CFAP54

Summary

CFAP54 (cilia and flagella associated protein 54, HGNC:26456) is a protein-coding gene on chromosome 12q23.1, encoding Cilia- and flagella-associated protein 54 (Q96N23). Required for assembly and function of cilia and flagella. It is a selective cancer dependency (DepMap: 17.8% of cell lines).

Predicted to be involved in cilium assembly; cilium movement involved in cell motility; and spermatogenesis. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and sperm flagellum assembly. Predicted to be located in axoneme.

Source: NCBI Gene 144535 — RefSeq curated summary.

At a glance

• Gene–disease (curated): ciliary dyskinesia, primary, 54 (Strong, ClinGen)
• GWAS associations: 6
• Clinical variants (ClinVar): 20 total — 9 pathogenic, 2 likely-pathogenic
• Phenotypes (HPO): 21
• Cancer dependency (DepMap): dependent in 17.8% of screened cell lines
• MANE Select transcript: NM_001306084

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26456
Approved symbol	CFAP54
Name	cilia and flagella associated protein 54
Location	12q23.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ31514, FLJ44112
Ensembl gene	ENSG00000188596
Ensembl biotype	protein_coding
OMIM	621121
Entrez	144535

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 3 retained_intron, 3 protein_coding, 2 protein_coding_CDS_not_defined, 1 non_stop_decay

ENST00000342887, ENST00000524981, ENST00000550977, ENST00000553778, ENST00000554108, ENST00000554621, ENST00000554821, ENST00000556591, ENST00000637336

RefSeq mRNA: 2 — MANE Select: NM_001306084 NM_001306084, NM_001367885

CCDS: CCDS76588

Canonical transcript exons

ENST00000524981 — 68 exons

Exon	Start	End
ENSE00001098718	96538384	96538518
ENSE00001098720	96506928	96507099
ENSE00001098722	96534062	96534227
ENSE00001098723	96500834	96500939
ENSE00001098725	96512986	96513044
ENSE00001098727	96533792	96533973
ENSE00001098728	96522088	96522189
ENSE00001098729	96503886	96504029
ENSE00001098730	96535515	96535600
ENSE00001098732	96521857	96521970
ENSE00001098734	96527246	96527444
ENSE00001098735	96518928	96519071
ENSE00002140299	96644178	96644408
ENSE00002142968	96765077	96765218
ENSE00002146946	96489577	96489926
ENSE00002151484	96630551	96630651
ENSE00002155585	96811736	96811842
ENSE00002160590	96786675	96786898
ENSE00002188627	96817775	96817913
ENSE00002194862	96829014	96829088
ENSE00002196247	96875118	96875555
ENSE00002200497	96784717	96784890
ENSE00002200837	96792329	96792499
ENSE00002201548	96860819	96860952
ENSE00003460474	96625718	96625807
ENSE00003461296	96693722	96693808
ENSE00003463199	96647875	96648017
ENSE00003464173	96764151	96764249
ENSE00003471196	96684648	96684735
ENSE00003472558	96679600	96679752
ENSE00003478953	96739956	96740061
ENSE00003483408	96658211	96658346
ENSE00003484633	96540837	96540987
ENSE00003485607	96663830	96663932
ENSE00003512781	96623767	96623881
ENSE00003522931	96704743	96704796
ENSE00003538196	96554182	96554310
ENSE00003541931	96744020	96744146
ENSE00003561555	96630093	96630204
ENSE00003569114	96720405	96720565
ENSE00003579120	96547902	96547978
ENSE00003581135	96699971	96700093
ENSE00003593394	96685029	96685238
ENSE00003599529	96743402	96743559
ENSE00003600731	96756458	96756563
ENSE00003601158	96688916	96688982
ENSE00003601791	96743731	96743910
ENSE00003605267	96753743	96753898
ENSE00003614268	96708608	96708803
ENSE00003614688	96757495	96757588
ENSE00003623803	96718443	96718522
ENSE00003626370	96651588	96651815
ENSE00003638770	96626813	96626939
ENSE00003650021	96657882	96658105
ENSE00003665991	96742439	96742586
ENSE00003674785	96649891	96650072
ENSE00003689202	96691128	96691310
ENSE00003702855	96621590	96621721
ENSE00003702979	96594291	96594446
ENSE00003703817	96576585	96576761
ENSE00003704769	96580920	96581105
ENSE00003706091	96589427	96589563
ENSE00003706629	96580597	96580689
ENSE00003706678	96598645	96598767
ENSE00003707936	96554676	96554802
ENSE00003709863	96564644	96564765
ENSE00003710012	96592490	96592637
ENSE00003710776	96564468	96564554

