CLEC4D

Summary

CLEC4D (C-type lectin domain family 4 member D, HGNC:14554) is a protein-coding gene on chromosome 12p13.31, encoding C-type lectin domain family 4 member D (Q8WXI8). Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi.

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Source: NCBI Gene 338339 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_080387

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14554
Approved symbol	CLEC4D
Name	C-type lectin domain family 4 member D
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	Mpcl, CD368, MCL, Dectin-3
Ensembl gene	ENSG00000166527
Ensembl biotype	protein_coding
OMIM	609964
Entrez	338339

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000299665, ENST00000382064, ENST00000959647

RefSeq mRNA: 1 — MANE Select: NM_080387 NM_080387

CCDS: CCDS8593

Canonical transcript exons

ENST00000299665 — 6 exons

Exon	Start	End
ENSE00001103860	8518164	8518274
ENSE00001103867	8515236	8515328
ENSE00001103870	8519009	8519160
ENSE00001103874	8520226	8520341
ENSE00001234025	8521124	8522366
ENSE00001234035	8513503	8513760

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 91.56.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 2.0182 / max 598.0148, expressed in 170 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123971	1.7460	147
123970	0.1918	84
123972	0.0341	9
123966	0.0190	4
123968	0.0127	4
123969	0.0084	4
123965	0.0034	1
123967	0.0027	1

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	91.56	gold quality
monocyte	CL:0000576	91.35	gold quality
leukocyte	CL:0000738	90.78	gold quality
bone marrow cell	CL:0002092	89.00	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.76	gold quality
blood	UBERON:0000178	83.23	gold quality
granulocyte	CL:0000094	82.36	gold quality
trabecular bone tissue	UBERON:0002483	80.93	gold quality
right lung	UBERON:0002167	75.00	gold quality
vermiform appendix	UBERON:0001154	74.32	gold quality
spleen	UBERON:0002106	71.65	gold quality
caecum	UBERON:0001153	66.99	gold quality
upper lobe of left lung	UBERON:0008952	65.51	gold quality
upper lobe of lung	UBERON:0008948	63.61	gold quality
buccal mucosa cell	CL:0002336	59.56	gold quality
tendon of biceps brachii	UBERON:0008188	57.71	silver quality
lung	UBERON:0002048	56.99	gold quality
myocardium	UBERON:0002349	56.26	gold quality
left uterine tube	UBERON:0001303	55.58	gold quality
descending thoracic aorta	UBERON:0002345	54.92	gold quality
smooth muscle tissue	UBERON:0001135	54.84	gold quality
gall bladder	UBERON:0002110	54.74	gold quality
oviduct epithelium	UBERON:0004804	54.50	gold quality
lymph node	UBERON:0000029	54.07	gold quality
omental fat pad	UBERON:0010414	53.84	gold quality
peritoneum	UBERON:0002358	53.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	53.62	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	53.61	gold quality
adipose tissue of abdominal region	UBERON:0007808	53.24	gold quality
fallopian tube	UBERON:0003889	50.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.37

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

69 targeting CLEC4D, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-12130	99.75	65.47	452
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-1251-3P	99.64	67.21	1408

Literature-anchored findings (GeneRIF, showing 6)

• Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor. (PMID:14971047)
• CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule (PMID:22689578)
• Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants. (PMID:24101491)
• The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells. (PMID:29616019)
• The Mincle/Syk/NF-kappaB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages. (PMID:32532809)
• C-type lectin receptor Dectin3 deficiency balances the accumulation and function of FoxO1-mediated LOX-1(+) M-MDSCs in relieving lupus-like symptoms. (PMID:34480018)

