CGB3

Summary

CGB3 (chorionic gonadotropin subunit beta 3, HGNC:1886) is a protein-coding gene on chromosome 19q13.33, encoding Choriogonadotropin subunit beta 3 (P0DN86). Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated.

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.

Source: NCBI Gene 1082 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 6 total
• MANE Select transcript: NM_000737

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1886
Approved symbol	CGB3
Name	chorionic gonadotropin subunit beta 3
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000104827
Ensembl biotype	protein_coding
OMIM	118860
Entrez	1082

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000357383

RefSeq mRNA: 1 — MANE Select: NM_000737 NM_000737

CCDS: CCDS12749

Canonical transcript exons

ENST00000357383 — 3 exons

Exon	Start	End
ENSE00002439903	49022869	49023200
ENSE00002898348	49023957	49024333
ENSE00003509711	49023436	49023603

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 85.24.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	85.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.90	silver quality
pituitary gland	UBERON:0000007	60.34	gold quality
adenohypophysis	UBERON:0002196	59.96	gold quality
body of pancreas	UBERON:0001150	57.56	gold quality
duodenum	UBERON:0002114	52.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.46	gold quality
granulocyte	CL:0000094	48.04	silver quality
adrenal tissue	UBERON:0018303	47.40	gold quality
pancreas	UBERON:0001264	47.35	gold quality
right testis	UBERON:0004534	47.33	gold quality
left testis	UBERON:0004533	46.57	gold quality
mucosa of stomach	UBERON:0001199	46.52	gold quality
testis	UBERON:0000473	45.91	gold quality
body of stomach	UBERON:0001161	45.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	43.82	gold quality
lower esophagus mucosa	UBERON:0035834	43.72	silver quality
apex of heart	UBERON:0002098	43.64	silver quality
stomach	UBERON:0000945	43.31	gold quality
left adrenal gland	UBERON:0001234	41.24	gold quality
left adrenal gland cortex	UBERON:0035825	40.62	gold quality
fundus of stomach	UBERON:0001160	40.34	gold quality
adrenal gland	UBERON:0002369	39.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	37.78	silver quality
small intestine	UBERON:0002108	37.58	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
small intestine Peyer’s patch	UBERON:0003454	37.01	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
right uterine tube	UBERON:0001302	36.36	silver quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-7407	yes	22446.20
E-HCAD-24	yes	6678.28
E-MTAB-10018	yes	1270.28
E-HCAD-23	yes	438.59
E-MTAB-3929	yes	169.91
E-HCAD-5	yes	29.23
E-MTAB-8060	no	7704.86
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EGR1, ETS2, JUN, KLF6, NANOG, POU5F1, PPARA, PPARG, RXRA, SP1, SP3, TFAP2A

Literature-anchored findings (GeneRIF, showing 40)

