CLN8-AS1

Summary

CLN8-AS1 (CLN8 antisense RNA 1, HGNC:55523) is a long non-coding RNA gene on chromosome 8p23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55523
Approved symbol	CLN8-AS1
Name	CLN8 antisense RNA 1
Location	8p23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253982
Ensembl biotype	lncRNA
Entrez	101927752
RNAcentral	URS0000A773E6 — lncRNA, 1117 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000517959, ENST00000518481, ENST00000518822, ENST00000633189, ENST00000659375, ENST00000665209, ENST00000687153, ENST00000727631, ENST00000727632, ENST00000727633, ENST00000727634, ENST00000727635, ENST00000727636, ENST00000727637

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517959 — 2 exons

Exon	Start	End
ENSE00002105005	1762081	1762928
ENSE00002108366	1764434	1764502

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 94.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1773 / max 108.5483, expressed in 1740 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91580	9.1371	1738
91576	0.0252	7
91581	0.0149	5

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	94.15	gold quality
substantia nigra	UBERON:0002038	93.77	gold quality
amygdala	UBERON:0001876	93.39	gold quality
monocyte	CL:0000576	93.28	gold quality
temporal lobe	UBERON:0001871	93.21	gold quality
Ammon’s horn	UBERON:0001954	92.56	gold quality
putamen	UBERON:0001874	92.55	gold quality
leukocyte	CL:0000738	92.51	gold quality
nucleus accumbens	UBERON:0001882	92.22	gold quality
blood	UBERON:0000178	92.12	gold quality
hypothalamus	UBERON:0001898	91.72	gold quality
caudate nucleus	UBERON:0001873	91.40	gold quality
anterior cingulate cortex	UBERON:0009835	91.27	gold quality
right adrenal gland	UBERON:0001233	90.90	gold quality
right adrenal gland cortex	UBERON:0035827	90.83	gold quality
left adrenal gland cortex	UBERON:0035825	90.71	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.22	gold quality
left adrenal gland	UBERON:0001234	90.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.10	gold quality
right atrium auricular region	UBERON:0006631	89.77	gold quality
cerebral cortex	UBERON:0000956	89.65	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.59	gold quality
apex of heart	UBERON:0002098	89.54	gold quality
adult mammalian kidney	UBERON:0000082	89.28	gold quality
right frontal lobe	UBERON:0002810	89.15	gold quality
brain	UBERON:0000955	88.88	gold quality
right lobe of liver	UBERON:0001114	88.80	gold quality
granulocyte	CL:0000094	88.77	gold quality
primary visual cortex	UBERON:0002436	88.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.