CMTM3

Summary

CMTM3 (CKLF like MARVEL transmembrane domain containing 3, HGNC:19174) is a protein-coding gene on chromosome 16q22.1, encoding CKLF-like MARVEL transmembrane domain-containing protein 3 (Q96MX0).

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5’ UTRs, but encoding the same protein, have been identified.

Source: NCBI Gene 123920 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 28 total
• MANE Select transcript: NM_181553

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19174
Approved symbol	CMTM3
Name	CKLF like MARVEL transmembrane domain containing 3
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ31762, BNAS2
Ensembl gene	ENSG00000140931
Ensembl biotype	protein_coding
OMIM	607886
Entrez	123920

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 23 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000361909, ENST00000424011, ENST00000460097, ENST00000562357, ENST00000562707, ENST00000563672, ENST00000564060, ENST00000564247, ENST00000565003, ENST00000565666, ENST00000565922, ENST00000566121, ENST00000566756, ENST00000567572, ENST00000568477, ENST00000885751, ENST00000885752, ENST00000885753, ENST00000885754, ENST00000885755, ENST00000918764, ENST00000918765, ENST00000967212, ENST00000967213, ENST00000967214

RefSeq mRNA: 4 — MANE Select: NM_181553 NM_001363918, NM_001363923, NM_144601, NM_181553

CCDS: CCDS10815

Canonical transcript exons

ENST00000567572 — 5 exons

Exon	Start	End
ENSE00000945627	66609435	66609530
ENSE00001517518	66612609	66613887
ENSE00002587833	66604704	66604952
ENSE00003461182	66609883	66610003
ENSE00003533463	66608309	66608464

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 96.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.3917 / max 238.5133, expressed in 1786 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154525	16.6217	1709
154526	15.4649	1715
154524	0.8418	317
154528	0.6653	428
154527	0.4111	232
154523	0.3870	188

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.91	gold quality
leukocyte	CL:0000738	95.62	gold quality
monocyte	CL:0000576	95.51	gold quality
right testis	UBERON:0004534	95.48	gold quality
stromal cell of endometrium	CL:0002255	95.31	gold quality
left testis	UBERON:0004533	95.22	gold quality
gall bladder	UBERON:0002110	94.83	gold quality
testis	UBERON:0000473	94.14	gold quality
blood	UBERON:0000178	94.00	gold quality
right lung	UBERON:0002167	93.81	gold quality
endocervix	UBERON:0000458	93.36	gold quality
decidua	UBERON:0002450	93.31	gold quality
right ovary	UBERON:0002118	93.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	92.89	gold quality
omental fat pad	UBERON:0010414	92.84	gold quality
peritoneum	UBERON:0002358	92.81	gold quality
adipose tissue of abdominal region	UBERON:0007808	92.59	gold quality
tibial nerve	UBERON:0001323	92.50	gold quality
left ovary	UBERON:0002119	92.36	gold quality
vermiform appendix	UBERON:0001154	92.25	gold quality
upper lobe of left lung	UBERON:0008952	91.99	gold quality
left uterine tube	UBERON:0001303	91.96	gold quality
lymph node	UBERON:0000029	91.70	gold quality
amniotic fluid	UBERON:0000173	91.61	gold quality
right coronary artery	UBERON:0001625	91.56	gold quality
pericardium	UBERON:0002407	91.56	gold quality
adipose tissue	UBERON:0001013	91.52	gold quality
cartilage tissue	UBERON:0002418	91.48	gold quality
ectocervix	UBERON:0012249	91.23	gold quality
mucosa of stomach	UBERON:0001199	91.21	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-8271	yes	14.98
E-ANND-3	yes	9.95
E-GEOD-100618	no	220.37
E-CURD-112	no	2.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

65 targeting CMTM3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-4743-3P	99.62	68.12	2095
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-377-3P	99.37	70.18	1905
HSA-MIR-135A-5P	99.36	71.85	1601
HSA-MIR-135B-5P	99.36	71.63	1613
HSA-MIR-3606-5P	99.31	69.67	1168
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-3064-5P	99.26	66.13	1497
HSA-MIR-3085-3P	99.26	66.16	1490
HSA-MIR-6504-5P	99.26	65.95	1487

Literature-anchored findings (GeneRIF, showing 17)

• Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized. (PMID:12782130)
• CMTM3/CKLFSF3 is an evolutionarily conserved gene that may have important roles in the male reproductive system and immune system. (PMID:17002874)
• CMTM3 inhibits prostate-specific antigen expression at both mRNA and protein levels with no obvious influence on androgen receptor expression. (PMID:18402773)
• CMTM3 is significantly down-regulated in clear cell renal cell carcinoma and exerts remarkable tumor-suppressive functions (PMID:23907292)
• Peritoneal disseminated metastases were significantly suppressed by CMTM3. (PMID:24131472)
• CMTM1 and 3 are priority targets in glioblastomas. First insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation was presented. (PMID:25931111)
• Low expression of CMTM3 was associated with metastasis and recurrence of oral squamous cell carcinoma. (PMID:25946973)
• Reduced expression of CMTM3 is associated with prostate cancer. (PMID:25990505)
• this study demonstrates that knockdown of CMTM3 promotes the metastasis of gastric cancer through the STAT3/Twist1/EMT pathway (PMID:27121055)
• identified CMTM3 as a novel secretory protein released via exosomes in the prostate (PMID:27125975)
• study indicates that elevated CMTM3 methylation is a risk factor in male LSCC patients, especially in the patients with age over 55years and with smoking behavior (PMID:27521994)
• Overexpression of CMTM3 attenuated the tumor growth of hepatocellular carcinoma. (PMID:27629543)
• CMTM3 decreases EGFR expression, facilitates EGFR degradation, and inhibits the EGF-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 activity. (PMID:27867015)
• CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting by regulation VE-cadherin turnover. (PMID:28428220)
• CMTM3 was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues. (PMID:28782576)
• CMTM3 exhibited a lower expression pattern in gastric cancer tissues.MiR-135b-5p promotes gastric cancer progression by targeting CMTM3. (PMID:29345297)
• Familial hypereosinophilia associated with eosinophilic gastrointestinal symptoms in individuals with a missense mutation in CKLF-like MARVEL transmembrane domain containing 3. (PMID:34048099)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cmtm3	ENSDARG00000008811
mus_musculus	Cmtm3	ENSMUSG00000031875
rattus_norvegicus	Cmtm3	ENSRNOG00000010691
caenorhabditis_elegans	F28H1.4	WBGENE00017909
caenorhabditis_elegans	F47B3.3	WBGENE00018527

Paralogs (14): CMTM1 (ENSG00000089505), CMTM6 (ENSG00000091317), PLP2 (ENSG00000102007), PLLP (ENSG00000102934), CMTM2 (ENSG00000140932), MALL (ENSG00000144063), MAL2 (ENSG00000147676), CMTM7 (ENSG00000153551), MARVELD1 (ENSG00000155254), CMTM5 (ENSG00000166091), CMTM8 (ENSG00000170293), MAL (ENSG00000172005), CMTM4 (ENSG00000183723), CKLF (ENSG00000217555)

Protein

Protein identifiers

CKLF-like MARVEL transmembrane domain-containing protein 3 — Q96MX0 (reviewed: Q96MX0)

Alternative names: Chemokine-like factor superfamily member 3

All UniProt accessions (8): Q96MX0, H3BN06, H3BU39, H3BUD5, I3L3C2, I3L540, J3KSM1, J3KSR6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Expressed in the leukocytes, placenta and testis.

Similarity. Belongs to the chemokine-like factor family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96MX0-1	1	yes
Q96MX0-2	2

RefSeq proteins (4): NP_001350847, NP_001350852, NP_653202, NP_853531* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008253	Marvel	Domain
IPR050578	MARVEL-CKLF_proteins	Family

Pfam: PF01284

UniProt features (9 total): transmembrane region 3, splice variant 2, chain 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96MX0-F1	79.99	0.44

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 191 (showing top): GOBP_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY, GOBP_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, chr16q22, GOBP_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY, GOBP_TAXIS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_DN, GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT, CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN, GOBP_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY, GOBP_BLASTOCYST_DEVELOPMENT, TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA, GOMF_CYTOKINE_ACTIVITY, GOBP_EMBRYO_DEVELOPMENT

