CITED1

Summary

CITED1 (Cbp/p300 interacting transactivator with ED-rich tail 1, HGNC:1986) is a protein-coding gene on chromosome Xq13.1, encoding Cbp/p300-interacting transactivator 1 (Q99966). Transcriptional coactivator of the p300/CBP-mediated transcription complex.

This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described.

Source: NCBI Gene 4435 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 27 total
• MANE Select transcript: NM_001144887

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1986
Approved symbol	CITED1
Name	Cbp/p300 interacting transactivator with ED-rich tail 1
Location	Xq13.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000125931
Ensembl biotype	protein_coding
OMIM	300149
Entrez	4435

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 protein_coding

ENST00000246139, ENST00000373619, ENST00000417400, ENST00000427412, ENST00000429794, ENST00000431381, ENST00000445983, ENST00000450875, ENST00000453707, ENST00000454225, ENST00000651998, ENST00000940527, ENST00000940528, ENST00000940529, ENST00000940530, ENST00000940531, ENST00000940532

RefSeq mRNA: 4 — MANE Select: NM_001144887 NM_001144885, NM_001144886, NM_001144887, NM_004143

CCDS: CCDS14419, CCDS48136

Canonical transcript exons

ENST00000651998 — 3 exons

Exon	Start	End
ENSE00001660579	72305825	72305914
ENSE00003841476	72301646	72302244
ENSE00003889983	72302810	72302934

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 98.93.

FANTOM5 (CAGE): breadth broad, TPM avg 8.5537 / max 615.7310, expressed in 525 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199587	5.6767	278
199592	1.4539	231
199589	0.8573	182
199591	0.3299	165
199590	0.1577	77
199588	0.0782	46

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	98.93	gold quality
left testis	UBERON:0004533	98.72	gold quality
adenohypophysis	UBERON:0002196	98.37	gold quality
pituitary gland	UBERON:0000007	98.35	gold quality
testis	UBERON:0000473	98.25	gold quality
hypothalamus	UBERON:0001898	91.15	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.88	gold quality
prefrontal cortex	UBERON:0000451	81.58	gold quality
anterior cingulate cortex	UBERON:0009835	81.35	gold quality
frontal cortex	UBERON:0001870	80.22	gold quality
amygdala	UBERON:0001876	80.15	gold quality
temporal lobe	UBERON:0001871	80.05	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.81	gold quality
cerebral cortex	UBERON:0000956	79.57	gold quality
superior frontal gyrus	UBERON:0002661	79.07	gold quality
brain	UBERON:0000955	78.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.73	gold quality
right frontal lobe	UBERON:0002810	78.61	gold quality
embryo	UBERON:0000922	78.43	gold quality
ganglionic eminence	UBERON:0004023	78.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.08	gold quality
Ammon’s horn	UBERON:0001954	77.22	gold quality
nucleus accumbens	UBERON:0001882	75.98	gold quality
primary visual cortex	UBERON:0002436	75.68	gold quality
caudate nucleus	UBERON:0001873	75.31	gold quality
ventricular zone	UBERON:0003053	74.44	gold quality
left lobe of thyroid gland	UBERON:0001120	73.63	gold quality
putamen	UBERON:0001874	73.16	gold quality
prostate gland	UBERON:0002367	73.11	gold quality
right lobe of thyroid gland	UBERON:0001119	73.07	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-GEOD-124263	yes	1037.51
E-GEOD-134144	yes	48.41
E-HCAD-10	yes	35.13
E-GEOD-135922	yes	26.60
E-ANND-3	yes	14.12
E-MTAB-6058	no	20.51

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HIF1A, TOX3

Literature-anchored findings (GeneRIF, showing 14)

• CITED1 functions as a cell cycle-dependent transcriptional cofactor whose activity is regulated by phosphorylation (PMID:16864582)
• CITED1 could play a role in Wilms’ tumor initiation and pathogenesis. (PMID:17710162)
• TOX3 induces transcription in neuron depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. (PMID:21172805)
• epigenetic regulation is involved in the overexpression of CITED1 in papillary thyroid cancer (PMID:21449767)
• CITED1 expression remains active across all disease characteristics of Wilms tumor. It is found in the nucleus & cytosol. It is not found in normal kidney. (PMID:22703800)
• The CITED1 expression is correlated with lymph node metastasis in patients with colorectal cancer. (PMID:23746764)
• Thus deficiency of Cited1 leads to hyper-activation of Wnt signaling and an exaggerated Wnt phenotype including elevated cell death (PMID:23935526)
• Forced nuclear enrichment of CITED1 in a human WT cell line appears to enhance tumorigenicity, whereas ectopic cytosolic expression confers stem-like properties and an embryonic phenotype. (PMID:24481423)
• Regulation of macrophage IFNgamma-stimulated gene expression by the transcriptional coregulator CITED1. (PMID:36594555)
• Role of cited-1 and caspase-6 expression in HELLP syndrome. (PMID:37070911)
• CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer. (PMID:37322548)
• Effect of silencing CITED1 gene to regulate PI3K/AKT pathway on the biological function of PTC cells and its mechanism. (PMID:37807325)
• Roles and signaling pathways of CITED1 in tumors: overview and novel insights. (PMID:38190845)
• CITED1 expression in odontogenic cysts. (PMID:38997708)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cited1	ENSDARG00000077769
mus_musculus	Cited1	ENSMUSG00000051159
rattus_norvegicus	Cited1	ENSRNOG00000003189