Cross-species orthologs

21 orthologs

Organism	Symbol	Gene ID
danio_rerio	asgr1c.2	ENSDARG00000046092
danio_rerio	si:dkey-61f9.1	ENSDARG00000070414
danio_rerio	asgr1a	ENSDARG00000095963
danio_rerio	si:cabz01007816.2	ENSDARG00000102537
danio_rerio	asgr1b	ENSDARG00000103480
danio_rerio	si:ch211-283g2.5	ENSDARG00000108953
danio_rerio		ENSDARG00000111755
danio_rerio		ENSDARG00000112842
mus_musculus	Clec4d	ENSMUSG00000030144
rattus_norvegicus	Clec4d	ENSRNOG00000067848
drosophila_melanogaster	tfc	FBGN0035199
drosophila_melanogaster	CG14866	FBGN0038315
drosophila_melanogaster	lectin-46Cb	FBGN0040092
drosophila_melanogaster	lectin-46Ca	FBGN0040093
drosophila_melanogaster	lectin-33A	FBGN0040096
drosophila_melanogaster	CG34033	FBGN0054033
caenorhabditis_elegans	clec-87	WBGENE00007709
caenorhabditis_elegans	clec-91	WBGENE00014117
caenorhabditis_elegans		WBGENE00016088
caenorhabditis_elegans		WBGENE00018692
caenorhabditis_elegans		WBGENE00019606

Paralogs (14): CD209 (ENSG00000090659), FCER2 (ENSG00000104921), CLEC4M (ENSG00000104938), CLEC4A (ENSG00000111729), CD207 (ENSG00000116031), CLEC10A (ENSG00000132514), ASGR1 (ENSG00000141505), CLEC4F (ENSG00000152672), ASGR2 (ENSG00000161944), CLEC4E (ENSG00000166523), CLEC4G (ENSG00000182566), CLEC17A (ENSG00000187912), CLEC4C (ENSG00000198178), CLEC6A (ENSG00000205846)

Protein

Protein identifiers

C-type lectin domain family 4 member D — Q8WXI8 (reviewed: Q8WXI8)

Alternative names: C-type lectin superfamily member 8, C-type lectin-like receptor 6, Dendritic cell-associated C-type lectin 3

All UniProt accessions (2): A6NHA5, Q8WXI8

UniProt curated annotations — full annotation on UniProt →

Function. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6’-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells.

Subunit / interactions. Heterodimer with CLEC4E; disulfide-linked. CLEC4E acts as a bridge for interaction between CLEC4D and FCER1G to form a functional complex. Heterodimer with CLEC6A; this heterodimer forms a pattern recognition receptor (PRR) against fungal infection.

Subcellular location. Cell membrane.

Tissue specificity. Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF and IFN-gamma.

Induction. By autocrine inflammatory stimuli.

RefSeq proteins (1): NP_525126* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001304	C-type_lectin-like	Domain
IPR016186	C-type_lectin-like/link_sf	Homologous_superfamily
IPR016187	CTDL_fold	Homologous_superfamily
IPR033989	CD209-like_CTLD	Domain
IPR050111	C-type_lectin/snaclec_domain	Family

Pfam: PF00059

UniProt features (32 total): strand 11, binding site 4, glycosylation site 3, disulfide bond 3, topological domain 2, mutagenesis site 2, helix 2, chain 1, sequence variant 1, transmembrane region 1, turn 1, domain 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
3WHD	X-RAY DIFFRACTION	2.29
2LS8	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WXI8-F1	86.58	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 173; 175; 195; 196

Disulfide bonds (3): 84–95, 112–207, 182–199

Glycosylation sites (3): 102, 111, 45

Mutagenesis-validated functional residues (2):

Position	Phenotype
173	no effect on already low affinity binding to trehalose-6,6’-dimycolate.
175	no effect on already low affinity binding to trehalose-6,6’-dimycolate.

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-5621480	Dectin-2 family
R-HSA-6798695	Neutrophil degranulation

MSigDB gene sets: 185 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GOBP_REGULATION_OF_CELL_ACTIVATION, REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, GOBP_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE, GOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION, GOCC_CELL_SURFACE, AP4_Q6, CAGCTG_AP4_Q5, GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE, TCF4_Q5, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE, GOBP_MYELOID_LEUKOCYTE_ACTIVATION

GO Biological Process (9): adaptive immune response (GO:0002250), T cell differentiation involved in immune response (GO:0002292), positive regulation of myeloid dendritic cell activation (GO:0030887), Fc-gamma receptor signaling pathway (GO:0038094), defense response to bacterium (GO:0042742), positive regulation of canonical NF-kappaB signal transduction (GO:0043123), antifungal innate immune response (GO:0061760), immune system process (GO:0002376), innate immune response (GO:0045087)

