CHKB-DT

Summary

CHKB-DT (CHKB divergent transcript, HGNC:40146) is a long non-coding RNA gene on chromosome 22q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40146
Approved symbol	CHKB-DT
Name	CHKB divergent transcript
Location	22q13.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00029632, HRAT
Ensembl gene	ENSG00000205559
Ensembl biotype	lncRNA
Entrez	100144603
RNAcentral	URS000075CF9B — lncRNA, 685 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000380711, ENST00000609758, ENST00000648558, ENST00000652967, ENST00000654355, ENST00000654727, ENST00000656328, ENST00000662119, ENST00000666183, ENST00000803312, ENST00000803313

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000380711 — 2 exons

Exon	Start	End
ENSE00001485992	50583598	50583877
ENSE00001485993	50583026	50583323

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 87.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5787 / max 54.2742, expressed in 1374 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193031	1.8013	1101
193030	0.7774	498

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	87.77	silver quality
right hemisphere of cerebellum	UBERON:0014890	85.41	gold quality
cerebellar hemisphere	UBERON:0002245	85.30	gold quality
cerebellar cortex	UBERON:0002129	85.21	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.11	gold quality
cerebellum	UBERON:0002037	83.91	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.93	gold quality
tibialis anterior	UBERON:0001385	80.26	silver quality
adenohypophysis	UBERON:0002196	80.17	gold quality
pituitary gland	UBERON:0000007	79.76	gold quality
cardiac muscle of right atrium	UBERON:0003379	79.64	gold quality
left ventricle myocardium	UBERON:0006566	79.47	gold quality
ileal mucosa	UBERON:0000331	78.52	silver quality
secondary oocyte	CL:0000655	77.32	silver quality
hypothalamus	UBERON:0001898	76.96	gold quality
cortical plate	UBERON:0005343	76.91	gold quality
right frontal lobe	UBERON:0002810	76.62	gold quality
right testis	UBERON:0004534	76.29	gold quality
apex of heart	UBERON:0002098	76.16	gold quality
right uterine tube	UBERON:0001302	76.00	gold quality
anterior cingulate cortex	UBERON:0009835	75.50	gold quality
left testis	UBERON:0004533	75.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.17	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.83	gold quality
nucleus accumbens	UBERON:0001882	74.29	gold quality
right adrenal gland	UBERON:0001233	73.96	gold quality
testis	UBERON:0000473	73.93	gold quality
kidney epithelium	UBERON:0004819	73.90	gold quality
spinal cord	UBERON:0002240	73.76	gold quality
brain	UBERON:0000955	73.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.