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 89.66.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4739 / max 66.3116, expressed in 620 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127485	1.4739	620

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.66	gold quality
right uterine tube	UBERON:0001302	87.39	gold quality
colonic epithelium	UBERON:0000397	80.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.10	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.20	gold quality
bone marrow cell	CL:0002092	76.28	gold quality
ventricular zone	UBERON:0003053	75.65	gold quality
bronchial epithelial cell	CL:0002328	74.50	gold quality
bronchus	UBERON:0002185	72.97	gold quality
oviduct epithelium	UBERON:0004804	72.05	gold quality
fallopian tube	UBERON:0003889	69.65	gold quality
adenohypophysis	UBERON:0002196	67.77	gold quality
buccal mucosa cell	CL:0002336	67.54	silver quality
pituitary gland	UBERON:0000007	66.00	gold quality
testis	UBERON:0000473	65.85	gold quality
ganglionic eminence	UBERON:0004023	65.20	gold quality
right testis	UBERON:0004534	64.30	gold quality
left testis	UBERON:0004533	64.25	gold quality
tonsil	UBERON:0002372	63.98	gold quality
left uterine tube	UBERON:0001303	63.89	gold quality
calcaneal tendon	UBERON:0003701	62.92	gold quality
corpus callosum	UBERON:0002336	62.91	gold quality
stromal cell of endometrium	CL:0002255	62.86	gold quality
body of uterus	UBERON:0009853	62.79	gold quality
thyroid gland	UBERON:0002046	62.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.39	gold quality
lower esophagus	UBERON:0013473	62.34	gold quality
left lobe of thyroid gland	UBERON:0001120	61.74	gold quality
right lung	UBERON:0002167	61.71	gold quality
right lobe of thyroid gland	UBERON:0001119	60.85	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	3295.68
E-GEOD-81547	yes	131.46
E-MTAB-5061	yes	13.91
E-ANND-3	yes	11.11
E-HCAD-35	yes	7.09
E-ENAD-20	no	105.77
E-MTAB-9067	no	3.63
E-GEOD-137537	no	3.38

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

31 targeting CFAP54, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-2681-5P	99.75	67.64	1655
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-18A-3P	99.56	65.68	1092
HSA-MIR-4696	99.48	67.48	1040
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-4784	99.15	67.41	1733
HSA-MIR-7160-5P	99.11	67.17	2207
HSA-MIR-622	98.99	66.48	1050
HSA-MIR-3150B-3P	98.81	67.21	1728
HSA-MIR-6755-3P	98.61	66.90	834
HSA-MIR-7158-3P	98.46	66.45	728
HSA-MIR-138-1-3P	98.25	67.89	867
HSA-MIR-4638-3P	97.90	65.75	905
HSA-MIR-6511A-3P	97.60	66.61	713
HSA-MIR-6511B-3P	97.60	66.61	713
HSA-MIR-320E	97.49	65.96	865

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 17.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• Biallelic mutations in CFAP54 cause male infertility with severe MMAF and NOA. (PMID:36593121)
• Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients. (PMID:37725231)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cfap54	ENSMUSG00000020014
rattus_norvegicus	Cfap54	ENSRNOG00000024494

Protein

Protein identifiers

Cilia- and flagella-associated protein 54 — Q96N23 (reviewed: Q96N23)

All UniProt accessions (4): A0A0A0MTQ3, A0A1B0GU80, Q96N23, H0YIB5

UniProt curated annotations — full annotation on UniProt →

Function. Required for assembly and function of cilia and flagella.

