CNIH4

Summary

CNIH4 (cornichon family member 4, HGNC:25013) is a protein-coding gene on chromosome 1q42.11, encoding Protein cornichon homolog 4 (Q9P003). Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. It is a selective cancer dependency (DepMap: 47.6% of cell lines).

Enables CCR5 chemokine receptor binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment.

Source: NCBI Gene 29097 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 31 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 47.6% of screened cell lines
• MANE Select transcript: NM_014184

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25013
Approved symbol	CNIH4
Name	cornichon family member 4
Location	1q42.11
Locus type	gene with protein product
Status	Approved
Aliases	HSPC163
Ensembl gene	ENSG00000143771
Ensembl biotype	protein_coding
OMIM	617483
Entrez	29097

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000366856, ENST00000366857, ENST00000366858, ENST00000366860, ENST00000465271, ENST00000468318, ENST00000469200, ENST00000477413, ENST00000895496, ENST00000895497, ENST00000933590, ENST00000933591, ENST00000933592, ENST00000933593

RefSeq mRNA: 5 — MANE Select: NM_014184 NM_001277197, NM_001277198, NM_001277199, NM_001277200, NM_014184

CCDS: CCDS1543, CCDS60429, CCDS60430

Canonical transcript exons

ENST00000465271 — 5 exons

Exon	Start	End
ENSE00000961880	224360495	224360563
ENSE00001949026	224356879	224356993
ENSE00001955275	224375795	224379452
ENSE00003478805	224365879	224365991
ENSE00003505731	224371283	224371423

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 97.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.2584 / max 362.7416, expressed in 1822 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8791	34.4167	1820
8790	4.8417	1651

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	97.55	gold quality
mammalian vulva	UBERON:0000997	97.41	gold quality
pericardium	UBERON:0002407	97.36	gold quality
heart right ventricle	UBERON:0002080	96.95	gold quality
penis	UBERON:0000989	96.87	gold quality
oral cavity	UBERON:0000167	96.72	gold quality
cartilage tissue	UBERON:0002418	96.67	gold quality
pharyngeal mucosa	UBERON:0000355	96.55	gold quality
adult organism	UBERON:0007023	96.51	gold quality
biceps brachii	UBERON:0001507	96.49	gold quality
esophagus squamous epithelium	UBERON:0006920	96.49	gold quality
gingiva	UBERON:0001828	96.48	gold quality
tendon of biceps brachii	UBERON:0008188	96.41	gold quality
upper leg skin	UBERON:0004262	96.33	gold quality
pigmented layer of retina	UBERON:0001782	96.21	gold quality
gingival epithelium	UBERON:0001949	96.17	gold quality
jejunum	UBERON:0002115	96.17	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	96.16	gold quality
trabecular bone tissue	UBERON:0002483	96.12	gold quality
body of tongue	UBERON:0011876	96.08	gold quality
squamous epithelium	UBERON:0006914	95.74	gold quality
lower lobe of lung	UBERON:0008949	95.65	gold quality
monocyte	CL:0000576	95.61	gold quality
decidua	UBERON:0002450	95.61	gold quality
epithelium of esophagus	UBERON:0001976	95.47	gold quality
mononuclear cell	CL:0000842	95.44	gold quality
stromal cell of endometrium	CL:0002255	95.43	gold quality
parietal pleura	UBERON:0002400	95.38	gold quality
colonic mucosa	UBERON:0000317	95.31	gold quality
leukocyte	CL:0000738	95.23	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	19.85
E-MTAB-6379	no	502.93

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1

miRNA regulators (miRDB)

54 targeting CNIH4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-518A-5P	99.70	69.01	2209
HSA-MIR-527	99.70	69.01	2209
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-5003-5P	99.61	69.13	1624
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-6513-3P	99.59	69.77	1102
HSA-MIR-182-3P	99.57	67.57	825
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-3128	99.50	67.85	1258
HSA-MIR-4441	99.49	66.56	3216

