CIDEB

Summary

CIDEB (cell death inducing DFFA like effector b, HGNC:1977) is a protein-coding gene on chromosome 14q12, encoding Lipid transferase CIDEB (Q9UHD4). Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion.

Enables identical protein binding activity. Involved in lipid droplet fusion and positive regulation of apoptotic process. Acts upstream of or within apoptotic process. Located in cytosol and perinuclear region of cytoplasm. Is active in lipid droplet.

Source: NCBI Gene 27141 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 117 total
• MANE Select transcript: NM_001393339

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1977
Approved symbol	CIDEB
Name	cell death inducing DFFA like effector b
Location	14q12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000136305
Ensembl biotype	protein_coding
OMIM	604441
Entrez	27141

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 22 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000258807, ENST00000336557, ENST00000554411, ENST00000555471, ENST00000555817, ENST00000556756, ENST00000885634, ENST00000885635, ENST00000885636, ENST00000885637, ENST00000885638, ENST00000885639, ENST00000885640, ENST00000885641, ENST00000885642, ENST00000885643, ENST00000885644, ENST00000885645, ENST00000885646, ENST00000885647, ENST00000885648, ENST00000885649, ENST00000885650, ENST00000967605

RefSeq mRNA: 9 — MANE Select: NM_001393339 NM_001318807, NM_001393334, NM_001393335, NM_001393336, NM_001393337, NM_001393338, NM_001393339, NM_001393340, NM_014430

CCDS: CCDS32056

Canonical transcript exons

ENST00000554411 — 5 exons

Exon	Start	End
ENSE00000654428	24305947	24306137
ENSE00000654429	24306374	24306523
ENSE00000654430	24307371	24307515
ENSE00002236572	24305187	24305765
ENSE00002456528	24307818	24307977

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 98.37.

FANTOM5 (CAGE): breadth broad, TPM avg 6.1223 / max 800.5828, expressed in 771 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142593	2.8201	570
142588	1.7297	83
142589	0.7156	69
142590	0.3889	195
142591	0.2928	163
142594	0.0947	41
142587	0.0464	14
142592	0.0341	12

Top tissues by expression

135 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	98.37	gold quality
liver	UBERON:0002107	98.33	gold quality
duodenum	UBERON:0002114	98.27	gold quality
spleen	UBERON:0002106	95.77	gold quality
granulocyte	CL:0000094	93.63	gold quality
leukocyte	CL:0000738	92.55	gold quality
monocyte	CL:0000576	92.54	gold quality
blood	UBERON:0000178	92.11	gold quality
adrenal tissue	UBERON:0018303	91.82	gold quality
small intestine	UBERON:0002108	91.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	91.15	gold quality
esophagus mucosa	UBERON:0002469	90.27	gold quality
adult mammalian kidney	UBERON:0000082	89.83	gold quality
left adrenal gland cortex	UBERON:0035825	89.29	gold quality
lower esophagus mucosa	UBERON:0035834	88.90	gold quality
left adrenal gland	UBERON:0001234	88.65	gold quality
adrenal gland	UBERON:0002369	88.37	gold quality
right adrenal gland	UBERON:0001233	88.28	gold quality
left ovary	UBERON:0002119	87.97	gold quality
right adrenal gland cortex	UBERON:0035827	87.60	gold quality
kidney	UBERON:0002113	87.55	gold quality
ovary	UBERON:0000992	87.36	gold quality
right ovary	UBERON:0002118	87.33	gold quality
cortex of kidney	UBERON:0001225	86.89	gold quality
bone marrow	UBERON:0002371	86.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.14	gold quality
bone marrow cell	CL:0002092	85.87	gold quality
skin of abdomen	UBERON:0001416	85.85	gold quality
zone of skin	UBERON:0000014	85.65	gold quality
skin of leg	UBERON:0001511	85.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.26

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTCF

miRNA regulators (miRDB)

