CLECL1

Summary

CLECL1 (C-type lectin like 1, HGNC:24462) is a protein-coding gene on chromosome 12p13.31, encoding C-type lectin-like domain family 1 (Q8IZS7). Functions in mediating immune cell-cell interactions.

This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 160365 — RefSeq curated summary.

At a glance

• Gene type: non-coding (transcribed_unitary_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24462
Approved symbol	CLECL1
Name	C-type lectin like 1
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	DCAL1
Ensembl gene	ENSG00000184293
Ensembl biotype	transcribed_unitary_pseudogene
OMIM	607467
Entrez	160365

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 transcribed_unitary_pseudogene

ENST00000621400

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621400 — 4 exons

Exon	Start	End
ENSE00002259296	9722644	9722813
ENSE00003923570	9732949	9733030
ENSE00003927152	9727565	9727658
ENSE00003931843	9729591	9729676

Expression profiles

Bgee: expression breadth ubiquitous, 199 present calls, max score 86.80.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6166 / max 121.8087, expressed in 262 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129427	0.4472	142
129425	0.4166	148
129424	0.4161	87
129426	0.1729	93
129423	0.1301	56
129428	0.0338	19

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	86.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.91	gold quality
lymph node	UBERON:0000029	84.25	gold quality
spleen	UBERON:0002106	83.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.67	gold quality
vermiform appendix	UBERON:0001154	81.19	gold quality
epithelium of nasopharynx	UBERON:0001951	79.03	gold quality
bone marrow cell	CL:0002092	78.17	gold quality
leukocyte	CL:0000738	78.10	gold quality
granulocyte	CL:0000094	77.92	gold quality
monocyte	CL:0000576	77.81	gold quality
superficial temporal artery	UBERON:0001614	77.10	gold quality
caecum	UBERON:0001153	76.08	gold quality
rectum	UBERON:0001052	74.21	gold quality
buccal mucosa cell	CL:0002336	73.80	silver quality
small intestine Peyer’s patch	UBERON:0003454	72.94	gold quality
ileal mucosa	UBERON:0000331	72.35	gold quality
bone marrow	UBERON:0002371	72.02	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	71.30	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	71.27	silver quality
small intestine	UBERON:0002108	70.82	gold quality
tonsil	UBERON:0002372	70.46	gold quality
oocyte	CL:0000023	69.96	silver quality
cartilage tissue	UBERON:0002418	69.85	silver quality
vena cava	UBERON:0004087	69.23	gold quality
gall bladder	UBERON:0002110	69.15	gold quality
jejunal mucosa	UBERON:0000399	69.02	gold quality
smooth muscle tissue	UBERON:0001135	68.99	gold quality
medial globus pallidus	UBERON:0002477	68.11	silver quality
blood	UBERON:0000178	67.69	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-32	yes	267.19
E-CURD-122	yes	20.39
E-ANND-3	yes	7.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• DCAL-1, highly expressed on dendritic cells and B lymphocytes, acts as a T cell costimulatory molecule which skews CD4+ T cells toward a Th2 response by enhancing their secretion of IL-4. (PMID:12421943)
• incubation of immature DCs (iDCs) with an anti-DCAL-1 monoclonal antibody (mAb) induced downstream signaling, including phosphorylation of c-Jun N-terminal kinase (JNK) and p44/42 MAP kinase. (PMID:19027044)
• C-type lectin-like molecule-1 is expressed in 86.5% of cases of acute myeloid leukemia, in 54.5% of acute myeloid leukemia CD34positiveCD38negative stem cells, but not in acute lymphoblastic leukemia blast cells. (PMID:19648166)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.