CNIH3

Summary

CNIH3 (cornichon family AMPA receptor auxiliary protein 3, HGNC:26802) is a protein-coding gene on chromosome 1q42.12, encoding Protein cornichon homolog 3 (Q8TBE1). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs).

Predicted to enable channel regulator activity and signaling receptor binding activity. Involved in regulation of AMPA receptor activity. Predicted to be located in dendritic shaft and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendrite and glutamatergic synapse.

Source: NCBI Gene 149111 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 34 total — 2 pathogenic
• MANE Select transcript: NM_152495

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26802
Approved symbol	CNIH3
Name	cornichon family AMPA receptor auxiliary protein 3
Location	1q42.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ38993, CNIH-3
Ensembl gene	ENSG00000143786
Ensembl biotype	protein_coding
Entrez	149111

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 13 protein_coding_CDS_not_defined, 3 protein_coding

ENST00000272133, ENST00000470602, ENST00000470788, ENST00000471578, ENST00000478120, ENST00000479227, ENST00000481095, ENST00000483512, ENST00000489556, ENST00000492470, ENST00000496277, ENST00000496372, ENST00000498126, ENST00000498382, ENST00000860910, ENST00000933029

RefSeq mRNA: 5 — MANE Select: NM_152495 NM_001322302, NM_001322303, NM_001322304, NM_001322305, NM_152495

CCDS: CCDS1544

Canonical transcript exons

ENST00000272133 — 6 exons

Exon	Start	End
ENSE00001147221	224739329	224740554
ENSE00001215659	224616317	224617255
ENSE00003466788	224734563	224734706
ENSE00003483736	224684796	224684843
ENSE00003527670	224730462	224730574
ENSE00003685214	224680958	224681026

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 86.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.1978 / max 158.4408, expressed in 1428 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8806	1.4976	519
8805	1.3510	533
8793	1.0371	630
8795	0.5274	177
8792	0.3980	193
8803	0.0833	30
8804	0.0817	25
8799	0.0744	23
8801	0.0523	20
8800	0.0497	18

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.65	gold quality
cortical plate	UBERON:0005343	86.56	gold quality
endothelial cell	CL:0000115	86.13	gold quality
prefrontal cortex	UBERON:0000451	85.47	gold quality
stromal cell of endometrium	CL:0002255	84.82	gold quality
buccal mucosa cell	CL:0002336	84.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.62	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.47	gold quality
right frontal lobe	UBERON:0002810	83.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.27	gold quality
cingulate cortex	UBERON:0003027	82.61	gold quality
anterior cingulate cortex	UBERON:0009835	82.38	gold quality
frontal cortex	UBERON:0001870	82.31	gold quality
neocortex	UBERON:0001950	82.11	gold quality
amygdala	UBERON:0001876	81.86	gold quality
nucleus accumbens	UBERON:0001882	81.59	gold quality
Ammon’s horn	UBERON:0001954	81.52	gold quality
cerebral cortex	UBERON:0000956	81.50	gold quality
body of pancreas	UBERON:0001150	81.12	gold quality
left ovary	UBERON:0002119	80.49	gold quality
telencephalon	UBERON:0001893	80.45	gold quality
Brodmann (1909) area 23	UBERON:0013554	80.42	gold quality
caudate nucleus	UBERON:0001873	79.68	gold quality
forebrain	UBERON:0001890	79.51	gold quality
right ovary	UBERON:0002118	79.44	gold quality
brain	UBERON:0000955	78.45	gold quality
pancreas	UBERON:0001264	78.40	gold quality
central nervous system	UBERON:0001017	78.31	gold quality
calcaneal tendon	UBERON:0003701	78.29	gold quality
temporal lobe	UBERON:0001871	78.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting CNIH3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-2116-3P	99.74	64.32	889
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-567	99.63	68.57	1219
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-3911	99.38	66.95	1087
HSA-MIR-190B-3P	99.33	68.29	1382
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312
HSA-MIR-4795-5P	99.11	66.90	876
HSA-MIR-622	98.99	66.48	1050
HSA-MIR-936	98.87	70.51	1124
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-1301-3P	98.64	68.27	1071
HSA-MIR-5047	98.64	68.62	1035
HSA-MIR-6811-3P	98.62	66.54	944

Literature-anchored findings (GeneRIF, showing 2)