35 targeting CIDEB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-4728-3P	99.47	68.94	981
HSA-MIR-3612	99.45	66.02	1333
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4695-5P	99.06	64.87	1151
HSA-MIR-3145-3P	98.85	69.07	2031
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-4450	98.26	68.35	725
HSA-MIR-12126	98.09	64.82	637
HSA-MIR-637	97.91	64.05	1517
HSA-MIR-6728-5P	97.79	66.33	891
HSA-MIR-6783-5P	97.67	67.21	1528
HSA-MIR-3127-5P	97.52	65.24	786
HSA-MIR-6069	97.45	65.88	357
HSA-MIR-194-3P	97.36	65.96	1027
HSA-MIR-215-3P	97.02	68.01	1209
HSA-MIR-4695-3P	96.71	67.21	836

Literature-anchored findings (GeneRIF, showing 14)

• A novel mechanism for the cell-specific transcription of the human CIDE-B gene, which involves epigenetic and genetic control at separate respective promoters is reported. (PMID:16248853)
• PGC-1alpha plays an important role in partitioning cytoplasmic TG toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CideB. (PMID:20551328)
• CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma. (PMID:23475172)
• this work highlights CIDEB’s role in lipid droplet (LD) fusion, and presents a new model system to study the PGC-1alpha/CIDEB pathway’s role in LD dynamics and the VLDL pathway. (PMID:24161736)
• Authors found CIDEB to be an essential cofactor for hepatitis C virus entry into hepatocytes. (PMID:24829338)
• these data revealed that Cideb plays an important role in controlling intestinal chylomicron lipidation. (PMID:24831470)
• CIDEB can act as an anti-HCV host factor and contribute to altered triglyceride homeostasis. (PMID:24980280)
• CIDEB downregulation may contribute to HCV-induced hepatic steatosis (PMID:26865724)
• this study shows that C5a signaling induces apoptosis in brain vascular endothelial cells in experimental lupus through activation of CIDEB (PMID:27213693)
• CIDEB interacts with the HCV NS5A protein, and the N terminus of CIDEB and the domain I of NS5A are involved in this interaction. (PMID:27282740)
• High Cideb expression is associated with Ulcerative Colitis. (PMID:28719542)
• The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis. (PMID:31097771)
• Association of CIDEB gene promoter methylation with overweight or obesity in adults. (PMID:35475772)
• Germline Mutations in CIDEB and Protection against Liver Disease. (PMID:35939579)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cideb	ENSDARG00000012640
mus_musculus	Cideb	ENSMUSG00000022219
rattus_norvegicus	Cideb	ENSRNOG00000020377
drosophila_melanogaster	Drep2	FBGN0028408

Paralogs (3): DFFA (ENSG00000160049), CIDEA (ENSG00000176194), CIDEC (ENSG00000187288)

Protein

Protein identifiers

Lipid transferase CIDEB — Q9UHD4 (reviewed: Q9UHD4)

Alternative names: Cell death activator CIDE-B, Cell death-inducing DFFA-like effector B

All UniProt accessions (2): Q9UHD4, G3V4E2

UniProt curated annotations — full annotation on UniProt →

Function. Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes. In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport. Required for very-low-density lipoprotein (VLDL) lipidation and maturation. Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles. Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles. May also activate apoptosis. (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes.

Subunit / interactions. Interacts with DFFA. Interacts with DFFB; inhibited by DFFB. Interacts with APOB. Interacts with PREB/SEC12; facilitating loading of SCAP-SREBP into COPII vesicles. (Microbial infection) Interacts (via N-terminus) with HCV non-structural protein 5A (via N-terminus); this interaction seems to regulate the association of HCV particles with ApoE.

Subcellular location. Lipid droplet. Endoplasmic reticulum membrane. Golgi apparatus. Cytoplasmic vesicle. COPI-coated vesicle.

Tissue specificity. Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.

Similarity. Belongs to the CIDE family.

RefSeq proteins (9): NP_001305736, NP_001380263, NP_001380264, NP_001380265, NP_001380266, NP_001380267, NP_001380268, NP_001380269, NP_055245 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003508	CIDE-N_dom	Domain

Pfam: PF02017

UniProt features (15 total): strand 7, sequence conflict 3, helix 2, chain 1, domain 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1D4B	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UHD4-F1	73.40	0.11

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 177 (showing top): GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS, GNF2_GSTM1, GOBP_VESICLE_ORGANIZATION, GCANCTGNY_MYOD_Q6, GNF2_HPN, LUCAS_HNF4A_TARGETS_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY, chr14q12, GOBP_GLYCEROLIPID_METABOLIC_PROCESS, GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOBP_APOPTOTIC_SIGNALING_PATHWAY, GOCC_COATED_VESICLE, GNF2_LCAT