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 47.6% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• hsa_circ_0000190 (gene symbol is CNIH4) may be a novel non-invasive biomarker for the diagnosis of gastric cancer (PMID:28130019)
• Screening and identification of CNIH4 gene associated with cell proliferation in gastric cancer based on a large-scale CRISPR-Cas9 screening database DepMap. (PMID:36220450)
• Potential roles of Cornichon Family AMPA Receptor Auxiliary Protein 4 (CNIH4) in head and neck squamous cell carcinoma. (PMID:36404537)
• Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer. (PMID:38087815)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cnih4	ENSDARG00000087759
mus_musculus	Cnih4	ENSMUSG00000062169
rattus_norvegicus	Cnih4	ENSRNOG00000003717
drosophila_melanogaster	cnir	FBGN0243513

Paralogs (4): CNIH1 (ENSG00000100528), PPCS (ENSG00000127125), CNIH3 (ENSG00000143786), CNIH2 (ENSG00000174871)

Protein

Protein identifiers

Protein cornichon homolog 4 — Q9P003 (reviewed: Q9P003)

Alternative names: Cornichon family AMPA receptor auxiliary protein 4

All UniProt accessions (3): Q9P003, A6NJ96, A6NLH6

UniProt curated annotations — full annotation on UniProt →

Function. Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.

Subunit / interactions. Interacts with Sec23/24 complex components SEC24B and SEC24D. Interacts with CCR5. Interacts with ADRB2 in the early secretory pathway.

Subcellular location. Membrane. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.

Similarity. Belongs to the cornichon family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9P003-1	1	yes
Q9P003-2	2

RefSeq proteins (5): NP_001264126, NP_001264127, NP_001264128, NP_001264129, NP_054903* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003377	Cornichon	Family

Pfam: PF03311

UniProt features (6 total): transmembrane region 3, chain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P003-F1	93.03	0.84

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 169 (showing top): GOBP_VESICLE_MEDIATED_TRANSPORT, PATIL_LIVER_CANCER, ONKEN_UVEAL_MELANOMA_UP, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOCC_COATED_VESICLE, CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING, DOUGLAS_BMI1_TARGETS_UP, GOMF_SIGNALING_RECEPTOR_BINDING, ACEVEDO_LIVER_CANCER_UP, LAIHO_COLORECTAL_CANCER_SERRATED_UP, TGGAAA_NFAT_Q4_01, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT

GO Biological Process (3): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192)

GO Molecular Function (3): signaling receptor binding (GO:0005102), CCR5 chemokine receptor binding (GO:0031730), protein binding (GO:0005515)

GO Cellular Component (5): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), COPII-coated ER to Golgi transport vesicle (GO:0030134), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
transport	2
intracellular membrane-bounded organelle	2
intercellular transport	1
intracellular transport	1
Golgi vesicle transport	1
intracellular protein localization	1
establishment of protein localization	1
cellular process	1
protein binding	1
CCR chemokine receptor binding	1
binding	1
endomembrane system	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
coated vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

910 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNIH4	CACNG8	Q8WXS5	908
CNIH4	GRIA1	P42261	865
CNIH4	NT5C1A	Q9BXI3	832
CNIH4	GRIA3	P42263	815
CNIH4	SHISA9	B4DS77	813
CNIH4	GRIA2	P42262	781
CNIH4	GSG1L	Q6UXU4	723
CNIH4	CACNG2	Q9Y698	722
CNIH4	GRIA4	P48058	643
CNIH4	SYNDIG1	Q9H7V2	624
CNIH4	DLG4	P78352	616
CNIH4	SEC24D	O94855	589
CNIH4	TGFA	P01135	561
CNIH4	NETO2	Q8NC67	505
CNIH4	GSG1L2	A8MUP6	499

