CHROMR

Summary

CHROMR (cholesterol induced regulator of metabolism RNA, HGNC:54059) is a long non-coding RNA gene on chromosome 2q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54059
Approved symbol	CHROMR
Name	cholesterol induced regulator of metabolism RNA
Location	2q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	CHROME
Ensembl gene	ENSG00000223960
Ensembl biotype	lncRNA
OMIM	621027
Entrez	101927027
RNAcentral	URS000075DD89 — lncRNA, 2364 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 75 — 75 lncRNA

ENST00000415236, ENST00000420672, ENST00000436616, ENST00000442036, ENST00000450044, ENST00000453026, ENST00000454488, ENST00000659708, ENST00000660374, ENST00000661271, ENST00000662743, ENST00000663803, ENST00000665039, ENST00000666480, ENST00000668138, ENST00000671256, ENST00000671679, ENST00000684892, ENST00000686412, ENST00000688261, ENST00000688877, ENST00000690483, ENST00000691078, ENST00000691493, ENST00000691722, ENST00000692047, ENST00000700940, ENST00000701108, ENST00000701496, ENST00000701883, ENST00000701929, ENST00000702167, ENST00000702484, ENST00000702755, ENST00000702767, ENST00000723111, ENST00000723112, ENST00000723113, ENST00000723114, ENST00000723115, ENST00000723116, ENST00000723117, ENST00000723118, ENST00000723119, ENST00000723120, ENST00000723121, ENST00000723122, ENST00000723123, ENST00000723124, ENST00000723125, ENST00000723126, ENST00000723127, ENST00000723128, ENST00000723129, ENST00000723130, ENST00000723131, ENST00000723132, ENST00000723133, ENST00000723134, ENST00000723135, ENST00000723136, ENST00000723137, ENST00000723138, ENST00000723139, ENST00000723140, ENST00000723141, ENST00000723142, ENST00000723143, ENST00000723144, ENST00000723145, ENST00000723146, ENST00000723147, ENST00000723148, ENST00000723149, ENST00000723150

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415236 — 4 exons

Exon	Start	End
ENSE00001625508	178430770	178430889
ENSE00001749173	178426366	178426703
ENSE00003932402	178413925	178414113
ENSE00004044407	178432170	178432324

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 85.64.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.2661 / max 204.9543, expressed in 1698 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23933	9.4795	1662
23932	1.7867	1116

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	85.64	gold quality
adenohypophysis	UBERON:0002196	84.99	gold quality
calcaneal tendon	UBERON:0003701	83.91	gold quality
body of uterus	UBERON:0009853	83.56	gold quality
left ovary	UBERON:0002119	83.51	gold quality
monocyte	CL:0000576	83.35	gold quality
bone marrow cell	CL:0002092	83.33	gold quality
right ovary	UBERON:0002118	83.25	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.12	gold quality
leukocyte	CL:0000738	83.08	gold quality
pituitary gland	UBERON:0000007	82.88	gold quality
descending thoracic aorta	UBERON:0002345	82.77	gold quality
body of pancreas	UBERON:0001150	82.38	gold quality
buccal mucosa cell	CL:0002336	82.34	gold quality
left testis	UBERON:0004533	82.28	gold quality
endocervix	UBERON:0000458	82.24	gold quality
thoracic aorta	UBERON:0001515	82.02	gold quality
ascending aorta	UBERON:0001496	81.99	gold quality
tibial nerve	UBERON:0001323	81.97	gold quality
right lung	UBERON:0002167	81.93	gold quality
left coronary artery	UBERON:0001626	81.85	gold quality
islet of Langerhans	UBERON:0000006	81.82	gold quality
left lobe of thyroid gland	UBERON:0001120	81.80	gold quality
sperm	CL:0000019	81.54	gold quality
right testis	UBERON:0004534	81.52	gold quality
colonic epithelium	UBERON:0000397	81.50	gold quality
smooth muscle tissue	UBERON:0001135	81.48	gold quality
testis	UBERON:0000473	81.34	gold quality
right lobe of thyroid gland	UBERON:0001119	81.31	gold quality
stromal cell of endometrium	CL:0002255	81.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA CHROMR regulates antiviral immunity in humans. (PMID:36001732)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.