CHRM3-AS2

Summary

CHRM3-AS2 (CHRM3 antisense RNA 2, HGNC:43725) is a long non-coding RNA gene on chromosome 1q43.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43725
Approved symbol	CHRM3-AS2
Name	CHRM3 antisense RNA 2
Location	1q43
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233355
Ensembl biotype	lncRNA
Entrez	100506915
RNAcentral	URS000075AB95 — lncRNA, 893 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 14 lncRNA, 1 retained_intron

ENST00000427859, ENST00000428176, ENST00000458325, ENST00000593855, ENST00000596999, ENST00000600831, ENST00000610890, ENST00000627761, ENST00000628573, ENST00000650922, ENST00000833732, ENST00000833733, ENST00000833734, ENST00000833735, ENST00000833736

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000427859 — 5 exons

Exon	Start	End
ENSE00001599988	239706322	239706496
ENSE00001678725	239707534	239707760
ENSE00001695809	239718950	239719066
ENSE00001702188	239714177	239714264
ENSE00001765616	239703892	239705715

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 92.02.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 2.6892 / max 402.7349, expressed in 137 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18247	2.6676	134
18249	0.0142	3
18248	0.0074	3

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	92.02	gold quality
right testis	UBERON:0004534	89.83	gold quality
kidney epithelium	UBERON:0004819	88.75	gold quality
left testis	UBERON:0004533	88.12	gold quality
lymph node	UBERON:0000029	87.89	gold quality
left ventricle myocardium	UBERON:0006566	85.26	gold quality
cardiac muscle of right atrium	UBERON:0003379	85.18	gold quality
caecum	UBERON:0001153	84.80	gold quality
testis	UBERON:0000473	84.49	gold quality
granulocyte	CL:0000094	83.10	gold quality
upper arm skin	UBERON:0004263	83.04	gold quality
colonic epithelium	UBERON:0000397	82.83	gold quality
buccal mucosa cell	CL:0002336	82.37	gold quality
blood	UBERON:0000178	82.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.06	gold quality
spleen	UBERON:0002106	79.52	gold quality
tonsil	UBERON:0002372	78.96	gold quality
small intestine	UBERON:0002108	77.66	gold quality
myocardium	UBERON:0002349	77.20	gold quality
bone marrow cell	CL:0002092	75.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.10	gold quality
rectum	UBERON:0001052	73.97	gold quality
stomach	UBERON:0000945	73.17	gold quality
body of stomach	UBERON:0001161	73.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.46	gold quality
gall bladder	UBERON:0002110	69.63	gold quality
fundus of stomach	UBERON:0001160	69.50	gold quality
adrenal tissue	UBERON:0018303	69.47	gold quality
nasal cavity epithelium	UBERON:0005384	68.70	gold quality
bone marrow	UBERON:0002371	68.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.79

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.