CHID1

Summary

CHID1 (chitinase domain containing 1, HGNC:28474) is a protein-coding gene on chromosome 11p15.5, encoding Chitinase domain-containing protein 1 (Q9BWS9). Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization.

Enables oligosaccharide binding activity. Involved in negative regulation of cytokine production involved in inflammatory response. Located in several cellular components, including late endosome; lysosome; and trans-Golgi network.

Source: NCBI Gene 66005 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 76 total — 1 pathogenic
• MANE Select transcript: NM_023947

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28474
Approved symbol	CHID1
Name	chitinase domain containing 1
Location	11p15.5
Locus type	gene with protein product
Status	Approved
Aliases	MGC3234, FLJ42707, SI-CLP
Ensembl gene	ENSG00000177830
Ensembl biotype	protein_coding
OMIM	615692
Entrez	66005

Gene structure

Transcript identifiers

Ensembl transcripts: 66 — 57 protein_coding, 5 nonsense_mediated_decay, 2 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000323578, ENST00000429789, ENST00000436108, ENST00000449825, ENST00000454838, ENST00000524538, ENST00000524832, ENST00000525225, ENST00000525840, ENST00000526714, ENST00000528154, ENST00000528426, ENST00000528521, ENST00000528534, ENST00000528581, ENST00000529539, ENST00000530939, ENST00000531010, ENST00000531859, ENST00000532909, ENST00000533056, ENST00000533059, ENST00000534207, ENST00000534254, ENST00000903752, ENST00000903753, ENST00000903754, ENST00000903755, ENST00000903756, ENST00000903757, ENST00000903758, ENST00000903759, ENST00000903760, ENST00000903761, ENST00000903762, ENST00000903763, ENST00000903764, ENST00000903765, ENST00000903766, ENST00000903767, ENST00000903768, ENST00000903769, ENST00000903770, ENST00000903771, ENST00000903772, ENST00000924111, ENST00000924112, ENST00000924113, ENST00000924114, ENST00000924115, ENST00000924116, ENST00000924117, ENST00000924118, ENST00000924119, ENST00000924120, ENST00000970720, ENST00000970721, ENST00000970722, ENST00000970723, ENST00000970724, ENST00000970725, ENST00000970726, ENST00000970727, ENST00000970728, ENST00000970729, ENST00000970730

RefSeq mRNA: 5 — MANE Select: NM_023947 NM_001142674, NM_001142675, NM_001142676, NM_001142677, NM_023947

CCDS: CCDS44510, CCDS44511, CCDS7722

Canonical transcript exons

ENST00000323578 — 13 exons

Exon	Start	End
ENSE00001958037	867859	869956
ENSE00002141308	910775	910810
ENSE00003481765	902198	902330
ENSE00003535970	870121	870163
ENSE00003538547	899340	899401
ENSE00003592892	883148	883303
ENSE00003594152	884068	884169
ENSE00003613969	902962	903111
ENSE00003621317	900004	900110
ENSE00003624404	900936	900980
ENSE00003657827	904706	904859
ENSE00003658118	870419	870499
ENSE00003693169	893427	893519

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 97.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.1529 / max 104.0594, expressed in 1813 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117847	28.6360	1811
117850	0.2646	103
117852	0.0734	34
117849	0.0591	29
117853	0.0575	14
117851	0.0239	11
117854	0.0213	8
117848	0.0076	2
206082	0.0059	4
117855	0.0035	1

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	97.86	gold quality
body of pancreas	UBERON:0001150	97.27	gold quality
right testis	UBERON:0004534	97.05	gold quality
left testis	UBERON:0004533	96.81	gold quality
pancreas	UBERON:0001264	96.14	gold quality
right lobe of liver	UBERON:0001114	96.07	gold quality
adenohypophysis	UBERON:0002196	96.00	gold quality
right adrenal gland cortex	UBERON:0035827	96.00	gold quality
islet of Langerhans	UBERON:0000006	95.97	gold quality
right uterine tube	UBERON:0001302	95.89	gold quality
right adrenal gland	UBERON:0001233	95.86	gold quality
left adrenal gland	UBERON:0001234	95.81	gold quality
left adrenal gland cortex	UBERON:0035825	95.61	gold quality
spleen	UBERON:0002106	95.59	gold quality
right coronary artery	UBERON:0001625	95.56	gold quality
right ovary	UBERON:0002118	95.36	gold quality
pituitary gland	UBERON:0000007	95.32	gold quality
left ovary	UBERON:0002119	95.32	gold quality
testis	UBERON:0000473	95.16	gold quality
right atrium auricular region	UBERON:0006631	94.92	gold quality
gall bladder	UBERON:0002110	94.87	gold quality
descending thoracic aorta	UBERON:0002345	94.72	gold quality
minor salivary gland	UBERON:0001830	94.71	gold quality
body of stomach	UBERON:0001161	94.67	gold quality
adrenal cortex	UBERON:0001235	94.64	gold quality
thoracic aorta	UBERON:0001515	94.63	gold quality
adrenal gland	UBERON:0002369	94.63	gold quality
ascending aorta	UBERON:0001496	94.59	gold quality
left coronary artery	UBERON:0001626	94.59	gold quality
endocervix	UBERON:0000458	94.56	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	27.39
E-ANND-3	yes	17.99
E-CURD-112	no	3.74

