CFAP20

Summary

CFAP20 (cilia and flagella associated protein 20, HGNC:29523) is a protein-coding gene on chromosome 16q21, encoding Cilia- and flagella-associated protein 20 (Q9Y6A4). Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. It is a selective cancer dependency (DepMap: 67.2% of cell lines).

Enables RNA binding activity. Involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cilium beat frequency involved in ciliary motility. Located in microtubule cytoskeleton and nucleoplasm.

Source: NCBI Gene 29105 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 26 total — 5 likely-pathogenic
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• Cancer dependency (DepMap): dependent in 67.2% of screened cell lines
• MANE Select transcript: NM_013242

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29523
Approved symbol	CFAP20
Name	cilia and flagella associated protein 20
Location	16q21
Locus type	gene with protein product
Status	Approved
Aliases	GTL3, fSAP23
Ensembl gene	ENSG00000070761
Ensembl biotype	protein_coding
OMIM	617906
Entrez	29105

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 6 protein_coding, 4 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000262498, ENST00000562443, ENST00000562622, ENST00000564150, ENST00000565880, ENST00000567092, ENST00000567660, ENST00000896541, ENST00000933126, ENST00000933127, ENST00000933128

RefSeq mRNA: 1 — MANE Select: NM_013242 NM_013242

CCDS: CCDS10793

Canonical transcript exons

ENST00000262498 — 6 exons

Exon	Start	End
ENSE00000686445	58115269	58115457
ENSE00000921088	58113592	58114030
ENSE00001100813	58129032	58129381
ENSE00003523794	58116041	58116152
ENSE00003616717	58114810	58114920
ENSE00003674010	58116872	58116951

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 98.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.9700 / max 200.2936, expressed in 1817 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157601	20.8007	1803
157602	10.3199	1779
157603	1.2948	883
157600	0.3090	121
157599	0.2109	76
157596	0.0346	6

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	98.09	gold quality
sperm	CL:0000019	97.15	gold quality
epithelium of bronchus	UBERON:0002031	96.98	gold quality
ventricular zone	UBERON:0003053	96.73	gold quality
adult organism	UBERON:0007023	96.64	gold quality
bronchus	UBERON:0002185	96.49	gold quality
endothelial cell	CL:0000115	96.03	gold quality
cortical plate	UBERON:0005343	95.92	gold quality
left testis	UBERON:0004533	95.87	gold quality
ganglionic eminence	UBERON:0004023	95.81	gold quality
middle temporal gyrus	UBERON:0002771	95.61	gold quality
right testis	UBERON:0004534	95.55	gold quality
embryo	UBERON:0000922	95.41	gold quality
male germ cell	CL:0000015	95.33	gold quality
calcaneal tendon	UBERON:0003701	95.29	gold quality
right uterine tube	UBERON:0001302	95.16	gold quality
upper leg skin	UBERON:0004262	95.11	gold quality
testis	UBERON:0000473	94.86	gold quality
prefrontal cortex	UBERON:0000451	94.76	gold quality
pigmented layer of retina	UBERON:0001782	94.59	gold quality
retina	UBERON:0000966	94.56	gold quality
Brodmann (1909) area 23	UBERON:0013554	94.19	gold quality
pituitary gland	UBERON:0000007	94.11	gold quality
adenohypophysis	UBERON:0002196	94.05	gold quality
caput epididymis	UBERON:0004358	94.04	gold quality
skin of hip	UBERON:0001554	93.89	gold quality
epithelium of nasopharynx	UBERON:0001951	93.89	gold quality
metanephric glomerulus	UBERON:0004736	93.74	gold quality
left ventricle myocardium	UBERON:0006566	93.50	gold quality
frontal cortex	UBERON:0001870	93.39	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-81547	yes	11.89
E-CURD-89	no	1104.20
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F4, RELA, TADA2A, TBP

miRNA regulators (miRDB)

39 targeting CFAP20, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-6503-5P	99.62	66.96	597
HSA-MIR-425-5P	99.59	67.67	900
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-1206	99.30	69.32	1016
HSA-MIR-488-5P	99.28	68.12	821
HSA-MIR-410-3P	99.27	69.98	2457
HSA-MIR-6843-3P	99.26	66.42	915
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312
HSA-MIR-6792-3P	98.41	66.86	1359

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 67.2% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cfap20	ENSDARG00000100514
mus_musculus	Cfap20	ENSMUSG00000031796
rattus_norvegicus	Cfap20	ENSRNOG00000042179
drosophila_melanogaster	Bug22	FBGN0032248
caenorhabditis_elegans		WBGENE00008288

Paralogs (1): CFAP20DC (ENSG00000163689)

Protein

Protein identifiers

Cilia- and flagella-associated protein 20 — Q9Y6A4 (reviewed: Q9Y6A4)

Alternative names: Basal body up-regulated protein 22, Transcription factor IIB

All UniProt accessions (2): Q9Y6A4, H3BPA3

UniProt curated annotations — full annotation on UniProt →

Function. Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.