Paralogs (2): CITED2 (ENSG00000164442), CITED4 (ENSG00000179862)

Protein

Protein identifiers

Cbp/p300-interacting transactivator 1 — Q99966 (reviewed: Q99966)

Alternative names: Melanocyte-specific protein 1

All UniProt accessions (6): Q99966, C9J1P6, C9J300, C9J7P8, C9JRD8, H7C2S6

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.

Subunit / interactions. Interacts (via C-terminus) with CREBBP. Interacts with EGR2. Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner. Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Expressed only in melanocytes and testis.

Post-translational modifications. Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.

Induction. Up-regulated by GPR39 in neuronal cells.

Similarity. Belongs to the CITED family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q99966-1	1	yes
Q99966-2	2

RefSeq proteins (4): NP_001138357, NP_001138358, NP_001138359, NP_004134 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007576	CITED	Family

Pfam: PF04487

UniProt features (24 total): mutagenesis site 16, region of interest 3, chain 1, short sequence motif 1, compositionally biased region 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99966-F1	60.42	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (16):

Position	Phenotype
67	strongly reduces phosphorylation but does not interfere with its nes-dependent nuclear export; when associated with a-16
71	strongly reduces phosphorylation but does not interfere with its nes-dependent nuclear export; when associated with a-16
91	does not change subcellular localization; when associated with a-95.
95	does not change subcellular localization; when associated with a-91.
137	strongly reduces phosphorylation; when associated with a-16; a-63; a-67 and a-71.
155–156	does not inhibit interaction with esr1 and er-coactivation activity.
157–158	inhibits interaction with esr1 and er-coactivation activity.
159–160	does not inhibit interaction with esr1 and er-coactivation activity.
161–162	does not inhibit interaction with esr1 and er-coactivation activity.
163–164	does not inhibit interaction with esr1 and er-coactivation activity.
165	does not inhibit interaction with esr1 and er-coactivation activity. localizes mainly in the nucleus; when associated wi
166–167	does not inhibit interaction with esr1 and er-coactivation activity. localizes mainly in the nucleus; when associated wi
176	does not change subcellular localization; when associated with a-178.
178	does not change subcellular localization; when associated with a-176.
16	strongly reduces phosphorylation but does not interfere with its nes-dependent nuclear export; when associated with a-63
63	strongly reduces phosphorylation but does not interfere with its nes-dependent nuclear export; when associated with a-16

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-8866907	Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-9018519	Estrogen-dependent gene expression

MSigDB gene sets: 261 (showing top): GOBP_SMAD_PROTEIN_SIGNAL_TRANSDUCTION, GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOBP_LABYRINTHINE_LAYER_DEVELOPMENT, BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, BENPORATH_ES_WITH_H3K27ME3, GOBP_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS, GOBP_METANEPHROS_DEVELOPMENT, GOBP_RESPONSE_TO_INTERLEUKIN_4, GOBP_RESPONSE_TO_PEPTIDE

GO Biological Process (42): vasculogenesis (GO:0001570), metanephros development (GO:0001656), branching involved in ureteric bud morphogenesis (GO:0001658), placenta development (GO:0001890), regulation of transcription by RNA polymerase II (GO:0006357), nucleocytoplasmic transport (GO:0006913), apoptotic process (GO:0006915), transforming growth factor beta receptor signaling pathway (GO:0007179), brain development (GO:0007420), positive regulation of gene expression (GO:0010628), negative regulation of Wnt signaling pathway (GO:0030178), melanocyte differentiation (GO:0030318), positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511), response to lipopolysaccharide (GO:0032496), response to insulin (GO:0032868), response to cytokine (GO:0034097), response to type II interferon (GO:0034341), melanin biosynthetic process (GO:0042438), regulation of apoptotic process (GO:0042981), pigmentation (GO:0043473), negative regulation of neuron apoptotic process (GO:0043524), response to estrogen (GO:0043627), negative regulation of osteoblast differentiation (GO:0045668), negative regulation of DNA-templated transcription (GO:0045892), positive regulation of DNA-templated transcription (GO:0045893), positive regulation of transcription by RNA polymerase II (GO:0045944), response to cAMP (GO:0051591), mesenchymal to epithelial transition (GO:0060231), SMAD protein signal transduction (GO:0060395), labyrinthine layer development (GO:0060711), response to interleukin-1 (GO:0070555), response to interleukin-2 (GO:0070669), response to interleukin-4 (GO:0070670), response to interleukin-6 (GO:0070741), response to interleukin-9 (GO:0071104), response to interleukin-11 (GO:0071105), response to parathyroid hormone (GO:0071107), response to transforming growth factor beta (GO:0071559), regulation of kidney development (GO:0090183), positive regulation of mesenchymal stem cell proliferation (GO:1902462)