IntAct

57 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
TSNARE1	CNIH4	psi-mi:“MI:0915”(physical association)	0.560
TMEM14B	CNIH4	psi-mi:“MI:0915”(physical association)	0.560
GPR25	CNIH4	psi-mi:“MI:0915”(physical association)	0.560
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
TACR3	C6orf47	psi-mi:“MI:0914”(association)	0.530
WLS	CNIH4	psi-mi:“MI:0915”(physical association)	0.490
WLS	CNIH4	psi-mi:“MI:0915”(physical association)	0.370
KSR1	DDX39A	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
DND1	RPSA2	psi-mi:“MI:0914”(association)	0.350
CCDC47	ESYT2	psi-mi:“MI:0914”(association)	0.350
LPAR2	EI24	psi-mi:“MI:0914”(association)	0.350
CMKLR1	BTAF1	psi-mi:“MI:0914”(association)	0.350
SERINC2	PGRMC2	psi-mi:“MI:0914”(association)	0.350
MFSD10	NDUFS8	psi-mi:“MI:0914”(association)	0.350
MFSD5	ILVBL	psi-mi:“MI:0914”(association)	0.350
MFSD8	STXBP3	psi-mi:“MI:0914”(association)	0.350
MFSD9	PGRMC1	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC1A4	MGST3	psi-mi:“MI:0914”(association)	0.350
SLC22A9	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC35A4	PGRMC1	psi-mi:“MI:0914”(association)	0.350
SLC37A1	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC39A4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC44A2	CLGN	psi-mi:“MI:0914”(association)	0.350
SLC51A	TNPO2	psi-mi:“MI:0914”(association)	0.350
SLC5A3	PGRMC1	psi-mi:“MI:0914”(association)	0.350
SLC5A4	CLGN	psi-mi:“MI:0914”(association)	0.350

BioGRID (79): CNIH4 (Affinity Capture-MS), CNIH4 (Affinity Capture-RNA), CNIH4 (Proximity Label-MS), CNIH4 (Proximity Label-MS), CNIH4 (PCA), CNIH4 (Affinity Capture-MS), CNIH4 (Affinity Capture-MS), CNIH4 (Affinity Capture-MS), CNIH4 (Affinity Capture-MS), CNIH4 (Affinity Capture-MS), CNIH4 (Affinity Capture-MS), CNIH4 (Proximity Label-MS), CNIH4 (Affinity Capture-MS), CNIH4 (Proximity Label-MS), CNIH4 (Two-hybrid)

ESM2 similar proteins: A0A8I3PI99, A0M8U1, A7Y521, B5DEN9, C5HGF3, O88544, O94973, P13666, P17427, P18484, P38024, Q00765, Q0VCK5, Q0X0A5, Q13098, Q1RLU8, Q28635, Q2PG42, Q3KNM2, Q3SZA0, Q3T0N3, Q3T126, Q3T178, Q3ZC24, Q4R5E6, Q5F418, Q5I0H4, Q5M7T4, Q5R648, Q5R9B0, Q5R9M4, Q5RE33, Q5ZJ41, Q5ZJD7, Q6DGW9, Q6GM44, Q6NRT5, Q7TQ48, Q8C407, Q8R1Z9

Diamond homologs: D0Q0Y7, O35089, O35372, O95406, P49858, P52159, Q0VFK3, Q22361, Q3T126, Q401C0, Q5BIN6, Q5BJU5, Q5BL21, Q5R9M4, Q5RDB5, Q68EY2, Q6P3N5, Q6PI25, Q6ZWS4, Q8TBE1, Q9CX13, Q9P003, O14038, P38312, P53173, Q0DET3, Q2QQ55, Q8GWT5, Q9C7D7, Q9P6K6, Q9SZ74, Q3EDD7, Q84W04

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 66 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Amino acid transport across the plasma membrane	6	41.9×	1e-06
R-HSA-425366	6	25.3×	9e-06
SLC-mediated transmembrane transport	9	12.4×	4e-06
Transport of small molecules	9	5.3×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
amino acid transport	7	37.0×	3e-07
transport across blood-brain barrier	6	18.2×	2e-04
sodium ion transmembrane transport	5	17.2×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

31 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	16
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
979935	GRCh37/hg19 1q42.11-42.12(chr1:224442473-224794913)x1	Pathogenic

SpliceAI

959 predictions. Top by Δscore:

Variant	Effect	Δscore
1:224365877:A:AG	acceptor_gain	1.0000
1:224365877:AGT:A	acceptor_gain	1.0000
1:224365877:AGTG:A	acceptor_gain	1.0000
1:224365877:AGTGG:A	acceptor_gain	1.0000
1:224365878:G:GA	acceptor_gain	1.0000
1:224365878:GT:G	acceptor_gain	1.0000
1:224365878:GTG:G	acceptor_gain	1.0000
1:224365878:GTGG:G	acceptor_gain	1.0000
1:224365878:GTGGG:G	acceptor_gain	1.0000
1:224365989:TCGGT:T	donor_loss	1.0000
1:224365990:CGG:C	donor_loss	1.0000
1:224365991:GGT:G	donor_loss	1.0000
1:224365992:G:A	donor_loss	1.0000
1:224365992:G:GG	donor_gain	1.0000
1:224365993:TGA:T	donor_loss	1.0000
1:224365994:G:GT	donor_loss	1.0000
1:224371277:TATCA:T	acceptor_loss	1.0000
1:224371278:ATCAG:A	acceptor_loss	1.0000
1:224371279:TCA:T	acceptor_loss	1.0000
1:224371281:A:AG	acceptor_gain	1.0000
1:224371281:AGATA:A	acceptor_loss	1.0000
1:224371282:G:GG	acceptor_gain	1.0000
1:224371282:GATAC:G	acceptor_gain	1.0000
1:224371421:TAG:T	donor_gain	1.0000
1:224371424:GT:G	donor_loss	1.0000
1:224371425:T:G	donor_loss	1.0000
1:224375869:T:G	donor_gain	1.0000
1:224357450:GGA:G	donor_gain	0.9900
1:224357451:GA:G	donor_gain	0.9900
1:224365874:TGCA:T	acceptor_loss	0.9900

AlphaMissense

920 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:224360514:T:C	L30S	0.999
1:224371333:T:A	I101K	0.999
1:224360523:A:T	D33V	0.998
1:224360545:T:G	C40W	0.998
1:224360548:C:G	C41W	0.998
1:224360556:T:C	L44S	0.998
1:224371321:A:G	D97G	0.998
1:224371333:T:C	I101T	0.998
1:224371333:T:G	I101R	0.998
1:224371386:G:C	G119R	0.998
1:224371417:T:C	L129P	0.998
1:224360507:T:C	S28P	0.997
1:224360510:G:C	D29H	0.997
1:224360511:A:C	D29A	0.997
1:224360511:A:G	D29G	0.997
1:224360511:A:T	D29V	0.997
1:224360522:G:C	D33H	0.997
1:224360523:A:C	D33A	0.997
1:224360533:T:A	N36K	0.997
1:224360533:T:G	N36K	0.997
1:224360543:T:C	C40R	0.997
1:224360544:G:A	C40Y	0.997
1:224360547:G:A	C41Y	0.997
1:224371324:C:A	P98Q	0.997
1:224371351:T:C	L107P	0.997
1:224371387:G:A	G119D	0.997
1:224371404:T:C	F125L	0.997
1:224371406:C:A	F125L	0.997
1:224371406:C:G	F125L	0.997
1:224371407:T:C	F126L	0.997

dbSNP variants (sampled 300 via entrez): RS1000050423 (1:224376610 A>G), RS1000061791 (1:224363349 T>C), RS1000092634 (1:224359297 CAAG>C), RS1000425144 (1:224359657 A>G), RS1000453330 (1:224378246 A>C,G), RS1000480488 (1:224367103 T>G), RS1000693742 (1:224373439 G>A), RS1000728900 (1:224373679 T>C), RS1000735489 (1:224360794 G>A), RS1000807880 (1:224378461 G>C,T), RS1000902398 (1:224356151 C>T), RS1001102924 (1:224371825 C>T), RS1001237458 (1:224360128 G>C,T), RS1001239200 (1:224367146 T>A), RS1001322763 (1:224366704 A>G)

Disease associations

OMIM: gene MIM:617483 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000856_1	Major depressive disorder	4.000000e-06
GCST010241_437	Apolipoprotein A1 levels	1.000000e-11
GCST010242_381	HDL cholesterol levels	4.000000e-10
GCST011743_68	HDL cholesterol levels in HIV infection	8.000000e-06
GCST90002385_109	High light scatter reticulocyte count	2.000000e-09
GCST90002386_229	High light scatter reticulocyte percentage of red cells	5.000000e-12
GCST90002405_102	Reticulocyte count	1.000000e-10
GCST90002406_123	Reticulocyte fraction of red cells	1.000000e-14

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tretinoin	decreases expression, increases expression	2
Valproic Acid	increases expression	2
dicrotophos	decreases expression	1
bisphenol A	increases expression	1
salinomycin	decreases expression	1
trichostatin A	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	decreases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
4-phenylbutyric acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	affects expression	1
Sunitinib	increases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Selenium	decreases expression	1
Smoke	decreases expression, increases abundance	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	increases expression	1
Copper Sulfate	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2UL	Abcam HEK293T CNIH4 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.