• Significant upregulation of CNIH-3 mRNA expression was found in schizophrenia. (PMID:23103966)
• Study’s convergent findings in humans and mice support CNIH3 involvement in the pathophysiology of opioid dependence, complementing prior studies implicating the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate system (PMID:26239289)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cnih3	ENSDARG00000014953
mus_musculus	Cnih3	ENSMUSG00000026514
rattus_norvegicus	Cnih3	ENSRNOG00000022724
drosophila_melanogaster	cni	FBGN0000339
caenorhabditis_elegans		WBGENE00011648

Paralogs (4): CNIH1 (ENSG00000100528), PPCS (ENSG00000127125), CNIH4 (ENSG00000143771), CNIH2 (ENSG00000174871)

Protein

Protein identifiers

Protein cornichon homolog 3 — Q8TBE1 (reviewed: Q8TBE1)

Alternative names: Cornichon family AMPA receptor auxiliary protein 3

All UniProt accessions (1): Q8TBE1

UniProt curated annotations — full annotation on UniProt →

Function. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

Subunit / interactions. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8.

Subcellular location. Postsynaptic cell membrane.

Tissue specificity. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).

Similarity. Belongs to the cornichon family.

RefSeq proteins (5): NP_001309231, NP_001309232, NP_001309233, NP_001309234, NP_689708* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003377	Cornichon	Family
IPR033466	Cornichon_conserved	Conserved_site

Pfam: PF03311

UniProt features (8 total): topological domain 4, transmembrane region 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TBE1-F1	85.15	0.48

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-5694530	Cargo concentration in the ER

MSigDB gene sets: 163 (showing top): BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_CELL_CELL_SIGNALING, GOCC_COATED_VESICLE, TGACATY_UNKNOWN, GOBP_SYNAPTIC_SIGNALING, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOCC_NEURON_PROJECTION, GOBP_PROTEIN_LOCALIZATION_TO_SYNAPSE, AML1_01, GOBP_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC, GOBP_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY, GOMF_SIGNALING_RECEPTOR_BINDING

GO Biological Process (5): vesicle-mediated transport (GO:0016192), synaptic transmission, glutamatergic (GO:0035249), regulation of membrane potential (GO:0042391), neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645), regulation of AMPA receptor activity (GO:2000311)

GO Molecular Function (3): signaling receptor binding (GO:0005102), channel regulator activity (GO:0016247), protein binding (GO:0005515)

GO Cellular Component (11): endoplasmic reticulum membrane (GO:0005789), ER to Golgi transport vesicle membrane (GO:0012507), dendrite (GO:0030425), AMPA glutamate receptor complex (GO:0032281), endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116), dendritic shaft (GO:0043198), synapse (GO:0045202), postsynaptic membrane (GO:0045211), glutamatergic synapse (GO:0098978), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
transport	1
cellular process	1
chemical synaptic transmission	1
monoatomic ion transmembrane transport	1
regulation of biological quality	1
protein-containing complex localization	1
receptor localization to synapse	1
regulation of postsynaptic membrane neurotransmitter receptor levels	1
protein localization to postsynaptic specialization membrane	1
AMPA glutamate receptor activity	1
regulation of transmembrane transporter activity	1
regulation of neurotransmitter receptor activity	1
protein binding	1
channel activity	1
transporter regulator activity	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
COPII-coated ER to Golgi transport vesicle	1
transport vesicle membrane	1
coated vesicle membrane	1
neuron projection	1
dendritic tree	1
ionotropic glutamate receptor complex	1
endoplasmic reticulum-Golgi intermediate compartment	1
bounding membrane of organelle	1
dendrite	1
cell junction	1
synaptic membrane	1
postsynapse	1
synapse	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

956 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNIH3	NT5C1A	Q9BXI3	815
CNIH3	KCNG2	Q9UJ96	748
CNIH3	GRIA3	P42263	731
CNIH3	GRIA2	P42262	690
CNIH3	GSG1L	Q6UXU4	646
CNIH3	GRIA1	P42261	598
CNIH3	SYNDIG1	Q9H7V2	582
CNIH3	GSG1L2	A8MUP6	564
CNIH3	TGFA	P01135	560
CNIH3	COL22A1	Q8NFW1	556
CNIH3	ADAMTS14	Q8WXS8	552
CNIH3	FAM53B	Q14153	550
CNIH3	COL4A6	Q14031	546
CNIH3	COL21A1	Q96P44	545
CNIH3	GRIA4	P48058	542