Subcellular location. Cytoplasm. Cytoskeleton. Cilium axoneme.

Disease relevance. Spermatogenic failure 98 (SPGF98) [MIM:621124] An autosomal recessive, male infertility disorder characterized by abnormal sperm morphology, and reduced sperm concentration and motility. The disease may be caused by variants affecting the gene represented in this entry. Ciliary dyskinesia, primary, 54 (CILD54) [MIM:621125] An autosomal recessive form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD54 affected individuals suffer from rhinitis, sinusitis, asthma, in addition to bronchiectasis. The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.

Miscellaneous. Gene prediction based on partial mRNA data. Incomplete sequence.

Similarity. Belongs to the CFAP54 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96N23-1	1	yes
Q96N23-2	2

RefSeq proteins (2): NP_001293013, NP_001354814 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027912	CFAP54	Family

Pfam: PF14858

UniProt features (20 total): sequence variant 9, sequence conflict 5, region of interest 2, splice variant 2, chain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

No AlphaFold model available for Q96N23 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 116 (showing top): GOBP_RESPIRATORY_GASEOUS_EXCHANGE_BY_RESPIRATORY_SYSTEM, GOBP_RESPIRATORY_SYSTEM_PROCESS, GOBP_MALE_GAMETE_GENERATION, GOBP_CILIUM_ORGANIZATION, GOBP_CILIUM_MOVEMENT, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY, GOBP_ORGANELLE_ASSEMBLY, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_MOTILE_CILIUM_ASSEMBLY, GOBP_CELL_PROJECTION_ORGANIZATION, GOCC_CYTOPLASMIC_REGION, GOCC_CILIUM, chr12q23, TCANNTGAY_SREBP1_01

GO Biological Process (9): spermatogenesis (GO:0007283), establishment of localization in cell (GO:0051649), cilium assembly (GO:0060271), cilium movement involved in cell motility (GO:0060294), cerebrospinal fluid circulation (GO:0090660), mucociliary clearance (GO:0120197), sperm flagellum assembly (GO:0120316), cell projection organization (GO:0030030), cell differentiation (GO:0030154)

GO Molecular Function (0):

GO Cellular Component (7): extracellular region (GO:0005576), axoneme (GO:0005930), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), cilium (GO:0005929), membrane (GO:0016020), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
developmental process involved in reproduction	2
epithelial cilium movement involved in extracellular fluid movement	2
male gamete generation	1
establishment of localization	1
cellular localization	1
axoneme assembly	1
intraciliary transport involved in cilium assembly	1
cilium organization	1
protein localization to cilium	1
organelle assembly	1
trans-Golgi to periciliary membrane compartment transport	1
plasma membrane bounded cell projection assembly	1
ciliary transition zone assembly	1
cilium movement	1
cell motility	1
cilium-dependent cell motility	1
nervous system process	1
respiratory system process	1
spermatid development	1
flagellated sperm motility	1
motile cilium assembly	1
cellular component organization	1
cellular developmental process	1
cytoskeleton	1
microtubule	1
ciliary plasm	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

1023 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CFAP54	SPEF2	Q9C093	707
CFAP54	C1D	Q13901	587
CFAP54	CFAP221	Q4G0U5	571
CFAP54	CALML6	Q8TD86	484
CFAP54	CALML3	P27482	484
CFAP54	CALML5	Q9NZT1	484
CFAP54	CALML4	Q96GE6	484
CFAP54	CALM1	P02593	482
CFAP54	SPAG6	O75602	479
CFAP54	HYDIN	Q4G0P3	479
CFAP54	GALNT18	Q6P9A2	439
CFAP54	RCL1	Q9Y2P8	438
CFAP54	PMIS2	A0A1W2PS18	434
CFAP54	CFAP52	Q8N1V2	421
CFAP54	R3HDM2	Q9Y2K5	413

IntAct

4 interactions, top by confidence:

A	B	Type	Score
CFAP54	NPM1	psi-mi:“MI:0915”(physical association)	0.400
CFAP54	AP2B1	psi-mi:“MI:0915”(physical association)	0.400
CFAP54	TSPY2	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A0A571BF63, A1L0Z4, A1ZAG4, A4IF93, A4QP31, A5HEI1, D3IUT5, F4JS25, F4KCC2, F6S215, O00443, O65418, Q08AV6, Q0JF48, Q4R6I5, Q5FVR8, Q5Q0E6, Q5RAY1, Q5RD58, Q5TEA3, Q5ZKT1, Q61194, Q61QK6, Q640P7, Q69KN0, Q6DRD4, Q7TT23, Q7XZU2, Q8BMQ2, Q8C6S9, Q8GYU3, Q8H1U4, Q8L6Y4, Q8LLD0, Q8N957, Q8NB91, Q8NHS4, Q8RWM3, Q96N23, Q9FFF9

Diamond homologs: Q8C6S9, Q96N23

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

20 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	9
Likely pathogenic	2
Uncertain significance	2
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (11)

Variant ID	HGVS	Classification
3767880	NM_001306084.2(CFAP54):c.3317del (p.Phe1106fs)	Pathogenic
3767881	NM_001306084.2(CFAP54):c.878G>A (p.Arg293His)	Pathogenic
3767882	NM_001306084.2(CFAP54):c.955C>T (p.Arg319Cys)	Pathogenic
3767883	NM_001306084.2(CFAP54):c.937G>A (p.Gly313Arg)	Pathogenic
3767884	NM_001306084.2(CFAP54):c.4885C>T (p.Arg1629Cys)	Pathogenic
3768007	CFAP54, DEL/INS NT2649	Pathogenic
3768008	CFAP54, 18-BP INS, NT7312	Pathogenic
3768009	CFAP54, GLU1371ALA	Pathogenic
3768010	CFAP54, PRO2187SER	Pathogenic
3778415	NM_001306084.2(CFAP54):c.4713_4716del (p.Phe1571fs)	Likely pathogenic
4526608	NM_001306084.2(CFAP54):c.8644_8645del (p.Leu2882fs)	Likely pathogenic

SpliceAI

11568 predictions. Top by Δscore:

Variant	Effect	Δscore
12:96489923:GTTG:G	donor_gain	1.0000
12:96489926:GGTA:G	donor_loss	1.0000
12:96489927:G:GG	donor_gain	1.0000
12:96489928:T:A	donor_loss	1.0000
12:96500936:GAAA:G	donor_gain	1.0000
12:96500937:AAAGT:A	donor_loss	1.0000
12:96500938:AAGTA:A	donor_loss	1.0000
12:96500939:AGT:A	donor_loss	1.0000
12:96500940:G:C	donor_loss	1.0000
12:96500940:G:GG	donor_gain	1.0000
12:96500941:T:G	donor_loss	1.0000
12:96503879:GTTTC:G	acceptor_loss	1.0000
12:96503880:TTTCA:T	acceptor_loss	1.0000
12:96503881:TTCA:T	acceptor_loss	1.0000
12:96503882:TCA:T	acceptor_loss	1.0000
12:96503883:CAGG:C	acceptor_loss	1.0000
12:96503884:A:C	acceptor_loss	1.0000
12:96503964:G:GT	donor_gain	1.0000
12:96504001:GCTT:G	donor_gain	1.0000
12:96504030:G:GG	donor_gain	1.0000
12:96506926:A:AG	acceptor_gain	1.0000
12:96506927:G:GG	acceptor_gain	1.0000
12:96527384:G:GT	donor_gain	1.0000
12:96527428:A:T	donor_gain	1.0000
12:96527440:GA:G	donor_gain	1.0000
12:96527441:A:AG	donor_gain	1.0000
12:96527441:A:G	donor_gain	1.0000
12:96527445:G:GG	donor_gain	1.0000
12:96533790:A:AG	acceptor_gain	1.0000
12:96533791:G:GG	acceptor_gain	1.0000