GO Molecular Function (6): chromatin binding (GO:0003682), transcription coactivator activity (GO:0003713), protein homodimerization activity (GO:0042803), LBD domain binding (GO:0050693), co-SMAD binding (GO:0070410), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	1
ESR-mediated signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
animal organ development	2
binding	2
cell differentiation	1
blood vessel morphogenesis	1
kidney development	1
branching morphogenesis of an epithelial tube	1
ureteric bud morphogenesis	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
nuclear transport	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
cellular response to transforming growth factor beta stimulus	1
transforming growth factor beta receptor superfamily signaling pathway	1
central nervous system development	1
head development	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
negative regulation of signal transduction	1
Wnt signaling pathway	1
regulation of Wnt signaling pathway	1
pigment cell differentiation	1
transforming growth factor beta receptor signaling pathway	1
regulation of transforming growth factor beta receptor signaling pathway	1
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
positive regulation of cellular response to transforming growth factor beta stimulus	1
response to molecule of bacterial origin	1
response to lipid	1
response to oxygen-containing compound	1
response to peptide hormone	1
response to peptide	1
response to cytokine	1
innate immune response	1
melanin metabolic process	1
secondary metabolite biosynthetic process	1
pigment biosynthetic process	1
phenol-containing compound biosynthetic process	1

Protein interactions and networks

STRING

908 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CITED1	SIX2	Q9NPC8	784
CITED1	EP300	Q09472	690
CITED1	SMAD4	Q13485	686
CITED1	TMEM26	Q6ZUK4	658
CITED1	EYA1	Q99502	634
CITED1	UCP1	P25874	600
CITED1	FOXD1	Q16676	591
CITED1	PAX2	Q02962	590
CITED1	WNT9B	O14905	589
CITED1	SALL1	Q9NSC2	588
CITED1	LHX1	P48742	584
CITED1	CIDEA	O60543	557
CITED1	TBX1	O43435	545
CITED1	WT1	P19544	538
CITED1	PRDM16	Q9HAZ2	524

IntAct

31 interactions, top by confidence:

A	B	Type	Score
CASP6	CITED1	psi-mi:“MI:0915”(physical association)	0.560
CCK	CITED1	psi-mi:“MI:0915”(physical association)	0.560
	CITED1	psi-mi:“MI:0915”(physical association)	0.560
FKBP1A	CITED1	psi-mi:“MI:0915”(physical association)	0.560
LAMP2	CITED1	psi-mi:“MI:0915”(physical association)	0.560
CITED1	ESR1	psi-mi:“MI:0915”(physical association)	0.520
ESR1	CITED1	psi-mi:“MI:0915”(physical association)	0.520
JUN	CITED1	psi-mi:“MI:0915”(physical association)	0.520
Twist1	CITED1	psi-mi:“MI:0915”(physical association)	0.400
CITED1		psi-mi:“MI:0915”(physical association)	0.400
ATF2	CITED1	psi-mi:“MI:0915”(physical association)	0.400
CITED1	E2	psi-mi:“MI:0915”(physical association)	0.400
	CITED1	psi-mi:“MI:0914”(association)	0.350
CITED1		psi-mi:“MI:0914”(association)	0.350
CITED1	RAD21	psi-mi:“MI:0914”(association)	0.350
CITED1	AURKA	psi-mi:“MI:0914”(association)	0.350