• Isolation and purification using affinity capture MALDI-TOF MS was enhanced 3-fold by a method of orienting immunoglobulin G using immobilized recombinant Fc receptor protein G. (PMID:12175153)
• Deleting the native acceptor sites exposes a new site for O-glycosylation and promotes a differential intracellular processing and folding of the beta subunit. (PMID:12242028)
• Expressed in human decidual tissue in patients during tubal pregnancy (PMID:12569177)
• Expression of the free beta-subunit of human chorionic gonadotropin in renal cell carcinoma: prognostic study on tissue and serum (PMID:12594819)
• Decrease in molecular weight of dimeric chimeras digested with endoglycosidase-F was greater in Calpha than that in alphaC after treatment with neuraminidase, revealing that both chimeras have different numbers of sialic acids on O-linked carbohydrates. (PMID:15004409)
• elevated b-HCG levels in our study were associated with pre-eclampsia.There is a statistically significant correlation between high levels of b-HCG and increased numbers of intrauterine growth restriction and newborns delivered in poor condition. (PMID:15048184)
• Substitution of arginine(68) of the beta-subunit (hCG(beta)) with glutamic acid (R68E) profoundly reduces the cross-reactivity while refocusing the immune response to the hCG(beta)-specific C-terminal peptide (CTP). (PMID:15718290)
• Overexpression of HCG beta is associated with adenoma formation (PMID:16007123)
• HCGbeta is directly responsible for changes in prostate carcinoma cells associated with an increased metastatic phenotype (PMID:16323172)
• the Gly residue at site X(3) (G(3)) in the CXGXC motif of hCG is essential for heterodimer formation of glycoprotein hormones (PMID:16543672)
• In pertussis toxin-treated BeWo cells, 6-chloromelatonin stimulated basal hCG-beta secretion (P < 0.001). (PMID:16632463)
• Kaplan-Meier plots and log-rank test revealed no significant difference in progression-free survival between patients with elevated or normal levels of serum and/or urinary total hCGbeta. (PMID:16651852)
• hCGB suppresses breast cancer growth by triggering apoptosis via Bax and p53 pathways. (PMID:16924466)
• The data presented here support the model of glycoprotein hormone-receptor interaction in which the hormone binds to the extracellular domain through the beta subunit and then the alpha subunit is brought in contact with the transmembrane domain. (PMID:17045394)
• An intracellular intact hCG beta-subunit form that showed the transient expression of the hCG-beta-core fragment epitope beta11 in the course of the maturation of this subunit, is described. (PMID:17059865)
• hCGalpha is not derived from heterodimeric glycoprotein hormones suggesting hCG-independent functions of hCGalpha and hCGbeta in male and female fertility. (PMID:17097221)
• The increased hCGbeta concentrations in body fluids of patients with aggressive bladder cancer may be due to overexpression of type II genes. (PMID:17139196)
• in patients with complex congenital malformations amniotic fluid levels of beta-hCG were higher than in controls (PMID:17141398)
• The approach of fusing the alpha and beta subunits of human Chorionic Gonadotropin (hCG) to produce a single chain hormone (phCGalphabeta) was used to investigate roles of critical residues of the alpha subunit in hormone receptor interaction. (PMID:17143726)
• Patients with preexisting systemic lupus erythematosus have increased maternal serum-free beta-hCG levels in the first-trimester. (PMID:17437322)
• Data shows that the GPHalpha in the hCG alphabeta-heterodimers decelerates the maturation of the hCGbeta portion in the heterodimer complex. (PMID:17761764)
• Endometrial IGF-I and -II are differentially regulated during decidualization and by human chorionic gonadotropin. (PMID:18022169)
• Data suggests that the expressional profile of CGB genes, activated already in blastocyst stage, is associated with the status of pregnancy. The presence of CGB transcripts in testes may indicate a role in male reproductive tract. (PMID:18048458)
• LH/hCGR, coexpressed with hCGbeta, may act as a potential mediator of hCG action in nontrophoblastic gynecological cancers (PMID:18217981)
• These data suggest that human chorionic gonadotropin beta subunit may act as a tumor growth-stimulating factor. (PMID:18339208)
• Alpha-fetoprotein and human chorionic gonadotropin beta are elevated in high-grade neuroendocrine tumors with a rapidly progressive course and poorer survival. (PMID:18577995)
• Elevated beta human chorionic gonadotrophin is associated with seminoma (PMID:18578862)
• Expression correlates with reduced cervical squamous carcinoma cell apoptosis and may be involved in tumor vascularization and dissemination. (PMID:18752498)
• Sensitivity of breast cancer cells to hormones that target beta-HCG may favor invasive breast cancer. (PMID:18758818)
• Elevated beta-human chorionic gonadotropin is associated with primary central nervous system germ cell tumors. (PMID:18802946)
• Early prediction of fetuses being SGA is feasible with the combination of first trimester PAPP-A, beta-hCG and ADAM12. (PMID:19003798)
• Although, beta-hCG is expressed in the majority of pituitary adenomas, more especially in NFPA, it is un-related to the risk of tumour recurrence or cellular proliferation as measured by Ki-67 nuclear labelling. (PMID:19005764)
• Median values in pregnant smokers versus nonsmokers does not affect diagnosis of Down syndrome in the first trimester. (PMID:19106261)
• Secretory trafficking signal encoded in the carboxyl-terminal region of the CGbeta-subunit. (PMID:19131508)
• maternal smoking associated with a reduction in cord blood beta-hCG (PMID:19290844)
• Data show that specific antibodies against purified beta-hCG forms had comparable titers and could be used in diagnostic kits. (PMID:19501580)
• beta-hCG has been found in a phyllodes tumor of the breast. (PMID:19624411)
• hCG gene expression is differentially regulated in villous and invasive extravillous trophoblasts during their in vitro differentiation and modulated in an opposite way by PPARgamma. (PMID:19846218)
• This is first evidence of a monoclonal antibody that recognizes a peptide derived from chorionic gonadotropin (hCG)-beta antigen and is capable of suppressing tumor growth, both dose-dependently and in a major histocompatibility (HLA-A*0201) context. (PMID:20065111)
• Case Report: Mediastinal tumor diagnosed as thymic adenocarcinoma producing beta-hCG, and the tumor had originated from the thymus. (PMID:20421278)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	Gpb5	FBGN0063368

