CFTR-AS2

Summary

CFTR-AS2 (CFTR antisense RNA 2, HGNC:40145) is a long non-coding RNA gene on chromosome 7q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40145
Approved symbol	CFTR-AS2
Name	CFTR antisense RNA 2
Location	7q31.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000083622
Ensembl biotype	lncRNA
Entrez	140577507

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456270

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456270 — 3 exons

Exon	Start	End
ENSE00001610972	117647351	117647415
ENSE00001762697	117616229	117616340
ENSE00001773205	117604791	117604989

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 75.33.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	75.33	gold quality
pancreas	UBERON:0001264	72.57	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.92	gold quality
gall bladder	UBERON:0002110	66.47	gold quality
islet of Langerhans	UBERON:0000006	65.02	gold quality
prefrontal cortex	UBERON:0000451	63.90	gold quality
tonsil	UBERON:0002372	62.94	silver quality
rectum	UBERON:0001052	61.80	gold quality
adrenal tissue	UBERON:0018303	61.42	gold quality
monocyte	CL:0000576	59.65	gold quality
superior frontal gyrus	UBERON:0002661	59.14	gold quality
corpus callosum	UBERON:0002336	58.95	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.86	gold quality
duodenum	UBERON:0002114	58.67	gold quality
cortex of kidney	UBERON:0001225	58.46	gold quality
bone marrow	UBERON:0002371	58.40	gold quality
blood	UBERON:0000178	58.16	gold quality
colon	UBERON:0001155	57.99	gold quality
transverse colon	UBERON:0001157	57.92	gold quality
saliva-secreting gland	UBERON:0001044	57.15	gold quality
minor salivary gland	UBERON:0001830	56.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.60	gold quality
intestine	UBERON:0000160	55.38	gold quality
zone of skin	UBERON:0000014	53.63	gold quality
skin of abdomen	UBERON:0001416	53.54	gold quality
skin of leg	UBERON:0001511	53.42	gold quality
liver	UBERON:0002107	53.04	gold quality
multicellular organism	UBERON:0000468	51.73	gold quality
kidney	UBERON:0002113	51.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.37

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.