosphorylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosphorylation of Cetn2. The cellular overexpression of Cetn3 attenuates the incorporation of Cetn2 into centrioles and centrosome reduplication, whereas depletion of Cetn3 generates extra centrioles. (PMID:26354417)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	cetn3	ENSDARG00000011825
mus_musculus	Cetn3	ENSMUSG00000021537
rattus_norvegicus	Cetn3	ENSRNOG00000050877
drosophila_melanogaster	TpnC4	FBGN0033027
caenorhabditis_elegans		WBGENE00000285
caenorhabditis_elegans		WBGENE00000287
caenorhabditis_elegans	pat-10	WBGENE00003934
caenorhabditis_elegans		WBGENE00006583
caenorhabditis_elegans		WBGENE00008453
caenorhabditis_elegans	F35C12.3	WBGENE00009408
caenorhabditis_elegans		WBGENE00015264

Paralogs (20): CABP7 (ENSG00000100314), CABP5 (ENSG00000105507), CALML4 (ENSG00000129007), CALM2 (ENSG00000143933), CETN2 (ENSG00000147400), CABP1 (ENSG00000157782), CALM3 (ENSG00000160014), CABP2 (ENSG00000167791), CALML6 (ENSG00000169885), EFCAB3 (ENSG00000172421), EFCAB12 (ENSG00000172771), CABP4 (ENSG00000175544), CETN1 (ENSG00000177143), CALML3 (ENSG00000178363), CALML5 (ENSG00000178372), CALN1 (ENSG00000183166), CALM1 (ENSG00000198668), EFCAB2 (ENSG00000203666), EFCAB7 (ENSG00000203965), EFCAB9 (ENSG00000214360)

Protein

Protein identifiers

Centrin-3 — O15182 (reviewed: O15182)

All UniProt accessions (6): O15182, E5RFM2, E5RH67, E5RJF8, E5RK82, H0YBL5

UniProt curated annotations — full annotation on UniProt →

Function. Plays a fundamental role in microtubule-organizing center structure and function. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.

Subunit / interactions. Monomer. Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153. Interacts with USP49.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Nucleus. Nucleolus. Nucleus envelope. Nuclear pore complex. Centriole.

Similarity. Belongs to the centrin family.

RefSeq proteins (3): NP_001284694, NP_001284697, NP_004356* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002048	EF_hand_dom	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR018247	EF_Hand_1_Ca_BS	Binding_site
IPR050230	CALM/Myosin/TropC-like	Family

Pfam: PF13499

UniProt features (12 total): binding site 5, domain 4, chain 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O15182-F1	88.95	0.79

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 147; 149; 151; 153; 158

Post-translational modifications (1): 135

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 202 (showing top): PAL_PRMT5_TARGETS_UP, MORF_BRCA1, MORF_ATRX, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, KAUFFMANN_DNA_REPAIR_GENES, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_NUCLEAR_TRANSPORT, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, MORF_PPP5C, GOCC_CENTROSOME, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP

GO Biological Process (5): microtubule cytoskeleton organization (GO:0000226), centrosome cycle (GO:0007098), protein transport (GO:0015031), mRNA transport (GO:0051028), cell division (GO:0051301)

GO Molecular Function (5): calcium ion binding (GO:0005509), microtubule binding (GO:0008017), G-protein beta/gamma-subunit complex binding (GO:0031683), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (14): nucleolus (GO:0005730), centrosome (GO:0005813), centriole (GO:0005814), microtubule organizing center (GO:0005815), photoreceptor connecting cilium (GO:0032391), ciliary basal body (GO:0036064), nuclear pore nuclear basket (GO:0044615), transcription export complex 2 (GO:0070390), nucleus (GO:0005634), nuclear envelope (GO:0005635), nuclear pore (GO:0005643), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), ciliary transition zone (GO:0035869)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	3
microtubule organizing center	3
cellular anatomical structure	3
nuclear protein-containing complex	3
cilium	2
cytoskeleton organization	1
microtubule-based process	1
cell cycle process	1
microtubule organizing center organization	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
RNA transport	1
cellular process	1
metal ion binding	1
tubulin binding	1
protein-containing complex binding	1
binding	1
cation binding	1
nuclear lumen	1
centriole	1
microtubule cytoskeleton	1
ciliary transition zone	1
photoreceptor cell cilium	1
nuclear pore	1
intracellular membrane-bounded organelle	1
nucleus	1
endomembrane system	1
organelle envelope	1
nuclear envelope	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