GO Molecular Function (6): D-mannose binding (GO:0005537), carbohydrate binding (GO:0030246), immunoglobulin receptor binding (GO:0034987), pattern recognition receptor activity (GO:0038187), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (6): plasma membrane (GO:0005886), external side of plasma membrane (GO:0009897), specific granule membrane (GO:0035579), tertiary granule membrane (GO:0070821), ficolin-1-rich granule membrane (GO:0101003), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
C-type lectin receptors (CLRs)	1
Innate Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
immune response	3
secretory granule membrane	3
binding	2
tertiary granule	2
T cell activation involved in immune response	1
T cell differentiation	1
myeloid dendritic cell activation	1
positive regulation of leukocyte activation	1
regulation of myeloid dendritic cell activation	1
Fc receptor signaling pathway	1
defense response	1
response to bacterium	1
canonical NF-kappaB signal transduction	1
regulation of canonical NF-kappaB signal transduction	1
positive regulation of intracellular signal transduction	1
innate immune response	1
defense response to fungus	1
biological_process	1
defense response to symbiont	1
monosaccharide binding	1
signaling receptor binding	1
signaling receptor activity	1
cation binding	1
membrane	1
cell periphery	1
plasma membrane	1
cell surface	1
side of membrane	1
specific granule	1
ficolin-1-rich granule	1
cellular anatomical structure	1

Protein interactions and networks

STRING

936 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CLEC4D	CLEC6A	Q6EIG7	950
CLEC4D	FCER1G	P30273	851
CLEC4D	SYK	P43405	798
CLEC4D	CLEC7A	Q9BXN2	798
CLEC4D	CLEC4E	Q9ULY5	739
CLEC4D	CARD9	Q9H257	706
CLEC4D	CLEC9A	Q6UXN8	698
CLEC4D	CLEC1A	Q8NC01	578
CLEC4D	PRRG4	Q9BZD6	572
CLEC4D	MALT1	Q9UDY8	521
CLEC4D	BCL10	O95999	517
CLEC4D	IL6	P05231	517
CLEC4D	CLEC12A	Q5QGZ9	493
CLEC4D	CLEC12B	Q2HXU8	458
CLEC4D	VNN1	O95497	438

IntAct

13 interactions, top by confidence:

A	B	Type	Score
ACTN2	CLEC4D	psi-mi:“MI:0915”(physical association)	0.560
JAGN1	CLEC4D	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC22	CLEC4D	psi-mi:“MI:0915”(physical association)	0.560
ANKRD46	CLEC4D	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC22	CLEC4D	psi-mi:“MI:0915”(physical association)	0.000
ANKRD46	CLEC4D	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (313): CLEC4D (Two-hybrid), JAGN1 (Two-hybrid), ZDHHC22 (Two-hybrid), ANKRD46 (Two-hybrid), MYO1C (Affinity Capture-MS), PGRMC1 (Affinity Capture-MS), CLIC1 (Affinity Capture-MS), IPO5 (Affinity Capture-MS), CLGN (Affinity Capture-MS), SPTBN2 (Affinity Capture-MS), SEC16A (Affinity Capture-MS), ARPC3 (Affinity Capture-MS), SPINT2 (Affinity Capture-MS), MYO1B (Affinity Capture-MS), LANCL1 (Affinity Capture-MS)

ESM2 similar proteins: A4KWA5, A4KWA6, A4KWA8, B2KG20, D4AD02, O54709, O70215, P26717, P26718, P27471, P27811, P27814, P37217, P61252, Q07108, Q07444, Q0H8B9, Q149M0, Q504P2, Q5DT36, Q5DT37, Q5DT39, Q5M9I1, Q5RFR2, Q60652, Q60654, Q68D85, Q6QLQ4, Q6UXN8, Q80XD9, Q80ZC8, Q8C1T8, Q8MI05, Q8MJH1, Q8VBX4, Q8VI21, Q8WXI8, Q91V08, Q925N7, Q95MI4

Diamond homologs: A5PMY6, A6QP79, D3ZWT9, O14594, P02706, P02707, P05451, P06734, P07306, P07307, P07897, P07898, P08290, P08661, P10716, P10758, P11226, P13608, P13611, P16112, P19999, P20693, P22897, P24721, P34927, P41317, P43137, P48304, P49300, P49301, P55066, P55067, P60883, P70194, P81282, P82596, P86854, Q28343, Q28670, Q29011

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

775 predictions. Top by Δscore:

Variant	Effect	Δscore
12:8513761:G:GG	donor_gain	1.0000
12:8515234:A:AG	acceptor_gain	1.0000
12:8515235:G:GG	acceptor_gain	1.0000
12:8518282:GT:G	donor_gain	1.0000
12:8518280:GAGT:G	donor_gain	0.9900
12:8519002:A:AG	acceptor_gain	0.9900
12:8519002:ACTT:A	acceptor_gain	0.9900
12:8520338:GAGT:G	donor_gain	0.9900
12:8520340:GT:G	donor_gain	0.9900
12:8521122:A:AG	acceptor_gain	0.9900
12:8521123:G:GG	acceptor_gain	0.9900
12:8513757:AAACG:A	donor_loss	0.9800
12:8513759:ACG:A	donor_loss	0.9800
12:8513760:CG:C	donor_loss	0.9800
12:8513761:G:C	donor_loss	0.9800
12:8513762:T:G	donor_loss	0.9800
12:8513763:GAGTA:G	donor_loss	0.9800
12:8513764:AGTAC:A	donor_loss	0.9800
12:8515227:T:TA	acceptor_gain	0.9800
12:8519005:T:TA	acceptor_gain	0.9800
12:8519008:G:A	acceptor_gain	0.9800
12:8520342:G:GG	donor_gain	0.9800
12:8521118:TTTCA:T	acceptor_loss	0.9800
12:8521119:TTCA:T	acceptor_loss	0.9800
12:8521120:TCA:T	acceptor_loss	0.9800
12:8521121:CAGA:C	acceptor_loss	0.9800
12:8521122:AGAT:A	acceptor_loss	0.9800
12:8513759:AC:A	donor_gain	0.9700
12:8515234:AGT:A	acceptor_gain	0.9700
12:8515235:GTG:G	acceptor_gain	0.9700

AlphaMissense

1441 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:8519098:A:C	S108R	0.937
12:8519100:T:A	S108R	0.937
12:8519100:T:G	S108R	0.937
12:8519091:G:C	W105C	0.924
12:8519091:G:T	W105C	0.924
12:8520265:T:C	F142L	0.917
12:8520267:C:A	F142L	0.917
12:8520267:C:G	F142L	0.917
12:8520309:G:C	W156C	0.908
12:8520309:G:T	W156C	0.908
12:8521199:G:C	W192C	0.904
12:8521199:G:T	W192C	0.904
12:8519040:G:C	W88C	0.901
12:8519040:G:T	W88C	0.901
12:8521205:G:C	W194C	0.895
12:8521205:G:T	W194C	0.895
12:8521130:G:C	W169C	0.888
12:8521130:G:T	W169C	0.888
12:8519047:T:C	F91L	0.885
12:8519049:C:A	F91L	0.885
12:8519049:C:G	F91L	0.885
12:8520303:G:C	W154C	0.882
12:8520303:G:T	W154C	0.882
12:8520229:T:C	F130L	0.869
12:8520231:T:A	F130L	0.869
12:8520231:T:G	F130L	0.869
12:8521242:T:A	C207S	0.869
12:8521243:G:C	C207S	0.869
12:8521203:T:A	W194R	0.863
12:8521203:T:C	W194R	0.863

dbSNP variants (sampled 300 via entrez): RS1000013317 (12:8530297 G>C), RS1000033961 (12:8514735 C>T), RS1000218007 (12:8512616 C>T), RS1000246294 (12:8517468 G>A,T), RS1000460248 (12:8511620 G>C), RS1000923363 (12:8522711 A>T), RS1000954094 (12:8523090 G>A), RS1001157723 (12:8528559 A>C), RS1001195402 (12:8524331 C>G), RS1001231782 (12:8512708 A>T), RS1001266200 (12:8528818 G>A), RS1001300101 (12:8518788 G>A), RS1001422210 (12:8528882 T>C), RS1001605625 (12:8519132 T>C), RS1001806911 (12:8512900 G>A,T)

Disease associations

OMIM: gene MIM:609964 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
sulforaphane	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Lipopolysaccharides	increases expression	1
Nickel	increases expression	1
Paraquat	decreases expression	1
Tretinoin	increases expression	1
Antirheumatic Agents	decreases expression	1
Nanotubes, Carbon	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.