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting CHID1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-7150	99.62	66.80	1322
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-3191-3P	99.45	63.94	356
HSA-MIR-4763-3P	99.10	67.83	2649
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-6751-3P	98.44	66.35	835
HSA-MIR-1199-5P	98.44	66.51	829
HSA-MIR-4736	97.96	65.89	1287
HSA-MIR-6810-3P	97.96	64.57	1023
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-4253	97.48	65.11	692
HSA-MIR-6862-5P	97.48	64.84	713
HSA-MIR-5699-5P	97.36	67.03	1014
HSA-MIR-7106-3P	97.33	65.33	644

Literature-anchored findings (GeneRIF, showing 8)

• The crystals of SI-CLP belong to the space group P3(2)21 with unit cell parameters a=b=99.79 A, c=250.53 A, alpha=beta=90 degrees, gamma=120 degrees. (PMID:19275751)
• Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. (PMID:20724479)
• stabilin-1-interacting chitinase-like protein functions as a regulator of the inflammatory response in rheumatoid arthritis by macrophages. (PMID:24470346)
• This review comprehensively analyzes recent data about expression pattern, and involvement of human YKL-40, YKL-39 and SI-CLP in cancer. [review] (PMID:26733160)
• These results indicate that CHID1 positively regulates RLR antiviral signal, revealing the novel mechanism of the RIG-I antiviral signaling pathway. (PMID:31106867)
• CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer. (PMID:33466316)
• Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients. (PMID:33924468)
• Chitinase domain containing 1 increase is associated with low survival rate and M0 macrophages infiltrates in colorectal cancer patients. (PMID:35932496)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	chid1	ENSDARG00000069673
mus_musculus	Chid1	ENSMUSG00000025512
rattus_norvegicus	Chid1	ENSRNOG00000063613
drosophila_melanogaster	CG8460	FBGN0031996
caenorhabditis_elegans		WBGENE00019980

Paralogs (6): CHI3L2 (ENSG00000064886), OVGP1 (ENSG00000085465), CTBS (ENSG00000117151), CHI3L1 (ENSG00000133048), CHIT1 (ENSG00000133063), CHIA (ENSG00000134216)

Protein

Protein identifiers

Chitinase domain-containing protein 1 — Q9BWS9 (reviewed: Q9BWS9)

Alternative names: Stabilin-1-interacting chitinase-like protein

All UniProt accessions (14): E9PI70, E9PIP0, E9PJ91, E9PJL0, E9PKF1, E9PPA0, E9PPH0, E9PQZ0, E9PRL3, Q9BWS9, H0YC89, H0YCC4, H0YDL6, H0YEA3

UniProt curated annotations — full annotation on UniProt →

Function. Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).

Subunit / interactions. Interacts with STAB1.

Subcellular location. Secreted. Lysosome.

Tissue specificity. Expressed in cells of monocytic, T, B and epithelial origin.

Induction. Up-regulated by IL4/interleukin-4 and dexamethasone in the macrophages. Up-regulated by glucocorticoid.

Similarity. Belongs to the glycosyl hydrolase 18 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9BWS9-1	1	yes
Q9BWS9-2	2
Q9BWS9-3	3

RefSeq proteins (5): NP_001136146, NP_001136147, NP_001136148, NP_001136149, NP_076436* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001223	Glyco_hydro18_cat	Domain
IPR011583	Chitinase_II/V-like_cat	Domain
IPR017853	GH_hydrolase_sf	Homologous_superfamily
IPR029070	Chitinase_insertion_sf	Homologous_superfamily

Pfam: PF00704

UniProt features (52 total): helix 16, strand 16, mutagenesis site 6, turn 6, splice variant 2, sequence variant 2, signal peptide 1, chain 1, sequence conflict 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3BXW	X-RAY DIFFRACTION	2.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BWS9-F1	91.61	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (6):

Position	Phenotype
261	significantly decreased carbohydrate binding.
277	no noticeable effect.
302	significantly decreased carbohydrate binding.
84	significantly decreased carbohydrate binding.
88	significantly decreased carbohydrate binding.
110	significantly decreased carbohydrate binding.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-114608	Platelet degranulation

