CFTR-AS1

Summary

CFTR-AS1 (CFTR antisense RNA 1, HGNC:40144) is a long non-coding RNA gene on chromosome 7q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40144
Approved symbol	CFTR-AS1
Name	CFTR antisense RNA 1
Location	7q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	BGas
Ensembl gene	ENSG00000232661
Ensembl biotype	lncRNA
Entrez	111082987
RNAcentral	URS0000BC4606 — lncRNA, 240 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000441019

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441019 — 2 exons

Exon	Start	End
ENSE00001757487	117564516	117564676
ENSE00001794659	117560733	117560792

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 69.25.

Top tissues by expression

193 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	69.25	gold quality
islet of Langerhans	UBERON:0000006	68.12	gold quality
pancreas	UBERON:0001264	68.00	gold quality
gall bladder	UBERON:0002110	67.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.97	gold quality
right frontal lobe	UBERON:0002810	65.93	gold quality
mucosa of transverse colon	UBERON:0004991	61.22	gold quality
rectum	UBERON:0001052	61.07	gold quality
body of stomach	UBERON:0001161	57.73	gold quality
right atrium auricular region	UBERON:0006631	57.73	gold quality
gastrocnemius	UBERON:0001388	57.29	gold quality
minor salivary gland	UBERON:0001830	57.06	gold quality
right lobe of liver	UBERON:0001114	54.61	gold quality
transverse colon	UBERON:0001157	54.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	54.30	gold quality
lower lobe of lung	UBERON:0008949	53.89	silver quality
muscle layer of sigmoid colon	UBERON:0035805	53.63	gold quality
skin of leg	UBERON:0001511	52.84	gold quality
mouth mucosa	UBERON:0003729	52.84	gold quality
tibial nerve	UBERON:0001323	52.80	gold quality
skin of abdomen	UBERON:0001416	52.46	gold quality
saliva-secreting gland	UBERON:0001044	52.44	gold quality
tonsil	UBERON:0002372	51.97	silver quality
upper lobe of lung	UBERON:0008948	51.88	gold quality
duodenum	UBERON:0002114	51.68	gold quality
small intestine Peyer’s patch	UBERON:0003454	51.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	51.45	gold quality
intestine	UBERON:0000160	50.93	gold quality
stomach	UBERON:0000945	50.70	gold quality
colon	UBERON:0001155	50.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The observations described here highlight a previously underappreciated mechanism of transcriptional control and suggest that BGas may serve as a therapeutic target for specifically activating expression of CFTR. (PMID:27434588)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.