IntAct

87 interactions, top by confidence:

A	B	Type	Score
CNIH3	AQP6	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	CLDN20	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	TMEM80	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	ERGIC3	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	FAM210B	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	SMIM3	psi-mi:“MI:0915”(physical association)	0.560
	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
PLD3	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
TMPRSS2	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	TMEM237	psi-mi:“MI:0915”(physical association)	0.560
BIK	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CEACAM3	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	SORT1	psi-mi:“MI:0915”(physical association)	0.560
AQP6	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
LRRC25	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CLDN20	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
STOM	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
ODF4	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	GPX8	psi-mi:“MI:0915”(physical association)	0.560
NEMP1	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
TMEM52B	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
LEUTX	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CD79A	CNIH3	psi-mi:“MI:0915”(physical association)	0.560
CNIH3	VSIR	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (29): CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), CNIH3 (Two-hybrid), SLC16A2 (Two-hybrid), STOM (Two-hybrid), TMEM237 (Two-hybrid), SUSD3 (Two-hybrid)

ESM2 similar proteins: A4IFN5, A6NI61, A6QQ59, B0CM95, B2KI79, B2LYG4, B2RZC9, D0Q0Y7, O35089, P22234, P86229, Q15546, Q1RMP9, Q2TA01, Q3ZCD7, Q5BJU5, Q5QJU3, Q5R589, Q5RB59, Q5RDB5, Q5RL79, Q5U3C3, Q64232, Q6IQ69, Q6PHN7, Q6PI25, Q6ZWS4, Q719N3, Q865K8, Q86WK9, Q86YN1, Q8BWB6, Q8IY49, Q8IZV2, Q8N6L1, Q8N6M3, Q8NBT3, Q8NFT2, Q8R189, Q8TBE1

Diamond homologs: D0Q0Y7, O35089, O35372, O95406, P49858, P52159, Q0VFK3, Q22361, Q3T126, Q401C0, Q5BIN6, Q5BJU5, Q5BL21, Q5R9M4, Q5RDB5, Q68EY2, Q6P3N5, Q6PI25, Q6ZWS4, Q8TBE1, Q9CX13, Q9P003, P53173, O14038, P38312, Q0DET3, Q3EDD7, Q84W04, Q9P6K6, Q9C7D7, Q2QQ55, Q8GWT5, Q9SZ74

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	24
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1703636	GRCh37/hg19 1q42.11-42.12(chr1:224432682-225142704)	Pathogenic
625540	GRCh37/hg19 1q42.11-42.12(chr1:224340881-225147932)	Pathogenic

SpliceAI

2129 predictions. Top by Δscore:

Variant	Effect	Δscore
1:224684781:T:A	acceptor_gain	1.0000
1:224734705:TGGT:T	donor_loss	1.0000
1:224734706:GGTG:G	donor_loss	1.0000
1:224734707:G:GG	donor_gain	1.0000
1:224734708:T:A	donor_loss	1.0000
1:224734709:GAGTA:G	donor_loss	1.0000
1:224673859:A:G	acceptor_gain	0.9900
1:224680957:GATA:G	acceptor_gain	0.9900
1:224681024:GCG:G	donor_gain	0.9900
1:224681024:GCGGT:G	donor_loss	0.9900
1:224681025:CGGT:C	donor_loss	0.9900
1:224681026:GGTA:G	donor_loss	0.9900
1:224681027:G:GC	donor_loss	0.9900
1:224681028:TAA:T	donor_loss	0.9900
1:224681029:A:AG	donor_loss	0.9900
1:224684783:T:TA	acceptor_gain	0.9900
1:224684786:ATCCT:A	acceptor_gain	0.9900
1:224684787:T:G	acceptor_gain	0.9900
1:224730460:AGCT:A	acceptor_gain	0.9900
1:224730461:GCTG:G	acceptor_gain	0.9900
1:224734559:GCA:G	acceptor_loss	0.9900
1:224734561:A:AC	acceptor_loss	0.9900
1:224734562:GGT:G	acceptor_gain	0.9900
1:224734704:CTG:C	donor_gain	0.9900
1:224734705:TG:T	donor_gain	0.9900
1:224734706:GG:G	donor_gain	0.9900
1:224617256:G:GG	donor_gain	0.9800
1:224632818:GTTC:G	donor_gain	0.9800
1:224680956:A:AG	acceptor_gain	0.9800
1:224680957:G:GG	acceptor_gain	0.9800