3223 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CETN3	SFI1	A8K8P3	914
CETN3	MCM3AP	O60318	899
CETN3	ENY2	Q9NPA8	899
CETN3	PCID2	Q5JVF3	864
CETN3	SASS6	Q6UVJ0	699
CETN3	FBXL13	Q8NEE6	680
CETN3	RPS4X	P12631	640
CETN3	PHKA1	P46020	638
CETN3	SEM1	Q6ZVN7	635
CETN3	POC5	Q8NA72	624
CETN3	CEP164	Q9UPV0	622
CETN3	CEP63	Q96MT8	617
CETN3	PCNT	O95613	614
CETN3	PLK4	O00444	606
CETN3	CEP135	Q66GS9	604
CETN3	CENPA	P49450	604

IntAct

136 interactions, top by confidence:

A	B	Type	Score
ZWINT	NDC80	psi-mi:“MI:0914”(association)	0.940
POC5	CETN3	psi-mi:“MI:0915”(physical association)	0.920
CETN3	POC5	psi-mi:“MI:0915”(physical association)	0.920
POC5	CETN3	psi-mi:“MI:0914”(association)	0.920
CETN3	POC5	psi-mi:“MI:0915”(physical association)	0.770
POC5	CETN3	psi-mi:“MI:0914”(association)	0.770
CETN2	SFI1	psi-mi:“MI:0914”(association)	0.740
XPC	CETN3	psi-mi:“MI:0914”(association)	0.730
CETN3	SGSM1	psi-mi:“MI:0915”(physical association)	0.720
SGSM1	CETN3	psi-mi:“MI:0915”(physical association)	0.720
CETN1	SFI1	psi-mi:“MI:0914”(association)	0.640
RHOD	PLXNB2	psi-mi:“MI:0914”(association)	0.640
BCKDK	CETN3	psi-mi:“MI:0914”(association)	0.640
DCAF12L2	CETN3	psi-mi:“MI:0914”(association)	0.640

BioGRID (111): SGSM1 (Two-hybrid), POC5 (Two-hybrid), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), CETN3 (Two-hybrid), CETN3 (Proximity Label-MS), CETN3 (Affinity Capture-MS), CETN3 (Affinity Capture-MS)

ESM2 similar proteins: A0A125YHX7, A0A125YZN2, J9W034, O15182, O23184, O35648, O74435, O82659, P02597, P02599, P04352, P05434, P05933, P06704, P27163, P27164, P27482, P41041, P41208, P41209, P41210, P43645, P43646, P49258, P53440, P53441, P54213, P60204, P60205, P60206, P61859, P61860, P61861, Q06827, Q12798, Q24956, Q27177, Q27178, Q27179, Q2TBN3

Diamond homologs: A0A125YHX7, A0A125YZN2, A2WN93, A2WNH1, A2Y609, A3E3H0, A3E4D8, A3E4F9, A4UHC0, A8CEP3, A8I1Q0, J9W034, O15182, O23184, O35648, O60041, O74435, O82018, O82659, O94739, O96102, P02597, P02598, P04352, P04353, P04464, P05419, P05434, P06704, P06787, P07463, P0DH95, P0DH96, P0DH97, P0DH98, P11120, P11121, P13868, P15094, P17928

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
CCP110	“up-regulates activity”	CETN3	binding
PCM1	up-regulates	CETN3	relocalization

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 89 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Loss of Nlp from mitotic centrosomes	5	13.9×	4e-03
Loss of proteins required for interphase microtubule organization from the centrosome	5	13.9×	4e-03
AURKA Activation by TPX2	5	13.4×	4e-03
Recruitment of mitotic centrosome proteins and complexes	5	11.9×	5e-03
Regulation of PLK1 Activity at G2/M Transition	5	11.1×	6e-03
Recruitment of NuMA to mitotic centrosomes	5	10.2×	8e-03
Anchoring of the basal body to the plasma membrane	5	9.9×	8e-03

GO biological processes:

GO term	Partners	Fold	FDR
centriole replication	6	57.1×	2e-07
regulation of cytokinesis	7	38.3×	2e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

22 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	15
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1010 predictions. Top by Δscore:

Variant	Effect	Δscore
5:90394108:C:CC	acceptor_gain	1.0000
5:90399356:A:AC	donor_gain	1.0000
5:90399357:C:CC	donor_gain	1.0000
5:90399357:CTTT:C	donor_gain	1.0000
5:90399545:TGTCA:T	acceptor_gain	1.0000
5:90399547:TCA:T	acceptor_gain	1.0000
5:90399548:CA:C	acceptor_gain	1.0000
5:90399548:CAC:C	acceptor_gain	1.0000
5:90399550:C:CC	acceptor_gain	1.0000
5:90405680:CACA:C	donor_loss	1.0000
5:90405682:CACC:C	donor_loss	1.0000
5:90405683:A:AC	donor_gain	1.0000
5:90405684:C:CC	donor_gain	1.0000
5:90405684:C:CT	donor_loss	1.0000
5:90405684:CCAA:C	donor_gain	1.0000
5:90405687:A:AC	donor_gain	1.0000
5:90405688:C:CC	donor_gain	1.0000
5:90405690:T:TA	donor_gain	1.0000
5:90405795:GCCAC:G	acceptor_gain	1.0000
5:90405796:CCAC:C	acceptor_gain	1.0000
5:90405796:CCACC:C	acceptor_gain	1.0000
5:90405797:CACC:C	acceptor_gain	1.0000
5:90405799:CCTT:C	acceptor_loss	1.0000
5:90405799:CCTTT:C	acceptor_gain	1.0000
5:90405801:T:A	acceptor_loss	1.0000
5:90405801:T:C	acceptor_gain	1.0000
5:90405801:T:TC	acceptor_gain	1.0000
5:90405803:T:C	acceptor_gain	1.0000
5:90405803:T:TC	acceptor_gain	1.0000
5:90405808:T:C	acceptor_gain	1.0000

AlphaMissense

1134 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:90405780:C:T	G58E	1.000
5:90405781:C:A	G58W	1.000
5:90394091:G:C	F159L	0.999
5:90394091:G:T	F159L	0.999
5:90394092:A:G	F159S	0.999
5:90394093:A:G	F159L	0.999
5:90399402:A:G	L139P	0.999
5:90399438:G:T	A127D	0.999
5:90399439:C:G	A127P	0.999
5:90399441:A:T	V126D	0.999
5:90399444:C:G	R125P	0.999
5:90399450:A:G	L123S	0.999
5:90399465:A:C	I118R	0.999
5:90399465:A:G	I118T	0.999
5:90399465:A:T	I118K	0.999
5:90399488:A:C	F110L	0.999
5:90399488:A:T	F110L	0.999
5:90399490:A:G	F110L	0.999
5:90399492:A:G	L109P	0.999
5:90399497:A:C	F107L	0.999
5:90399497:A:T	F107L	0.999
5:90399498:A:G	F107S	0.999
5:90399499:A:G	F107L	0.999
5:90405696:A:G	F86S	0.999
5:90405780:C:A	G58V	0.999
5:90405781:C:G	G58R	0.999
5:90405781:C:T	G58R	0.999
5:90405795:G:T	A53E	0.999
5:90405796:C:G	A53P	0.999
5:90407745:A:G	L36P	0.999

dbSNP variants (sampled 300 via entrez): RS1000037514 (5:90393268 C>G), RS1000156640 (5:90400739 G>A), RS1000223089 (5:90408463 A>G,T), RS1000434154 (5:90397271 A>G), RS1000455198 (5:90397576 T>C), RS1000527948 (5:90406351 T>C), RS1000638146 (5:90391813 G>A), RS1000733844 (5:90401217 G>C), RS1000756068 (5:90398945 A>G), RS1001161121 (5:90400569 T>C), RS1001345871 (5:90393295 C>T), RS1001555780 (5:90396746 A>C), RS1001592001 (5:90397102 C>T), RS1001783143 (5:90408059 C>A), RS1001798760 (5:90400283 A>C)

Disease associations

OMIM: gene MIM:602907 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000478_3	Type 2 diabetes	7.000000e-07
GCST005790_49	Rosacea symptom severity	7.000000e-06
GCST90011900_56	Serum alkaline phosphatase levels	4.000000e-17

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009180	rosacea severity measurement
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
potassium chromate(VI)	affects cotreatment, decreases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases expression, decreases expression	2
Ethanol	affects cotreatment, increases abundance, decreases expression	2
Valproic Acid	increases expression, affects expression, decreases methylation	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	increases expression	1
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases expression, increases abundance, affects cotreatment	1
arsenite	increases reaction, affects binding	1
methylparaben	affects splicing, increases expression	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression	1
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	1
beta-methylcholine	affects expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression	1
azoxystrobin	increases expression	1
CGP 52608	affects binding, increases reaction	1
deguelin	decreases expression	1
bisphenol S	increases expression, affects cotreatment	1
Rosiglitazone	decreases expression	1
Decitabine	affects expression	1
Acrolein	increases expression, increases abundance, affects cotreatment	1
Antimycin A	decreases expression	1
Cisplatin	affects expression	1
Dexamethasone	affects cotreatment, increases expression	1
Estradiol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.