MSigDB gene sets: 114 (showing top): GOBP_INFLAMMATORY_RESPONSE, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, AP4_Q6, CAGCTG_AP4_Q5, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOCC_TRANS_GOLGI_NETWORK, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE, GOBP_CYTOKINE_PRODUCTION, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, AACTTT_UNKNOWN, GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION, CETS1P54_01, GOCC_LYSOSOMAL_LUMEN, GOCC_VACUOLAR_LUMEN

GO Biological Process (4): carbohydrate metabolic process (GO:0005975), innate immune response (GO:0045087), negative regulation of cytokine production involved in inflammatory response (GO:1900016), immune system process (GO:0002376)

GO Molecular Function (3): chitin binding (GO:0008061), oligosaccharide binding (GO:0070492), protein binding (GO:0005515)

GO Cellular Component (10): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), nucleus (GO:0005634), lysosome (GO:0005764), late endosome (GO:0005770), trans-Golgi network (GO:0005802), endomembrane system (GO:0012505), membrane (GO:0016020), lysosomal lumen (GO:0043202), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Response to elevated platelet cytosolic Ca2+	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
primary metabolic process	1
immune response	1
defense response to symbiont	1
negative regulation of cytokine production	1
cytokine production involved in inflammatory response	1
regulation of cytokine production involved in inflammatory response	1
biological_process	1
carbohydrate derivative binding	1
carbohydrate binding	1
binding	1
intracellular membrane-bounded organelle	1
lytic vacuole	1
endosome	1
Golgi apparatus subcompartment	1
vacuole	1
plasma membrane	1
lysosome	1
vacuolar lumen	1
extracellular vesicle	1

Protein interactions and networks

STRING

1055 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CHID1	STAB1	Q9NY15	840
CHID1	CHI3L2	Q15782	745
CHID1	CHIT1	Q13231	683
CHID1	CHIA	Q9BZP6	665
CHID1	CHI3L1	P30923	599
CHID1	OVGP1	Q12889	565
CHID1	SLC35A3	Q9Y2D2	488
CHID1	SLC35D2	Q76EJ3	473
CHID1	SLC35B4	Q969S0	453
CHID1	TIMM21	Q9BVV7	433
CHID1	CHIC1	Q5VXU3	427
CHID1	CNDP1	Q96KN2	402
CHID1	RAB29	O14966	396
CHID1	CNDP2	Q96KP4	388
CHID1	SLC35B3	Q9H1N7	375

IntAct

57 interactions, top by confidence:

A	B	Type	Score
C1QTNF9	C1QTNF9B	psi-mi:“MI:0914”(association)	0.780
B3GNT3	PGRMC1	psi-mi:“MI:0914”(association)	0.670
C1orf54	EXTL3	psi-mi:“MI:0914”(association)	0.530
GPIHBP1	ADAM10	psi-mi:“MI:0914”(association)	0.530
CHID1	HSPA5	psi-mi:“MI:0915”(physical association)	0.400
rep	UQCRB	psi-mi:“MI:0914”(association)	0.350
	PLXNB2	psi-mi:“MI:0914”(association)	0.350
TMEM106A	QSOX1	psi-mi:“MI:0914”(association)	0.350
KLK15	SPINT1	psi-mi:“MI:0914”(association)	0.350
PDGFRA	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CLEC12B	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CCL3	KRBA1	psi-mi:“MI:0914”(association)	0.350
PSCA	METTL15	psi-mi:“MI:0914”(association)	0.350
ST14	LIPT2	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	RTL8C	psi-mi:“MI:0914”(association)	0.350
GPIHBP1	SAC3D1	psi-mi:“MI:0914”(association)	0.350
C1QTNF7	AGRN	psi-mi:“MI:0914”(association)	0.350
TMEM25	NME4	psi-mi:“MI:0914”(association)	0.350
HPN	TOR1A	psi-mi:“MI:0914”(association)	0.350
PCDHB3	ESYT2	psi-mi:“MI:0914”(association)	0.350
TMEM106A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
LY86	TMEM131L	psi-mi:“MI:0914”(association)	0.350
P2RX2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
ASIC4	TMEM131L	psi-mi:“MI:0914”(association)	0.350
TMEM87A	POTEF	psi-mi:“MI:0914”(association)	0.350
NCR3	POTEF	psi-mi:“MI:0914”(association)	0.350
PI15		psi-mi:“MI:0914”(association)	0.350
MFAP4	QSOX1	psi-mi:“MI:0914”(association)	0.350
DPEP2	QSOX1	psi-mi:“MI:0914”(association)	0.350
PRG2	QSOX1	psi-mi:“MI:0914”(association)	0.350

