CHL1-AS1

Summary

CHL1-AS1 (CHL1 antisense RNA 1, HGNC:40148) is a long non-coding RNA gene on chromosome 3p26.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40148
Approved symbol	CHL1-AS1
Name	CHL1 antisense RNA 1
Location	3p26.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234661
Ensembl biotype	lncRNA
Entrez	101927193
RNAcentral	URS000075A688 — lncRNA, 910 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000417612, ENST00000608098

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417612 — 3 exons

Exon	Start	End
ENSE00001631050	382567	382732
ENSE00001707670	363370	364023
ENSE00001757081	385703	385795

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 84.20.

Top tissues by expression

229 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.20	gold quality
bone marrow cell	CL:0002092	72.81	gold quality
tibial nerve	UBERON:0001323	72.27	gold quality
colonic epithelium	UBERON:0000397	70.84	gold quality
ventricular zone	UBERON:0003053	68.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.74	gold quality
sural nerve	UBERON:0015488	64.73	gold quality
ganglionic eminence	UBERON:0004023	63.20	gold quality
cortical plate	UBERON:0005343	61.24	gold quality
metanephros cortex	UBERON:0010533	58.42	gold quality
monocyte	CL:0000576	57.16	gold quality
skin of leg	UBERON:0001511	56.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.31	gold quality
left ovary	UBERON:0002119	55.12	gold quality
corpus callosum	UBERON:0002336	53.79	gold quality
right ovary	UBERON:0002118	53.55	gold quality
zone of skin	UBERON:0000014	53.34	gold quality
skin of abdomen	UBERON:0001416	53.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	52.93	gold quality
lower esophagus	UBERON:0013473	52.90	gold quality
ovary	UBERON:0000992	52.66	gold quality
left coronary artery	UBERON:0001626	52.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.08	gold quality
vermiform appendix	UBERON:0001154	52.04	gold quality
islet of Langerhans	UBERON:0000006	51.82	gold quality
prefrontal cortex	UBERON:0000451	51.41	gold quality
tonsil	UBERON:0002372	51.38	gold quality
metanephros	UBERON:0000081	51.35	gold quality
cortex of kidney	UBERON:0001225	51.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer. (PMID:31736153)
• Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis. (PMID:34408418)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.