Paralogs (9): CGB2 (ENSG00000104818), LHB (ENSG00000104826), FSHB (ENSG00000131808), TSHB (ENSG00000134200), GPHB5 (ENSG00000179600), CGB5 (ENSG00000189052), CGB7 (ENSG00000196337), CGB8 (ENSG00000213030), CGB1 (ENSG00000267631)

Protein

Protein identifiers

Choriogonadotropin subunit beta 3 — P0DN86 (reviewed: P0DN86)

Alternative names: Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta

All UniProt accessions (2): P0DN86, A0A0F7RQP8

UniProt curated annotations — full annotation on UniProt →

Function. Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Subunit / interactions. Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.

Subcellular location. Secreted.

Tissue specificity. High expression in the placenta throughout pregnancy.

Miscellaneous. Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

Similarity. Belongs to the glycoprotein hormones subunit beta family.

Isoforms (2)

UniProt ID	Names	Canonical?
P0DN86-1	1	yes
P0DN86-2	2

RefSeq proteins (1): NP_000728* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001545	Gonadotropin_bsu	Family
IPR006208	Glyco_hormone_CN	Domain
IPR018245	Gonadotropin_bsu_CS	Conserved_site
IPR029034	Cystine-knot_cytokine	Homologous_superfamily

Pfam: PF00007

UniProt features (37 total): sequence variant 9, disulfide bond 6, strand 6, glycosylation site 6, sequence conflict 4, signal peptide 1, chain 1, splice variant 1, region of interest 1, compositionally biased region 1, turn 1

Structure

Experimental structures (PDB)

7 structures.

PDB	Method	Resolution (Å)
1HCN	X-RAY DIFFRACTION	2.6
9RHU	ELECTRON MICROSCOPY	2.65
1HRP	X-RAY DIFFRACTION	3
7FIH	ELECTRON MICROSCOPY	3.2
1QFW	X-RAY DIFFRACTION	3.5
7FIG	ELECTRON MICROSCOPY	3.9
7FII	ELECTRON MICROSCOPY	4.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DN86-F1	79.10	0.47

Antibody-complex structures (SAbDab): 2 — 1QFW, 7FIG

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (6): 29–77, 43–92, 46–130, 54–108, 58–110, 113–120

Glycosylation sites (6): 33, 50, 141, 147, 152, 158

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-209822	Glycoprotein hormones
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