GO Biological Process (11): apoptotic process (GO:0006915), intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630), lipid storage (GO:0019915), response to nutrient levels (GO:0031667), very-low-density lipoprotein particle assembly (GO:0034379), positive regulation of apoptotic process (GO:0043065), COPII-coated vesicle cargo loading (GO:0090110), regulation of triglyceride metabolic process (GO:0090207), execution phase of apoptosis (GO:0097194), lipid droplet fusion (GO:0160077), intermembrane lipid transfer (GO:0120009)

GO Molecular Function (5): identical protein binding (GO:0042802), molecular adaptor activity (GO:0060090), phosphatidic acid binding (GO:0070300), lipid transfer activity (GO:0120013), protein binding (GO:0005515)

GO Cellular Component (11): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), lipid droplet (GO:0005811), cytosol (GO:0005829), COPII vesicle coat (GO:0030127), COPI-coated vesicle (GO:0030137), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	5
cellular anatomical structure	4
apoptotic process	2
binding	2
endomembrane system	2
intracellular membrane-bounded organelle	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
DNA damage response	1
intrinsic apoptotic signaling pathway	1
nutrient storage	1
response to stimulus	1
plasma lipoprotein particle assembly	1
regulation of apoptotic process	1
positive regulation of programmed cell death	1
vesicle cargo loading	1
intracellular transport	1
COPII-coated vesicle budding	1
triglyceride metabolic process	1
regulation of lipid metabolic process	1
cellular process	1
bleb assembly	1
lipid droplet organization	1
organelle fusion	1
lipid transport	1
membrane organization	1
protein binding	1
molecular_function	1
phospholipid binding	1
anion binding	1
transporter activity	1
lipid carrier activity	1
intermembrane lipid transfer	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
intracellular membraneless organelle	1
ER to Golgi transport vesicle membrane	1
vesicle coat	1

Protein interactions and networks

STRING

943 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CIDEB	DFFA	O00273	937
CIDEB	DFFB	O76075	904
CIDEB	LAMP1	P11279	871
CIDEB	APOB	P04114	789
CIDEB	PLIN1	O60240	729
CIDEB	FAS	P25445	629
CIDEB	CASP3	P42574	601
CIDEB	AOC3	Q16853	599
CIDEB	MTTP	P55157	551
CIDEB	LAMP2	P13473	545
CIDEB	EEA1	Q15075	544
CIDEB	KLRG1	Q96E93	540
CIDEB	PTPRC	P08575	528
CIDEB	IFNG	P01579	526
CIDEB	PLIN2	Q99541	521

IntAct

225 interactions, top by confidence:

A	B	Type	Score
CIDEB	CIDEB	psi-mi:“MI:0915”(physical association)	0.700
CIDEB	MVB12A	psi-mi:“MI:0915”(physical association)	0.560
TBX2	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
FUNDC2	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
SMARCC1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
NFU1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
CIDEB	RHBDD2	psi-mi:“MI:0915”(physical association)	0.560
COL10A1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
SCO2	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
MEST	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
SPG21	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
TEX44	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
TIMM17B	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
ABHD16A	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
CLCN1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
PPIF	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
DHRSX	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
TSR1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
PBX3	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
PDHX	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
PISD	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
CAND2	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
SCO1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
FKBP8	CIDEB	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (81): MVB12A (Affinity Capture-MS), MVB12A (Affinity Capture-MS), CIDEB (Affinity Capture-RNA), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid), CIDEB (Two-hybrid)

ESM2 similar proteins: A0A8M9QN10, A1BPI0, A2ARM1, A2CI97, A2CI98, A2CJ06, C9JE40, O15055, O43147, O54943, O70173, O70303, O70361, O95238, P0C2N6, P0C6P5, P56645, P59025, P59729, P97433, Q0P4K8, Q3TD16, Q5EB20, Q5PQS0, Q5SSZ5, Q5VUB5, Q6IRN0, Q6P4K6, Q76I79, Q7TSI1, Q80TQ5, Q80UW3, Q810F8, Q8C8C1, Q8CCC3, Q8CJE2, Q8N1W1, Q8ND61, Q8TB24, Q8WWF5

