CHASERR

Summary

CHASERR (CHD2 adjacent suppressive regulatory RNA, HGNC:48626) is a long non-coding RNA gene on chromosome 15q26.1.

Predicted to be involved in several processes, including adipose tissue development; regulation of gene expression; and thymus development. Predicted to be active in chromatin and nucleus.

Source: NCBI Gene 100507217 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48626
Approved symbol	CHASERR
Name	CHD2 adjacent suppressive regulatory RNA
Location	15q26.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272888
Ensembl biotype	lncRNA
OMIM	620993
Entrez	100507217
RNAcentral	URS000075A1CF — lncRNA, 1787 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 18 lncRNA, 2 retained_intron

ENST00000553829, ENST00000554133, ENST00000554669, ENST00000554894, ENST00000555227, ENST00000555520, ENST00000556895, ENST00000557147, ENST00000557682, ENST00000610332, ENST00000653163, ENST00000692976, ENST00000803209, ENST00000803210, ENST00000803211, ENST00000803212, ENST00000803213, ENST00000803214, ENST00000816678, ENST00000816679

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553829 — 2 exons

Exon	Start	End
ENSE00002491754	92883585	92883861
ENSE00002520755	92882732	92883186

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 99.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 157.8072 / max 2561.5140, expressed in 1827 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148635	143.2544	1827
148634	13.1516	1799
148636	0.5369	254
148637	0.4728	208
148638	0.3916	175

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vena cava	UBERON:0004087	99.50	gold quality
calcaneal tendon	UBERON:0003701	99.40	gold quality
ventricular zone	UBERON:0003053	99.38	gold quality
trachea	UBERON:0003126	99.38	gold quality
parotid gland	UBERON:0001831	99.35	gold quality
ganglionic eminence	UBERON:0004023	99.30	gold quality
upper arm skin	UBERON:0004263	99.28	gold quality
oviduct epithelium	UBERON:0004804	99.28	gold quality
synovial joint	UBERON:0002217	99.18	gold quality
urethra	UBERON:0000057	99.17	gold quality
pericardium	UBERON:0002407	99.17	gold quality
pons	UBERON:0000988	99.13	gold quality
cartilage tissue	UBERON:0002418	99.10	gold quality
corpus callosum	UBERON:0002336	99.09	gold quality
subthalamic nucleus	UBERON:0001906	99.04	gold quality
layer of synovial tissue	UBERON:0007616	99.00	gold quality
lateral globus pallidus	UBERON:0002476	98.96	gold quality
cardia of stomach	UBERON:0001162	98.95	gold quality
renal medulla	UBERON:0000362	98.94	gold quality
penis	UBERON:0000989	98.92	gold quality
medulla oblongata	UBERON:0001896	98.91	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.91	gold quality
inferior vagus X ganglion	UBERON:0005363	98.90	gold quality
saphenous vein	UBERON:0007318	98.90	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.88	gold quality
tendon	UBERON:0000043	98.86	gold quality
trigeminal ganglion	UBERON:0001675	98.79	gold quality
thymus	UBERON:0002370	98.78	gold quality
superior surface of tongue	UBERON:0007371	98.75	gold quality
ventral tegmental area	UBERON:0002691	98.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF-kappaB/YY1 axis. (PMID:33040438)
• LINC01578 affects the radiation resistance of lung cancer cells through regulating microRNA-216b-5p/TBL1XR1 axis. (PMID:35475502)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.