GO Biological Process (4): blastocyst hatching (GO:0001835), chemotaxis (GO:0006935), positive regulation of B cell receptor signaling pathway (GO:0050861), signal transduction (GO:0007165)

GO Molecular Function (2): cytokine activity (GO:0005125), protein binding (GO:0005515)

GO Cellular Component (6): obsolete extracellular space (GO:0005615), cytosol (GO:0005829), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410), nuclear membrane (GO:0031965), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
blastocyst development	1
hatching	1
response to chemical	1
taxis	1
B cell receptor signaling pathway	1
regulation of B cell receptor signaling pathway	1
positive regulation of antigen receptor-mediated signaling pathway	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
receptor ligand activity	1
binding	1
intracellular vesicle	1
nucleus	1
nuclear envelope	1
organelle membrane	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

626 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CMTM3	CMTM1	Q8IZ96	975
CMTM3	CMTM2	Q8TAZ6	968
CMTM3	CKLF	Q9UBR5	967
CMTM3	CMTM4	Q8IZR5	966
CMTM3	CMTM7	Q96FZ5	887
CMTM3	CMTM8	Q8IZV2	761
CMTM3	CMTM6	Q9NX76	750
CMTM3	SF3B3	Q15393	496
CMTM3	KYNU	Q16719	474
CMTM3	BEAN1	Q3B7T3	443
CMTM3	ZNF354A	O60765	433
CMTM3	DCTPP1	Q9H773	427
CMTM3	NSA2	O95478	422
CMTM3	UBAC2	Q8NBM4	416
CMTM3	SNRPF	P62306	410
CMTM3	PRRG1	O14668	410

IntAct

70 interactions, top by confidence:

A	B	Type	Score
CMTM3	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	MOB1A	psi-mi:“MI:0915”(physical association)	0.560
MOB3C	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
MOB1A	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
LRRC59	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
CREB3L1	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
IKBIP	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
GJB1	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
LEUTX	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
ARL13B	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
RETREG3	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	STMN4	psi-mi:“MI:0915”(physical association)	0.560
APOA5	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
IL10RA	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	REEP4	psi-mi:“MI:0915”(physical association)	0.560
SYT2	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
HSD17B11	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	ELOVL4	psi-mi:“MI:0915”(physical association)	0.560
SLC10A1	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
MFSD14B	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
AQP6	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
MRM1	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	F13A1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (31): CMTM3 (Two-hybrid), MOB3C (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Negative Genetic), CMTM3 (Synthetic Lethality), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), CMTM3 (Two-hybrid), FAM134C (Two-hybrid), SYT2 (Two-hybrid)

ESM2 similar proteins: A2VE13, A6QNL6, B6ID01, O09198, P16646, P20274, P21145, P25094, P54825, P55344, P56563, Q01453, Q04941, Q17R16, Q1RMP9, Q28296, Q2TA01, Q3ZBY0, Q4PNJ2, Q5BJS2, Q5R6H1, Q5RAI2, Q5RAZ3, Q5U1W4, Q5U4E0, Q5VXU1, Q64349, Q6WL85, Q6Y1E2, Q7TSY2, Q7Z7J7, Q86UP9, Q8BI08, Q8BM86, Q8IZV2, Q91XQ6, Q95MN6, Q969L2, Q96FZ5, Q96MX0

Diamond homologs: Q96MX0, Q99LJ5, Q9D6G9, Q9R1Q7, Q04941, Q6P742, Q6Y1E2, Q95MN6, Q96DZ9, Q28597

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1262 predictions. Top by Δscore:

Variant	Effect	Δscore
16:66609433:A:AG	acceptor_gain	1.0000
16:66609433:AG:A	acceptor_gain	1.0000
16:66609434:G:GG	acceptor_gain	1.0000
16:66609434:GG:G	acceptor_gain	1.0000
16:66609528:GGG:G	donor_gain	1.0000
16:66609529:GG:G	donor_gain	1.0000
16:66609529:GGG:G	donor_gain	1.0000
16:66609530:GG:G	donor_gain	1.0000
16:66609531:G:GG	donor_gain	1.0000
16:66609531:GTGAG:G	donor_loss	1.0000
16:66609532:T:G	donor_loss	1.0000
16:66609877:CCACA:C	acceptor_loss	1.0000
16:66609878:CACA:C	acceptor_loss	1.0000
16:66609879:ACAG:A	acceptor_loss	1.0000
16:66609880:CA:C	acceptor_loss	1.0000
16:66609881:A:AC	acceptor_loss	1.0000
16:66609882:GGT:G	acceptor_gain	1.0000
16:66609999:AGAAG:A	donor_gain	1.0000
16:66610000:GAAG:G	donor_gain	1.0000
16:66610000:GAAGG:G	donor_gain	1.0000
16:66610001:AAG:A	donor_gain	1.0000
16:66610002:AG:A	donor_gain	1.0000
16:66610002:AGGTA:A	donor_loss	1.0000
16:66610003:GG:G	donor_gain	1.0000
16:66610003:GGTA:G	donor_loss	1.0000
16:66610004:G:GA	donor_loss	1.0000
16:66610004:G:GG	donor_gain	1.0000
16:66604949:GTCG:G	donor_gain	0.9900
16:66607693:GGCAC:G	donor_gain	0.9900
16:66608307:AG:A	acceptor_gain	0.9900

AlphaMissense

1178 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:66609914:C:A	A144E	0.981
16:66609910:T:C	F143L	0.979
16:66609912:T:A	F143L	0.979
16:66609912:T:G	F143L	0.979
16:66609890:G:A	G136D	0.977
16:66609457:C:A	A109E	0.975
16:66608333:T:C	C58R	0.974
16:66609526:C:A	A132D	0.974
16:66609449:T:G	C106W	0.971
16:66609899:C:A	A139D	0.969
16:66604949:G:C	E48D	0.967
16:66604949:G:T	E48D	0.967
16:66609908:T:A	V142E	0.967
16:66604929:G:C	G42R	0.966
16:66609889:G:C	G136R	0.965
16:66609438:T:C	F103L	0.963
16:66609440:C:A	F103L	0.963
16:66609440:C:G	F103L	0.963
16:66609913:G:C	A144P	0.961
16:66608309:G:C	G50R	0.960
16:66609529:G:A	G133E	0.960
16:66609481:C:A	S117Y	0.958
16:66608373:C:A	P71H	0.956
16:66609447:T:C	C106R	0.956
16:66608373:C:G	P71R	0.955
16:66609481:C:T	S117F	0.955
16:66609460:C:A	A110D	0.954
16:66604928:A:C	K41N	0.953
16:66604928:A:T	K41N	0.953
16:66609925:T:G	Y148D	0.952

dbSNP variants (sampled 300 via entrez): RS1000200038 (16:66605063 C>A,G,T), RS1000626248 (16:66611219 G>A), RS1000739094 (16:66606618 T>C), RS1000830569 (16:66613833 G>A), RS1000982628 (16:66606349 G>C), RS1001393590 (16:66611536 G>A), RS1001396513 (16:66602353 T>C), RS1001465762 (16:66611935 C>T), RS1001481110 (16:66608041 T>A), RS1001547184 (16:66610744 T>C,G), RS1001645509 (16:66605879 G>A,C), RS1001904161 (16:66606945 G>A), RS1001975223 (16:66605601 G>A), RS1002377789 (16:66607176 C>G), RS1002785603 (16:66613438 G>A,C)

Disease associations

OMIM: gene MIM:607886 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, increases expression, affects cotreatment	3
Benzo(a)pyrene	increases expression, increases methylation	3
Tetrachlorodibenzodioxin	increases expression	3
sodium arsenite	decreases expression, increases abundance, increases expression	2
Arsenic	increases expression, decreases expression, increases abundance	2
Estradiol	affects cotreatment, decreases expression, increases expression	2
Valproic Acid	decreases expression, increases methylation, affects expression	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
tris(2-butoxyethyl) phosphate	affects expression	1
beta-lapachone	increases expression	1
cobaltous chloride	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
manganese chloride	increases abundance, decreases expression	1
potassium chromate(VI)	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
K 7174	increases expression	1
bisphenol S	decreases methylation	1
Air Pollutants	affects expression, increases abundance	1
Ethanol	affects cotreatment, increases abundance, increases expression	1
Calcitriol	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Manganese	decreases expression, increases abundance	1
Ozone	affects expression, increases abundance	1
Polycyclic Aromatic Hydrocarbons	increases abundance, increases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.