Diamond homologs: F1MN90, O00273, O54786, O60543, O70302, O70303, P56198, Q3T191, Q5XI33, Q96AQ7, Q9UHD4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 65 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Aerobic respiration and respiratory electron transport	6	14.8×	5e-04
Respiratory electron transport	5	13.2×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

117 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	98
Likely benign	2
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

667 predictions. Top by Δscore:

Variant	Effect	Δscore
14:24306134:CACT:C	acceptor_gain	1.0000
14:24306136:CT:C	acceptor_gain	1.0000
14:24306370:TTACC:T	donor_loss	1.0000
14:24306371:TACC:T	donor_loss	1.0000
14:24306372:A:AC	donor_gain	1.0000
14:24306372:AC:A	donor_gain	1.0000
14:24306372:ACC:A	donor_gain	1.0000
14:24306372:ACCC:A	donor_loss	1.0000
14:24306373:C:CC	donor_gain	1.0000
14:24306373:CC:C	donor_gain	1.0000
14:24306373:CCC:C	donor_gain	1.0000
14:24306402:TGCAA:T	donor_gain	1.0000
14:24306519:AATGC:A	acceptor_gain	1.0000
14:24306520:ATGC:A	acceptor_gain	1.0000
14:24306521:TGC:T	acceptor_gain	1.0000
14:24306522:GC:G	acceptor_gain	1.0000
14:24306523:CC:C	acceptor_gain	1.0000
14:24306523:CCT:C	acceptor_loss	1.0000
14:24306524:C:CC	acceptor_gain	1.0000
14:24306528:CCAA:C	acceptor_gain	1.0000
14:24306529:C:CT	acceptor_gain	1.0000
14:24306529:C:T	acceptor_gain	1.0000
14:24306530:A:T	acceptor_gain	1.0000
14:24306531:A:AC	acceptor_gain	1.0000
14:24306531:A:C	acceptor_gain	1.0000
14:24306535:C:CT	acceptor_gain	1.0000
14:24306536:A:T	acceptor_gain	1.0000
14:24307365:A:AC	donor_gain	1.0000
14:24307366:C:CC	donor_gain	1.0000
14:24307366:CTTA:C	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000076387 (14:24308808 C>A), RS1000519268 (14:24309126 A>C), RS1000657788 (14:24313263 G>A), RS1001512399 (14:24310053 C>T), RS1001777583 (14:24312013 T>A,C), RS1001807949 (14:24308372 A>G), RS1002566053 (14:24313250 C>T), RS1003131748 (14:24307754 G>A), RS1003612742 (14:24308066 C>T), RS1003777466 (14:24304905 G>A), RS1003797456 (14:24305241 A>C,G), RS1003920918 (14:24305611 G>A,C,T), RS1004174576 (14:24304827 A>C), RS1004288668 (14:24310888 C>T), RS1004397389 (14:24305083 A>C,G)

Disease associations

OMIM: gene MIM:604441 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002371_1	Parent of origin effect on language impairment (paternal)	4.000000e-08
GCST008163_14	Height	4.000000e-06
GCST010206_7	Anorectal malformation	4.000000e-16

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression, increases expression	3
Cyclosporine	decreases expression	3
sodium arsenite	decreases expression, increases expression	2
Arsenic Trioxide	decreases expression, increases expression	2
Fluorouracil	increases expression	2
Silicon Dioxide	decreases expression	2
Aflatoxin B1	decreases expression, affects expression	2
methyleugenol	decreases expression	1
propionaldehyde	decreases expression	1
VX-agent	increases expression	1
cobaltous chloride	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
2,3-dimethoxy-1,4-naphthoquinone	decreases expression	1
usnic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
pinostrobin	increases expression	1
Bortezomib	decreases expression	1
Rosiglitazone	decreases expression	1
Troglitazone	decreases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases expression	1
Cadmium	decreases expression	1
Cisplatin	increases expression	1
Dimethylnitrosamine	decreases expression	1
Endosulfan	decreases expression, affects cotreatment	1
Estradiol	decreases expression	1
Fluorides	affects cotreatment, decreases expression	1
Folic Acid	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.