AlphaMissense

1061 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:224680977:T:C	L34S	0.999
1:224730545:T:A	N94K	0.999
1:224730545:T:G	N94K	0.999
1:224730550:C:G	P96R	0.999
1:224734665:G:C	K138N	0.999
1:224734665:G:T	K138N	0.999
1:224617199:T:C	C9R	0.998
1:224617200:G:A	C9Y	0.998
1:224617215:T:C	L14P	0.998
1:224617233:T:C	L20P	0.998
1:224730550:C:A	P96H	0.998
1:224734663:A:G	K138E	0.998
1:224617201:C:G	C9W	0.997
1:224730561:T:G	Y100D	0.997
1:224734687:T:C	F146L	0.997
1:224734689:C:A	F146L	0.997
1:224734689:C:G	F146L	0.997
1:224734700:T:C	L150P	0.997
1:224617223:T:C	C17R	0.996
1:224730498:T:C	C79R	0.996
1:224730508:T:C	F82S	0.996
1:224730553:T:G	L97R	0.996
1:224734667:T:C	L139P	0.996
1:224734679:T:C	L143P	0.996
1:224734700:T:A	L150H	0.996
1:224617215:T:G	L14R	0.995
1:224617227:C:A	A18D	0.995
1:224684836:T:C	L64P	0.995
1:224730553:T:A	L97Q	0.995
1:224734693:T:G	Y148D	0.995

dbSNP variants (sampled 300 via entrez): RS1000000663 (1:224529421 G>T), RS1000011439 (1:224493211 A>G), RS1000016082 (1:224648609 T>G), RS1000031254 (1:224628005 A>C), RS1000069345 (1:224578013 G>T), RS1000079348 (1:224674674 C>T), RS1000083767 (1:224668381 CAG>C), RS1000086597 (1:224637024 T>C), RS1000105762 (1:224446484 A>G), RS1000116201 (1:224692812 T>C), RS1000117547 (1:224465510 C>T), RS1000139495 (1:224661213 G>A), RS1000141838 (1:224535440 T>C), RS1000142582 (1:224554023 T>C), RS1000145491 (1:224635607 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes: MIM:612530

GenCC curated gene-disease

Mondo (1): chromosome 1q41-q42 deletion syndrome (MONDO:0012927)

Orphanet (2): Holoprosencephaly (Orphanet:2162), 1q41q42 microdeletion syndrome (Orphanet:250999)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST003614_1	Opioid dependence	4.000000e-09
GCST005275_21	Cancer	9.000000e-07
GCST010204_162	Low density lipoprotein cholesterol levels	1.000000e-09
GCST011780_14	Neonatal white matter microstructure	5.000000e-06
GCST90002390_339	Mean corpuscular hemoglobin	5.000000e-12
GCST90002398_511	Neutrophil count	8.000000e-25
GCST90002399_19	Neutrophil percentage of white cells	2.000000e-10
GCST90002407_202	White blood cell count	4.000000e-24
GCST90006991_8	Gut microbiota relative abundance (Streptococcus)	6.000000e-06

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0005674	white matter microstructure measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0004833	neutrophil count
EFO:0007990	neutrophil percentage of leukocytes
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs10799590	Toxicity	3	opioids	Opioid-Related Disorders

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10799590	CNIH3	3	1.75	1	opioids

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	3
bisphenol A	increases expression	2
Estradiol	decreases expression, affects cotreatment	2
Progesterone	affects cotreatment, decreases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	increases reaction, affects binding	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
ormosil	affects binding, increases expression	1
licochalcone B	increases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	decreases expression	1
Acetaminophen	decreases expression	1
Amiodarone	increases expression	1
Cadmium	increases abundance, increases expression	1
Cisplatin	decreases expression, increases expression	1
Dexamethasone	decreases expression	1
Lead	affects expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Methapyrilene	increases methylation	1
Phenobarbital	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Polyethylene Glycols	affects binding, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.