BioGRID (42): CITED1 (Affinity Capture-Western), CTNNB1 (Affinity Capture-Western), EP300 (Affinity Capture-Western), CITED1 (Affinity Capture-Western), SMAD4 (Two-hybrid), TFAP2B (Reconstituted Complex), CITED1 (Affinity Capture-Western), CITED1 (Affinity Capture-Western), CITED1 (Reconstituted Complex), HSPA8 (Affinity Capture-Western), HSPA8 (Phenotypic Suppression), RLIM (Affinity Capture-MS), RAD21 (Affinity Capture-MS), RB1 (Affinity Capture-MS), CCNA2 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GUA6, A2BIL8, A4IGV6, A6H5Y1, A8E653, B3DHS1, D6RIA3, E0CYV9, E9Q309, O14513, P05432, P08651, P09414, P09511, P0CAX8, P17923, P21999, Q02780, Q12857, Q1KN21, Q1T763, Q32LN6, Q3URK1, Q3ZBS1, Q5RDK8, Q5U4U4, Q5VT06, Q5ZM13, Q62417, Q68D20, Q6DFB0, Q6NWJ0, Q6P1U0, Q6P9N1, Q6PKN7, Q811V6, Q86YL5, Q8BLN6, Q8N2C7, Q8VEB3

Diamond homologs: A1YFU7, O35740, P97769, Q0VCT9, Q2HJ78, Q5XGW7, Q6NX30, Q96RK1, Q99966, Q99967, Q99MA0, Q9BDI3, Q9I8K7, Q9WUL8

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
NfKb-p65/p50	up-regulates	CITED1	binding
RELA	up-regulates	CITED1	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

27 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	18
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

730 predictions. Top by Δscore:

Variant	Effect	Δscore
X:72302241:CATC:C	acceptor_gain	1.0000
X:72302242:ATC:A	acceptor_gain	1.0000
X:72302243:TC:T	acceptor_gain	1.0000
X:72302244:CC:C	acceptor_gain	1.0000
X:72302245:C:CA	acceptor_loss	1.0000
X:72302245:C:CC	acceptor_gain	1.0000
X:72302246:T:A	acceptor_loss	1.0000
X:72302805:ATTAC:A	donor_loss	1.0000
X:72302807:TA:T	donor_loss	1.0000
X:72302808:A:AT	donor_loss	1.0000
X:72302808:ACCT:A	donor_gain	1.0000
X:72302809:CCTC:C	donor_gain	1.0000
X:72302811:T:TA	donor_gain	1.0000
X:72302930:TTGTG:T	acceptor_gain	1.0000
X:72302931:TGTG:T	acceptor_gain	1.0000
X:72302933:TG:T	acceptor_gain	1.0000
X:72302935:C:CC	acceptor_gain	1.0000
X:72302135:G:A	donor_gain	0.9900
X:72302154:C:CT	donor_gain	0.9900
X:72302155:T:TT	donor_gain	0.9900
X:72302932:GTG:G	acceptor_gain	0.9900
X:72302933:TGC:T	acceptor_loss	0.9900
X:72302934:GC:G	acceptor_loss	0.9900
X:72302935:CTG:C	acceptor_loss	0.9900
X:72302941:G:C	acceptor_gain	0.9900
X:72302941:G:GC	acceptor_gain	0.9900
X:72305696:A:AC	donor_gain	0.9900
X:72305697:C:CC	donor_gain	0.9900
X:72302195:TTC:T	donor_gain	0.9800
X:72302240:GCATC:G	acceptor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000067267 (X:72303942 C>A,G), RS1000356406 (X:72304379 G>C), RS1000739321 (X:72308529 A>C), RS1001429042 (X:72305307 G>C), RS1001664209 (X:72306740 A>C), RS1001796187 (X:72306660 A>ACCGCG), RS1002143891 (X:72306233 C>G,T), RS1002746540 (X:72303340 C>T), RS1003129186 (X:72307538 G>A), RS1003523516 (X:72308069 G>A,T), RS1003871549 (X:72303430 C>A,T), RS1004759327 (X:72305742 C>G), RS1005258728 (X:72307287 G>A,T), RS1005917294 (X:72308121 G>T), RS1006005727 (X:72305466 C>T)

Disease associations

OMIM: gene MIM:300149 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006030_19	Chloride levels	8.000000e-21
GCST006032_1	Sodium levels	6.000000e-35
GCST012466_5	Autism spectrum disorder	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009282	sodium measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression, increases mutagenesis	3
Valproic Acid	affects expression, decreases expression, increases expression	3
methylmercuric chloride	decreases expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
butyraldehyde	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Decitabine	increases expression	1
Acetaminophen	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dexamethasone	decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	decreases expression	1
Dust	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Quercetin	decreases expression	1
Dihydrotestosterone	increases expression	1
Tretinoin	decreases expression	1
Tunicamycin	increases expression	1
Aflatoxin B1	decreases methylation	1
Asbestos, Serpentine	increases expression	1
Okadaic Acid	increases expression	1
Copper Sulfate	increases expression	1
Chlorodiphenyl (54% Chlorine)	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A0R7	SEES3-1V human CITED1, clone1	Embryonic stem cell	Male
CVCL_A0R8	SEES3-1V human CITED1, clone2	Embryonic stem cell	Male
CVCL_A0R9	SEES3-1V human CITED1, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.