AlphaMissense

20344 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:96626839:T:C	F1335L	0.997
12:96626841:T:A	F1335L	0.997
12:96626841:T:G	F1335L	0.997
12:96792452:T:A	W2935R	0.997
12:96792452:T:C	W2935R	0.997
12:96651612:T:A	W1633R	0.996
12:96651612:T:C	W1633R	0.996
12:96685045:T:A	W1941R	0.996
12:96685045:T:C	W1941R	0.996
12:96625772:T:A	V1314D	0.995
12:96658059:T:A	W1760R	0.995
12:96658059:T:C	W1760R	0.995
12:96757515:T:C	L2656P	0.995
12:96784827:T:A	W2798R	0.995
12:96784827:T:C	W2798R	0.995
12:96580986:G:C	A986P	0.994
12:96626840:T:C	F1335S	0.994
12:96644299:T:A	W1480R	0.994
12:96644299:T:C	W1480R	0.994
12:96651601:G:C	R1629P	0.994
12:96594339:A:C	S1137R	0.993
12:96594341:C:A	S1137R	0.993
12:96594341:C:G	S1137R	0.993
12:96658264:T:C	L1793P	0.993
12:96651595:C:A	A1627D	0.992
12:96651622:T:C	L1636P	0.992
12:96756538:A:C	S2641R	0.992
12:96756540:C:A	S2641R	0.992
12:96756540:C:G	S2641R	0.992
12:96786780:T:C	L2854P	0.992

dbSNP variants (sampled 300 via entrez): RS1000014607 (12:96570139 C>T), RS1000017026 (12:96705048 A>T), RS1000019277 (12:96544067 CCTAAAT>C), RS1000029484 (12:96534503 A>T), RS1000041661 (12:96841623 A>G), RS1000044297 (12:96574069 C>A,T), RS1000044617 (12:96759132 A>G), RS1000056564 (12:96617249 A>G), RS1000067706 (12:96703840 G>A), RS1000068183 (12:96794935 G>A,T), RS1000097066 (12:96622123 G>A), RS1000098343 (12:96704164 A>C), RS1000106746 (12:96616987 G>A), RS1000126338 (12:96845392 A>T), RS1000134255 (12:96604466 T>C)

Disease associations

OMIM: gene MIM:621121 | disease phenotypes: MIM:621124, MIM:621125

GenCC curated gene-disease

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
ciliary dyskinesia, primary, 54	Strong	AR

Mondo (2): spermatogenic failure 98 (MONDO:0700290), ciliary dyskinesia, primary, 54 (MONDO:0100607)

Orphanet (0):

HPO phenotypes

21 total (21 of 21 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000798	Oligozoospermia
HP:0002090	Pneumonia
HP:0002099	Asthma
HP:0002110	Bronchiectasis
HP:0002837	Recurrent bronchitis
HP:0003251	Male infertility
HP:0011462	Young adult onset
HP:0011463	Childhood onset
HP:0012207	Reduced sperm motility
HP:0025708	Early young adult onset
HP:0031245	Productive cough
HP:0032558	Absent sperm flagella
HP:0032559	Short sperm flagella
HP:0032560	Coiled sperm flagella
HP:0033393	Irregularly shaped sperm tail
HP:0033524	Abnormal sperm axoneme morphology
HP:0034011	Reduced progressive sperm motility
HP:0034811	Bent sperm flagella
HP:0100750	Atelectasis
HP:6000135	Low semen volume

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST000837_3	Weight	4.000000e-06
GCST005050_6	Obstructive sleep apnea during REM sleep (apnea hypopnea index)	6.000000e-07
GCST007231_5	Tuberculosis	3.000000e-06
GCST007637_21	Diffusing capacity of carbon monoxide	2.000000e-06
GCST009222_4	Corpus callosum posterior volume	7.000000e-06
GCST009391_187	Metabolite levels	2.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004338	body weight
EFO:0008455	sleep apnea measurement during REM sleep
EFO:0009369	diffusing capacity of the lung for carbon monoxide
EFO:0010482	gamma-aminoisobutyric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Smoke	decreases expression, increases abundance, increases expression	2
FR900359	increases phosphorylation	1
sodium arsenite	decreases expression	1
2-palmitoylglycerol	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	affects methylation	1
Caffeine	increases phosphorylation	1
Tobacco Smoke Pollution	affects expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.