BioGRID (92): CHID1 (Affinity Capture-MS), CHID1 (Co-fractionation), GAA (Co-fractionation), MAN2B1 (Co-fractionation), CHID1 (Proximity Label-MS), CHID1 (Affinity Capture-MS), CHID1 (Co-fractionation), CHID1 (Co-fractionation), CHID1 (Proximity Label-MS), CHID1 (Affinity Capture-RNA), CHID1 (Proximity Label-MS), CHID1 (Proximity Label-MS), CHID1 (Proximity Label-MS), CHID1 (Proximity Label-MS), CHID1 (Proximity Label-MS)

ESM2 similar proteins: A0JPQ9, O14657, O14672, O19015, O35598, P09958, P16098, P23188, P23377, P58780, P82993, Q01458, Q01460, Q08169, Q0JJD4, Q10741, Q10743, Q10RB4, Q1L8D2, Q28193, Q29LW1, Q29NU5, Q4V8H8, Q58D55, Q5EAB4, Q5GF25, Q5RFF6, Q66IL0, Q68EX9, Q6NXH2, Q6ZJJ0, Q7SYK0, Q7Z1Z1, Q8BH64, Q8MLZ7, Q8MX31, Q8MX32, Q8MX40, Q8T0R7, Q922Q9

Diamond homologs: A0JPQ9, Q54G42, Q5EAB4, Q5RFF6, Q66IL0, Q68EX9, Q7SYK0, Q922Q9, Q9BWS9, P37531

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	54
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1808628	GRCh37/hg19 11p15.5(chr11:461373-2157956)x4	Pathogenic

SpliceAI

3003 predictions. Top by Δscore:

Variant	Effect	Δscore
11:870117:GCAC:G	donor_loss	1.0000
11:870118:CA:C	donor_loss	1.0000
11:870119:A:AC	donor_gain	1.0000
11:870119:A:AG	donor_loss	1.0000
11:870120:C:CC	donor_gain	1.0000
11:870120:CCTT:C	donor_gain	1.0000
11:870159:GGCTC:G	acceptor_gain	1.0000
11:870161:CTC:C	acceptor_gain	1.0000
11:870162:TC:T	acceptor_gain	1.0000
11:870163:CC:C	acceptor_gain	1.0000
11:870164:C:CC	acceptor_gain	1.0000
11:870415:TCA:T	donor_loss	1.0000
11:870416:CACTT:C	donor_loss	1.0000
11:870417:A:AC	donor_gain	1.0000
11:870417:ACTT:A	donor_gain	1.0000
11:870418:C:CT	donor_gain	1.0000
11:870418:CT:C	donor_gain	1.0000
11:870418:CTT:C	donor_gain	1.0000
11:870418:CTTC:C	donor_gain	1.0000
11:870420:T:TA	donor_gain	1.0000
11:870495:TGTAC:T	acceptor_gain	1.0000
11:870497:TAC:T	acceptor_gain	1.0000
11:870498:AC:A	acceptor_gain	1.0000
11:870499:CC:C	acceptor_gain	1.0000
11:870500:C:CA	acceptor_loss	1.0000
11:884066:A:AC	donor_gain	1.0000
11:884067:C:CT	donor_gain	1.0000
11:884067:CTG:C	donor_gain	1.0000
11:884165:CGGTC:C	acceptor_gain	1.0000
11:884168:TC:T	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000075417 (11:880567 G>A), RS1000113020 (11:893442 G>A), RS1000118894 (11:886972 C>T), RS1000188214 (11:891354 T>A,G), RS1000215750 (11:877439 GTCTC>G,GTCTCTC), RS1000240364 (11:917176 G>A), RS1000295247 (11:899716 C>T), RS1000363576 (11:904461 T>G), RS1000385292 (11:897408 G>A), RS1000416172 (11:904180 C>G), RS1000436990 (11:902581 G>A), RS1000444226 (11:871697 G>A), RS1000450014 (11:894751 G>A), RS1000628612 (11:868466 C>T), RS1000653503 (11:873992 T>C)

Disease associations

OMIM: gene MIM:615692 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002625_2	Chronic bronchitis and chronic obstructive pulmonary disease	5.000000e-08
GCST010988_457	Adult body size	3.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, decreases expression, affects cotreatment, increases abundance, increases expression	3
bisphenol A	increases expression, affects cotreatment, affects methylation, decreases methylation	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Dexamethasone	decreases reaction, affects cotreatment, increases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
tremortin	decreases expression	1
beta-lapachone	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
aflatoxin B2	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
Fulvestrant	affects cotreatment, affects methylation, decreases methylation	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	decreases expression	1
Dinitrochlorobenzene	affects binding	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Lead	affects splicing	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Aflatoxin B1	decreases expression	1
Cadmium Chloride	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E8NR	LN229-CHID1	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.