Subunit / interactions. Microtubule inner protein component of sperm flagellar doublet microtubules. Interacts with CFAP65.

Subcellular location. Nucleus. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Cilium basal body. Cilium axoneme. Flagellum axoneme.

Similarity. Belongs to the CFAP20 family.

RefSeq proteins (1): NP_037374* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007714	CFA20_dom	Domain
IPR040441	CFA20/CFAP20DC	Family

Pfam: PF05018

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
7UNG	ELECTRON MICROSCOPY	3.6
8J07	ELECTRON MICROSCOPY	4.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y6A4-F1	91.81	0.83

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 188 (showing top): GOBP_BEHAVIOR, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, CMYB_01, RACCACAR_AML_Q6, GOBP_POSITIVE_REGULATION_OF_BEHAVIOR, GOCC_MICROTUBULE_ORGANIZING_CENTER, WEI_MYCN_TARGETS_WITH_E_BOX, PAX8_B, GOBP_REGULATION_OF_BEHAVIOR, GOBP_REGULATION_OF_FEEDING_BEHAVIOR, AML_Q6, GOBP_CILIUM_ORGANIZATION, GOBP_CILIUM_MOVEMENT, GOBP_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY

GO Biological Process (6): protein polyglutamylation (GO:0018095), flagellated sperm motility (GO:0030317), cilium assembly (GO:0060271), regulation of cilium beat frequency involved in ciliary motility (GO:0060296), positive regulation of cell motility (GO:2000147), positive regulation of feeding behavior (GO:2000253)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (15): nucleoplasm (GO:0005654), centriole (GO:0005814), axonemal microtubule (GO:0005879), cilium (GO:0005929), motile cilium (GO:0031514), ciliary basal body (GO:0036064), sperm flagellum (GO:0036126), extracellular exosome (GO:0070062), sperm principal piece (GO:0097228), axonemal B tubule inner sheath (GO:0160112), nucleus (GO:0005634), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), microtubule (GO:0005874), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
microtubule organizing center	2
intracellular membraneless organelle	2
cilium	2
peptidyl-glutamic acid modification	1
cilium-dependent cell motility	1
cilium movement involved in cell motility	1
sperm motility	1
axoneme assembly	1
intraciliary transport involved in cilium assembly	1
cilium organization	1
protein localization to cilium	1
organelle assembly	1
trans-Golgi to periciliary membrane compartment transport	1
plasma membrane bounded cell projection assembly	1
ciliary transition zone assembly	1
regulation of cilium beat frequency	1
regulation of cilium movement involved in cell motility	1
regulation of biological quality	1
positive regulation of locomotion	1
positive regulation of cellular process	1
cell motility	1
regulation of cell motility	1
feeding behavior	1
positive regulation of behavior	1
regulation of feeding behavior	1
nucleic acid binding	1
binding	1
nuclear lumen	1
cytoplasmic microtubule	1
axoneme	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
9+2 motile cilium	1
extracellular vesicle	1
sperm flagellum	1
A axonemal microtubule	1
axonemal microtubule doublet inner sheath	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1535 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CFAP20	TBP	P20226	912
CFAP20	GTF2B	Q00403	880
CFAP20	DRAP1	Q14919	804
CFAP20	DR1	Q01658	702
CFAP20	TBC1D32	Q96NH3	528
CFAP20	REL	Q04864	481
CFAP20	FAHD2A	Q96GK7	468
CFAP20	H2BC21	Q16778	461
CFAP20	H2AC19	P20670	458
CFAP20	H2AC20	Q16777	458
CFAP20	RELA	Q04206	443
CFAP20	HNF4A	P41235	428
CFAP20	CFAP298	P57076	425
CFAP20	TMEM17	Q86X19	422
CFAP20	CEP41	Q9BYV8	403

IntAct

73 interactions, top by confidence:

A	B	Type	Score
PLK1	SPAG9	psi-mi:“MI:0914”(association)	0.790
CLASRP	CFAP20	psi-mi:“MI:0915”(physical association)	0.790
ARL2BP	CFAP20	psi-mi:“MI:0915”(physical association)	0.790
FOXJ1	RFX3	psi-mi:“MI:0914”(association)	0.730
LUC7L2	ZRANB2	psi-mi:“MI:0914”(association)	0.640
CFAP20	SFSWAP	psi-mi:“MI:0914”(association)	0.620
SFSWAP	CFAP20	psi-mi:“MI:0915”(physical association)	0.620
CFAP20	YWHAG	psi-mi:“MI:0915”(physical association)	0.590
CFAP20	LRRK2	psi-mi:“MI:0407”(direct interaction)	0.590
CFAP20	KPNA4	psi-mi:“MI:0914”(association)	0.510
PRPF38A	H2BC17	psi-mi:“MI:0914”(association)	0.510
SF3A2	CFAP20	psi-mi:“MI:0915”(physical association)	0.400
CFAP20	TFCP2L1	psi-mi:“MI:0915”(physical association)	0.370
Pqbp1	PRPF4	psi-mi:“MI:0914”(association)	0.350
Kif19		psi-mi:“MI:0914”(association)	0.350
FOXJ1	ACSL4	psi-mi:“MI:0914”(association)	0.350
JUN		psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
CFAP20	PRPF40A	psi-mi:“MI:0914”(association)	0.350
ENG	IGKV2-28	psi-mi:“MI:0914”(association)	0.350
CLK3	AIP	psi-mi:“MI:0914”(association)	0.350
DYRK2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
CEP135	MCRIP1	psi-mi:“MI:0914”(association)	0.350
CEP135	WWP2	psi-mi:“MI:0914”(association)	0.350
CEP135	WDR91	psi-mi:“MI:0914”(association)	0.350

BioGRID (129): CFAP20 (Affinity Capture-MS), CFAP20 (Affinity Capture-MS), CFAP20 (Affinity Capture-MS), CFAP20 (Affinity Capture-MS), CFAP20 (Affinity Capture-MS), CFAP20 (Affinity Capture-MS), SFSWAP (Affinity Capture-MS), CLASRP (Affinity Capture-MS), U2AF1 (Affinity Capture-MS), SFSWAP (Affinity Capture-MS), TBC1D32 (Affinity Capture-MS), CDK20 (Affinity Capture-MS), ARL2BP (Affinity Capture-MS), CLASRP (Affinity Capture-MS), RABEPK (Affinity Capture-MS)

ESM2 similar proteins: A0A1S4A695, A0CDD4, A2VE01, A8IU92, B0R0D7, D3ZRP6, O88958, O97556, P46926, P48454, P50397, P50399, P62495, P62496, P62497, P62498, Q0VCX5, Q1W377, Q24208, Q259G4, Q3SYW1, Q499T7, Q4R7R3, Q503E1, Q5PQL4, Q5R4C7, Q5R8T8, Q5U2Q7, Q5ZHP3, Q5ZJL4, Q61598, Q64422, Q6B857, Q6GL74, Q6GPY6, Q6PBJ2, Q6Q7J2, Q7XPW5, Q8BTU1, Q8BWY3

Diamond homologs: A0CDD4, A8IU92, Q499T7, Q5ZHP3, Q61JK7, Q6B857, Q6GL74, Q6GPY6, Q6PBJ2, Q86D25, Q8BTU1, Q9VKV8, Q9Y6A4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 72 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Polyadenylation	6	10.8×	3e-03
mRNA Splicing - Major Pathway	8	8.9×	9e-04

GO biological processes:

GO term	Partners	Fold	FDR
mRNA splicing, via spliceosome	8	11.1×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

26 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	5
Uncertain significance	17
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (5)

Variant ID	HGVS	Classification
1701087	NM_013242.3(CFAP20):c.305G>A (p.Arg102His)	Likely pathogenic
1701088	NM_013242.3(CFAP20):c.257A>G (p.Tyr86Cys)	Likely pathogenic
1701089	NM_013242.3(CFAP20):c.397del (p.Gln133fs)	Likely pathogenic
1701090	NM_013242.3(CFAP20):c.164+1G>A	Likely pathogenic
1701091	NM_013242.3(CFAP20):c.457A>G (p.Arg153Gly)	Likely pathogenic

SpliceAI

610 predictions. Top by Δscore:

Variant	Effect	Δscore
16:58114028:TTG:T	acceptor_gain	1.0000
16:58115263:CAGTA:C	donor_loss	1.0000
16:58115264:AGTAC:A	donor_loss	1.0000
16:58115265:GTACC:G	donor_loss	1.0000
16:58115266:TA:T	donor_loss	1.0000
16:58115267:A:C	donor_loss	1.0000
16:58115268:C:CA	donor_loss	1.0000
16:58115268:CCT:C	donor_gain	1.0000
16:58115270:TGC:T	donor_gain	1.0000
16:58115271:G:A	donor_gain	1.0000
16:58115453:AGTAC:A	acceptor_gain	1.0000
16:58115454:GTAC:G	acceptor_gain	1.0000
16:58115455:TAC:T	acceptor_gain	1.0000
16:58115456:AC:A	acceptor_gain	1.0000
16:58115457:CC:C	acceptor_gain	1.0000
16:58115458:C:CA	acceptor_loss	1.0000
16:58115458:C:CC	acceptor_gain	1.0000
16:58115458:C:T	acceptor_gain	1.0000
16:58115459:T:A	acceptor_loss	1.0000
16:58115460:G:C	acceptor_gain	1.0000
16:58115460:G:GC	acceptor_gain	1.0000
16:58115465:A:AC	acceptor_gain	1.0000
16:58115465:A:C	acceptor_gain	1.0000
16:58115468:C:CT	acceptor_gain	1.0000
16:58116038:TACC:T	donor_loss	1.0000
16:58116039:A:AC	donor_gain	1.0000
16:58116039:AC:A	donor_gain	1.0000
16:58116039:ACCTG:A	donor_gain	1.0000
16:58116040:C:CG	donor_gain	1.0000
16:58116040:CC:C	donor_gain	1.0000

AlphaMissense

1276 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:58115347:C:A	W129C	1.000
16:58115347:C:G	W129C	1.000
16:58115349:A:G	W129R	1.000
16:58115349:A:T	W129R	1.000
16:58115426:A:G	F103S	1.000
16:58129043:A:G	W25R	1.000
16:58129043:A:T	W25R	1.000
16:58114895:C:G	R164P	0.999
16:58114904:C:G	R161P	0.999
16:58115348:C:G	W129S	0.999
16:58115369:G:T	P122H	0.999
16:58115377:G:C	C119W	0.999
16:58115378:C:T	C119Y	0.999
16:58115416:A:C	S106R	0.999
16:58115416:A:T	S106R	0.999
16:58115417:C:A	S106I	0.999
16:58115418:T:G	S106R	0.999
16:58115423:C:G	R104P	0.999
16:58115432:C:G	R101P	0.999
16:58115433:G:T	R101S	0.999
16:58116885:C:A	G51W	0.999
16:58116885:C:G	G51R	0.999
16:58116885:C:T	G51R	0.999
16:58129068:G:C	S16R	0.999
16:58129068:G:T	S16R	0.999
16:58129070:T:G	S16R	0.999
16:58114856:A:G	L177P	0.998
16:58114892:A:T	V165D	0.998
16:58114898:C:G	R163P	0.998
16:58114913:G:T	A158E	0.998

dbSNP variants (sampled 300 via entrez): RS1000101082 (16:58123622 A>C), RS1000358958 (16:58119848 C>A), RS1000360398 (16:58123738 T>C), RS1000453905 (16:58123403 T>C), RS1000460580 (16:58113463 T>C), RS1000529050 (16:58126895 T>C,G), RS1000582756 (16:58119458 A>G), RS1000811652 (16:58126570 A>C), RS1001364229 (16:58125440 T>C), RS1001483907 (16:58119297 G>A), RS1001537450 (16:58131104 C>T), RS1001572566 (16:58118683 G>T), RS1001668848 (16:58118730 G>A), RS1001701552 (16:58118934 C>T), RS1002464647 (16:58126303 G>T)

Disease associations

OMIM: gene MIM:617906 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005790_39	Rosacea symptom severity	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009180	rosacea severity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724749 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.38	Kd	42	nM	MOLIBRESIB
7.10	IC50	80	nM	MOLIBRESIB

PubChem BioAssay actives

2 with measured affinity, of 7 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2179219: Binding affinity against C16ORF80 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	kd	0.0420	uM

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	increases expression, affects response to substance	3
Smoke	decreases expression, increases abundance, increases expression	3
sodium arsenite	affects expression, increases expression	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
bisphenol A	affects cotreatment, increases methylation	1
2-methyl-4-isothiazolin-3-one	increases expression	1
arsenite	affects binding, increases reaction	1
butyraldehyde	increases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
licochalcone B	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants, Occupational	increases expression	1
Cisplatin	increases expression	1
Coumestrol	increases expression	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	increases expression	1
Methyl Methanesulfonate	increases expression	1
Nickel	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Urethane	increases expression	1
Valproic Acid	increases expression	1
Cyclosporine	decreases expression	1
Copper Sulfate	decreases expression	1
Vitamin K 3	affects expression	1
Particulate Matter	increases abundance, decreases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697589	Binding	Inhibition of C16ORF80 (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.