MSigDB gene sets: 49 (showing top): MODULE_92, CHIBA_RESPONSE_TO_TSA_UP, ENK_UV_RESPONSE_KERATINOCYTE_UP, KORKOLA_CHORIOCARCINOMA, GOBP_CELL_CELL_SIGNALING, GOBP_HORMONE_MEDIATED_SIGNALING_PATHWAY, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_RESPONSE_TO_HORMONE, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, GOBP_FEMALE_GAMETE_GENERATION, GOMF_SIGNALING_RECEPTOR_BINDING, MODULE_38, HUANG_FOXA2_TARGETS_DN, BALDWIN_PRKCI_TARGETS_UP, MODULE_382

GO Biological Process (6): apoptotic process (GO:0006915), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), cell-cell signaling (GO:0007267), female gamete generation (GO:0007292), hormone-mediated signaling pathway (GO:0009755)

GO Molecular Function (3): hormone activity (GO:0005179), signaling receptor binding (GO:0005102), protein binding (GO:0005515)

GO Cellular Component (4): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), cytoplasm (GO:0005737), pituitary gonadotropin complex (GO:0061696)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Peptide hormone biosynthesis	1
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	2
signaling	2
signal transduction	2
cellular anatomical structure	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
cellular process	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
gamete generation	1
cellular response to hormone stimulus	1
receptor ligand activity	1
protein binding	1
binding	1
intracellular anatomical structure	1
extracellular protein-containing complex	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

10 interactions, top by confidence:

A	B	Type	Score
CGA	CGB5	psi-mi:“MI:0407”(direct interaction)	0.590
CGA	CGB5	psi-mi:“MI:0915”(physical association)	0.590
CGB5	SMCP	psi-mi:“MI:0915”(physical association)	0.560
CGB5	GPHA2	psi-mi:“MI:0915”(physical association)	0.370
CGB5	CFTR	psi-mi:“MI:0915”(physical association)	0.370
CGB5	IGSF3	psi-mi:“MI:0914”(association)	0.350
CGB5	DNAJC5	psi-mi:“MI:2364”(proximity)	0.270
CGB5	SMCP	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A6NKQ9, B1AWI6, G7PWZ3, I6M4H4, O09108, O46482, O46483, O46641, O77805, O77835, P01229, P01230, P01231, P01232, P04651, P07434, P08751, P0DN86, P0DN87, P17490, P19794, P27767, P30984, P43021, P45646, P45657, P51500, Q04997, Q1L6U9, Q2Q1P0, Q2Q1P1, Q2Q1P2, Q3HRV3, Q3S2X5, Q6EV78, Q6HA10, Q6NT52, Q6PX77, Q7ZZV4, Q8CB67

Diamond homologs: A1BN60, A1BN61, A6NKQ9, O09108, O13050, O46430, O46482, O46483, O46641, O57340, O73824, O77805, O77835, P01222, P01223, P01224, P01225, P01226, P01227, P01228, P01229, P01230, P01231, P01232, P01235, P04651, P04652, P04837, P07434, P07732, P08751, P0DN86, P0DN87, P10256, P10257, P12656, P12837, P18427, P19794, P25330

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	2
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

360 predictions. Top by Δscore:

Variant	Effect	Δscore
19:49023431:CTCA:C	donor_loss	1.0000
19:49023432:TCACC:T	donor_loss	1.0000
19:49023433:CACCA:C	donor_loss	1.0000
19:49023434:A:AC	donor_gain	1.0000
19:49023434:A:T	donor_loss	1.0000
19:49023435:C:CC	donor_gain	1.0000
19:49023600:GCCCC:G	acceptor_loss	1.0000
19:49023601:CCCCT:C	acceptor_loss	1.0000
19:49023602:CC:C	acceptor_gain	1.0000
19:49023603:CC:C	acceptor_gain	1.0000
19:49023604:C:T	acceptor_gain	1.0000
19:49023604:CTGGG:C	acceptor_loss	1.0000
19:49023605:T:A	acceptor_loss	1.0000
19:49023605:T:G	acceptor_loss	1.0000
19:49023434:AC:A	donor_gain	0.9900
19:49023435:CC:C	donor_gain	0.9900
19:49023435:CCATG:C	donor_gain	0.9900
19:49023599:AGCCC:A	acceptor_gain	0.9900
19:49023600:GCCC:G	acceptor_gain	0.9900
19:49023601:CCC:C	acceptor_gain	0.9900
19:49023601:CCCC:C	acceptor_gain	0.9900
19:49023602:CCC:C	acceptor_gain	0.9900
19:49023604:C:CC	acceptor_gain	0.9900
19:49023435:CCA:C	donor_gain	0.9800
19:49023435:CCAT:C	donor_gain	0.9800
19:49023209:C:CT	acceptor_gain	0.9700
19:49023209:CG:C	acceptor_gain	0.9700
19:49023210:G:C	acceptor_gain	0.9700
19:49023196:CGGGT:C	acceptor_gain	0.9600
19:49023208:CCG:C	acceptor_gain	0.9600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000188204 (19:49024229 A>G), RS1001094233 (19:49022790 C>G,T), RS1002922053 (19:49025469 C>T), RS1003371215 (19:49024504 C>G,T), RS1003446977 (19:49025577 T>A), RS1003664234 (19:49024265 G>A,C), RS1004927151 (19:49023200 T>C), RS1005175015 (19:49026184 G>T), RS1005451326 (19:49023695 C>G,T), RS1006843500 (19:49025658 C>A,T), RS1006874808 (19:49025768 C>T), RS1007663726 (19:49025236 G>C), RS1010073014 (19:49025807 C>G,T), RS1010104150 (19:49025897 G>A), RS1011782493 (19:49025445 G>A,T)

Disease associations

OMIM: gene MIM:118860 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

92 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Progesterone	increases chemical synthesis, increases abundance, affects abundance, affects cotreatment, decreases activity (+6 more)	15
Testosterone	affects cotreatment, increases secretion, decreases abundance, decreases reaction, increases abundance (+1 more)	9
Atrazine	increases abundance, increases chemical synthesis, increases secretion, increases reaction, increases expression (+1 more)	6
Estradiol	affects abundance, increases abundance, increases chemical synthesis, decreases reaction, increases activity (+2 more)	6
Cyclic AMP	increases secretion, increases abundance, increases reaction, increases activity, affects cotreatment (+1 more)	5
Colforsin	increases secretion, affects cotreatment, affects reaction, decreases reaction, increases abundance (+2 more)	4
Androgens	increases reaction, increases abundance, decreases reaction, increases chemical synthesis	3
tributyltin	increases expression, increases secretion	2
triphenyltin chloride	increases expression, increases secretion	2
cobaltous chloride	decreases reaction, increases expression, increases reaction, decreases secretion	2
bromodichloromethane	decreases secretion	2
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	decreases reaction, increases abundance, increases reaction, affects reaction, increases expression	2
diphenyltin chloride	increases expression, increases secretion	2
tetrabutyltin	increases expression, increases secretion	2
Rosiglitazone	increases expression, increases secretion	2
Resveratrol	affects cotreatment, decreases expression, increases expression	2
Chlorpyrifos	increases expression, increases secretion	2
Plant Extracts	affects cotreatment, decreases expression	2
Tretinoin	decreases expression, increases expression	2
Valproic Acid	decreases reaction, increases expression, increases reaction, increases methylation	2
Aflatoxin B1	increases expression	2
cyhexatin	increases expression, increases secretion	1
triptolide	decreases reaction, increases abundance	1
testosterone enanthate	decreases reaction, increases abundance, decreases response to substance	1
triphenyl phosphate	affects cotreatment, increases secretion, decreases reaction, increases expression	1
uranyl acetate	affects expression	1
pirinixic acid	decreases expression	1
bisphenol A	increases secretion	1
triphenyltin hydroxide	increases expression, increases secretion	1
mecoprop	decreases reaction, increases abundance, increases reaction	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_6618	CSMalphabeta1h	Cancer cell line	Female
CVCL_6619	CSMalphabeta6C	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.